Single molecule tracking fluorescence microscopy in mitochondria reveals highly dynamic but confined movement of Tom40.

abstract：:Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an appro...

journal_title：Scientific reports

authors： Kageyama T,Chun YS,Fukuda J

更新日期：2021-01-12 00:00:00

abstract：:The healthy adult heart primarily relies on fatty acid oxidation (FAO) for energy production but instantaneously adapts its substrate preference in response to physiological or pathological challenges. Accurate FAO measurements are crucial to investigate early metabolic (mal)adaptations. While measurements in intact c...

journal_title：Scientific reports

authors： Rech M,Luiken JJFP,Glatz JFC,van Bilsen M,Schroen B,Nabben M

更新日期：2018-01-24 00:00:00

abstract：:Southern hemisphere humpback whales are classified as high-fidelity Antarctic krill consumers and as such are vulnerable to variability and long-term changes in krill biomass. Evidence of heterogeneous feeding patterns of east coast of Australia migrating humpback whales has been observed, warranting a comprehensive a...

journal_title：Scientific reports

authors： Groß J,Virtue P,Nichols PD,Eisenmann P,Waugh CA,Bengtson Nash S

更新日期：2020-10-26 00:00:00

abstract：:Human corneal endothelial cells (HCECs) easily become fibroblastic-like when cultured, rendering them unsuitable for tissue engineering of the cornea. Transforming growth factor β (TGF-β) could be a key factor in this phenomenon; however, TGF-β is also known to maintain the endothelium in a quiescent state in vivo. Th...

journal_title：Scientific reports

authors： Beaulieu Leclerc V,Roy O,Santerre K,Proulx S

更新日期：2018-03-13 00:00:00

abstract：:We report the development of complete structural AlGaN-based deep-ultraviolet light-emitting diodes with an aluminum thin layer for increasing light extraction efficiency. A 217% enhancement in peak photoluminescence intensity at 294 nm is observed. Cathodoluminescence measurement demonstrates that the internal quantu...

journal_title：Scientific reports

authors： Gao N,Huang K,Li J,Li S,Yang X,Kang J

更新日期：2012-01-01 00:00:00

abstract：:This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff value...

journal_title：Scientific reports

authors： Lee J,Kim B,Kim W,Ahn C,Choi HY,Kim JG,Kim J,Shin H,Kang JG,Moon S

更新日期：2021-01-27 00:00:00

abstract：:The function of Latexin (LXN) in inflammation has attracted attention. However, no data are available regarding its role in colitis. We report that LXN is a suppressor of colitis. LXN deficiency leads to the severity of colitis in DSS-induced mice, and LXN is required for the therapeutic effect of retinoic acid on col...

journal_title：Scientific reports

authors： Li Y,Huang B,Yang H,Kan S,Yao Y,Liu X,Pu S,He G,Khan TM,Qi G,Zhou Z,Shu W,Chen M

更新日期：2020-06-17 00:00:00

abstract：:Lateral organ boundaries domain (LBD) proteins are plant-specific transcription factors that play a crucial role in growth and development, as well as metabolic processes. However, knowledge of the function of LBD proteins in Camellia sinensis is limited, and no systematic investigations of the LBD family have been re...

journal_title：Scientific reports

authors： Zhang X,He Y,He W,Su H,Wang Y,Hong G,Xu P

更新日期：2019-10-30 00:00:00

abstract：:Free standing, atomically thin transition metal dichalcogenides are a new class of ultralightweight nanoelectromechanical systems with potentially game-changing electro- and opto-mechanical properties, however, the energy dissipation pathways that fundamentally limit the performance of these systems is still poorly un...

journal_title：Scientific reports

authors： Matis BR,Houston BH,Baldwin JW

更新日期：2017-07-18 00:00:00

abstract：:The exopeptidases of family S46 are exceptional, as the closest homologs of these enzymes are the endopeptidases of clan PA. The three-dimensional structure of S46 enzymes is unknown and only one of the catalytic residues, the serine, has been identified. The catalytic histidine and aspartate residues are not experime...

journal_title：Scientific reports

authors： Suzuki Y,Sakamoto Y,Tanaka N,Okada H,Morikawa Y,Ogasawara W

更新日期：2014-03-06 00:00:00

abstract：:This research investigates the applicability of an ANN and genetic algorithms for modeling and multiobjective optimization of the thermal conductivity and viscosity of water-based spinel-type MnFe2O4 nanofluid. Levenberg-Marquardt, quasi-Newton, and resilient backpropagation methods are employed to train the ANN. The ...

journal_title：Scientific reports

authors： Amani M,Amani P,Kasaeian A,Mahian O,Pop I,Wongwises S

更新日期：2017-12-12 00:00:00

abstract：:Chemical separation has great importance in industrial applications. Separation of xylene isomers still prevails to be one of the most important challenges in chemical industry, due to the large amount of commercial use of p-xylene in the production of beverage bottles, fibers and films. A novel Zn(II)-based dynamic c...

journal_title：Scientific reports

authors： Mukherjee S,Joarder B,Manna B,Desai AV,Chaudhari AK,Ghosh SK

更新日期：2014-07-21 00:00:00

abstract：:Frataxin is a highly conserved protein encoded by the frataxin (FXN) gene. The full-length 210-amino acid form of protein frataxin (1-210; isoform A) expressed in the cytosol of cells rapidly translocates to the mitochondria, where it is converted to the mature form (81-210) by mitochondrial processing peptidase. Matu...

journal_title：Scientific reports

authors： Guo L,Wang Q,Weng L,Hauser LA,Strawser CJ,Mesaros C,Lynch DR,Blair IA

更新日期：2018-11-19 00:00:00

abstract：:Liraglutide, a glucagon-like peptide-1 receptor (GLP-1R) agonist, is widely used to treat diabetes. However, its effect on pulmonary arterial hypertension (PAH) is unknown. In this study, we investigated its effects on rats with monocrotaline (MCT)-induced PAH and mechanisms on rat pulmonary artery smooth muscle cells...

journal_title：Scientific reports

authors： Lee MY,Tsai KB,Hsu JH,Shin SJ,Wu JR,Yeh JL

更新日期：2016-09-01 00:00:00

abstract：:Studies have demonstrated that inflammatory bowel disease (IBD) patients are at an increased risk of developing anxiety and/or depression. IBD patients with depression/anxiety have higher rates of hospitalization and increased disease severity than those without. So far, there is a paucity of data concerning the impac...

journal_title：Scientific reports

authors： Gao X,Tang Y,Lei N,Luo Y,Chen P,Liang C,Duan S,Zhang Y

更新日期：2021-01-14 00:00:00

abstract：:The intercellular spreading of protein assemblies is a major factor in the progression of neurodegenerative disorders. The quantitative study and visualization of cell-to-cell propagation using tagged-proteins is challenging due to the steric effect of relatively large fluorescence tags and the risk of 'false positive...

journal_title：Scientific reports

authors： Peled S,Sade D,Bram Y,Porat Z,Kreiser T,Mimouni M,Lichtenstein A,Segal D,Gazit E

更新日期：2017-03-28 00:00:00

abstract：:Accurate detection of accelerometer non-wear time is crucial for calculating physical activity summary statistics. In this study, we evaluated three epoch-based non-wear algorithms (Hecht, Troiano, and Choi) and one raw-based algorithm (Hees). In addition, we performed a sensitivity analysis to provide insight into th...

journal_title：Scientific reports

authors： Syed S,Morseth B,Hopstock LA,Horsch A

更新日期：2020-04-03 00:00:00

abstract：:Carcinomas constitute over 80% of all human cancer types with no effective therapy for metastatic disease. Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is downregulated in various human carcinoma...

journal_title：Scientific reports

authors： Mishel S,Shneyer B,Korsensky L,Goldshmidt-Tran O,Haber T,Machluf M,Ron D

更新日期：2017-11-08 00:00:00

abstract：:The capacity of healthy adult listeners to accommodate to altered spectral cues to the source locations of broadband sounds has now been well documented. In recent years we have demonstrated that the degree and speed of accommodation are improved by using an integrated sensory-motor training protocol under anechoic co...

journal_title：Scientific reports

authors： Watson CJG,Carlile S,Kelly H,Balachandar K

更新日期：2017-09-14 00:00:00

abstract：:Bacillus megaterium is a microorganism widely used in industrial biotechnology for production of enzymes and recombinant proteins, as well as in bioleaching processes. Precise understanding of its metabolism is essential for designing engineering strategies to further optimize B. megaterium for biotechnology applicati...

journal_title：Scientific reports

authors： Aminian-Dehkordi J,Mousavi SM,Jafari A,Mijakovic I,Marashi SA

更新日期：2019-12-10 00:00:00

abstract：:Current robots can manipulate only surface-attached cells seriously limiting the fields of their application for single cell handling. We developed a computer vision-based robot applying a motorized microscope and micropipette to recognize and gently isolate intact individual cells for subsequent analysis, e.g., DNA/R...

journal_title：Scientific reports

authors： Ungai-Salánki R,Gerecsei T,Fürjes P,Orgovan N,Sándor N,Holczer E,Horvath R,Szabó B

更新日期：2016-02-09 00:00:00

abstract：:The fluorination of p-type metal phthalocyanines produces n-type semiconductors, allowing the design of organic electronic circuits that contain inexpensive heterojunctions made from chemically and thermally stable p- and n-type organic semiconductors. For the evaluation of close to intrinsic transport properties, hig...

journal_title：Scientific reports

authors： Jiang H,Ye J,Hu P,Wei F,Du K,Wang N,Ba T,Feng S,Kloc C

更新日期：2014-12-19 00:00:00

abstract：:Here we report the discovery and partial characterization of a novel herpesvirus tentatively named Bufonid herpesvirus 1 (BfHV1) from severe dermatitis in free ranging common toads (Bufo bufo) in Switzerland. The disease has been observed in toads every year since 2014, in spring, during the mating season, at differen...

journal_title：Scientific reports

authors： Origgi FC,Schmidt BR,Lohmann P,Otten P,Meier RK,Pisano SRR,Moore-Jones G,Tecilla M,Sattler U,Wahli T,Gaschen V,Stoffel MH

更新日期：2018-10-03 00:00:00

abstract：:The endo-levanase BT1760 of a human gut commensal Bacteroides thetaiotaomicron randomly cuts a β-2,6-linked fructan, levan, into fructo-oligosaccharides providing a prebiotic substrate for gut microbiota. Here we introduce the crystal structure of BT1760 at resolution of 1.65 Å. The fold of the enzyme is typical for G...

journal_title：Scientific reports

authors： Ernits K,Eek P,Lukk T,Visnapuu T,Alamäe T

更新日期：2019-06-11 00:00:00

abstract：:Macrophages are an important component of the innate immune response. Priming and activation of macrophages is stimulated by cytokines (i.e IFNγ). However, growth hormone (GH) can also stimulate macrophage activation. Based on these observations, the goal of this work was to 1) to compare the transcriptome profile of ...

journal_title：Scientific reports

authors： Schneider A,Wood HN,Geden S,Greene CJ,Yates RM,Masternak MM,Rohde KH

更新日期：2019-12-18 00:00:00

abstract：:Cu removal by a novel multi-amines decorated resin (PAMD) from wastewater in the absence or presence of citric acid (CA) was examined. Adsorption capacity of Cu onto PAMD markedly increased by 186% to 5.07 mmol/g in the presence of CA, up to 7 times of that onto four commercial resins under the same conditions. Preloa...

journal_title：Scientific reports

authors： Ling C,Liu F,Pei Z,Zhang X,Wei M,Zhang Y,Zheng L,Zhang J,Li A,Xing B

更新日期：2015-05-12 00:00:00

abstract：:Coupled networks are extremely fragile because a node failure of a network would trigger a cascade of failures on the entire system. Existing studies mainly focused on the cascading failures and the robustness of coupled networks when the networks suffer from attacks. In reality, it is necessary to recover the damaged...

journal_title：Scientific reports

authors： Gong M,Ma L,Cai Q,Jiao L

更新日期：2015-02-13 00:00:00

abstract：:The near infrared (NIR) absorption and average particle size of gold nanostars (GNSs) can be precisely controlled by varying the molar ratios of cucurbit[7]urils (CB[7]) and GNSs in aqueous solution. GNSs modified with CB[7] achieved high cargo loading with thermally activated release upon the NIR laser irradiation. ...

journal_title：Scientific reports

authors： Han Y,Yang X,Liu Y,Ai Q,Liu S,Sun C,Liang F

更新日期：2016-02-26 00:00:00

abstract：:Rapid histopathological evaluation of fresh, unfixed human tissue using optical sectioning microscopy would have applications to intraoperative surgical margin assessment. Microscopy with ultraviolet surface excitation (MUSE) is a low-cost optical sectioning technique using ultraviolet illumination which limits fluore...

journal_title：Scientific reports

authors： Yoshitake T,Giacomelli MG,Quintana LM,Vardeh H,Cahill LC,Faulkner-Jones BE,Connolly JL,Do D,Fujimoto JG

更新日期：2018-03-14 00:00:00

abstract：:Receptor trafficking is pivotal for the temporal and spatial control of GPCR signaling and is regulated by multiple cellular proteins. We provide evidence that GPCRs interact with 14-3-3 signal adaptor/scaffold proteins and that this interaction regulates receptor trafficking in two ways. We found GPCR/14-3-3 interact...

journal_title：Scientific reports

authors： Yuan L,Barbash S,Kongsamut S,Eishingdrelo A,Sakmar TP,Eishingdrelo H

更新日期：2019-08-01 00:00:00