Intra-epidemic evolutionary dynamics of a Dengue virus type 1 population reveal mutant spectra that correlate with disease transmission.

abstract：:The Plasmodium life cycle within the mosquito involves the gamete, zygote, motile ookinete, and the oocyst stage that supports sporogony and sporozoite formation. We mapped the P. falciparum transcriptome as the parasite progresses through the oocyst stage of development on days 2, 4, 6, and 8 post-P. falciparum infec...

journal_title：Scientific reports

authors： Oakley MS,Verma N,Myers TG,Zheng H,Locke E,Morin MJ,Tripathi AK,Mlambo G,Kumar S

更新日期：2018-08-01 00:00:00

abstract：:Early fruit development is crucial for crop production in tomato. After fertilization, the ovary undergoes cell division and cell expansion before maturation. Although the roles of regulatory signals such as hormone and carbohydrate during early fruit development have been studied, the spatial distribution and the seq...

journal_title：Scientific reports

authors： Zhang S,Xu M,Qiu Z,Wang K,Du Y,Gu L,Cui X

更新日期：2016-03-18 00:00:00

abstract：:Cells harboring latent HIV-1 pose a major obstacle to eradication of the virus. The 'shock and kill' strategy has been broadly explored to purge the latent reservoir; however, none of the current latency-reversing agents (LRAs) can safely and effectively activate the latent virus in patients. In this study, we report ...

journal_title：Scientific reports

authors： Wang P,Lu P,Qu X,Shen Y,Zeng H,Zhu X,Zhu Y,Li X,Wu H,Xu J,Lu H,Ma Z,Zhu H

更新日期：2017-08-25 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis, which urgently demanding new drugs for treating infection. Two homologous insect CSαβ peptides-DLP2 and DLP4 from Hermetia illucens were firstly expressed in Pichia pastoris, with the yields of 873.5 and 801.3 mg/l, respectively...

journal_title：Scientific reports

authors： Li Z,Mao R,Teng D,Hao Y,Chen H,Wang X,Wang X,Yang N,Wang J

更新日期：2017-09-21 00:00:00

abstract：:Pesticides, including neonicotinoids, typically target pest insects by being neurotoxic. Inadvertent exposure to foraging insect pollinators is usually sub-lethal, but may affect cognition. One cognitive trait, spatial working memory, may be important in avoiding previously-visited flowers and other spatial tasks such...

journal_title：Scientific reports

authors： Samuelson EE,Chen-Wishart ZP,Gill RJ,Leadbeater E

更新日期：2016-12-13 00:00:00

abstract：:Many established inflammation- and nutrition-related factors have been investigated as potential independent prognostic factors in various cancers, including the C-reactive protein/albumin ratio (CAR), lymphocyte/monocyte ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutr...

journal_title：Scientific reports

authors： Zhang W,Ye B,Liang W,Ren Y

更新日期：2017-08-25 00:00:00

abstract：:In order to improve the accuracy and reliability of micropipetting, a method of micro-pipette detection and calibration combining the dynamic pressure monitoring in pipetting process and quantitative identification of pipette volume in image processing was proposed. Firstly, the normalized pressure model for the pipet...

journal_title：Scientific reports

authors： Shang Z,Zhou X,Li C,Tsai SB

更新日期：2018-04-10 00:00:00

abstract：:The threshold size for enlarged abdominal lymph nodes (E-ALNs), a common pediatric disorder, has yet to be standardized. According to the maximum short-axis diameter, this study divided ALNs into Grade A (≥ 10 mm), Grade B (8-10 mm), Grade C (5-8 mm), and Grade D (< 5 mm, normal). To identify the threshold size for E-...

journal_title：Scientific reports

authors： He L,Sun Y,Huang G

更新日期：2021-01-19 00:00:00

abstract：:Developing rationally controlled bottom-up device fabrication processes is essential for the achievement of high performance optimal devices. We report a controlled, seedless and site-selective hydrothermal technique to fabricate high-performance nanostructured ZnO UV-detectors directly on-chip. We demonstrate that by...

journal_title：Scientific reports

authors： Alenezi MR,Henley SJ,Silva SR

更新日期：2015-02-17 00:00:00

abstract：:Urban water supplies are critical to the growth of the city and the wellbeing of its citizens. However, these supplies can be vulnerable to hydrological extremes, such as droughts and floods, especially if they are the main source of water for the city. Maintaining these supplies and preparing for future conditions is...

journal_title：Scientific reports

authors： Obringer R,Nateghi R

更新日期：2018-03-26 00:00:00

abstract：:In this paper, we propose a real time, ultrahigh accuracy and full-field-of-view (RUF) algorithm for full field of view (FOV) imaging system. The proposed algorithm combines rough matching and precise matching method to stitch multiple images with the whole FOV in short time and high imaging quality. In order to verif...

journal_title：Scientific reports

authors： Liu SB,Wang JH,Yuan RY,Zhao WX,Li L,Wang QH

更新日期：2020-07-24 00:00:00

abstract：:Fractal behavior is scale-invariant and widely characterized by fractal dimension. However, the cor-respondence between them is that fractal behavior uniquely determines a fractal dimension while a fractal dimension can be related to many possible fractal behaviors. Therefore, fractal behavior is independent of the fr...

journal_title：Scientific reports

authors： Jin Y,Wu Y,Li H,Zhao M,Pan J

更新日期：2017-04-24 00:00:00

abstract：:Identifying the vital nodes in networks is of great significance for understanding the function of nodes and the nature of networks. Many centrality indices, such as betweenness centrality (BC), eccentricity centrality (EC), closeness centricity (CC), structural holes (SH), degree centrality (DC), PageRank (PR) and ei...

journal_title：Scientific reports

authors： Xu X,Zhu C,Wang Q,Zhu X,Zhou Y

更新日期：2020-02-14 00:00:00

abstract：:Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions ...

journal_title：Scientific reports

authors： Tu S,Yuan GC,Shao Z

更新日期：2017-01-31 00:00:00

abstract：:In day-to-day life, humans usually perceive the location of sound sources as outside their heads. This externalized auditory spatial perception can be reproduced through headphones by recreating the sound pressure generated by the source at the listener's eardrums. This requires the acoustical features of the recordin...

journal_title：Scientific reports

authors： Gil-Carvajal JC,Cubick J,Santurette S,Dau T

更新日期：2016-11-17 00:00:00

abstract：:Marek's disease virus (MDV) is a highly cell-associated alphaherpesvirus that causes deadly lymphomas in chickens. While vaccination protects against clinical symptoms, MDV field strains can still circulate in vaccinated flocks and continuously evolve towards greater virulence. MDV vaccines do not provide sterilizing ...

journal_title：Scientific reports

authors： Hagag IT,Wight DJ,Bartsch D,Sid H,Jordan I,Bertzbach LD,Schusser B,Kaufer BB

更新日期：2020-07-02 00:00:00

abstract：:Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important roles in modulating he...

journal_title：Scientific reports

authors： Wang RH,Zhao T,Cui K,Hu G,Chen Q,Chen W,Wang XW,Soto-Gutierrez A,Zhao K,Deng CX

更新日期：2016-06-27 00:00:00

abstract：:Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J...

journal_title：Scientific reports

authors： Kaushik A,Jayant RD,Nikkhah-Moshaie R,Bhardwaj V,Roy U,Huang Z,Ruiz A,Yndart A,Atluri V,El-Hage N,Khalili K,Nair M

更新日期：2016-05-04 00:00:00

abstract：:Molecular dynamics (MD) simulations lasting 500 ns were performed in explicit water to investigate the effect of polarization on the binding of ligands to human α-thrombin based on the standard nonpolarizable AMBER force field and the quantum-derived polarized protein-specific charge (PPC). The PPC includes the electr...

journal_title：Scientific reports

authors： Duan LL,Feng GQ,Zhang QG

更新日期：2016-08-10 00:00:00

abstract：:Brain imaging genetics intends to uncover associations between genetic markers and neuroimaging quantitative traits. Sparse canonical correlation analysis (SCCA) can discover bi-multivariate associations and select relevant features, and is becoming popular in imaging genetic studies. The L1-norm function is not only ...

journal_title：Scientific reports

authors： Du L,Liu K,Yao X,Yan J,Risacher SL,Han J,Guo L,Saykin AJ,Shen L,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2017-10-25 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disease. Increasing the chances of success for future clinical strategies requires more in-depth knowledge of the molecular basis underlying disease heterogeneity. We recently laid the foundation for a molecular taxonomy of ALS by whole-ge...

journal_title：Scientific reports

authors： Morello G,Guarnaccia M,Spampinato AG,Salomone S,D'Agata V,Conforti FL,Aronica E,Cavallaro S

更新日期：2019-07-10 00:00:00

abstract：:This study evaluates the forensic utility of 23 autosomal short tandem repeat markers in 400 samples from the Kuwaiti population, of which four markers (D10S1248, D22S1045, D2S441 and SE33) are reported for the first time for Kuwait. All the markers were shown to exhibit no deviation from Hardy-Weinberg equilibrium, n...

journal_title：Scientific reports

authors： Haidar M,Abbas FA,Alsaleh H,Haddrill PR

更新日期：2021-01-21 00:00:00

abstract：:One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report he...

journal_title：Scientific reports

authors： Schroeder K,Chiggiato J,Bryden HL,Borghini M,Ben Ismail S

更新日期：2016-03-11 00:00:00

abstract：:Surface-enhanced Raman spectroscopy (SERS) is considered a highly promising technology for different analytical purposes. The applications of SERS are still quite limited due its relatively poor quantitative repeatability and the fact that SERS is very sensitive to oxidation, which is a challenge especially with silve...

journal_title：Scientific reports

authors： Matikainen A,Nuutinen T,Itkonen T,Heinilehto S,Puustinen J,Hiltunen J,Lappalainen J,Karioja P,Vahimaa P

更新日期：2016-11-16 00:00:00

abstract：:This study investigated how changes in reservoir water level affect mosquito abundance and malaria transmission in Ethiopia. Digital elevation models of three Ethiopian dams at lowland, midland and highland elevations were used to quantify water surface area and wetted shoreline at different reservoir water levels (70...

journal_title：Scientific reports

authors： Kibret S,Ryder D,Wilson GG,Kumar L

更新日期：2019-12-02 00:00:00

abstract：:Quantitative measurement and analysis of tumor metabolic activities could provide a more optimal solution to personalized accurate dose painting. We collected PET images of 58 lung cancer patients, in which the tumor exhibits heterogeneous FDG uptake. We design an automated delineation and quantitative heterogeneity m...

journal_title：Scientific reports

authors： Wang X,Cui H,Gong G,Fu Z,Zhou J,Gu J,Yin Y,Feng D

更新日期：2018-07-13 00:00:00

abstract：:Many community detection algorithms have been developed to uncover the mesoscopic properties of complex networks. However how good an algorithm is, in terms of accuracy and computing time, remains still open. Testing algorithms on real-world network has certain restrictions which made their insights potentially biased...

journal_title：Scientific reports

authors： Yang Z,Algesheimer R,Tessone CJ

更新日期：2016-08-01 00:00:00

abstract：:Up to 90% of people with neurological deficits following whiplash injury report chronic symptoms. A recent unique study of neck-specific exercise showed positive results (post-intervention at 12 weeks), regarding arm pain and neurological deficits in people with chronic whiplash associated disorders (WAD). This 1-year...

journal_title：Scientific reports

authors： Ludvigsson ML,Peterson G,Peolsson A

更新日期：2020-04-21 00:00:00

abstract：:Inhibitors of PD-1 signaling have revolutionized cancer therapy. PD-1 and PD-L1 antibodies have been approved for the treatment of cancer. To date, therapeutic PD-1 inhibitors have not been compared in a functional assay. We used an efficient T cell reporter platform to evaluate the efficacy of five clinically used PD...

journal_title：Scientific reports

authors： De Sousa Linhares A,Battin C,Jutz S,Leitner J,Hafner C,Tobias J,Wiedermann U,Kundi M,Zlabinger GJ,Grabmeier-Pfistershammer K,Steinberger P

更新日期：2019-08-07 00:00:00

abstract：:Fabrication of uniform vertically-aligned titanium dioxide nanorods (TiO2 NRs) was achieved by hydrothermal growth on a fluorine-doped tin oxide (FTO) glass substrate. The substrate was coated by a TiO2 seed layer composed of titanium (IV) butoxide (TBO) as a precursor in an HCl solution. To reduce the amount of toxic...

journal_title：Scientific reports

authors： Prathan A,Sanglao J,Wang T,Bhoomanee C,Ruankham P,Gardchareon A,Wongratanaphisan D

更新日期：2020-05-15 00:00:00