Tuning of nanoparticle biological functionality through controlled surface chemistry and characterisation at the bioconjugated nanoparticle surface.

Abstract:

:We have used a silica - PEG based bionanoconjugate synthetic scheme to study the subtle connection between cell receptor specific recognition and architecture of surface functionalization chemistry. Extensive physicochemical characterization of the grafted architecture is capable of capturing significant levels of detail of both the linker and grafted organization, allowing for improved reproducibility and ultimately insight into biological functionality. Our data suggest that scaffold details, propagating PEG layer architecture effects, determine not only the rate of uptake of conjugated nanoparticles into cells but also, more significantly, the specificity of pathways via which uptake occurs.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hristov DR,Rocks L,Kelly PM,Thomas SS,Pitek AS,Verderio P,Mahon E,Dawson KA

doi

10.1038/srep17040

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

17040

issn

2045-2322

pii

srep17040

journal_volume

5

pub_type

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