Abstract：
:This study evaluates the forensic utility of 23 autosomal short tandem repeat markers in 400 samples from the Kuwaiti population, of which four markers (D10S1248, D22S1045, D2S441 and SE33) are reported for the first time for Kuwait. All the markers were shown to exhibit no deviation from Hardy-Weinberg equilibrium, nor any linkage disequilibrium between and within loci, indicating that these loci are inherited independently, and their allele frequencies can be used to estimate match probabilities in the Kuwaiti population. The low combined match probability of 7.37 × 10-30 and the high paternity indices generated by these loci demonstrate the usefulness of the PowerPlex Fusion 6C kit for human identification in this population, as well as to strengthen the power of paternity testing. Off-ladder alleles were seen at several loci, and these were identified by examining their underlying nucleotide sequences. Principal component analysis (PCA) and STRUCTURE showed no genetic structure within the Kuwaiti population. However, PCA revealed a correlation between geographic and genetic distance. Finally, phylogenetic trees demonstrated a close relationship between Kuwaitis and Middle Easterners at a global level, and a recent common ancestry for Kuwait with its northern neighbours of Iraq and Iran, at a regional level.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Haidar M,Abbas FA,Alsaleh H,Haddrill PRdoi
10.1038/s41598-021-81425-ysubject
Has Abstractpub_date
2021-01-21 00:00:00pages
1865issue
1issn
2045-2322pii
10.1038/s41598-021-81425-yjournal_volume
11pub_type
杂志文章abstract：:Endoplasmic reticulum (ER) stress preconditioning protects cells against methylmercury (MeHg) cytotoxicity by inducing integrated stress responses such as eIF2α phosphorylation, ATF4 accumulation, and nonsense-mediated mRNA decay (NMD) suppression. Here we demonstrated that ER stress preconditioning results in the upr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09435-3
更新日期：2017-09-28 00:00:00
abstract：:Biological hydrogen production is based on activity of specific enzymes called hydrogenases. Hydrogenases are oxygen sensitive metalloenzymes containing Ni and/or Fe atoms at the active site, catalyzing reversible reduction of protons. Generally, [Fe-Fe] hydrogenases prefer proton reduction to molecular hydrogen, a po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36034
更新日期：2016-10-27 00:00:00
abstract：:In order to elucidate features of the denatured state ensembles that exist in equilibrium with the native state under physiological conditions, we performed 1.4-μs molecular dynamics (MD) simulations at 400 K and 450 K using the monomer subunits of three CutA1 mutants from Escherichia coli: an SH-free mutant (Ec0SH) w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25825-7
更新日期：2018-05-16 00:00:00
abstract：:Spitzoid neoplasms constitute a morphologically distinct category of melanocytic tumors, encompassing Spitz nevus (benign), atypical Spitz tumor (intermediate malignant potential), and spitzoid melanoma (fully malignant). Currently, no reliable histopathological criteria or molecular marker is known to distinguish bor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11200
更新日期：2015-06-10 00:00:00
abstract：:Many established inflammation- and nutrition-related factors have been investigated as potential independent prognostic factors in various cancers, including the C-reactive protein/albumin ratio (CAR), lymphocyte/monocyte ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10328-8
更新日期：2017-08-25 00:00:00
abstract：:The influence of three-dimensional facial contour and dynamic evaluation decoding on factors of smile esthetics is essential for facial beauty improvement. However, the kinematic features of the facial smile contour and the contribution from the soft tissue and underlying skeleton are uncharted. Here, the cheekbone-ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22103
更新日期：2016-02-25 00:00:00
abstract：:The mechanisms contributing to collective attention in humans remain unclear. Research indicates that pedestrians utilise the gaze direction of others nearby to acquire environmentally relevant information, but it is not known which, if any, additional social cues influence this transmission. Extending upon previous f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05794
更新日期：2014-07-23 00:00:00
abstract：:Gayal (Bos frontalis) is a semi-wild and endangered bovine species that differs from domestic cattle (Bos taurus and Bos indicus), and its genetic background remains unclear. Here, we performed whole-genome sequencing of one Gayal for the first time, with one Red Angus cattle and one Japanese Black cattle as controls....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19787
更新日期：2016-01-25 00:00:00
abstract：:Isolating actively proliferating cardioblasts is the first crucial step for cardiac regeneration through cell implantation. However, the origin and identity of putative cardioblasts are still unclear. Here, we uncover a novel class of cardiac lineage cells, PDGFRα+Flk1- cardioblasts (PCBs), from mouse and human plurip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41840
更新日期：2017-02-06 00:00:00
abstract：:New monosaccharide-based lipid A analogues were rationally designed through MD-2 docking studies. A panel of compounds with two carboxylate groups as phosphates bioisosteres, was synthesized with the same glucosamine-bis-succinyl core linked to different unsaturated and saturated fatty acid chains. The binding of the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37421-w
更新日期：2019-01-29 00:00:00
abstract：:This paper presents an ultracompact tunable device for power splitting and switching by tuning the Fermi energy level of monolayer patternless graphene underneath a slotted multimode interference (MMI) coupler operating in the mid-infrared, λ = 9-11 μm. By introducing a high-index silicon slot in the central region of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49186-x
更新日期：2019-09-04 00:00:00
abstract：:H. pylori-induced chronic inflammation is considered the most important cause of gastric cancer. The actual process how chronic inflammation triggers gastric carcinogenesis is still not clear. In this study, neutrophils and relative markers in gastric cancer development were examined with immunohistochemistry and fluo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29762
更新日期：2016-07-14 00:00:00
abstract：:Mechanosensitive ion channels are pore-forming transmembrane proteins that allow ions to move down their electrochemical gradient in response to mechanical stimuli. They participate in many plant developmental processes including the maintenance of plastid shape, pollen tube growth, etc. Herein, a total of 11, 10, 6, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73627-7
更新日期：2020-10-06 00:00:00
abstract：:Spatial organization of G-protein coupled receptors (GPCRs) into dimers and higher order oligomers has been demonstrated in vitro and in vivo. The pharmacological readout was shown to depend on the specific interfaces, but why particular regions of the GPCR structure are involved, and how ligand-determined states chan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02909
更新日期：2013-10-09 00:00:00
abstract：:Grapevine (Vitis vinifera L.) is one of the classical fruits of the Old World. Among the thousands of domesticated grapevine varieties and variable wild sylvestris populations, the range of variation in pip morphology is very wide. In this study we scanned representative samples of grape pip populations, in an attempt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24738-9
更新日期：2018-04-25 00:00:00
abstract：:Here, we report results on systematic analysis of DNA substrate preferences of three N6-adenine β-class DNA methyltransferases that are part of the type II restriction-modification systems. The studied enzymes were: M.EcoVIII, M.HindIII and M.LlaCI, which although found in phylogenetically distant bacteria (γ-proteoba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26434-0
更新日期：2018-05-29 00:00:00
abstract：:Breast cancer is the most common cancer among women, and its incidence is on a constant rise. Previous studies suggest that higher levels of plasma prolactin are associated with escalated risk of breast cancer, however, these results are contradictory and inconclusive. PubMed and Medline were used to search and identi...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep25998
更新日期：2016-05-17 00:00:00
abstract：:Power consumption is the main limitation in the development of new high performance random access memory for portable electronic devices. Magnetic RAM (MRAM) with CoFeB/MgO based magnetic tunnel junctions (MTJs) is a promising candidate for reducing the power consumption given its non-volatile nature while achieving h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16911-3
更新日期：2017-12-01 00:00:00
abstract：:Few neuroimaigng studies on reading comprehension have been conducted under natural reading settings. In this study, we showed texts presented in a natural way during functional MRI (fMRI) measurements to reveal brain areas sensitive to reading comprehension. Specifically, this paradigm independently manipulated two h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49632-w
更新日期：2019-09-13 00:00:00
abstract：:Structural isomers, molecules having the same chemical formula but with atoms bonded in different order, are hard to identify using conventional spectroscopy and mass spectrometry. They exhibit virtually indistinguishable mass spectra when ionized by electrons. Laser mass spectrometry based on photoionization of the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22055-9
更新日期：2018-02-28 00:00:00
abstract：:Growth factors have great therapeutic potential for various disease therapy and tissue engineering applications. However, their clinical efficacy is hampered by low bioavailability, rapid degradation in vivo and non-specific biodistribution. Nanoparticle based delivery systems are being evaluated to overcome these lim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14040-5
更新日期：2017-10-30 00:00:00
abstract：:Plant cis-elements play important roles in global regulation of gene expression. Based on microarray data from rice flag leaves during early senescence, we identified W-box and G-box cis-elements as positive regulators of senescence in the important rice variety Minghui 63. Both cis-elements were bound by leaf senesce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20881
更新日期：2016-02-11 00:00:00
abstract：:As antibody-based diagnosis and therapy grow at an increased pace, there is a need for methods which rapidly and accurately determine antibody-antigen interactions. Here, we report a method for the multiplex determination of antibody epitopes using bacterial cell-surface display. A protein-fragment library with 10(7) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00706
更新日期：2012-01-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-63126-0
更新日期：2020-04-20 00:00:00
abstract：:It is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other membrane-distal. Previous studies had implicated only the membrane-distal subdomain in ligand recognition. Here, we report ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14372-2
更新日期：2017-10-26 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep46130. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46820
更新日期：2017-05-26 00:00:00
abstract：:Polycrystalline CeGe is investigated by means of DC and AC susceptibility, non-linear DC susceptibility, electrical transport and heat capacity measurements in the low temperature regime. This compound shows two peaks at low magnetic field around TI ~ 10.7 and TII ~ 7.3 K due to antiferromagnetic ordering and subseque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41565-8
更新日期：2019-03-26 00:00:00
abstract：:Chemical reagents used in traditional mineral processing can be toxic and hazardous for the environment. Therefore, the use of biotechnological methods is becoming increasingly important. Great hopes are being placed in the use of microorganisms for bio-beneficiation of raw materials. However, assessment of adhesion a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49406-4
更新日期：2019-09-10 00:00:00
abstract：:A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variabi...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-72062-y
更新日期：2020-09-16 00:00:00
abstract：:Disease associated genetic variations often cause intracellular enzyme inactivation, dysregulation and instability. However, allosteric communication of mutational effects to distant functional sites leading to loss-of-function remains poorly understood. We characterize here interdomain site-to-site communication by w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44532
更新日期：2017-03-14 00:00:00
