Abstract：
:African swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ and WSL, were compared to porcine alveolar macrophage (PAM) in terms of surface marker phenotype, susceptibility to ASFV infection and virus production. The virulent ASFV Armenia/07, E70 or the naturally attenuated NHV/P68 strains were used as viral models. Cells expressed only low levels of specific receptors linked to the monocyte/macrophage lineage, with low levels of infection overall, with the exception of WSL, which showed more efficient production of strain NHV/P68 but not of strains E70 and Armenia/07.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sánchez EG,Riera E,Nogal M,Gallardo C,Fernández P,Bello-Morales R,López-Guerrero JA,Chitko-McKown CG,Richt JA,Revilla Ydoi
10.1038/s41598-017-09948-xsubject
Has Abstractpub_date
2017-09-04 00:00:00pages
10369issue
1issn
2045-2322pii
10.1038/s41598-017-09948-xjournal_volume
7pub_type
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