Abstract：
:Genetic divergences among mammalian strains are presented phenotypically in various aspects of physical appearance such as body shape and facial features. Yet how genetic diversity is expressed in brain function still remains unclear. Functional connectivity has been shown to be a valuable approach in characterizing the relationship between brain functions and behaviors. Alterations in the brain default mode network (DMN) have been found in human neuropsychological disorders. In this study we selected the spontaneously hypertensive rat (SHR) and the Wistar Kyoto rat (WKY), two inbred rat strains with close genetic origins, to investigate variations in the DMN. Our results showed that the major DMN differences are the activities in hippocampal area and caudate putamen region. This may be correlated to the hyperactive behavior of the SHR strain. Advanced animal model studies on variations in the DMN may have potential to shed new light on translational medicine, especially with regard to neuropsychological disorders.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Huang SM,Wu YL,Peng SL,Peng HH,Huang TY,Ho KC,Wang FNdoi
10.1038/srep21697subject
Has Abstractpub_date
2016-02-22 00:00:00pages
21697issn
2045-2322pii
srep21697journal_volume
6pub_type
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