Publisher Correction: Total synthesis of the reported structure of 13a-hydroxytylophorine.

abstract：:Plants exude a diverse cocktail of metabolites into the soil as response to exogenous and endogenous factors. So far, root exudates have mainly been studied under artificial conditions due to methodological difficulties. In this study, each five perennial grass and forb species were investigated for polar and semi-pol...

journal_title：Scientific reports

authors： Dietz S,Herz K,Gorzolka K,Jandt U,Bruelheide H,Scheel D

更新日期：2020-07-01 00:00:00

abstract：:The original motivation of the article is to give a systematic investigation on the protocol of combining computer simulation and accurate synthesis of serial peptide protected gold clusters for potent tumor targeting therapy. Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant selenoenzyme that regulates cellul...

journal_title：Scientific reports

authors： Liu M,Gao L,Zhao L,He J,Yuan Q,Zhang P,Zhao Y,Gao X

更新日期：2017-03-09 00:00:00

abstract：:Ion mobility mass spectrometry (IM-MS) is a technique capable of investigating structural changes of biomolecules based on their collision cross section (CCS). Recent advances in IM-MS allow us to separate carbohydrate isomers with subtle conformational differences, but the relationship between CCS and atomic structur...

journal_title：Scientific reports

authors： Re S,Watabe S,Nishima W,Muneyuki E,Yamaguchi Y,MacKerell AD Jr,Sugita Y

更新日期：2018-01-26 00:00:00

abstract：:We evaluate the track segment yield G' of typical water radiolysis products (eaq-, ·OH and H2O2) under heavy ions (He, C and Fe ions) using a Monte Carlo simulation code in the Geant4-DNA. Furthermore, we reproduce experimental results of ·OH of He and C ions around the Bragg peak energies (< 6 MeV/u). In the relative...

journal_title：Scientific reports

authors： Baba K,Kusumoto T,Okada S,Ogawara R,Kodaira S,Raffy Q,Barillon R,Ludwig N,Galindo C,Peaupardin P,Ishikawa M

更新日期：2021-01-15 00:00:00

abstract：:The onset of inversion in the metal-oxide-semiconductor field-effect transistor (MOSFET) takes place when the surface potential is approximately twice the bulk potential. In contrast, the conduction threshold in accumulation mode transistors, such as the oxide thin film transistor (TFT), has remained ambiguous in view...

journal_title：Scientific reports

authors： Lee S,Nathan A

更新日期：2016-03-02 00:00:00

abstract：:The dorsal striatum is a brain region involved in action control, with dorsomedial striatum (DMS) mediating goal-directed actions and dorsolateral striatum (DLS) mediating habitual actions. Presynaptic long-term synaptic depression (LTD) plasticity at glutamatergic inputs to dorsal striatum mediates many dorsal striat...

journal_title：Scientific reports

authors： Muñoz B,Haggerty DL,Atwood BK

更新日期：2020-04-29 00:00:00

abstract：:INK4 locus at chromosome 9p21 has been reported to be associated with primary open angle glaucoma (POAG) and its subtypes along with the associated optic disc parameters across the populations of European, Japanese and African ancestries. The locus encodes three tumor suppressor genes namely CDKN2A, ARF, CDKN2B and a ...

journal_title：Scientific reports

authors： Vishal M,Sharma A,Kaurani L,Chakraborty S,Ray J,Sen A,Mukhopadhyay A,Ray K

更新日期：2014-05-30 00:00:00

abstract：:We propose a novel method to achieve tunable plasmon focusing in graphene/photonic-crystal hybrid structure exhibiting all-angle negative refraction at terahertz frequencies. A two-dimensional photonic crystal composed of a square lattice of dielectric rods is constructed on the substrate of a graphene sheet to provid...

journal_title：Scientific reports

authors： Zhong S,Lu Y,Li C,Xu H,Shi F,Chen Y

更新日期：2017-02-02 00:00:00

abstract：:Many outbreaks of A(H1N1)pdm09 influenza have occurred in schools with a high population density. Containment of school outbreaks is predicted to help mitigate pandemic influenza. Understanding disease transmission characteristics within the school setting is critical to implementing effective control measures. Based ...

journal_title：Scientific reports

authors： Wang L,Chu C,Yang G,Hao R,Li Z,Cao Z,Qiu S,Li P,Wu Z,Yuan Z,Xu Y,Zeng D,Wang Y,Song H

更新日期：2014-08-07 00:00:00

abstract：:Niemann-Pick type C1 (NPC1) disease is a rare autosomal recessive, neurodegenerative lysosomal storage disorder, which presents with a range of clinical phenotypes and hence diagnosis remains a challenge. In view of these difficulties, the search for a novel, NPC1-specific biomarker (or set of biomarkers) is a topic o...

journal_title：Scientific reports

authors： Probert F,Ruiz-Rodado V,Vruchte DT,Nicoli ER,Claridge TDW,Wassif CA,Farhat N,Porter FD,Platt FM,Grootveld M

更新日期：2017-07-24 00:00:00

abstract：:The recent Paris UNFCCC climate meeting discussed the possibility of limiting global warming to 2 °C since pre-industrial times, or possibly even 1.5 °C, which would require major future emissions reductions. However, even if climate is stabilised at current atmospheric greenhouse gas (GHG) concentrations, those warmi...

journal_title：Scientific reports

authors： Huntingford C,Mercado LM

更新日期：2016-07-27 00:00:00

abstract：:A number of Bruton's tyrosine kinase (BTK) inhibitors are currently in development, yet it has been difficult to visualize BTK expression and pharmacological inhibition in vivo in real time. We synthesized a fluorescent, irreversible BTK binder based on the drug Ibrutinib and characterized its behavior in cells and in...

journal_title：Scientific reports

authors： Turetsky A,Kim E,Kohler RH,Miller MA,Weissleder R

更新日期：2014-04-24 00:00:00

abstract：:F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (Arg465, Arg479, and ...

journal_title：Scientific reports

authors： Ikenoue T,Terakado Y,Zhu C,Liu X,Ohsugi T,Matsubara D,Fujii T,Kakuta S,Kubo S,Shibata T,Yamaguchi K,Iwakura Y,Furukawa Y

更新日期：2018-01-31 00:00:00

abstract：:Prostate cancer (PCa) is the most common solid neoplasm diagnosed in developed countries. Nerve-sparing radical prostatectomy (NS-RP) has been widely accepted as the best choice treatment for localised PCa. However, erectile dysfunction (ED) and urinary incontinence are commonly observed after NS-RP. Using meta-analys...

journal_title：Scientific reports

authors： Li J,Shi Q,Pu C,Tang Y,Bai Y,Yuan H,Li X,Dong Q,Wei Q,Yuan J,Han P

更新日期：2014-07-23 00:00:00

abstract：:In recent years it has been shown that the therapeutic benefits of human mesenchymal stem/stromal cells (hMSCs) in the Central Nervous System (CNS) are mainly attributed to their secretome. The implementation of computer-controlled suspension bioreactors has shown to be a viable route for the expansion of these cells ...

journal_title：Scientific reports

authors： Teixeira FG,Panchalingam KM,Assunção-Silva R,Serra SC,Mendes-Pinheiro B,Patrício P,Jung S,Anjo SI,Manadas B,Pinto L,Sousa N,Behie LA,Salgado AJ

更新日期：2016-06-15 00:00:00

abstract：:Non-homologous end-joining (NHEJ), which can promote genomic instability when dysfunctional, is a major DNA double-strand break (DSB) repair pathway. Although ubiquitylation of the core NHEJ factor, Ku (Ku70-Ku80), which senses broken DNA ends, is important for its removal from sites of damage upon completion of NHEJ,...

journal_title：Scientific reports

authors： Nishi R,Wijnhoven PWG,Kimura Y,Matsui M,Konietzny R,Wu Q,Nakamura K,Blundell TL,Kessler BM

更新日期：2018-12-17 00:00:00

abstract：:We present a new method for the design of devices to manipulate the displacement field in Elastic materials. It consists of solving a nonlinear optimization problem where the objective function defines the error in matching a desired displacement field, and the design variables determine the required material distribu...

journal_title：Scientific reports

authors： Fachinotti VD,Peralta I,Albanesi AE

更新日期：2018-06-29 00:00:00

abstract：:Current medications inadequately treat the symptoms of chronic pain experienced by over 50 million people in the United States, and may come with substantial adverse effects signifying the need to find novel treatments. One novel therapeutic target is the Transient Receptor Potential A1 channel (TRPA1), an ion channel...

journal_title：Scientific reports

authors： Ko MJ,Ganzen LC,Coskun E,Mukadam AA,Leung YF,van Rijn RM

更新日期：2019-02-20 00:00:00

abstract：:Rapid urbanization is a global phenomenon that has altered many ecosystems, generating ecological risks such as causing a decline in many ecosystem services. In this study, ecosystem service oriented risk assessment combined with PSR were quantifying how urbanization influences the ecosystem services about Beijing-Tia...

journal_title：Scientific reports

authors： Kang P,Chen W,Hou Y,Li Y

更新日期：2019-11-14 00:00:00

abstract：:Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encoura...

journal_title：Scientific reports

authors： Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B

更新日期：2017-11-02 00:00:00

abstract：:The rapid increase in the number of genetically modified (GM) varieties has led to a demand for high-throughput methods to detect genetically modified organisms (GMOs). We describe a new dynamic array-based high throughput method to simultaneously detect 48 targets in 48 samples on a Fludigm system. The test targets i...

journal_title：Scientific reports

authors： Li X,Wu Y,Li J,Li Y,Long L,Li F,Wu G

更新日期：2015-01-05 00:00:00

abstract：:Recently, extracorporeal shock wave therapy (ESWT) has been shown to be a novel therapy for carpal tunnel syndrome (CTS). However, previous studies did not examine the diverse effects of different-session ESWT for different-grades CTS. Thus, we conducted a randomized, single-blind, placebo-controlled study. Sixty-nine...

journal_title：Scientific reports

authors： Ke MJ,Chen LC,Chou YC,Li TY,Chu HY,Tsai CK,Wu YT

更新日期：2016-12-02 00:00:00

abstract：:AMPA subtype ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission across excitatory synapses in the central nervous system. Each AMPA receptor is composed of four multi-domain subunits that are organized into layers of two amino-terminal domain (ATD) dimers, two ligand-binding domain ...

journal_title：Scientific reports

authors： Yelshanskaya MV,Saotome K,Singh AK,Sobolevsky AI

更新日期：2016-01-07 00:00:00

abstract：:The work describes the development of a flexible, hydrogel embedded pH-sensor that can be integrated in inexpensive wearable and non-invasive devices at epidermal level for electrochemical quantification of H+ ions in sweat. Such a device can be useful for swift, real time diagnosis and for monitoring specific conditi...

journal_title：Scientific reports

authors： Diculescu VC,Beregoi M,Evanghelidis A,Negrea RF,Apostol NG,Enculescu I

更新日期：2019-06-20 00:00:00

abstract：:Chaetosiphella stipae stipae is a xerothermophilous aphid, associated with Palaearctic temperate steppe zones or dry mountain valleys, where there are grasses from the genus Stipa. Its geographical distribution shows several populations that are spread from Spain, across Europe and Asia Minor, to Mongolia and China. G...

journal_title：Scientific reports

authors： Wieczorek K,Bugaj-Nawrocka A,Kanturski M,Miller GL

更新日期：2017-03-08 00:00:00

abstract：:Peripheral nerve long gap defects are a clinical challenge in the regeneration field. Despite the wide variety of surgical techniques and therapies, autografting is the "gold standard" for peripheral nerve gap reconstruction. The pathological process of Wallerian degeneration from the time of acute injury to efficient...

journal_title：Scientific reports

authors： Ge J,Zhu S,Yang Y,Liu Z,Hu X,Huang L,Quan X,Wang M,Huang J,Li Y,Luo Z

更新日期：2016-12-23 00:00:00

abstract：:Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investiga...

journal_title：Scientific reports

authors： Won E,Kang J,Choi S,Kim A,Han KM,Yoon HK,Cho SH,Tae WS,Lee MS,Joe SH,Kim YK,Ham BJ

更新日期：2017-08-29 00:00:00

abstract：:Emergence of resistant Plasmodium species makes drug efficacy testing a crucial part of malaria control. Here we describe a novel assay for sensitive, fast and simple drug screening via the magneto-optical detection of hemozoin, a natural biomarker formed during the hemoglobin metabolism of Plasmodium species. By quan...

journal_title：Scientific reports

authors： Molnár P,Orbán Á,Izrael R,Babai R,Marton L,Butykai Á,Karl S,Vértessy BG,Kézsmárki I

更新日期：2020-08-20 00:00:00

abstract：:A 3D cell culture is preferred to 2D cell culture since it allows cells to grow in all directions in vitro, similar to how they would in vivo. 3D cell culture plates currently used in tissue engineering research have limited access to control the geometry. Furthermore, 3D cell culture plate manufacturing methods are r...

journal_title：Scientific reports

authors： Lee D,Pathak S,Jeong JH

更新日期：2019-09-27 00:00:00

abstract：:Birgus latro (coconut crab) is an edible crustacean that has experienced serious overharvesting throughout its whole habitat range; however, the negative effects of overharvesting on the genetic diversity within B. latro populations have not been elucidated. Here, we report sex ratio, body size, and genetic diversity ...

journal_title：Scientific reports

authors： Yorisue T,Iguchi A,Yasuda N,Yoshioka Y,Sato T,Fujita Y

更新日期：2020-06-22 00:00:00