Abstract:
:Up to 90% of people with neurological deficits following whiplash injury report chronic symptoms. A recent unique study of neck-specific exercise showed positive results (post-intervention at 12 weeks), regarding arm pain and neurological deficits in people with chronic whiplash associated disorders (WAD). This 1-year follow-up of that randomised controlled study with assessor blinding aimed to examine whether neck-specific exercise with (NSEB) or without (NSE) a behavioural approach has long-term benefits over physical activity prescription (PPA) regarding arm pain and neurological deficits (n = 171). Interventions were: NSE, NSEB, or PPA. Follow-up of arm pain, paraesthesia bothersomeness (questionnaires) and clinical neurological tests were performed after 3, 6 and 12 months and analysed with Linear Mixed Models and General Estimating Equations. The NSE and/or NSEB groups reported significantly less pain and paraesthesia bothersomeness as well as higher odds of normal key muscle arm strength and of normal upper limb neural tension over the year (all p < 0.03), compared with PPA. In conclusion, results suggest that neck-specific exercise with or without a behavioural approach may have persisting long term benefits over PPA regarding arm pain and clinical signs associated with neurological deficits in chronic WAD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ludvigsson ML,Peterson G,Peolsson Adoi
10.1038/s41598-020-62722-4subject
Has Abstractpub_date
2020-04-21 00:00:00pages
6758issue
1issn
2045-2322pii
10.1038/s41598-020-62722-4journal_volume
10pub_type
杂志文章,随机对照试验abstract::The brain is organized into large scale spatial networks that can be detected during periods of rest using fMRI. The brain is also a dynamic organ with activity that changes over time. We developed a method and investigated properties where the connections as a function of time are derived and quantified. The point ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39156
更新日期:2016-12-19 00:00:00
abstract::Psychopathy is a personality disorder characterised by atypical moral behaviour likely rooted in atypical affective/motivational processing, as opposed to an inability to judge the wrongness of an action. Guilt is a moral emotion believed to play a crucial role in adherence to moral and social norms, but the mechanism...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36273
更新日期:2016-11-03 00:00:00
abstract::When searching a target in a natural scene, it has been shown that both the target's visual properties and similarity to the background influence whether and how fast humans are able to find it. So far, it was unclear whether searchers adjust the dynamics of their eye movements (e.g., fixation durations, saccade ampli...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37548-w
更新日期:2019-02-07 00:00:00
abstract::The establishment of a healthy gastrointestinal milieu may not only offer an opportunity to reduce swine production costs but could also open the way for a lifetime of human health improvement. This study investigates the effects of feeding soluble fibre from flaxseed meal-containing diet (FM) and insoluble fibre from...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24043-5
更新日期:2018-04-12 00:00:00
abstract::Intracellular ion channels are involved in multiple signaling processes, including such crucial ones as regulation of cellular motility and fate. With 95% of the cellular membrane belonging to intracellular organelles, it is hard to overestimate the importance of intracellular ion channels. Multiple studies have been ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13968-y
更新日期:2017-10-26 00:00:00
abstract::This study examined the performance and photo-bias stability of double-channel ZnSnO/InZnO (ZTO/IZO) thin-film transistors. The field-effect mobility (μFE) and photo-bias stability of the double-channel device were improved by increasing the thickness of the front IZO film (t(int)) compared to the single-ZTO-channel d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03765
更新日期:2014-01-20 00:00:00
abstract::Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by creating constitutively active forms (Smad(DVD)). Transcriptional activity of Smad9(DVD) was lower than that of Smad1(DVD) ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07596
更新日期:2014-12-23 00:00:00
abstract::Whether age has any impact on the risk of lymph node (LN) metastasis in patients with early-stage non-small cell lung cancer (NSCLC) remains controversial. Therefore, we aimed to objectively compare the risk of LN metastasis between elderly and young patients so as to justify for age-different extent of surgical resec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66509-5
更新日期:2020-06-12 00:00:00
abstract::The formation of amyloid-β plaques is one of the hallmarks of Alzheimer's disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer's disease. We have prepared unsaturated anionic membranes ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30431-8
更新日期:2018-08-17 00:00:00
abstract::Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen infections due to impaired immune responses. Elimination of infected cells is achieved by cytotoxic CD8(+) T cells that are activated by MHC I-mediated presen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10230
更新日期:2015-05-19 00:00:00
abstract::The prominent comprehensive properties of solid-solution- and intermetallic-based Ti alloys are derived from their diverse microstructures induced by multi-component alloying, which results in a chemical composition complexity. A cluster-plus-glue-atom model, characterizing the chemical short-range orders, was introdu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40302-5
更新日期:2019-03-04 00:00:00
abstract::Alcohol consumption is one of the major causes of hepatic steatosis, fibrosis, cirrhosis, and superimposed hepatocellular carcinoma. Ethanol metabolism alters the NAD(+)/NADH ratio, thereby suppressing the activity of sirtuin family proteins, which may affect lipid metabolism in liver cells. However, it is not clear h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29352
更新日期:2016-07-11 00:00:00
abstract::Circular RNAs (circRNAs) are covalently closed circular non-coding RNAs. Due to their structure, circRNAs are more stable and have longer half-lives than linear RNAs making them good candidates for disease biomarkers. Despite the scientific relevance of these molecules, the study of circRNAs in non-model organisms is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79781-2
更新日期:2021-01-11 00:00:00
abstract::Rapid, sensitive, point-of-care diagnostics are critical for managing infectious diseases. Here we adapt the CRISPR-based SHERLOCK method to develop a rapid, accurate, single copy detection assay for White Spot Syndrome Virus, the most devastating virus impacting global shrimp aquaculture. Further, we combine paper ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56170-y
更新日期:2019-12-23 00:00:00
abstract::A fundamental challenge for behavioral neuroscientists is to accurately quantify (dis)similarities in animal behavior without excluding inherent variability present between individuals. We explored two new applications of curve and shape alignment techniques to address this issue. As a proof-of-concept we applied thes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52300-8
更新日期:2019-11-12 00:00:00
abstract::This corrects the article DOI: 10.1038/srep42627. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/srep46966
更新日期:2018-04-06 00:00:00
abstract::This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46499-9
更新日期:2019-07-11 00:00:00
abstract::Triple-negative breast cancers (TNBC) are unlikely to respond to hormonal therapies and anti-HER2-targeted therapies. TNBCs overexpress EGFR and exhibit constitutive activation of the PI3K/AKT/mTOR signalling pathway. We hypothesized that simultaneously blocking EGFR and mTOR could be a potential therapeutic strategy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63310-2
更新日期:2020-04-14 00:00:00
abstract::Regional brain sizes of very-preterm infants at term-equivalent age differ from those of term-born peers, which have been linked with later cognitive impairments. However, dependence of regional brain volume loss on gestational age has not been studied in detail. To investigate the spatial pattern of brain growth in n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33995
更新日期:2016-09-23 00:00:00
abstract::Low pH in the tumor micromilieu is a recognized pathological feature of cancer. This attribute of cancerous cells has been targeted herein for the controlled release of chemotherapeutics at the tumour site, while sparing healthy tissues. To this end, pH-sensitive, hollow ZnO-nanocarriers loaded with paclitaxel were sy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11760
更新日期:2015-07-06 00:00:00
abstract::Aberrant regulation of BCL-2 family members enables evasion of apoptosis and tumor resistance to chemotherapy. BCL-2 and functionally redundant counterpart, MCL-1, are frequently over-expressed in high-risk diffuse large B-cell lymphoma (DLBCL). While clinical inhibition of BCL-2 has been achieved with the BH3 mimetic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18368-w
更新日期:2017-12-21 00:00:00
abstract::Learning disability varies by month of conception. The underlying mechanism is unknown but vitamin D, necessary for normal brain development, is commonly deficient over winter in high latitude countries due to insufficient ultraviolet radiation. We linked the 2007-2016 Scottish School Pupil Censuses to Scottish matern...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45562-9
更新日期:2019-06-27 00:00:00
abstract::Saturn rings are most beautiful and dynamic places in the solar system, consisting of ice particles in a constant battle between the gravitational forces of Saturn and its many moons. Fan, spiral, propellers, moonlets and streamer-channels observed by CASSINI in the F-ring have been attributed to encounters by Prometh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01276
更新日期:2013-01-01 00:00:00
abstract::The nervous system controls most rhythmic behaviors, with a remarkable exception. In Caenorhabditis elegans periodic defecation rhythm does not appear to involve the nervous system. Such oscillations are studied in detail with genetic and molecular biology tools. The small size of C. elegans cells impairs the use of s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18118-y
更新日期:2017-12-19 00:00:00
abstract::This corrects the article DOI: 10.1038/srep40037. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/srep46991
更新日期:2018-05-22 00:00:00
abstract::We present a new method for the design of devices to manipulate the displacement field in Elastic materials. It consists of solving a nonlinear optimization problem where the objective function defines the error in matching a desired displacement field, and the design variables determine the required material distribu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28069-7
更新日期:2018-06-29 00:00:00
abstract::In Taiwan, beginning in 2013, the 13-valent pneumococcal conjugate vaccine (PCV13) was provided free of charge to children 2-5 years of age. In 2014, this was extended to children 1-5 years old. During 2012-2014, 953 cases of culture-confirmed pneumococcal disease (CCPD), including 104 invasive pneumococcal disease (I...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15843
更新日期:2015-11-02 00:00:00
abstract::It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33247-8
更新日期:2018-10-04 00:00:00
abstract::Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs). USP45 is a ubiquitin specific protease about which little is known, aside from roles in DNA damage repair and differentiation of the vertebrate retina. Here, by ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32685-8
更新日期:2018-09-26 00:00:00
abstract::The future Internet is very likely the mixture of all-optical Internet with low power consumption and quantum Internet with absolute security guaranteed by the laws of quantum mechanics. Photons would be used for processing, routing and com-munication of data, and photonic transistor using a weak light to control a st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45582
更新日期:2017-03-28 00:00:00