Abstract：
:The prognosis of patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) remains unsatisfactory and, despite major advances in genomic studies, the biological mechanisms underlying chemoresistance are still poorly understood. We conducted for the first time a large-scale differential multi-omics investigation on DLBCL patient's samples in order to identify new biomarkers that could early identify patients at risk of R/R disease and to identify new targets that could determine chemorefractoriness. We compared a well-characterized cohort of R/R versus chemosensitive DLBCL patients by combining label-free quantitative proteomics and targeted RNA sequencing performed on the same tissues samples. The cross-section of both data levels allowed extracting a sub-list of 22 transcripts/proteins pairs whose expression levels significantly differed between the two groups of patients. In particular, we identified significant targets related to tumor metabolism (Hexokinase 3), microenvironment (IDO1, CXCL13), cancer cells proliferation, migration and invasion (S100 proteins) or BCR signaling pathway (CD79B). Overall, this study revealed several extremely promising biomarker candidates related to DLBCL chemorefractoriness and highlighted some new potential therapeutic drug targets. The complete datasets have been made publically available and should constitute a valuable resource for the future research.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fornecker LM,Muller L,Bertrand F,Paul N,Pichot A,Herbrecht R,Chenard MP,Mauvieux L,Vallat L,Bahram S,Cianférani S,Carapito R,Carapito Cdoi
10.1038/s41598-018-37273-4subject
Has Abstractpub_date
2019-01-29 00:00:00pages
895issue
1issn
2045-2322pii
10.1038/s41598-018-37273-4journal_volume
9pub_type
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