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Loss of NMDA receptors in dopamine neurons leads to the development of affective disorder-like symptoms in mice.

Abstract：

:The role of changes in dopamine neuronal activity during the development of symptoms in affective disorders remains controversial. Here, we show that inactivation of NMDA receptors on dopaminergic neurons in adult mice led to the development of affective disorder-like symptoms. The loss of NMDA receptors altered activity and caused complete NMDA-insensitivity in dopamine-like neurons. Mutant mice exhibited increased immobility in the forced swim test and a decrease in social interactions. Mutation also led to reduced saccharin intake, however the preference of sweet taste was not significantly decreased. Additionally, we found that while mutant mice were slower to learn instrumental tasks, they were able to reach the same performance levels, had normal sensitivity to feedback and showed similar motivation to exert effort as control animals. Taken together these results show that inducing the loss of NMDA receptor-dependent activity in dopamine neurons is associated with development of affective disorder-like symptoms.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Jastrzębska K,Walczak M,Cieślak PE,Szumiec Ł,Turbasa M,Engblom D,Błasiak T,Parkitna JR

doi

10.1038/srep37171

subject

Has Abstract

pub_date

2016-11-17 00:00:00

pages

37171

issn

2045-2322

pii

srep37171

journal_volume

6

pub_type

杂志文章

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