Abstract:
:We have used a silica - PEG based bionanoconjugate synthetic scheme to study the subtle connection between cell receptor specific recognition and architecture of surface functionalization chemistry. Extensive physicochemical characterization of the grafted architecture is capable of capturing significant levels of detail of both the linker and grafted organization, allowing for improved reproducibility and ultimately insight into biological functionality. Our data suggest that scaffold details, propagating PEG layer architecture effects, determine not only the rate of uptake of conjugated nanoparticles into cells but also, more significantly, the specificity of pathways via which uptake occurs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hristov DR,Rocks L,Kelly PM,Thomas SS,Pitek AS,Verderio P,Mahon E,Dawson KAdoi
10.1038/srep17040subject
Has Abstractpub_date
2015-12-01 00:00:00pages
17040issn
2045-2322pii
srep17040journal_volume
5pub_type
杂志文章abstract::This study was carried out for rapid and noninvasive determination of the class of sorghum species by using the manifold dimensionality reduction (MDR) method and the nonlinear regression method of least squares support vector machines (LS-SVM) combing with the mid-infrared spectroscopy (MIRS) techniques. The methods ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19917
更新日期:2016-01-28 00:00:00
abstract::Immunoaffinity enrichment of proteotypic peptides, coupled with selected reaction monitoring, enables indirect protein quantification. However the lack of suitable antibodies limits its widespread application. We developed a method in which multi-specific antibodies are used to enrich groups of peptides, thus facilita...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08759
更新日期:2015-03-04 00:00:00
abstract::Brain hypometabolism is a common epilepsy-related finding in both patients and animal models. Fluorodeoxyglucose positron emission tomography studies have shown that recurrent seizures lead to reduced glucose metabolism in certain brain regions, but no studies have definitively determined whether this induces epilepto...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05038-0
更新日期:2017-07-19 00:00:00
abstract::We study the dynamical Casimir-Polder force on a two-level atom with different initial states in the one-dimensional dielectric cavity with output coupling, and obtain the analytical expression of the expectation value of dynamical Casimir-Polder force. Results show that the expectation values of dynamical Casimir-Pol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68546-6
更新日期:2020-07-20 00:00:00
abstract::An aberrant artery (AA) can frequently be observed coursing through the fissure for the ligamentum venosum (FLV) which was termed the "vessel through strait" sign (VTSS) by us. Fundamental data including the incidence, anatomical composition and clinical significance of VTSS and the AAs composing VTSS are still lackin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23922
更新日期:2016-04-04 00:00:00
abstract::The classical view of nerve growth factor (NGF) action in the nervous system is linked to its retrograde axonal transport. However, almost nothing is known on the trafficking properties of its unprocessed precursor proNGF, characterized by different and generally opposite biological functions with respect to its matur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20272
更新日期:2016-02-01 00:00:00
abstract::Several systems can be represented as multiplex networks, i.e. in terms of a superposition of various graphs, each related to a different mode of connection between nodes. Hence, the definition of proper mathematical quantities aiming at capturing the added level of complexity of those systems is required. Various ste...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09120
更新日期:2015-03-13 00:00:00
abstract::During inflammatory response, blood leukocytes adhere to the endothelium. This process involves numerous adhesion molecules, including a transmembrane chemokine, CX3CL1, which behaves as a molecular cluster. How this cluster assembles and whether this association has a functional role remain unknown. The analysis of C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65988-w
更新日期:2020-06-03 00:00:00
abstract::Since the propagation of plant viruses depends on various host susceptibility factors, deficiency in them can prevent viral infection in cultivated and model plants. Recently, we identified the susceptibility factor Essential for poteXvirus Accumulation 1 (EXA1) in Arabidopsis thaliana, and revealed that EXA1-mediated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42400-w
更新日期:2019-04-11 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-65027-8
更新日期:2020-05-20 00:00:00
abstract::Bone is the most common site of metastasis in metastatic castration-resistant prostate cancer (mCRPC), which is associated with pain and skeletal events. Radium-223 dichloride (Xofigo) is an alpha-emitting radioactive isotope that can specifically target bone lesions. Herein, we report the results of a retrospective a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63302-2
更新日期:2020-04-21 00:00:00
abstract::Gastroenteritis is common among children. Campylobacter jejuni is one of the main causative bacterial pathogens, together with Shigella, Salmonella and invasive Escherichia coli. Campylobacteriosis is a zoonotic, usually self-limited disease that does not always require antibiotic treatment. In cases of protracted dia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62744-y
更新日期:2020-04-02 00:00:00
abstract::This study aimed to develop and validate a model for the preoperative prediction of the effectiveness of hysteroscopic resection of a uterine cesarean niche in patients with postmenstrual spotting. The predictive model was developed in a primary prospective cohort consisting of 208 patients with niche treated by hyste...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74622-8
更新日期:2020-10-15 00:00:00
abstract::In long-lived species, the age-, stage- and/or sex-dependent patterns of survival and reproduction determine the evolution of life history strategies, the shape of the reproductive value, and ultimately population dynamics. We evaluate the combined effects of age and sex in recruitment, breeder survival and breeding s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40204
更新日期:2017-01-11 00:00:00
abstract::Undertaking behaviour is an essential activity in social insects. Corpses are often recognized by a postmortem change in a chemical signature. Reticulitermes flavipes responded to corpses within minutes of death. This undertaking behaviour did not change with longer postmortem time (24 h); however, R. flavipes exhibit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01650
更新日期:2013-01-01 00:00:00
abstract::We consider an optimal quantum key distribution setup based on minimal number of measurement bases with binary yields used by parties against an eavesdropper limited only by the no-signaling principle. We note that in general, the maximal key rate can be achieved by determining the optimal tradeoff between measurement...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30959
更新日期:2016-08-03 00:00:00
abstract::High levels of reproductive failure were detected in some Spanish sow farms in the Spring of 2010. Regular returns to estrus and variable reductions in litter size were observed. The problem started suddenly and did not appear to be related to the quality of the ejaculates, disease, alterations of body condition or an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04913
更新日期:2014-05-09 00:00:00
abstract::Pterostilbene (PT), the natural dimethylated analog of resveratrol (RSV), is a potent anticarcinogen for non-small-cell lung cancer (NSCLC), but its anti-NSCLC mechanisms remain unclear. In this study, we show that PT treatment time- and dose-dependently enhanced the endoplasmic reticulum stress (ERS) signaling (i.e.,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08547-0
更新日期:2017-08-14 00:00:00
abstract::Transcriptome expression reflects genetic response in diverse conditions. In this study, RNA sequencing was utilized to profile multiple tissues such as liver, breast, caecum, and gizzard of Korean commercial chicken raised in Korea and Kyrgyzstan. We analyzed ten samples per tissue from each location to identify cand...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76234-8
更新日期:2020-11-06 00:00:00
abstract::In this paper, we propose a feasible tool that uses a terahertz (THz) imaging system for identifying wheat grains at different stages of germination. The THz spectra of the main changed components of wheat grains, maltose and starch, which were obtained by THz time spectroscopy, were distinctly different. Used for ori...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21299
更新日期:2016-02-19 00:00:00
abstract::To determine whether regular cervical dilatation is effective for preventing cervical stenosis, and to identify the associated risk factors, in postmenopausal women after LEEP. This was a prospective randomized clinical trial in postmenopausal women who underwent LEEP at our hospital between August 2018 and May 2019. ...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-65170-2
更新日期:2020-05-22 00:00:00
abstract::Diffuse myocardial fibrosis is a key pathophysiologic feature in heart failure and can be quantified by cardiac magnetic resonance (CMR) T1 mapping. However, increases in myocardial free water also prolong native T1 times and may impact fibrosis quantification. Thus far, the impact of systemic patient volume status re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23868-4
更新日期:2018-04-03 00:00:00
abstract::Recently, graphene nanomesh (GNM) has attracted great attentions due to its unique porous structure, abundant active sites, finite band gap and possesses potential applications in the fields of electronics, gas sensor/storage, catalysis, etc. Therefore, diverse GNMs with different physical and chemical properties are ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32310
更新日期:2016-08-26 00:00:00
abstract::To date, the cell and molecular mechanisms regulating tendon healing are poorly understood. Here, we establish a novel model of tendon regeneration using neonatal mice and show that neonates heal via formation of a 'neo-tendon' that differentiates along the tendon specific lineage with functional restoration of gait a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45238
更新日期:2017-03-23 00:00:00
abstract::Colistin remains one of the few antibiotics effective against multi-drug resistant (MDR) hospital pathogens, such as Klebsiella pneumoniae. Yet resistance to this last-line drug is rapidly increasing. Characterized mechanisms of colR in K. pneumoniae are largely due to chromosomal mutations in two-component regulators...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28199-y
更新日期:2018-06-29 00:00:00
abstract::The ultrathin SmCo5 nanoflakes with average thickness smaller than 50 nm are prepared by a novel method of solid particle (NaCl) and surfactant co-assisted ball milling. The as-prepared nanoflakes exhibit a narrower thickness distribution of 10-50 nm and high coercivity of 23 kOe. The possible formation mechanism of n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25805
更新日期:2016-05-13 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-69680-x
更新日期:2020-08-27 00:00:00
abstract::Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron's membrane potential, providing an important component of inhibition in the brain. In addition to the canonical G protein-activation pathway, GIRK channels are activated by small molecules but less is...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04681-x
更新日期:2017-07-04 00:00:00
abstract::Amorphophallus paeoniifolius, is a commercially important vegetable crop because of its high production potential. In this study, we generated a total of 166 Gb of genomic data from 16 wild and 20 cultivated A. paeoniifolius individuals in southwestern China using restriction site associated DNA sequencing (RAD-seq). ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14738-6
更新日期:2017-10-27 00:00:00
abstract::Naturally occurring metals and metalloids [metal(loid)s] are essential for the physiological functioning of wildlife; however, environmental contamination by metal(loid) and plastic pollutants is a health hazard. Metal(loid)s may interact with plastic in the environment and there is mixed evidence about whether plasti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75024-6
更新日期:2020-10-22 00:00:00