Phosphodiesterase type 5 inhibitors for the treatment of post-nerve sparing radical prostatectomy erectile dysfunction in men.

abstract：:Myeloid-derived suppressor cells (MDSCs) expand during inflammation and exhibit immunomodulatory functions on innate and adaptive immunity. However, their impact on trauma-induced immune responses, characterized by an early pro-inflammatory phase and dysregulated adaptive immunity involving lymphocyte apoptosis, exhau...

journal_title：Scientific reports

authors： Kustermann M,Klingspor M,Huber-Lang M,Debatin KM,Strauss G

更新日期：2019-05-29 00:00:00

abstract：:This study was to evaluate the prognostic value of pretreatment inflammatory indexes including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) in colorectal cancer (CRC) patients receiving neoadjuvant chemoradiot...

journal_title：Scientific reports

authors： Yang J,Xu H,Guo X,Zhang J,Ye X,Yang Y,Ma X

更新日期：2018-02-14 00:00:00

abstract：:Although gut microbiota and early life events are likely involved in the development of irritable bowel syndrome (IBS), it remains unclear how these factors interact in the pathophysiology of IBS. In the present study, using rats subjected to maternal separation (MS) as a model of IBS, we investigated interrelationshi...

journal_title：Scientific reports

authors： Fukui H,Oshima T,Tanaka Y,Oikawa Y,Makizaki Y,Ohno H,Tomita T,Watari J,Miwa H

更新日期：2018-08-17 00:00:00

abstract：:The most downstream elements of the Hippo pathway, the TEAD transcription factors, are regulated by several cofactors, such as Vg/VGLL1-3. Earlier findings on human VGLL1 and here on human VGLL3 show that these proteins interact with TEAD via a conserved amino acid motif called the TONDU domain. Surprisingly, our stud...

journal_title：Scientific reports

authors： Mesrouze Y,Aguilar G,Bokhovchuk F,Martin T,Delaunay C,Villard F,Meyerhofer M,Zimmermann C,Fontana P,Wille R,Vorherr T,Erdmann D,Furet P,Scheufler C,Schmelzle T,Affolter M,Chène P

更新日期：2020-10-15 00:00:00

abstract：:Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis. From 24 weeks of age, NZB/NZW F1 mice were injected with alpha-galactosylceramide (α-GalCer) or vehicle once a week for four weeks. In the α-GalC...

journal_title：Scientific reports

authors： Uchida T,Nakashima H,Yamagata A,Ito S,Ishikiriyama T,Nakashima M,Seki S,Kumagai H,Oshima N

更新日期：2018-05-29 00:00:00

abstract：:β-Glucosidases are enzymes that hydrolyze β-glycosidic bonds to release non-reducing terminal glucosyl residues from glycosides and oligosaccharides, and thus have significant application potential in industries. However, most β-glucosidases are feedback inhibited by the glucose product, which restricts their applicat...

journal_title：Scientific reports

authors： Yang Y,Zhang X,Yin Q,Fang W,Fang Z,Wang X,Zhang X,Xiao Y

更新日期：2015-11-25 00:00:00

abstract：:A classical model for social-influence-driven opinion change is the threshold model. Here we study cascades of opinion change driven by threshold model dynamics in the case where multiple initiators trigger the cascade, and where all nodes possess the same adoption threshold ϕ. Specifically, using empirical and styliz...

journal_title：Scientific reports

authors： Singh P,Sreenivasan S,Szymanski BK,Korniss G

更新日期：2013-01-01 00:00:00

abstract：:Stem and progenitor cells are the critical units for tissue maintenance, regeneration, and repair. The activation of regenerative events in response to tissue injury has been correlated with mobilization of tissue-resident progenitor cells, which is functional to the wound healing process. However, until now there has...

journal_title：Scientific reports

authors： Lo Sicco C,Tasso R,Reverberi D,Cilli M,Pfeffer U,Cancedda R

更新日期：2015-11-12 00:00:00

abstract：:Inconsistent findings have reported on the inflammatory potential of diet and cardiovascular disease (CVD) and mortality risk. The aim of this meta-analysis was to investigate the association between the inflammatory potential of diet as estimated by the dietary inflammatory index (DII) score and CVD or mortality risk...

journal_title：Scientific reports

authors： Zhong X,Guo L,Zhang L,Li Y,He R,Cheng G

更新日期：2017-07-25 00:00:00

abstract：:Heterostructures based on two-dimensional (2D) materials have sparked wide interests in both fundamental physics and applied devices. Recently, Dirac/Weyl semimetals are emerging as capable functional materials for optoelectronic devices. However, thus far the interfacial coupling of an all-semimetal 2D heterostructur...

journal_title：Scientific reports

authors： Liu Y,Liu C,Wang X,He L,Wan X,Xu Y,Shi Y,Zhang R,Wang F

更新日期：2018-08-27 00:00:00

abstract：:We present a detailed experimental and theoretical study of the acoustic phonon modes in rolled-up multilayers with thickness of the layers in the nanometre and diameters in the micrometre range. We compare our results to planar, unrolled multilayers grown by molecular beam epitaxy. For the planar multilayers the expe...

journal_title：Scientific reports

authors： Brick D,Engemaier V,Guo Y,Grossmann M,Li G,Grimm D,Schmidt OG,Schubert M,Gusev VE,Hettich M,Dekorsy T

更新日期：2017-07-14 00:00:00

abstract：:Early treatment, soon after infection, reduces HIV transmissions and benefits patients. The Transmission Reduction Intervention Project (TRIP) evaluated a network intervention to detect individuals recently infected (in the past 6 months). TRIP was conducted in Greece (2013-2015) and focused on drug injector networks....

journal_title：Scientific reports

authors： Nikolopoulos GK,Pavlitina E,Muth SQ,Schneider J,Psichogiou M,Williams LD,Paraskevis D,Sypsa V,Magiorkinis G,Smyrnov P,Korobchuk A,Vasylyeva TI,Skaathun B,Malliori M,Kafetzopoulos E,Hatzakis A,Friedman SR

更新日期：2016-12-05 00:00:00

abstract：:Recent results have shown that participants can enumerate multiple parts of a single object as efficiently as multiple distinct objects, suggesting a shared mechanism for individuation of objects and object parts. Here we used the subitizing phenomenon to investigate the neural mechanism underlying the individuation o...

journal_title：Scientific reports

authors： Poncet M,Caramazza A,Mazza V

更新日期：2016-12-07 00:00:00

abstract：:Dengue virus (DENV) is currently the most prevalent mosquito-borne viral pathogen. DENVs naturally exist as highly heterogeneous populations. Even though the descriptions on DENV diversity are plentiful, only a few studies have narrated the dynamics of intra-epidemic virus diversity at a fine scale. Such accounts are ...

journal_title：Scientific reports

authors： Hapuarachchi HC,Koo C,Kek R,Xu H,Lai YL,Liu L,Kok SY,Shi Y,Chuen RL,Lee KS,Maurer-Stroh S,Ng LC

更新日期：2016-03-04 00:00:00

abstract：:The effect of n-type interlayer in hybrid white organic light-emitting diodes (WOLEDs) has been systematically investigated by using various n-type materials. A new finding, that the triplet energy rather than electron mobility or hole-blocking ability of interlayer plays a more positive role in the performance of hyb...

journal_title：Scientific reports

authors： Liu B,Wang L,Xu M,Tao H,Zou J,Gao D,Lan L,Ning H,Peng J,Cao Y

更新日期：2014-11-26 00:00:00

abstract：:Carbon nanotubes exhibit mechanical properties ideally suited for reinforced structural composites and surface area and conductivity attractive for electrochemical capacitors. Here we demonstrate the multifunctional synergy between these properties in a composite material exhibiting simultaneous mechanical and energy ...

journal_title：Scientific reports

authors： Muralidharan N,Teblum E,Westover AS,Schauben D,Itzhak A,Muallem M,Nessim GD,Pint CL

更新日期：2018-12-05 00:00:00

abstract：:The oral environment affects not only oral health, but also general health, and the importance of oral self-care has recently been recognised. Although toothbrushes are the most important self-care product, there are few toothbrushes that have an inhibitory effect on oral bacteria. In the present study, monofilaments ...

journal_title：Scientific reports

authors： Matayoshi S,Nomura R,Kitamura T,Okawa R,Nakano K

更新日期：2021-01-08 00:00:00

abstract：:A previous study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium channel of Culex quinquefasciatus, the prevalence of which were strongly correlated with levels of resistance and increased dramatically following insecticide selection. However, it is unclear whether this is unique to...

journal_title：Scientific reports

authors： Li T,Zhang L,Reid WR,Xu Q,Dong K,Liu N

更新日期：2012-01-01 00:00:00

abstract：:The roles of multifunctional CD4 T cells in human tuberculosis are not well defined. In this study, we found that patients with tuberculosis had decreased PMA/ionomycin stimulated multifunctional CD4 T cells, and increased Mycobacterium tuberculosis antigen-specific multifunctional CD4 T cells, when compared to indivi...

journal_title：Scientific reports

authors： Qiu Z,Zhang M,Zhu Y,Zheng F,Lu P,Liu H,Graner MW,Zhou B,Chen X

更新日期：2012-01-01 00:00:00

abstract：:The current research on cellular heat stress management focuses on the roles of heat shock proteins (HSPs) and the proteostasis network under severe stress conditions. The mild, fever-type stress and the maintenance of membrane homeostasis are less well understood. Herein, we characterized the acute effect of mild, fe...

journal_title：Scientific reports

authors： Peksel B,Gombos I,Péter M,Vigh L Jr,Tiszlavicz Á,Brameshuber M,Balogh G,Schütz GJ,Horváth I,Vigh L,Török Z

更新日期：2017-11-15 00:00:00

abstract：:Perinatal piglet mortality is an important factor in pig production from economic and animal welfare perspectives; however, the statistical analysis of mortality is difficult because of its categorical nature. Recent studies have suggested that a binomial model for the survival of each specific piglet with a logit app...

journal_title：Scientific reports

authors： Varona L,Noguera JL,Casellas J,de Hijas MM,Rosas JP,Ibáñez-Escriche N

更新日期：2020-12-03 00:00:00

abstract：:We show an annual overview of the sea-air CO2 exchanges and primary drivers in the Gerlache Strait, a hotspot for climate change that is ecologically important in the northern Antarctic Peninsula. In autumn and winter, episodic upwelling events increase the remineralized carbon in the sea surface, leading the region t...

journal_title：Scientific reports

authors： Monteiro T,Kerr R,Machado EDC

更新日期：2020-09-10 00:00:00

abstract：:In recent years, numerous methods have emerged for the synthesis of trifluoromethylated arenes based on the late-stage introduction of a trifluoromethyl group onto an aryl ring. In sharp comparison, the synthesis of trifluoromethylated arenes based on the pre-introduction of a trifluoromethyl group onto an "aromatic t...

journal_title：Scientific reports

authors： Dong J,Shi L,Pan L,Xu X,Liu Q

更新日期：2016-06-01 00:00:00

abstract：:Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflam...

journal_title：Scientific reports

authors： Xiao Q,Dong N,Yao X,Wu D,Lu Y,Mao F,Zhu J,Li J,Huang J,Chen A,Huang L,Wang X,Yang G,He G,Xu Y,Lu W

更新日期：2016-04-29 00:00:00

abstract：:We study the spreading of cell aggregates deposited on adhesive substrates decorated with microparticles (MPs). A cell monolayer expands around the aggregate. The cells on the periphery of the monolayer take up the MPs, clearing the substrate as they progress and forming an aureole of cells filled with MPs. We study t...

journal_title：Scientific reports

authors： Beaune G,Lam AYW,Dufour S,Winnik FM,Brochard-Wyart F

更新日期：2017-11-16 00:00:00

abstract：:The quest to 'forward-engineer' and fabricate biological machines remains a grand challenge. Towards this end, we have fabricated locomotive "bio-bots" from hydrogels and cardiomyocytes using a 3D printer. The multi-material bio-bot consisted of a 'biological bimorph' cantilever structure as the actuator to power the ...

journal_title：Scientific reports

authors： Chan V,Park K,Collens MB,Kong H,Saif TA,Bashir R

更新日期：2012-01-01 00:00:00

abstract：:Renal fibrosis, the characteristic feature of progressive chronic kidney disease, is associated with unremitting renal inflammation. Although it is reported that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, elicits an anti-renal fibrotic effect, its molecular mechanism is still unknown. In thi...

journal_title：Scientific reports

authors： Bi J,Watanabe H,Fujimura R,Nishida K,Nakamura R,Oshiro S,Imafuku T,Komori H,Miyahisa M,Tanaka M,Matsushita K,Maruyama T

更新日期：2018-11-26 00:00:00

abstract：:The unfolded protein response (UPR) not only resolves endoplasmic reticulum (ER) stress, but also regulates cellular physiological functions. In this study, we first linked the UPR to the physiological roles of brown adipose tissue (BAT). BAT is one of the tissues that control energy homeostasis in the body. Brown adi...

journal_title：Scientific reports

authors： Asada R,Kanemoto S,Matsuhisa K,Hino K,Cui M,Cui X,Kaneko M,Imaizumi K

更新日期：2015-11-16 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Pham TQ,Kawaue T,Hoshi T,Tanaka Y,Miyata T,Sano A

更新日期：2018-09-07 00:00:00

abstract：:The static synchronous series compensator (SSSC) can add a series reactance to the transmission line, and when it is fed using auxiliary signals, it can participate in damping inter-area oscillations by changing the series reactance. In this paper, the effect of the SSSC on small-signal stability is investigated. The ...

journal_title：Scientific reports

authors： Naderipour A,Abdul-Malek Z,Ramachandaramurthy VK,Miveh MR,Moghaddam MJH,Guerrero JM

更新日期：2020-07-22 00:00:00