Abstract：
:Growth factors have great therapeutic potential for various disease therapy and tissue engineering applications. However, their clinical efficacy is hampered by low bioavailability, rapid degradation in vivo and non-specific biodistribution. Nanoparticle based delivery systems are being evaluated to overcome these limitations. Herein, we have developed a thermosensitive heparin nanosponge (Hep-NS) by a one step photopolymerization reaction between diacrylated pluronic and thiolated heparin molecules. The amount of heparin in Hep-NS was precisely controlled by varying the heparin amount in the reaction feed. Hep-NS with varying amounts of heparin showed similar size and shape properties, though surface charge decreased with an increase in the amount of heparin conjugation. The anticoagulant activity of the Hep-NS decreased by 65% compared to free heparin, however the Hep-NS retained their growth factor binding ability. Four different growth factors, bFGF, VEGF, BMP-2, and HGF were successfully encapsulated into Hep-NS. In vitro studies showed sustained release of all the growth factors for almost 60 days and the rate of release was directly dependent on the amount of heparin in Hep-NS. The released growth factors retained their bioactivity as assessed by a cell proliferation assay. This heparin nanosponge is therefore a promising nanocarrier for the loading and controlled release of growth factors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Choi WI,Sahu A,Vilos C,Kamaly N,Jo SM,Lee JH,Tae Gdoi
10.1038/s41598-017-14040-5subject
Has Abstractpub_date
2017-10-30 00:00:00pages
14351issue
1issn
2045-2322pii
10.1038/s41598-017-14040-5journal_volume
7pub_type
杂志文章abstract：:The poor control of the adhesion of TiO2 nanotubes (TNTs) layers to a non-anodized titanium (Ti) substrate has limited their widespread application, because the stripping mechanism has not yet been revealed. Here, we report a novel method to control the detachment of TNTs by post-treatment of the as-fabricated samples...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07178
更新日期：2014-11-24 00:00:00
abstract：:An impairment of cardiac function is a key feature of the cardiovascular failure associated with sepsis. Although there is some evidence that suppression of sarcoplasmic reticulum Ca2+-ATP-ase (SERCA2) contributes to septic cardiomyopathy, it is not known whether prevention of the down-regulation of SERCA2 improves ou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37277
更新日期：2016-11-17 00:00:00
abstract：:Ti3+ species are highly unstable in air owing to their facile oxidation into Ti4+ species, and thus they cannot concentrate in the surface layer of TiO2 but are mainly present in its bulk. We report generation of abundant and stable Ti3+ species in the surface layer of TiO2 by boron doping for efficient utilization of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34765
更新日期：2016-10-06 00:00:00
abstract：:Detonation nanodiamonds (NDs) were deposited on the surface of aligned carbon nanotubes (CNTs) by immersing a CNT array in an aqueous suspension of NDs in dimethylsulfoxide (DMSO). The structure and electronic state of the obtained CNT-ND hybrid material were studied using optical and electron microscopy and Infrared,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09379
更新日期：2015-03-23 00:00:00
abstract：:Sorption and desorption determine the amount of an herbicide in soil solution. Therefore, knowledge of the sorption and desorption coefficients in different soils is an essential factor to estimate the potential for environmental contamination by herbicides. We evaluated the feasibility of multivariate and linear disc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44405-x
更新日期：2019-05-27 00:00:00
abstract：:Visualization of morphological dynamics of live cells with nanometer resolution under physiological conditions is highly desired, but challenging. It has been demonstrated that high-speed atomic force microscopy is a powerful technique for visualizing dynamics of biomolecules under physiological conditions. However, a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08724
更新日期：2015-03-04 00:00:00
abstract：:The aim of this systematic review was taken to investigate the efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone for treating androgen-independent prostate cancer (AIPC). Data were collected from different databases independently by three researchers according to the pre-defined inclusion and exclu...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep04818
更新日期：2014-04-28 00:00:00
abstract：:As an emerging sterilization technology, cold atmospheric plasma offers a dry, non-thermal, rapid process that is minimally damaging to a majority of substrates. However, the mechanisms by which plasma interacts with living cells are poorly understood and the plasma generation apparatuses are complex and resource-inte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35166-0
更新日期：2018-11-12 00:00:00
abstract：:This study presents, attenuated total reflection Fourier transforms infrared spectroscopy of dried serum samples in an effort to assess biochemical changes induced by non-Hodgkin's lymphoma and subcutaneous melanoma. An EL4 mouse model of non-Hodgkin lymphoma and a B16 mouse model of subcutaneous melanoma are used to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17027-4
更新日期：2017-12-05 00:00:00
abstract：:The interlocking roles of lexical, syntactic and semantic processing in language comprehension has been the subject of longstanding debate. Recently, the cortical response to a frequency-tagged linguistic stimulus has been shown to track the rate of phrase and sentence, as well as syllable, presentation. This could be...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81901-5
更新日期：2021-01-28 00:00:00
abstract：:High-throughput technology can now provide rich information on a person's biological makeup and environmental surroundings. Important discoveries have been made by relating these data to various health outcomes in fields such as genomics, proteomics, and medical imaging. However, cross-investigations between several h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36076
更新日期：2016-10-26 00:00:00
abstract：:Alzheimer's disease (AD), an irreversible progressive neurodegenerative disease, causes characteristic cognitive impairment, and no curative treatments are currently available. Stem cell transplantation offers a powerful tool for the treatment of AD. We conducted a systematic review and meta-analysis of data from cont...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep12134
更新日期：2015-07-10 00:00:00
abstract：:An important step in oxide photochemistry, the loading of electrons into shallow trap states, was studied using infrared (IR) spectroscopy on both, rutile TiO2 powders and single-crystal, r-TiO2(110) oriented samples. After UV-irradiation or n-doping by exposure to H-atoms broad IR absorption lines are observed for th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03808
更新日期：2014-01-22 00:00:00
abstract：:Invariant Natural killer T (iNKT) cells rapidly produce copious amounts of multiple cytokines after in vivo activation, allowing for the direct detection of a number of cytokines directly ex vivo. However, for some cytokines this approach is suboptimal. Here, we report technical variations that allow the improved dete...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16832-1
更新日期：2017-11-30 00:00:00
abstract：:Cenozoic plant relicts are those groups that were once widespread in the Northern Hemisphere but are now restricted to some small isolated areas as a result of drastic climatic changes. They are good proxies to study how plants respond to climatic changes since their modern climatic requirements are known. Herein we l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14212
更新日期：2015-09-15 00:00:00
abstract：:Most tropical evergreen rain forests are characterised by varying degrees of precipitation seasonality that influence plant phenology and litterfall dynamics. Soil microbes are sensitive to soil water:air ratio and to nutrient availability. We studied if within-year seasonality in precipitation and litterfall-derived ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22380-z
更新日期：2018-03-12 00:00:00
abstract：:In this study, we have employed graphene oxide as a matrix to simultaneously and directly quantify serum nonesterified and esterified fatty acids (FAs) using matrix-assisted laser/desorption ionization-Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR MS). Twelve serum nonesterified FAs combined...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34201
更新日期：2016-09-30 00:00:00
abstract：:Plant seed germination is a crucial developmental event that has significant effects on seedling establishment and yield production. This process is controlled by multiple intrinsic signals, particularly phytohormones. The gaseous hormone ethylene stimulates seed germination; however, the genetic basis of ethylene pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58607-1
更新日期：2020-02-03 00:00:00
abstract：:Outer hair cells in the cochlea have a unique motility in their cell body based on mechanoelectric coupling, with which voltage changes generated by stimuli at their hair bundles drive the cell body and, in turn, it has been assumed, amplifies the signal. In vitro experiments show that the movement of the charges of t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12411-6
更新日期：2017-09-21 00:00:00
abstract：:Quantum walk is a key operation in quantum computing, simulation, communication and information. Here, we report for the first time the demonstration of quantum walks and localized quantum walks in a new type of optical fibers having a ring of cores constructed with both periodic and quasiperiodic Fibonacci sequences,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64065-6
更新日期：2020-04-28 00:00:00
abstract：:A record 500,000 hectares burned in Portugal during the extreme wildfire season of 2017, with more than 120 human lives lost. Here we analyse the climatic factors responsible for the burned area (BA) from June to October series in Portugal for the period 1980-2017. Superposed onto a substantially stationary trend on B...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50281-2
更新日期：2019-10-10 00:00:00
abstract：:Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link of observed alterations to specific neurophysiological processes. In particular, the sensitivity of cerebral blood flow to activity changes in specific neurotransmitter syst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22444-0
更新日期：2018-03-06 00:00:00
abstract：:Aquatic phytoplankton experience large fluctuations in environmental conditions during seasonal succession and across salinity gradients, but the impact of this variation on their diversity is poorly understood. We examined spatio-temporal variation in nano- and microphytoplankton (> 2 µm) community structure using al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74428-8
更新日期：2020-10-19 00:00:00
abstract：:The flagellum is a rotary motor that enables bacteria to swim in liquids and swarm over surfaces. Numerous global regulators control flagellar assembly in response to cellular and environmental factors. Previous studies have also shown that flagellar assembly is affected by the growth-rate of the cell. However, a syst...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41189
更新日期：2017-01-24 00:00:00
abstract：:The role of changes in dopamine neuronal activity during the development of symptoms in affective disorders remains controversial. Here, we show that inactivation of NMDA receptors on dopaminergic neurons in adult mice led to the development of affective disorder-like symptoms. The loss of NMDA receptors altered activ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37171
更新日期：2016-11-17 00:00:00
abstract：:Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-course changes of the c-miRNAs profiles in young males. The subjects (n = 45) were randomly divided into three...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02294-y
更新日期：2017-05-19 00:00:00
abstract：:We report on an all-dielectric, polarization-independent angular filter with one-dimension (1D) photonic crystal (PC) composed of semiconductor compatible Si/SiO2 pairs. The near-symmetric directional band gap of p- and s-polarized components and Fabry-Pérot (F-P) resonances are utilized to realize efficient polarizat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16837-w
更新日期：2017-11-29 00:00:00
abstract：:Lung adenosquamous cell carcinomas (ASCs) is a rare variant of NSCLC with a poorer prognosis and fewer treatment option than the more common variants. PD-L1 expression is reported to be the predictor of clinical response in trials of NSCLC. In our study, PD-L1 expression was evaluated via immunohistochemistry using a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46209
更新日期：2017-04-07 00:00:00
abstract：:Healthy neonates exhibit a well-functioning haemostatic system despite peculiarities regarding composition of clotting factors and inhibitors as well as impaired platelet aggregation. Thrombocytopenia and severe bleeding events are feared in sick infants. Recombinant factor VIIa (rFVIIa) is a haemostatic agent used as...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44199-y
更新日期：2019-05-29 00:00:00
abstract：:Drying and aging paint dispersions display a wealth of complex phenomena that make their study fascinating yet challenging. To meet the growing demand for sustainable, high-quality paints, it is essential to unravel the microscopic mechanisms underlying these phenomena. Visualising the governing dynamics is, however, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34383
更新日期：2016-09-29 00:00:00
