Paternal obesity modifies the effect of an antenatal lifestyle intervention in women who are overweight or obese on newborn anthropometry.


:The contribution of paternal obesity to pregnancy outcomes has been little described. Our aims were to determine whether the effect of an antenatal maternal dietary and lifestyle intervention among women who are overweight or obese on newborn adiposity, was modified by paternal obesity. We conducted a secondary analysis of a multicenter randomised trial. Pregnant women with BMI ≥25 kg/m2 received either Lifestyle Advice or Standard Care. Paternal anthropometric measures included height, weight, BMI; waist, hip, calf and mid-upper arm circumferences; biceps and calf skinfold thickness measurements (SFTM); and percentage body fat. Newborn anthropometric outcomes included length; weight; head, arm, abdominal, and chest circumferences; biceps, triceps, subscapular, suprailiac, thigh, and lateral abdominal wall SFTM; and percentage body fat. The effect of an antenatal maternal dietary and lifestyle intervention among women who were overweight or obese on neonatal anthropometric measures, was significantly modified by paternal BMI ≥35.0 kg/m2, with a significantly smaller infant triceps, suprailiac, and thigh SFTM, and percent fat mass, compared with that observed in offspring of lean fathers. Further research is required to determine whether our observed associations are causal, and whether paternal weight loss prior to conception is a potential strategy to reduce the intergenerational effects of obesity.


Sci Rep


Scientific reports


Dodd JM,Du Plessis LE,Deussen AR,Grivell RM,Yelland LN,Louise J,Mcphee AJ,Robinson JS,Owens JA




Has Abstract


2017-05-08 00:00:00












  • PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis.

    abstract::In the jejunum, PepT1 is particularly enriched in the well-differentiated absorptive epithelial cells in the villi. Studies of expression and function of PepT1 along the crypt-villus axis demonstrated that this protein is crucial to the process of di/tripeptide absorption. We recently exhibited that PepT1 plays an imp...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhang Y,Viennois E,Zhang M,Xiao B,Han MK,Walter L,Garg P,Merlin D

    更新日期:2016-06-01 00:00:00

  • Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2.

    abstract::Psoriatic arthritis (PsA) patients have increased risk of both atherosclerosis and osteoporosis. Previous studies revealed that IL-33/ST2 axis may be related to both conditions; however, these associations were never evaluated in a single patients' group. Here we explored the association among plasma levels of IL-33 a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Shen J,Shang Q,Wong CK,Li EK,Kun EW,Cheng IT,Li M,Li TK,Zhu TY,Yu CM,Qin L,Tam LS

    更新日期:2016-08-24 00:00:00

  • Chromium exposure and incidence of metabolic syndrome among American young adults over a 23-year follow-up: the CARDIA Trace Element Study.

    abstract::Studies suggest that chromium deficiency is associated with elevated levels of fasting blood glucose, circulating insulin, cholesterol and triglycerides, and decreased proportion of lean body mass. However, data directly relating chromium levels to metabolic syndrome (MetS) risk are lacking. A total of 3,648 American ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bai J,Xun P,Morris S,Jacobs DR Jr,Liu K,He K

    更新日期:2015-10-22 00:00:00

  • Parametric study on the geometrical parameters of a lab-on-a-chip platform with tilted planar electrodes for continuous dielectrophoretic manipulation of microparticles.

    abstract::Advances in lab-on-a-chip (LOC) devices have led to significant improvements in the on-chip manipulation, separation, sorting, and isolation of particles and cells. Among various LOC-based approaches such as inertia-based methods, acoustophoresis, and magnetophoresis, the planar-slanted-electrode dielectrophoresis (DE...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dalili A,Taatizadeh E,Tahmooressi H,Tasnim N,Rellstab-Sánchez PI,Shaunessy M,Najjaran H,Hoorfar M

    更新日期:2020-07-16 00:00:00

  • Physical and mechanical properties of wood and their geographic variations in Larix sibirica trees naturally grown in Mongolia.

    abstract::We examined the physical and mechanical properties of wood in Siberian larch (Larix sibirica) trees that grow naturally in five Mongolian provenances (Khentii, Arkhangai, Zavkhan, Khuvsgul, and Selenge) and the geographic variations between them. Five trees with stem diameters of 20 to 30 cm at 1.3 m above ground were...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Tumenjargal B,Ishiguri F,Aiso H,Takahashi Y,Nezu I,Takashima Y,Baasan B,Chultem G,Ohshima J,Yokota S

    更新日期:2020-07-31 00:00:00

  • Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects.

    abstract::A lack of information regarding whether genetic polymorphisms of SLCO1B1 and ABCG2 affect the pharmacokinetics (PKs)/pharmacodynamics (PDs) of rosuvastatin in elderly subjects prevents optimal individualized pharmacotherapy of rosuvastatin in clinical settings. This study aimed to investigate the effect of age and gen...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章


    authors: Kim Y,Yoon S,Choi Y,Yoon SH,Cho JY,Jang IJ,Yu KS,Chung JY

    更新日期:2019-12-19 00:00:00

  • Prenatal Maternal Stress from a Natural Disaster Alters Urinary Metabolomic Profiles in Project Ice Storm Participants.

    abstract::Prenatal stress is known to epigenetically program offspring physiology and behaviour, and may become a risk factor for adult complex diseases. To gain insight into the underlying environment-gene interactions, we used proton nuclear magnetic resonance spectroscopy to analyze urinary metabolomes of male and female ado...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章


    authors: Paxman EJ,Boora NS,Kiss D,Laplante DP,King S,Montina T,Metz GAS

    更新日期:2018-08-28 00:00:00

  • Gearing Up the Human Ankle-Foot System to Reduce Energy Cost of Fast Walking.

    abstract::During locomotion, the human ankle-foot system dynamically alters its gearing, or leverage of the ankle joint on the ground. Shifting ankle-foot gearing regulates speed of plantarflexor (i.e., calf muscle) contraction, which influences economy of force production. Here, we tested the hypothesis that manipulating ankle...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ray SF,Takahashi KZ

    更新日期:2020-05-29 00:00:00

  • Electroluminescence from μLED without external charge injection.

    abstract::Stable electroluminescence from micro-pixelated light-emitting diode (μLED) occurs when electrons and holes are continuously injected from external electrodes. Different from the general recognition, in this work, μLED works in an operation mode, namely, non-electrical contact and non-carrier injection mode, and can b...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang K,Liu Y,Wu C,Li D,Lv S,Zhang Y,Zhou X,Guo T

    更新日期:2020-05-15 00:00:00

  • Author Correction: Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: John SE,Opie NL,Wong YT,Rind GS,Ronayne SM,Gerboni G,Bauquier SH,O'Brien TJ,May CN,Grayden DB,Oxley TJ

    更新日期:2018-11-27 00:00:00

  • Bacillus amyloliquefaciens MBI600 differentially induces tomato defense signaling pathways depending on plant part and dose of application.

    abstract::The success of Bacillus amyloliquefaciens as a biological control agent relies on its ability to outgrow plant pathogens. It is also thought to interact with its plant host by inducing systemic resistance. In this study, the ability of B. amyloliquefaciens MBI600 to elicit defense (or other) responses in tomato seedli...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dimopoulou A,Theologidis I,Liebmann B,Kalantidis K,Vassilakos N,Skandalis N

    更新日期:2019-12-13 00:00:00

  • Analysis of inter-system variability of systolic and diastolic intraventricular pressure gradients derived from color Doppler M-mode echocardiography.

    abstract::Assessment of intraventricular pressure gradients (IVPG) using color Doppler M-mode echocardiography has gained increasing interest in the evaluation of cardiac function. However, standardized analysis tools for IVPG quantification are missing. We aimed to evaluate the feasibility, the test-retest observer reproducibi...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章


    authors: Hodzic A,Bonnefous O,Langet H,Hamiche W,Chaufourier L,Tournoux F,Milliez P,Normand H,Saloux E

    更新日期:2020-04-28 00:00:00

  • Iron Pyrite/Titanium Dioxide Photoanode for Extended Near Infrared Light Harvesting in a Photoelectrochemical Cell.

    abstract::The design of active and stable semiconducting composites with enhanced photoresponse from visible light to near infrared (NIR) is a key to improve solar energy harvesting for photolysis of water in photoelectrochemical cell. In this study, we prepared earth abundant semiconducting composites consisting of iron pyrite...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang DY,Li CH,Li SS,Kuo TR,Tsai CM,Chen TR,Wang YC,Chen CW,Chen CC

    更新日期:2016-02-08 00:00:00

  • Cross-tissue Analysis of Gene and Protein Expression in Normal and Cancer Tissues.

    abstract::The central dogma of molecular biology describes the translation of genetic information from mRNA to protein, but does not specify the quantitation or timing of this process across the genome. We have analyzed protein and gene expression in a diverse set of human tissues. To study concordance and discordance of gene a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kosti I,Jain N,Aran D,Butte AJ,Sirota M

    更新日期:2016-05-04 00:00:00

  • Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy.

    abstract::Dysregulation of autophagy-mediated podocyte homeostasis is proposed to play a role in idiopathic membranous nephropathy (IMN). In the present study, autophagic activity and lysosomal alterations were investigated in podocytes of IMN patients and in cultured podocytes exposed to sublytic terminal complement complex, C...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu WJ,Li ZH,Chen XC,Zhao XL,Zhong Z,Yang C,Wu HL,An N,Li WY,Liu HF

    更新日期:2017-08-17 00:00:00

  • Local adaptation to temperature and precipitation in naturally fragmented populations of Cephalotaxus oliveri, an endangered conifer endemic to China.

    abstract::Cephalotaxus oliveri is an endangered tertiary relict conifer endemic to China. The species survives in a wide range from west to east with heterogeneous climatic conditions. Precipitation and temperature are main restrictive factors for distribution of C. oliveri. In order to comprehend the mechanism of adaptive evol...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang T,Wang Z,Xia F,Su Y

    更新日期:2016-04-26 00:00:00

  • Soil fungal and bacterial communities in southern boreal forests of the Greater Khingan Mountains and their relationship with soil properties.

    abstract::Little is known about the relationship between soil microbial communities and soil properties in southern boreal forests. To further our knowledge about that relationship, we compared the soil samples in southern boreal forests of the Greater Khingan Mountains-the southernmost boreal forest biome in the world. The for...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Vuong TM,Zeng JY,Man XL

    更新日期:2020-12-16 00:00:00

  • Local management and landscape structure determine the assemblage patterns of spiders in vegetable fields.

    abstract::Both field- and landscape-scale factors can influence the predator communities of agricultural pests, but the relative importance and interactions between these scales are poorly understood. Focusing on spiders, an important taxon for providing biological control, we tested the influence of field- and landscape-scale ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Saqib HSA,Chen J,Chen W,Pozsgai G,Akutse KS,Ashraf MF,You M,Gurr GM

    更新日期:2020-09-15 00:00:00

  • Enhanced intracellular delivery and antibacterial efficacy of enrofloxacin-loaded docosanoic acid solid lipid nanoparticles against intracellular Salmonella.

    abstract::Enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) with different physicochemical properties were developed to enhance activity against intracellular Salmonella. Their cellular uptake, intracellular elimination and antibacterial activity were studied in RAW 264.7 cells. During the experimental period...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Xie S,Yang F,Tao Y,Chen D,Qu W,Huang L,Liu Z,Pan Y,Yuan Z

    更新日期:2017-01-23 00:00:00

  • Ubiquitin-specific Protease 15 Negatively Regulates Virus-induced Type I Interferon Signaling via Catalytically-dependent and -independent Mechanisms.

    abstract::Viral infection triggers a series of signaling cascades, which converge to activate the transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3), thereby inducing the transcription of type I interferons (IFNs). Although not fully characterized, these innate antiviral responses are fine...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhang H,Wang D,Zhong H,Luo R,Shang M,Liu D,Chen H,Fang L,Xiao S

    更新日期:2015-06-10 00:00:00

  • Quantum gates by periodic driving.

    abstract::Topological quantum computation has been extensively studied in the past decades due to its robustness against decoherence. One way to realize the topological quantum computation is by adiabatic evolutions-it requires relatively long time to complete a gate, so the speed of quantum computation slows down. In this work...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Shi ZC,Wang W,Yi XX

    更新日期:2016-02-25 00:00:00

  • Manipulating nanostructure to simultaneously improve the electrical conductivity and strength in microalloyed Al-Zr conductors.

    abstract::To elude the strength-electrical conductivity trade-off dilemma, a nanostructuring strategy was achieved in microalloyed Al-0.1wt.% Zr conductor by optimizing the processing route, leading to enhanced strength and simultaneously improved electrical conductivity. The nanostructural design involved ultrafine grains with...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Jiang SY,Wang RH

    更新日期:2018-04-18 00:00:00

  • Controlled generation of nanopatterned electrical DNA interface.

    abstract::Techniques that manipulate DNA, a biomolecule with electrical properties, are in demand in various medical fields. This study fabricated a nanochannel with a conductive/semi-conductive interface using focused ion beams (FIBs) and introduced a nanochip technology to freely align, attach, and detach lambda DNAs in the i...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kang K,Jang Y,Jung J,Oh J

    更新日期:2019-02-26 00:00:00

  • Protein-bound uremic toxins are associated with cognitive function among patients undergoing maintenance hemodialysis.

    abstract::Patients with chronic kidney disease have a greater risk of cognitive impairment. Cerebral uremic solute accumulation causes uremic encephalopathy; however, the association of protein-bound uremic toxins on cognitive function remains unclear. The present study aimed to investigate the association of two protein-bound ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lin YT,Wu PH,Liang SS,Mubanga M,Yang YH,Hsu YL,Kuo MC,Hwang SJ,Kuo PL

    更新日期:2019-12-31 00:00:00

  • One Dimensional(1D)-to-2D Crossover of Spin Correlations in the 3D Magnet ZnMn2O4.

    abstract::We report on the intriguing evolution of the dynamical spin correlations of the frustrated spinel ZnMn2O4. Inelastic neutron scattering and magnetization studies reveal that the dynamical correlations at high temperatures are 1D. At lower temperature, these dynamical correlations become 2D. Surprisingly, the dynamical...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Disseler SM,Chen Y,Yeo S,Gasparovic G,Piccoli PM,Schultz AJ,Qiu Y,Huang Q,Cheong SW,Ratcliff W

    更新日期:2015-12-08 00:00:00

  • Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance.

    abstract::Clinical trials have recently demonstrated the effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV infection. Consequently, PrEP may soon be used for epidemic control. We model the dynamic interactions that will occur between treatment programs and potential PrEP interventions in resource-constrained co...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Supervie V,Barrett M,Kahn JS,Musuka G,Moeti TL,Busang L,Blower S

    更新日期:2011-01-01 00:00:00

  • Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining.

    abstract::Onychomycosis (OM) is a common nail disease. Although controversial, vascular diseases are considered independent predictors of OM and vice versa. Sequential pattern mining (SPM) has not been previously used for statistical analysis in dermatology, but it is an efficient method for identifying frequent association rul...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Bang CH,Yoon JW,Lee HJ,Lee JY,Park YM,Lee SJ,Lee JH

    更新日期:2018-12-14 00:00:00

  • Inverted U-shaped response of a standardized extract of Centella asiatica (ECa 233) on memory enhancement.

    abstract::The herb Centella asiatica has long been considered a memory tonic. A recent review found no strong evidence for improvement of cognitive function, suggesting negative results were due to limitations in dose, standardization and product variation. We used a standardized extract of C. asiatica (ECa 233) to study behavi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Boondam Y,Songvut P,Tantisira MH,Tapechum S,Tilokskulchai K,Pakaprot N

    更新日期:2019-06-10 00:00:00

  • Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner.

    abstract::A peptide vaccine designed to induce T-cell immunity to telomerase, GV1001, has been shown to modulate cellular signaling pathways and confer a direct anti-cancer effect through the interaction with heat shock protein (HSP) 90 and 70. Here, we have found that GV1001 can modulate transactivation protein-mediated human ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kim H,Choi MS,Inn KS,Kim BJ

    更新日期:2016-07-01 00:00:00

  • Characterization of efficiency-limiting resistance losses in monolithically integrated Cu(In,Ga)Se2 solar modules.

    abstract::The cell-to-module efficiency gap in Cu(In,Ga)Se2 (CIGS) monolithically integrated solar modules is enhanced by contact resistance between the Al-doped ZnO (AZO) and Mo back contact layers, the P2 contact, which connects adjacent cells. The present work evaluated the P2 contact resistance, in addition to the TCO resis...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yoon JH,Park JK,Kim WM,Lee J,Pak H,Jeong JH

    更新日期:2015-01-09 00:00:00