Selective alteration of human value decisions with medial frontal tDCS is predicted by changes in attractor dynamics.

Abstract:

:During value-based decision making, ventromedial prefrontal cortex (vmPFC) is thought to support choices by tracking the expected gain from different outcomes via a competition-based process. Using a computational neurostimulation approach we asked how perturbing this region might alter this competition and resulting value decisions. We simulated a perturbation of neural dynamics in a biophysically informed model of decision-making through in silico depolarization at the level of neuronal ensembles. Simulated depolarization increased baseline firing rates of pyramidal neurons, which altered their susceptibility to background noise, and thereby increased choice stochasticity. These behavioural predictions were compared to choice behaviour in healthy participants performing similar value decisions during transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique. We placed the soma depolarizing electrode over medial frontal PFC. In line with model predictions, this intervention resulted in more random choices. By contrast, no such effect was observed when placing the depolarizing electrode over lateral PFC. Using a causal manipulation of ventromedial and lateral prefrontal function, these results provide support for competition-based choice dynamics in human vmPFC, and introduce computational neurostimulation as a mechanistic assay for neurostimulation studies of cognition.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hämmerer D,Bonaiuto J,Klein-Flügge M,Bikson M,Bestmann S

doi

10.1038/srep25160

subject

Has Abstract

pub_date

2016-05-05 00:00:00

pages

25160

issn

2045-2322

pii

srep25160

journal_volume

6

pub_type

杂志文章
  • Cerium/diethyldithiocarbamate complex as a novel corrosion inhibitive pigment for AA2024-T3.

    abstract::In this work, cerium-diethyldithiocarbamate (Ce-DEDTC) complex was synthesized as a novel anti-corrosion pigment. The structure of the synthesized pigment was characterized by employing Fourier transfer infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, inductively coupled plasma optical emission sp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61946-8

    authors: Mohammadi I,Shahrabi T,Mahdavian M,Izadi M

    更新日期:2020-03-19 00:00:00

  • Effect of Light Scattering and Higher-order Aberrations on Visual Performance in Eyes with Granular Corneal Dystrophy.

    abstract::This study was aimed to assess the relationship of intraocular forward scattering, corneal backward scattering, and corneal higher-order aberrations (HOAs) with corrected distance visual acuity (CDVA) in eyes with granular corneal dystrophy (GCD). We retrospectively examined forty two eyes of 42 consecutive patients w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24677

    authors: Kamiya K,Kobashi H,Igarashi A,Shoji N,Shimizu K

    更新日期:2016-04-18 00:00:00

  • Strong quantum scarring by local impurities.

    abstract::We discover and characterise strong quantum scars, or quantum eigenstates resembling classical periodic orbits, in two-dimensional quantum wells perturbed by local impurities. These scars are not explained by ordinary scar theory, which would require the existence of short, moderately unstable periodic orbits in the p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37656

    authors: Luukko PJ,Drury B,Klales A,Kaplan L,Heller EJ,Räsänen E

    更新日期:2016-11-28 00:00:00

  • Open-label placebos reduce test anxiety and improve self-management skills: A randomized-controlled trial.

    abstract::Test anxiety is a condition in which people experience extreme distress and anxiety before and in test situations. It affects up to 40 percent of all students. Conventional treatment includes both medication and psychotherapy, but studies also demonstrated that placebos affect anxiety symptoms. Although in the traditi...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-019-49466-6

    authors: Schaefer M,Denke C,Harke R,Olk N,Erkovan M,Enge S

    更新日期:2019-09-16 00:00:00

  • Blastocyst hatching site is regularly distributed and does not influence foetal development in mice.

    abstract::Hatching out from the zona pellucida (ZP) is a crucial step for blastocyst implantation and development. However, it is still unknown whether the location of the hatching site relative to the inner cell mass (ICM) affects embryo implantation and foetal development. Here, we classified hatching blastocysts into three c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59424-2

    authors: Liu SJ,Sun JB,Hao X,Han Z,Wen X,Wang XY,Zhou CJ,Liang CG

    更新日期:2020-02-12 00:00:00

  • Social content and emotional valence modulate gaze fixations in dynamic scenes.

    abstract::Previous research has shown that low-level visual features (i.e., low-level visual saliency) as well as socially relevant information predict gaze allocation in free viewing conditions. However, these studies mainly used static and highly controlled stimulus material, thus revealing little about the robustness of atte...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22127-w

    authors: Rubo M,Gamer M

    更新日期:2018-02-28 00:00:00

  • Application of galangin, an active component of Alpinia officinarum Hance (Zingiberaceae), for use in drug-eluting stents.

    abstract::In clinical pathology, stent interposition is used to treat vascular disease but can lead to restenosis. Drug-eluting stents (DES) are most commonly used to suppress restenosis but can also have side effects. Therefore, we investigated the anti-proliferative effect and its possible target in vitro and in vivo. We foun...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08410-2

    authors: Lee JJ,Lee JH,Yim NH,Han JH,Ma JY

    更新日期:2017-08-15 00:00:00

  • Humans best judge how much to cooperate when facing hard problems in large groups.

    abstract::We report the results of a game-theoretic experiment with human players who solve problems of increasing complexity by cooperating in groups of increasing size. Our experimental environment is set up to make it complicated for players to use rational calculation for making the cooperative decisions. This environment i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41773-2

    authors: Guazzini A,Stefanelli F,Imbimbo E,Vilone D,Bagnoli F,Levnajić Z

    更新日期:2019-04-02 00:00:00

  • Fragile aspects of topological transition in lossy and parity-time symmetric quantum walks.

    abstract::Quantum walks often provide telling insights about the structure of the system on which they are performed. In [Formula: see text]-symmetric and lossy dimer lattices, the topological properties of the band structure manifest themselves in the quantization of the mean displacement of such a walker. We investigate the f...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-30344-6

    authors: Harter AK,Saxena A,Joglekar YN

    更新日期:2018-08-13 00:00:00

  • Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

    abstract::The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endangered list of threat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28880-2

    authors: Smedley CJ,Stanley PA,Qazzaz ME,Prota AE,Olieric N,Collins H,Eastman H,Barrow AS,Lim KH,Kam TS,Smith BJ,Duivenvoorden HM,Parker BS,Bradshaw TD,Steinmetz MO,Moses JE

    更新日期:2018-07-13 00:00:00

  • The PEG-responding desiccome of the alder microsymbiont Frankia alni.

    abstract::Actinorhizal plants are ecologically and economically important. Symbiosis with nitrogen-fixing bacteria allows these woody dicotyledonous plants to colonise soils under nitrogen deficiency, water-stress or other extreme conditions. However, proteins involved in xerotolerance of symbiotic microorganisms have yet to be...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18839-0

    authors: Ghedira K,Harigua-Souiai E,Ben Hamda C,Fournier P,Pujic P,Guesmi S,Guizani I,Miotello G,Armengaud J,Normand P,Sghaier H

    更新日期:2018-01-15 00:00:00

  • Computational modelling of patient specific spring assisted lambdoid craniosynostosis correction.

    abstract::Lambdoid craniosynostosis (LC) is a rare non-syndromic craniosynostosis characterised by fusion of the lambdoid sutures at the back of the head. Surgical correction including the spring assisted cranioplasty is the only option to correct the asymmetry at the skull in LC. However, the aesthetic outcome from spring assi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75747-6

    authors: Bozkurt S,Borghi A,van de Lande LS,Jeelani NUO,Dunaway DJ,Schievano S

    更新日期:2020-10-29 00:00:00

  • Ligand induced switching of the band alignment in aqueous synthesized CdTe/CdS core/shell nanocrystals.

    abstract::CdTe/CdS core/shell quantum dots (QDs) are formed in aqueous synthesis via the partial decomposition of hydrophilic thiols, used as surface ligands. In this work, we investigate the influence of the chemical nature (functional group and chain length) of the used surface ligands on the shell formation. Four different s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44787-y

    authors: Vale BRC,Mourão RS,Bettini J,Sousa JCL,Ferrari JL,Reiss P,Aldakov D,Schiavon MA

    更新日期:2019-06-06 00:00:00

  • Histopathological imaging features- versus molecular measurements-based cancer prognosis modeling.

    abstract::For lung and many other cancers, prognosis is essentially important, and extensive modeling has been carried out. Cancer is a genetic disease. In the past 2 decades, diverse molecular data (such as gene expressions and DNA mutations) have been analyzed in prognosis modeling. More recently, histopathological imaging da...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72201-5

    authors: Zhang S,Fan Y,Zhong T,Ma S

    更新日期:2020-09-14 00:00:00

  • A dual drug regimen synergistically blocks human parainfluenza virus infection.

    abstract::Human parainfluenza type-3 virus (hPIV-3) is one of the principal aetiological agents of acute respiratory illness in infants worldwide and also shows high disease severity in the elderly and immunocompromised, but neither therapies nor vaccines are available to treat or prevent infection, respectively. Using a multid...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24138

    authors: Bailly B,Dirr L,El-Deeb IM,Altmeyer R,Guillon P,von Itzstein M

    更新日期:2016-04-07 00:00:00

  • Prevalence and associated factors of glaucoma in the Russian Ural Eye and Medical Study.

    abstract::To assess the prevalence and associated factors of glaucoma in a Russian population. The population-based Ural Eye and Medical Study included 5899 (mean age 59.0 ± 10.7 years; range 40-94 years). Glaucomatous optic neuropathy was diagnosed using International Society of Geographical and Epidemiological Ophthalmology (...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77344-z

    authors: Bikbov MM,Gilmanshin TR,Zainullin RM,Kazakbaeva GM,Arslangareeva II,Panda-Jonas S,Khikmatullin RI,Aminev SK,Nuriev IF,Zaynetdinov AF,Uzianbaeva YV,Nikitin NA,Mukhamadieva SR,Yakupova DF,Rakhimova EM,Rusakova IA,Bolshakova

    更新日期:2020-11-20 00:00:00

  • Reconstruction of the cropland cover changes in eastern China between the 10th century and 13th century using historical documents.

    abstract::To evaluate and improve datasets of anthropogenic land cover change used in local and global climate models, great efforts were made to reconstruct historical land use, including the LandCover 6k project which dedicated to reconstructing human land use over the past 10,000 years. In this study, we utilized historical ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31807-6

    authors: Li M,He F,Li S,Yang F

    更新日期:2018-09-10 00:00:00

  • In situ estimation of optical properties of rat and monkey brains using femtosecond time-resolved measurements.

    abstract::An accurate knowledge of tissue optical properties (absorption coefficients, μa, and reduced scattering coefficients, μs') is critical for precise modeling of light propagation in biological tissue, essential for developing diagnostic and therapeutic optical techniques that utilize diffusive photons. A great number of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45736-5

    authors: Hoshi Y,Tanikawa Y,Okada E,Kawaguchi H,Nemoto M,Shimizu K,Kodama T,Watanabe M

    更新日期:2019-06-24 00:00:00

  • Predicting Radiation Resistance in Breast Cancer with Expression Status of Phosphorylated S6K1.

    abstract::Emerging evidence suggests that the mammalian target of rapamcyin (mTOR) pathway is associated with radio-resistance in cancer treatment. We hypothesised that phosphorylated ribosomal S6 kinase 1 (p-S6K1), a major downstream regulator of the mTOR pathway, may play a role in predicting radio-resistance. Therefore, we e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57496-8

    authors: Choi J,Yoon YN,Kim N,Park CS,Seol H,Park IC,Kim HA,Noh WC,Kim JS,Seong MK

    更新日期:2020-01-20 00:00:00

  • Discovery of Amorphous Iron Hydrides via Novel Quiescent Reaction in Aqueous Solution.

    abstract::Novel amorphous iron hydrides (AIHs) are synthesized for the first time under ambient conditions by employing novel "quiescent reaction", without stirring for mixing solutions, during a conventional aqueous reduction-precipitation process. The kind and morphology of AIHs are dependent on the processing condition, wher...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63124-2

    authors: Taguchi K,Shinozaki K,Okumura H,Michioka C,Yoshimura K,Ishihara KN

    更新日期:2020-04-10 00:00:00

  • Aspirin metabolite sodium salicylate selectively inhibits transcriptional activity of ATF6α and downstream target genes.

    abstract::In response to ER stress, activating transcription factor 6 (ATF6) traffics from ER to Golgi apparatus where it is activated by cleavage before being translocated as transcription factor to the cell nucleus. In this work we describe ATF6α as a newly target of the aspirin metabolite sodium salicylate (NaSal). NaSal tre...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09500-x

    authors: Mügge FLB,Silva AM

    更新日期:2017-08-23 00:00:00

  • PEDLA: predicting enhancers with a deep learning-based algorithmic framework.

    abstract::Transcriptional enhancers are non-coding segments of DNA that play a central role in the spatiotemporal regulation of gene expression programs. However, systematically and precisely predicting enhancers remain a major challenge. Although existing methods have achieved some success in enhancer prediction, they still su...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28517

    authors: Liu F,Li H,Ren C,Bo X,Shu W

    更新日期:2016-06-22 00:00:00

  • Evening home lighting adversely impacts the circadian system and sleep.

    abstract::The regular rise and fall of the sun resulted in the development of 24-h rhythms in virtually all organisms. In an evolutionary heartbeat, humans have taken control of their light environment with electric light. Humans are highly sensitive to light, yet most people now use light until bedtime. We evaluated the impact...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75622-4

    authors: Cain SW,McGlashan EM,Vidafar P,Mustafovska J,Curran SPN,Wang X,Mohamed A,Kalavally V,Phillips AJK

    更新日期:2020-11-05 00:00:00

  • Cost-effectiveness of newer technologies for the diagnosis of Mycobacterium tuberculosis infection in Brazilian people living with HIV.

    abstract::Tuberculosis is the leading cause of death among people living with HIV (PLH). Preventive tuberculosis therapy reduces mortality in PLH, especially in those with a positive tuberculin skin test (TST). New, more specific technologies for detecting latent tuberculosis infection (LTBI) are now commercially available. We ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78737-w

    authors: Steffen RE,Pinto M,Kritski A,Trajman A

    更新日期:2020-12-11 00:00:00

  • Tyrosine kinase receptor TIE-1 mediates platinum resistance by promoting nucleotide excision repair in ovarian cancer.

    abstract::Platinum resistance is one of the most challenging problems in ovarian cancer treatment. High-throughput functional siRNA screening identified tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE-1) as a gene that confers cells resistant to cisplatin. Conversely enforced over-expression of TIE-1 was va...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31069-2

    authors: Ishibashi M,Toyoshima M,Zhang X,Hasegawa-Minato J,Shigeta S,Usui T,Kemp CJ,Grandori C,Kitatani K,Yaegashi N

    更新日期:2018-09-04 00:00:00

  • Effects of Leisure-Time Physical Activity on Vertebral Dimensions in the Northern Finland Birth Cohort 1966.

    abstract::Vertebral fractures are a common burden amongst elderly and late middle aged people. Vertebral cross-sectional area (CSA) is a major determinant of vertebral strength and thus associated with vertebral fracture risk. Previous studies suggest that physical activity affects vertebral CSA. We aimed to investigate the rel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27844

    authors: Oura P,Paananen M,Niinimäki J,Tammelin T,Herrala S,Auvinen J,Korpelainen R,Junno JA,Karppinen J

    更新日期:2016-06-10 00:00:00

  • Developing dual herbicide tolerant transgenic rice plants for sustainable weed management.

    abstract::Herbicides are important constituents of modern integrated weed management system. However, the continuous use of a single herbicide leads to the frequent evolution of resistant weeds which further challenges their management. To overcome this situation, alternating use of multiple herbicides along with conventional w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29554-9

    authors: Fartyal D,Agarwal A,James D,Borphukan B,Ram B,Sheri V,Agrawal PK,Achary VMM,Reddy MK

    更新日期:2018-08-02 00:00:00

  • Tulane virus recognizes sialic acids as cellular receptors.

    abstract::The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11784

    authors: Tan M,Wei C,Huang P,Fan Q,Quigley C,Xia M,Fang H,Zhang X,Zhong W,Klassen JS,Jiang X

    更新日期:2015-07-06 00:00:00

  • Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion.

    abstract::Olfactory receptors (ORs) mediate olfactory chemo-sensation in OR neurons. Herein, we have demonstrated that the OR chemo-sensing machinery functions in pancreatic β-cells and modulates insulin secretion. First, we found several OR isoforms, including OLFR15 and OLFR821, to be expressed in pancreatic islets and a β-ce...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19765-5

    authors: Munakata Y,Yamada T,Imai J,Takahashi K,Tsukita S,Shirai Y,Kodama S,Asai Y,Sugisawa T,Chiba Y,Kaneko K,Uno K,Sawada S,Hatakeyama H,Kanzaki M,Miyazaki JI,Oka Y,Katagiri H

    更新日期:2018-01-24 00:00:00

  • Pattern invariance for reaction-diffusion systems on complex networks.

    abstract::Given a reaction-diffusion system interacting via a complex network, we propose two different techniques to modify the network topology while preserving its dynamical behaviour. In the region of parameters where the homogeneous solution gets spontaneously destabilized, perturbations grow along the unstable directions ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34372-0

    authors: Cencetti G,Clusella P,Fanelli D

    更新日期:2018-11-01 00:00:00