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Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice.

Abstract：

:Lupus nephritis is a crucial complication of systemic lupus erythematosus. In this study, we investigated the roles of mouse natural killer T (NKT) cells in lupus nephritis. From 24 weeks of age, NZB/NZW F1 mice were injected with alpha-galactosylceramide (α-GalCer) or vehicle once a week for four weeks. In the α-GalCer group, the levels of proteinuria and blood urea nitrogen were significantly lower than those in the vehicle group. The histological evaluation showed a decrease in glomerular immune complex deposits and an alleviation of podocyte injury. The proportion of NKT cells in the mononuclear cell (MNC) fraction in the α-GalCer group was significantly decreased in the liver, kidney, and spleen. The proliferation and cytokine production in α-GalCer-stimulated liver MNCs were markedly diminished in the α-GalCer group (anergy). The IFN-γ production in liver MNCs stimulated by concanavalin A or an anti-CD3 antibody did not differ between the two groups, whereas the IL-4 production was significantly lower in the α-GalCer group. In addition, the IgM production in CpG-oligodeoxynucleotide-stimulated spleen MNCs was significantly lower in the α-GalCer group. These results suggest that α-GalCer suppressed Th2 immune responses in NKT cells and B cell function, thereby slowing the progression of lupus nephritis.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Uchida T,Nakashima H,Yamagata A,Ito S,Ishikiriyama T,Nakashima M,Seki S,Kumagai H,Oshima N

doi

10.1038/s41598-018-26470-w

subject

Has Abstract

pub_date

2018-05-29 00:00:00

pages

8225

issue

1

issn

2045-2322

pii

10.1038/s41598-018-26470-w

journal_volume

8

pub_type

杂志文章

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