Computational modelling of patient specific spring assisted lambdoid craniosynostosis correction.

Abstract:

:Lambdoid craniosynostosis (LC) is a rare non-syndromic craniosynostosis characterised by fusion of the lambdoid sutures at the back of the head. Surgical correction including the spring assisted cranioplasty is the only option to correct the asymmetry at the skull in LC. However, the aesthetic outcome from spring assisted cranioplasty may remain suboptimal. The aim of this study is to develop a parametric finite element (FE) model of the LC skulls that could be used in the future to optimise spring surgery. The skull geometries from three different LC patients who underwent spring correction were reconstructed from the pre-operative computed tomography (CT) in Simpleware ScanIP. Initially, the skull growth between the pre-operative CT imaging and surgical intervention was simulated using MSC Marc. The osteotomies and spring implantation were performed to simulate the skull expansion due to the spring forces and skull growth between surgery and post-operative CT imaging in MSC Marc. Surface deviation between the FE models and post-operative skull models reconstructed from CT images changed between ± 5 mm over the skull geometries. Replicating spring assisted cranioplasty in LC patients allow to tune the parameters for surgical planning, which may help to improve outcomes in LC surgeries in the future.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Bozkurt S,Borghi A,van de Lande LS,Jeelani NUO,Dunaway DJ,Schievano S

doi

10.1038/s41598-020-75747-6

subject

Has Abstract

pub_date

2020-10-29 00:00:00

pages

18693

issue

1

issn

2045-2322

pii

10.1038/s41598-020-75747-6

journal_volume

10

pub_type

杂志文章
  • Metabolic and protein interaction sub-networks controlling the proliferation rate of cancer cells and their impact on patient survival.

    abstract::Cancer cells can have a broad scope of proliferation rates. Here we aim to identify the molecular mechanisms that allow some cancer cell lines to grow up to 4 times faster than other cell lines. The correlation of gene expression profiles with the growth rate in 60 different cell lines has been analyzed using several ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03041

    authors: Feizi A,Bordel S

    更新日期:2013-10-24 00:00:00

  • Gene expression profile in patients with Gaucher disease indicates activation of inflammatory processes.

    abstract::Gaucher disease (GD) is a rare inherited metabolic disease caused by pathogenic variants in the GBA1 gene. So far, the pathomechanism of GD was investigated mainly in animal models. In order to delineate the molecular changes in GD cells we analysed gene expression profile in cultured skin fibroblasts from GD patients...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42584-1

    authors: Ługowska A,Hetmańczyk-Sawicka K,Iwanicka-Nowicka R,Fogtman A,Cieśla J,Purzycka-Olewiecka JK,Sitarska D,Płoski R,Filocamo M,Lualdi S,Bednarska-Makaruk M,Koblowska M

    更新日期:2019-04-15 00:00:00

  • Fine-tuning of synaptic upscaling at excitatory synapses by endocannabinoid signaling is mediated via the CB1 receptor.

    abstract::The endocannabinoid 2-arachidonoylglycerol (2-AG) functions as a retrograde signaling molecule mediating synaptic transmission and plasticity at both inhibitory and excitatory synapses. However, little is known about whether 2-AG signaling is involved in homeostatic regulation of miniature synaptic events at excitator...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16257

    authors: Song Y,Zhang J,Chen C

    更新日期:2015-11-06 00:00:00

  • Evidence of language-related left hypofrontality in Major Depression: An EEG Beta band study.

    abstract::Major depression (MDD) has been associated with an altered EEG frontal asymmetry measured in resting state; nevertheless, this association has showed a weak consistency across studies. In the present study, which starts from an evolutionistic view of psychiatric disorders, we investigated frontal asymmetry in MDD, usi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65168-w

    authors: Spironelli C,Maffei A,Romeo Z,Piazzon G,Padovan G,Magnolfi G,Pasini I,Gomez Homen F,Concari G,Angrilli A

    更新日期:2020-05-18 00:00:00

  • Machine learning as an improved estimator for magnetization curve and spin gap.

    abstract::The magnetization process is a very important probe to study magnetic materials, particularly in search of spin-liquid states in quantum spin systems. Regrettably, however, progress of the theoretical analysis has been unsatisfactory, mostly because it is hard to obtain sufficient numerical data to support the theory....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70389-0

    authors: Nakamura T

    更新日期:2020-08-26 00:00:00

  • Addressing reliability and degradation of chemitransistor sensors by electrical tuning of the sensitivity.

    abstract::Here we show that electrical tuning of the sensitivity of chemitransistor sensors, namely field-effect-transistors (FETs) exploiting nano/mesostructured sensing materials, can be used to effectively address two chief problems of state-of-the-art gas sensors, specifically fabrication reliability and degradation by agin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01161

    authors: Lazzerini GM,Strambini LM,Barillaro G

    更新日期:2013-01-01 00:00:00

  • MEN1/Menin regulates milk protein synthesis through mTOR signaling in mammary epithelial cells.

    abstract::The MEN1 gene, which encodes the protein Menin, was investigated for its regulatory role in milk protein synthesis in mammary glands. Menin responds to nutrient and hormone levels via the PI3K/Akt/mTOR pathway. Bovine mammary epithelial cells and tissues were used as experimental models in this study. The results reve...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06054-w

    authors: Li H,Liu X,Wang Z,Lin X,Yan Z,Cao Q,Zhao M,Shi K

    更新日期:2017-07-14 00:00:00

  • A 64-pin Nanowire Surface Fastener Like a Ball Grid Array Applied for Room-temperature Electrical Bonding.

    abstract::Surface-mount techniques primarily depend on soldering. However, soldering techniques have encountered some challenges in recent years. These challenges include rare metal recycling, thermal problems, and Pb toxicity. We recently developed a metallic nanowire surface fastener (NSF) to resolve the abovementioned proble...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37693-2

    authors: Toku Y,Ichioka K,Morita Y,Ju Y

    更新日期:2019-01-31 00:00:00

  • Form and function of the human and chimpanzee forefoot: implications for early hominin bipedalism.

    abstract::During bipedal walking, modern humans dorsiflex their forefoot at the metatarsophalangeal joints (MTPJs) prior to push off, which tightens the plantar soft tissues to convert the foot into a stiff propulsive lever. Particular features of metatarsal head morphology such as "dorsal doming" are thought to facilitate this...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30532

    authors: Fernández PJ,Holowka NB,Demes B,Jungers WL

    更新日期:2016-07-28 00:00:00

  • Genetic insights into underground responses to Fusarium graminearum infection in wheat.

    abstract::The ongoing global intensification of wheat production will likely be accompanied by a rising pressure of Fusarium diseases. While utmost attention was given to Fusarium head blight (FHB) belowground plant infections of the pathogen have largely been ignored. The current knowledge about the impact of soil borne Fusari...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31544-w

    authors: Voss-Fels KP,Qian L,Gabur I,Obermeier C,Hickey LT,Werner CR,Kontowski S,Frisch M,Friedt W,Snowdon RJ,Gottwald S

    更新日期:2018-09-03 00:00:00

  • Observation of positive-negative sub-wavelength interference without intensity correlation calculation.

    abstract::We report an experimental demonstration of positive-negative sub-wavelength interference without correlation. Typically, people can achieve sub-wavelength effects with correlation measurement no matter by using bi-photon or thermal light sources. In this paper, we adopt a thermal light source, and we count the realiza...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-82030-9

    authors: Dou LY,Cao DZ,Xu DQ,Zhang AN,Song XB

    更新日期:2021-01-28 00:00:00

  • Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model.

    abstract::The role of transforming growth factor-β (TGF-β) signaling in cancer progression is still under debate. To determine the function of TGF-β signaling in bladder cancer progression, we conditionally knocked out the Tgfbr2 in mouse model after a N-butyl-N-4-hydroxybutyl Nitrosamine induced bladder carcinogenesis. We foun...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29479

    authors: Liang Y,Zhu F,Zhang H,Chen D,Zhang X,Gao Q,Li Y

    更新日期:2016-07-05 00:00:00

  • Cortical mechanisms for afterimage formation: evidence from interocular grouping.

    abstract::Whether the retinal process alone or retinal and cortical processes jointly determine afterimage (AI) formation has long been debated. Based on the retinal rebound responses, recent work proposes that afterimage signals are exclusively generated in the retina, although later modified by cortical mechanisms. We tested ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41101

    authors: Dong B,Holm L,Bao M

    更新日期:2017-01-23 00:00:00

  • The effect of unilateral mean luminance on binocular combination in normal and amblyopic vision.

    abstract::Luminance plays a modulating role in the processes of several visual tasks, which in turn provides significant information for the understanding of visual processing. Here, using a binocular phase combination paradigm, we studied the effect of unilateral changes in mean luminance on binocular combination in both norma...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02012

    authors: Zhou J,Jia W,Huang CB,Hess RF

    更新日期:2013-01-01 00:00:00

  • Whole genome sequencing, analyses of drug resistance-conferring mutations, and correlation with transmission of Mycobacterium tuberculosis carrying katG-S315T in Hanoi, Vietnam.

    abstract::Drug-resistant tuberculosis (TB) is a serious global problem, and pathogen factors involved in the transmission of isoniazid (INH)-resistant TB have not been fully investigated. We performed whole genome sequencing of 332 clinical Mycobacterium tuberculosis (Mtb) isolates collected from patients newly diagnosed with s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51812-7

    authors: Hang NTL,Hijikata M,Maeda S,Thuong PH,Ohashi J,Van Huan H,Hoang NP,Miyabayashi A,Cuong VC,Seto S,Van Hung N,Keicho N

    更新日期:2019-10-25 00:00:00

  • Silibinin, A Natural Blend In Polytherapy Formulation For Targeting Cd44v6 Expressing Colon Cancer Stem Cells.

    abstract::Colon cancer stem cells have been attributed to poor prognosis, therapeutic resistance and aggressive nature of the malignancy. Recent reports associated CD44v6 expression with relapse, metastasis and reduced 5-year survival of colon cancer patients, thereby making it a potential therapeutic target. Thus, in this stud...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35069-0

    authors: Patel S,Waghela B,Shah K,Vaidya F,Mirza S,Patel S,Pathak C,Rawal R

    更新日期:2018-11-19 00:00:00

  • The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes.

    abstract::Survivin is an independent prognostic factor for joint destruction in rheumatoid arthritis (RA). However, the expression and function of survivin in RA synoviocytes remain unclear. We certified the expression of survivin in RA synovial tissues and performed the experiment using RA fibroblast-like synoviocytes (RA-FLS)...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09795

    authors: Mokuda S,Miyazaki T,Ito Y,Yamasaki S,Inoue H,Guo Y,Kong WS,Kanno M,Takasugi K,Sugiyama E,Masumoto J

    更新日期:2015-05-22 00:00:00

  • Resonance phenomena controlled by external feedback signals and additive noise in neural systems.

    abstract::Chaotic resonance is a phenomenon that can replace the fluctuation source in stochastic resonance from additive noise to chaos. We previously developed a method to control the chaotic state for suitably generating chaotic resonance by external feedback even when the external adjustment of chaos is difficult, establish...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48950-3

    authors: Nobukawa S,Shibata N,Nishimura H,Doho H,Wagatsuma N,Yamanishi T

    更新日期:2019-09-02 00:00:00

  • Vacancy-induced brittle to ductile transition of W-M co-doped Al3Ti (M=Si, Ge, Sn and Pb).

    abstract::We investigated the effect of vacancy formation on brittle (D022) to ductile (L12-like) transition in Al3Ti using DFT calculations. The well-known pseudogap on the density of states of Al3Ti migrates towards its Fermi level from far above, via a W - M co-doping strategy, where M is Si, Ge, Sn or Pb respectively. In pa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14398-6

    authors: Zhu M,Wu P,Li Q,Xu B

    更新日期:2017-10-25 00:00:00

  • Proton pump inhibitors act synergistically with fluconazole against resistant Candida albicans.

    abstract::The incidence of resistant Candida isolates, especially Candida albicans, has increased continuously. To overcome the resistance, research on antifungal agent sensitizers has attracted considerable attention. Omeprazole and lansoprazole were found to inhibit the growth of sensitive C. albicans and hyphae formation in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-57174-4

    authors: Lu M,Yan H,Yu C,Yuan L,Sun S

    更新日期:2020-01-16 00:00:00

  • Paternal obesity modifies the effect of an antenatal lifestyle intervention in women who are overweight or obese on newborn anthropometry.

    abstract::The contribution of paternal obesity to pregnancy outcomes has been little described. Our aims were to determine whether the effect of an antenatal maternal dietary and lifestyle intervention among women who are overweight or obese on newborn adiposity, was modified by paternal obesity. We conducted a secondary analys...

    journal_title:Scientific reports

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1038/s41598-017-01672-w

    authors: Dodd JM,Du Plessis LE,Deussen AR,Grivell RM,Yelland LN,Louise J,Mcphee AJ,Robinson JS,Owens JA

    更新日期:2017-05-08 00:00:00

  • Mobile nucleic acid amplification testing (mobiNAAT) for Chlamydia trachomatis screening in hospital emergency department settings.

    abstract::Management of curable sexually-transmitted infections (STI) such as Chlamydia can be revolutionized by highly sensitive nucleic acid testing that is deployable at the point-of-care (POC). Here we report the development of a mobile nucleic acid amplification testing (mobiNAAT) platform utilizing a mobile phone and drop...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04781-8

    authors: Shin DJ,Athamanolap P,Chen L,Hardick J,Lewis M,Hsieh YH,Rothman RE,Gaydos CA,Wang TH

    更新日期:2017-07-03 00:00:00

  • Neuronal imaging with ultrahigh dynamic range multiphoton microscopy.

    abstract::Multiphoton microscopes are hampered by limited dynamic range, preventing weak sample features from being detected in the presence of strong features, or preventing the capture of unpredictable bursts in sample strength. We present a digital electronic add-on technique that vastly improves the dynamic range of a multi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06065-7

    authors: Yang R,Weber TD,Witkowski ED,Davison IG,Mertz J

    更新日期:2017-07-19 00:00:00

  • Structural colour in Chondrus crispus.

    abstract::The marine world is incredibly rich in brilliant and intense colours. Photonic structures are found in many different species and provide extremely complex optical responses that cannot be achieved solely by pigments. In this study we examine the cuticular structure of the red alga Chondrus crispus (Irish Moss) using ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11645

    authors: Chandler CJ,Wilts BD,Vignolini S,Brodie J,Steiner U,Rudall PJ,Glover BJ,Gregory T,Walker RH

    更新日期:2015-07-03 00:00:00

  • Hedgehog-Interacting Protein (HIP) Regulates Apoptosis Evasion and Angiogenic Function of Late Endothelial Progenitor Cells.

    abstract::Late endothelial progenitor cells (LEPCs) are derived from mononuclear cells (MNCs) and are thought to directly incorporate into blood vessels and differentiate into mature endothelial cells (ECs). Using transcriptome and proteome analysis, we identified distinctive LEPC profiles and found that Hedgehog-interacting pr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12571-5

    authors: Lee BNR,Son YS,Lee D,Choi YJ,Kwon SM,Chang HK,Kim PH,Cho JY

    更新日期:2017-09-29 00:00:00

  • Using Artificial Intelligence and Novel Polynomials to Predict Subjective Refraction.

    abstract::This work aimed to use artificial intelligence to predict subjective refraction from wavefront aberrometry data processed with a novel polynomial decomposition basis. Subjective refraction was converted to power vectors (M, J0, J45). Three gradient boosted trees (XGBoost) algorithms were trained to predict each power ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65417-y

    authors: Rampat R,Debellemanière G,Malet J,Gatinel D

    更新日期:2020-05-22 00:00:00

  • Rapid acquisition of polymorphic virulence markers during adaptation of highly pathogenic avian influenza H5N8 virus in the mouse.

    abstract::Emergence of a highly pathogenic avian influenza (HPAI) H5N8 virus in Asia and its spread to Europe and North America has caused great concern for human health. Although the H5N8 virus has been only moderately pathogenic to mammalian hosts, virulence can still increase. We evaluated the pathogenic potential of several...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40667

    authors: Choi WS,Baek YH,Kwon JJ,Jeong JH,Park SJ,Kim YI,Yoon SW,Hwang J,Kim MH,Kim CJ,Webby RJ,Choi YK,Song MS

    更新日期:2017-01-17 00:00:00

  • Free Flap Outcomes of Microvascular Reconstruction after Repeated Segmental Mandibulectomy in Head and Neck Cancer Patients.

    abstract::This is the first study to investigate the impact of a second fibula flap or a soft tissue flap combined with bridging plate for a repeated segmental mandibulectomy reconstruction on flap outcomes in head and neck cancer patients. A retrospective comparative analysis (2007-2016) of 61 patients who underwent a second s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44467-x

    authors: Lin JA,Loh CYY,Tsai CH,Chang KP,Wu JC,Kao HK

    更新日期:2019-05-28 00:00:00

  • Dopamine functionalized tannic-acid-templated mesoporous silica nanoparticles as a new sorbent for the efficient removal of Cu2+ from aqueous solution.

    abstract::A simple, environmentally friendly and cost-effective nonsurfactant template method was used to synthesize tannic-acid-templated mesoporous silica nanoparticles (TMSNs), and then dopamine functionalized TMSNs (Dop-TMSNs) which was synthesized by a facile and biomimetic coating strategy, was developed as a new sorbent ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45215

    authors: Gao J,Lei H,Han Z,Shi Q,Chen Y,Jiang Y

    更新日期:2017-03-22 00:00:00

  • Quantum Secure Group Communication.

    abstract::We propose a quantum secure group communication protocol for the purpose of sharing the same message among multiple authorized users. Our protocol can remove the need for key management that is needed for the quantum network built on quantum key distribution. Comparing with the secure quantum network based on BB84, we...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21743-w

    authors: Li ZH,Zubairy MS,Al-Amri M

    更新日期:2018-03-01 00:00:00