Abstract:
:A growing interest in healthy eating has lead to an increase in the consumption of vegetables, associated with a rising number of bacterial outbreaks related to fresh produce. This is the case of the outbreak in Germany, caused by a O104:H4 enteroaggregative E. coli strain lysogenic for a Stx phage. Temperate Stx phages released from their hosts occur as free particles in various environments. This study reports the occurrence of Stx phages in vegetables (lettuce, cucumber, and spinach) and cropland soil samples. Infectious Stx2 phages were found in all samples and many carried also Stx1 phages. Their persistence in vegetables, including germinated sprouts, of Stx phage 933 W and an E. coli C600 (933 W∆stx::gfp-cat) lysogen used as surrogate, showed reductions below 2 log10 units of both microorganisms at 23 °C and 4 °C over 10 days. Higher reductions (up to 3.9 log10) units were observed in cropland soils at both temperatures. Transduction of a recombinant 933 W∆stx::kan phage was observed in all matrices. Protecting against microbial contamination of vegetables is imperative to ensure a safe food chain. Since the emergence of new Stx strains by Stx phage transduction is possible in vegetable matrices, methods aimed at reducing microbial risks in vegetables should not neglect phages.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Quirós P,Muniesa Mdoi
10.1038/s41598-017-08169-6subject
Has Abstractpub_date
2017-08-10 00:00:00pages
7796issue
1issn
2045-2322pii
10.1038/s41598-017-08169-6journal_volume
7pub_type
杂志文章abstract::California has experienced a dry 21(st) century capped by severe drought from 2012 through 2015 prompting questions about hydroclimatic sensitivity to anthropogenic climate change and implications for the future. We address these questions using a Holocene lake sediment record of hydrologic change from the Sierra Neva...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33325
更新日期:2016-09-15 00:00:00
abstract::Neuroscience findings have recently received critique on the lack of replications. To examine the reproducibility of brain indices of speech sound discrimination and their role in dyslexia, a specific reading difficulty, brain event-related potentials using EEG were measured using the same cross-linguistic passive odd...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41992-7
更新日期:2019-06-11 00:00:00
abstract::Dementia is a major cause of disability and dependency among older people. If the lives of people with dementia are to be improved, research and its translation into druggable target are crucial. Ancient systems of healthcare (Ayurveda, Siddha, Unani and Sowa-Rigpa) have been used from centuries for the treatment vasc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57199-9
更新日期:2020-01-14 00:00:00
abstract::Melanoma is the most lethal cutaneous cancer. New drugs have recently appeared; however, not all patients obtain a benefit of these new drugs. For this reason, it is still necessary to characterize melanoma at molecular level. The aim of this study was to explore the molecular differences between melanoma tumor subtyp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43512-z
更新日期:2019-05-10 00:00:00
abstract::BPA is an oestrogenic endocrine disrupting chemical compound. Exposure to BPA in as early as pregnancy leads to lifelong effects. Since endocrine and immune systems interact in a bidirectional manner, endocrine disruption may cause permanent alterations of the immune system, affecting a future anti-tumoral response. N...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10135-1
更新日期:2017-09-05 00:00:00
abstract::We previously demonstrated that ABCD4 does not localize to peroxisomes but rather, the endoplasmic reticulum (ER), because it lacks the NH2-terminal hydrophilic region required for peroxisomal targeting. It was recently reported that mutations in ABCD4 result in a failure to release vitamin B12 from lysosomes. A simil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30183
更新日期:2016-07-26 00:00:00
abstract::High-throughput sequencing was applied to analyze the effects of toxic Microcystis aeruginosa on the silver carp Hypophthalmichthys molitrix. Silver carps were exposed to two cyanobacteria species (toxic and non-toxic) for RNA-seq and miRNA-seq analysis. RNA-seq revealed that the liver tissue contained 105,379 unigene...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10335-9
更新日期:2017-09-05 00:00:00
abstract::Knockin (KI) mouse carrying a point mutation has been an invaluable tool for disease modeling and analysis. Genome editing technologies using the CRISPR/Cas system has emerged as an alternative way to create KI mice. However, if the mice carry nucleotide insertions and/or deletions (InDels) in other genes, which could...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34703
更新日期:2016-10-04 00:00:00
abstract::Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a nov...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11030
更新日期:2015-06-05 00:00:00
abstract::During value-based decision making, ventromedial prefrontal cortex (vmPFC) is thought to support choices by tracking the expected gain from different outcomes via a competition-based process. Using a computational neurostimulation approach we asked how perturbing this region might alter this competition and resulting ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25160
更新日期:2016-05-05 00:00:00
abstract::Articular cartilage (AC) lacks the ability to self-repair and cell-based approaches, primarily based on using chondrocytes and mesenchymal stem cells (MSCs), are emerging as effective technology to restore cartilage functionality, because cells synergic functionality may support the maintenance of chondrogenic phenoty...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51070-7
更新日期:2019-10-10 00:00:00
abstract::Transposable elements (TEs) are genomic sequences that can move, multiply, and often form sizable fractions of vertebrate genomes. Fish belong to a unique group of vertebrates, since their karyotypes and genome sizes are more diverse and complex, with probably higher diversity and evolution specificity of TE. To inves...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51888-1
更新日期:2019-10-28 00:00:00
abstract::Almost half of the groundwater in the Pearl River Delta (PRD) contains salt water originally derived from paleo-seawater due to the Holocene transgression, which then generates intense physicochemical gradients in the mixing zone between freshwater and saltwater. Although some studies have been conducted on the hydrol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35350-2
更新日期:2018-11-23 00:00:00
abstract::Human protein tyrosine phosphatase non-receptor type 4 (PTPN4) has been shown to prevent cell death. The active form of human PTPN4 consists of two globular domains, a PDZ (PSD-95/Dlg/ZO-1) domain and a phosphatase domain, tethered by a flexible linker. Targeting its PDZ domain abrogates this protection and triggers a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08193-6
更新日期:2017-08-11 00:00:00
abstract::Spiders can cause trophic cascades affecting litter decomposition rates. However, it remains unclear how spiders with different foraging strategies influence faunal communities, or present cascading effects on decomposition. Furthermore, increased dry periods predicted in future climates will likely have important con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12396
更新日期:2015-07-23 00:00:00
abstract::Host-genetic control of influenza virus infection has been the object of little attention. In this study we determined that two inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectively relatively resistant and susceptible to infection with the low pathogenicity influenza vir...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26787
更新日期:2016-06-09 00:00:00
abstract::Medical folk wisdom (MFW) refers to widely held, but factually inaccurate, beliefs about disease, immunity, pregnancy, and other medically-relevant topics. Examples include the idea that fasting when feverish ("starving a fever") can increase the pace of recovery, or that showering after sex can prevent pregnancy. The...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67744-6
更新日期:2020-07-01 00:00:00
abstract::Global climate change is predicted to alter precipitation and temperature patterns across the world, affecting a range of infectious diseases and particularly foodborne infections such as Campylobacter. In this study, we used national surveillance data to analyse the relationship between climate and campylobacteriosis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70593-y
更新日期:2020-08-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-63873-0
更新日期:2020-04-17 00:00:00
abstract::F-box and WD40 domain protein 7 (FBXW7) is a component of the SKP1-CUL1-F-box protein (SCF) complex that mediates the ubiquitination of diverse oncogenic target proteins. The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (Arg465, Arg479, and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19769-1
更新日期:2018-01-31 00:00:00
abstract::Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed and quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there is a paucity of data examining whether OCT-A metrics are ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02767-0
更新日期:2017-05-31 00:00:00
abstract::To investigate the influence of chemical weathering on CO2 consumption, an analysis was performed of water chemistry by applying water chemistry equilibria methods in the Bishuiyan subterranean basin, SW China. The average value of total ion concentrations (TZ+) was 1,854.97 μEq/L, which was significantly higher than ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68572-4
更新日期:2020-07-15 00:00:00
abstract::Nitrogen metabolism in gut systems remains poorly studied in spite of its importance for microbial growth and its implications for the metabolism of the host. Prevotella spp. are the most predominant bacteria detected in the rumen, but their presence has also been related to health and disease states in the human gut ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08463-3
更新日期:2017-08-10 00:00:00
abstract::The seven-helical bundle of rhodopsin and other G-protein coupled receptors undergoes structural rearrangements as the transmembrane receptor protein is activated. These structural changes are known to involve tilting and bending of various transmembrane helices. However, the cause and effect relationship among struct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34129
更新日期:2016-09-23 00:00:00
abstract::Psychological distress induces oxidative stress and alters mitochondrial metabolism in the nervous and immune systems. Psychological distress promotes alterations in brain metabolism and neurochemistry in wild-type (WT) rats in a similar manner as in Parkinsonian rats lacking endogenous PTEN-induced kinase 1 (PINK1), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66745-9
更新日期:2020-06-17 00:00:00
abstract::Structural isomers, molecules having the same chemical formula but with atoms bonded in different order, are hard to identify using conventional spectroscopy and mass spectrometry. They exhibit virtually indistinguishable mass spectra when ionized by electrons. Laser mass spectrometry based on photoionization of the i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22055-9
更新日期:2018-02-28 00:00:00
abstract::We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80389-9
更新日期:2021-01-13 00:00:00
abstract::Quantum walk is a key operation in quantum computing, simulation, communication and information. Here, we report for the first time the demonstration of quantum walks and localized quantum walks in a new type of optical fibers having a ring of cores constructed with both periodic and quasiperiodic Fibonacci sequences,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64065-6
更新日期:2020-04-28 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24117-4
更新日期:2018-04-17 00:00:00
abstract::Particle transport phenomena in the deep alveolated airways of the lungs (i.e. pulmonary acinus) govern deposition outcomes following inhalation of hazardous or pharmaceutical aerosols. Yet, there is still a dearth of experimental tools for resolving acinar particle dynamics and validating numerical simulations. Here,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14071
更新日期:2015-09-11 00:00:00