Abstract：
:We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Debortoli G,de Araujo GS,Fortes-Lima C,Parra EJ,Suarez-Kurtz Gdoi
10.1038/s41598-020-80389-9subject
Has Abstractpub_date
2021-01-13 00:00:00pages
1007issue
1issn
2045-2322pii
10.1038/s41598-020-80389-9journal_volume
11pub_type
杂志文章abstract：:Lipopolysaccharide (LPS) is a major component of the outer wall of gram negative bacteria. In high doses LPS contributes to the inflammation in gram negative sepsis, and in low doses contributes to the low grade inflammation characteristic of the metabolic syndrome. We wanted to assess the role of beta2-glycoprotein I...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-09-27 00:00:00
abstract：:The phase behaviour of a system composed of amino acid-based surfactant (sodium N-lauroylsarcosinate hydrate), 1-decanol and deionised water was investigated for vesicle formation. Changing the molar ratio of the amphiphiles, two important aggregate structures were observed in the aqueous corner of the phase diagram. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00071
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13081
更新日期：2015-08-14 00:00:00
abstract：:Asymmetric cell divisions are of fundamental importance for the development of multicellular organisms, e.g. for the generation of founder cells. Prime examples are asymmetric cell divisions in germline precursors during the early embryogenesis of the transparent roundworm Caenorhabditis elegans, one of the major deve...
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pub_type： 杂志文章
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更新日期：2017-08-24 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-03-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-11-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-08-27 00:00:00
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journal_title：Scientific reports
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更新日期：2017-03-06 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
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journal_title：Scientific reports
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