Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways.

abstract：:In the current research, to find if the combination of chitosan nerve conduits seeded with autologous bone marrow mononuclear cells (BM-MNCs) can be used to bridge 30 mm long peroneal nerve defects in goats, 15 animals were separated into BM-MNC group (n = 5), vehicle group (n = 5), and autologous nerve graft group (n...

journal_title：Scientific reports

authors： Muheremu A,Chen L,Wang X,Wei Y,Gong K,Ao Q

更新日期：2017-03-13 00:00:00

abstract：:Solar-cells based on Schottky junctions between metals and semiconductors (without or with an intermediate insulator) are among the main possibilities towards economical photovoltaic conversion of the solar energy. This is mainly due to their structural simplicity and hence the ease of their realization. We propose he...

journal_title：Scientific reports

authors： Farhat M,Kais S,Alharbi FH

更新日期：2017-10-27 00:00:00

abstract：:Lavender (Lavandula angustifolia) is an important economic plant because of the value of its essential oil (EO). The Yili Valley in Xinjiang has become the largest lavender planting base in China. However, there is a lack of research on the gene expression regulation of EO biosynthesis and metabolism in local varietie...

journal_title：Scientific reports

authors： Guo D,Kang K,Wang P,Li M,Huang X

更新日期：2020-04-24 00:00:00

abstract：:Candida glabrata CCTCC M202019 as an industrial yeast strain that is widely used to produce α-oxocarboxylic acid. Strain M202019 has been proven to have a higher pyruvate-producing capacity than the reference strain CBS138. To characterize the genotype of the M202019 strain, we generated a draft sequence of its genome...

journal_title：Scientific reports

authors： Xu N,Ye C,Chen X,Liu J,Liu L,Chen J

更新日期：2016-10-07 00:00:00

abstract：:Recently, the use of a liquid biopsy has shown promise in monitoring tumor burden. While point mutations have been extensively studied, chromosomal rearrangements have demonstrated greater tumor specificity. Such rearrangements can be identified in the tumor and subsequently detected in the plasma of patients using qu...

journal_title：Scientific reports

authors： Harris FR,Kovtun IV,Smadbeck J,Multinu F,Jatoi A,Kosari F,Kalli KR,Murphy SJ,Halling GC,Johnson SH,Liu MC,Mariani A,Vasmatzis G

更新日期：2016-07-20 00:00:00

abstract：:Nerve fibers are known to reside within malignant tumors and the greater the neuronal density the worse prognosis for the patient. Recent discoveries using tumor bearing animal models have eluded to the autonomic nervous system having a direct effect on tumor growth and metastasis. We report the first direct and chron...

journal_title：Scientific reports

authors： McCallum GA,Shiralkar J,Suciu D,Covarrubias G,Yu JS,Karathanasis E,Durand DM

更新日期：2020-09-09 00:00:00

abstract：:A junction between two boundaries of a topological superconductor (TSC), mediated by localized edge modes of Majorana fermions, is investigated. The tunneling of fermions across the junction depends on the magnetic flux. It breaks the time-reversal symmetry at the boundary of the sample. The persistent current is dete...

journal_title：Scientific reports

authors： Karnaukhov IN

更新日期：2017-08-02 00:00:00

abstract：:Novel tools in humane animal research should benefit the animal as well as the experimentally obtained data. Imaging technologies have proven to be versatile and also in accordance with the demands of the 3 R principle. However, most imaging technologies are either limited by the target organs, number of repetitive im...

journal_title：Scientific reports

authors： Bahlmann J,Madrahimov N,Daniel F,Theidel D,DeTemple DE,Buettner M,Bleich A,Haverich A,Heisterkamp A,Kalies S

更新日期：2020-06-08 00:00:00

abstract：:Melon (Cucumis melo L.) is a very important crop throughout the world and has great economic importance, in part due to its nutritional properties. It prefers well-drained soil with low acidity and has a strong demand for water during fruit set. Therefore, a correct water balance-involving aquaporins-is necessary to m...

journal_title：Scientific reports

authors： Lopez-Zaplana A,Nicolas-Espinosa J,Carvajal M,Bárzana G

更新日期：2020-12-17 00:00:00

abstract：:The positioning of electrodes in electrical impedance myography (EIM) is critical for accurately assessing disease progression and effectiveness of treatment. In human and animal trials for neuromuscular disorders, inconsistent electrode positioning adds errors to the muscle impedance. Despite its importance, how the ...

journal_title：Scientific reports

authors： Sanchez B,Pacheck A,Rutkove SB

更新日期：2016-09-02 00:00:00

abstract：:Age-hardening in Al alloys has been used for over a century to improve its mechanical properties. However, the lack of direct observation limits our understanding of the dynamic nature of the evolution of nanoprecipitates during age-hardening. Using in-situ (scanning) transmission electron microscopy (S/TEM) while hea...

journal_title：Scientific reports

authors： Liu C,Malladi SK,Xu Q,Chen J,Tichelaar FD,Zhuge X,Zandbergen HW

更新日期：2017-05-19 00:00:00

abstract：:Metallic glass (MG) generally fails in a brittle manner under uniaxial tension loading at room temperature. The lack of plastic strain of MG is due to the severe plastic instability via the easily formed one dominate shear band. There have been several approaches to improve the ductility in MG, but achieving uniform t...

journal_title：Scientific reports

authors： Lu XL,Lu QH,Li Y,Lu L

更新日期：2013-11-25 00:00:00

abstract：:Technical advances including liquid chromatography-tandem mass spectrometry and its data analysis enable detailed proteomic analysis of the nasal mucus. Alterations of the nasal mucus proteome may provoke substantial changes of the nasal physiology and have already been associated with rhinologic diseases such as alle...

journal_title：Scientific reports

authors： Wolf A,Liesinger L,Spoerk S,Schittmayer M,Lang-Loidolt D,Birner-Gruenberger R,Tomazic PV

更新日期：2018-12-03 00:00:00

abstract：:Interferons (IFNs) are key cytokines identified in vertebrates and evolutionary dominance of intronless IFN genes in amniotes is a signature event in IFN evolution. For the first time, we show that the emergence and expansion of intronless IFN genes is evident in amphibians, shown by 24-37 intronless IFN genes in each...

journal_title：Scientific reports

authors： Sang Y,Liu Q,Lee J,Ma W,McVey DS,Blecha F

更新日期：2016-06-30 00:00:00

abstract：:Roquins are a family of highly conserved RNA-binding proteins that also contain a RING-type E3 ubiquitin ligase domain. They repress constitutive decay elements containing mRNAs and play a critical role in RNA homeostasis and immunological self-tolerance. Here we present the crystal structures of the RNA-binding regio...

journal_title：Scientific reports

authors： Zhang Q,Fan L,Hou F,Dong A,Wang YX,Tong Y

更新日期：2015-10-22 00:00:00

abstract：:A collection of ancient Roman orichalcum coins, i.e., a copper-zinc alloy, minted under the reigns from Caesar to Domitianus, have been characterised using scanning electron microscopy (SEM-EDS) and electron microprobe analysis (EMPA). We studied, for the first time, coins emitted by Romans after the reforms of August...

journal_title：Scientific reports

authors： Di Fazio M,Felici AC,Catalli F,De Vito C

更新日期：2019-09-03 00:00:00

abstract：:Detection of nitroaromatic explosives with high sensitivity and selectivity is extremely important for civilian and military safety. Here, we report the synthesis and multimodal sensing applications of an emissive alanine based dansyl tagged copolymer P(MMA-co-Dansyl-Ala-HEMA) (DCP), synthesized by RAFT copolymerizati...

journal_title：Scientific reports

authors： Kumar V,Maiti B,Chini MK,De P,Satapathi S

更新日期：2019-05-13 00:00:00

abstract：:Peritrichously-flagellated bacteria, such as Escherichia coli, self-propel in fluids by using specialised motors to rotate multiple helical filaments. The rotation of each motor is transmitted to a short flexible segment called the hook which in turn transmits it to a flagellar filament, enabling swimming of the whole...

journal_title：Scientific reports

authors： Riley EE,Das D,Lauga E

更新日期：2018-07-16 00:00:00

abstract：:Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential as...

journal_title：Scientific reports

authors： Jiang W,Sun H,Zhang J,Zhou Q,Wu Q,Li T,Zhang C,Li W,Zhang M,Xia X

更新日期：2015-10-16 00:00:00

abstract：:Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regulation of ABCB4 in ...

journal_title：Scientific reports

authors： Kiehl S,Herkt SC,Richter AM,Fuhrmann L,El-Nikhely N,Seeger W,Savai R,Dammann RH

更新日期：2014-11-04 00:00:00

abstract：:Ancestral stress can program stress sensitivity and health trajectories across multiple generations. While ancestral stress is uncontrollable to the filial generations, it is critical to identify therapies that overcome transgenerational programming. Here we report that prenatal stress in rats generates a transgenerat...

journal_title：Scientific reports

authors： McCreary JK,Erickson ZT,Hao Y,Ilnytskyy Y,Kovalchuk I,Metz GA

更新日期：2016-11-24 00:00:00

abstract：:Animal societies exhibit remarkable variation in their breeding strategies. Individuals can maximize their fitness by either reproducing or by helping relatives. Social hymenopterans have been key taxa for the study of Hamilton's inclusive fitness theory because the haplodiploid sex-determination system results in asy...

journal_title：Scientific reports

authors： Andrade AC,Miranda EA,Del Lama MA,Nascimento FS

更新日期：2016-05-23 00:00:00

abstract：:In dentistry, the wet-bonding approach relies on water to maintain demineralized collagen expanded for proper resin infiltration; nevertheless, hydrolytic instability of the resin-dentin interface is inevitable with current bonding techniques. Considering dimethyl sulfoxide's (DMSO) ability to "biomodify" collagen and...

journal_title：Scientific reports

authors： Stape THS,Seseogullari-Dirihan R,Tjäderhane L,Abuna G,Martins LRM,Tezvergil-Mutluay A

更新日期：2018-11-15 00:00:00

abstract：:Fibulins are extracellular matrix proteins associated with elastic fibres. Homozygous Fibulin-4 mutations lead to life-threatening abnormalities such as aortic aneurysms. Aortic aneurysms in Fibulin-4 mutant mice were associated with upregulation of TGF-β signalling. How Fibulin-4 deficiency leads to deregulation of t...

journal_title：Scientific reports

authors： Ramnath NW,Hawinkels LJ,van Heijningen PM,te Riet L,Paauwe M,Vermeij M,Danser AH,Kanaar R,ten Dijke P,Essers J

更新日期：2015-11-26 00:00:00

abstract：:Arrays of sub-wavelength, sub-10 nm air-gap plasmonic ring resonators are fabricated using nanoimprinting. In near infra-red (NIR) range, the resonator supports a single dipole mode which is excited and identified via simple normal illumination and explored through transmission measurements. By controlling both latera...

journal_title：Scientific reports

authors： Lee J,Sung S,Choi JH,Eom SC,Mortensen NA,Shin JH

更新日期：2016-02-29 00:00:00

abstract：:Previous studies have shown that it is possible to nutritionally program gilthead seabream offspring through fish oil (FO) replacement by vegetable oils (VO) in the broodstock diet, to improve their ability to grow fast when fed low fish meal (FM) and FO diets during grow-out phase. However, in those studies broodstoc...

journal_title：Scientific reports

authors： Ferosekhan S,Xu H,Turkmen S,Gómez A,Afonso JM,Fontanillas R,Rosenlund G,Kaushik S,Izquierdo M

更新日期：2020-09-23 00:00:00

abstract：:The arbitrary control of the polarization states of light has attracted the interest of the scientific community because of the wide range of modern optical applications that such control can afford. However, conventional polarization control setups are bulky and very often operate only within a narrow wavelength rang...

journal_title：Scientific reports

authors： Li Z,Liu W,Cheng H,Chen S,Tian J

更新日期：2015-12-15 00:00:00

abstract：:Given the importance of aerosol particles to radiative transfer via aerosol-radiation interactions, a methodology for tracking and diagnosing causes of temporal changes in regional-scale aerosol populations is illustrated. The aerosol optical properties tracked include estimates of total columnar burden (aerosol optic...

journal_title：Scientific reports

authors： Sullivan RC,Levy RC,da Silva AM,Pryor SC

更新日期：2017-12-22 00:00:00

abstract：:Damage of enteric neurons and partial or total loss of selective neuronal populations are reported in intestinal disorders including inflammatory bowel diseases and necrotizing enterocolitis. To develop three-dimensional scaffolds for enteric neurons we propose the decoration of ionic-complementary self-assembling pep...

journal_title：Scientific reports

authors： Brun P,Zamuner A,Peretti A,Conti J,Messina GML,Marletta G,Dettin M

更新日期：2019-04-03 00:00:00

abstract：:Duckweed species have a great potential to develop into fast-growing crops for water remediation and bioenergy production. Seed production and utilization of hybrid vigour are essential steps in this process. However, even in the extensively-studied duckweed species, Lemna gibba, flower primordia were often aborted pr...

journal_title：Scientific reports

authors： Fu L,Huang M,Han B,Sun X,Sree KS,Appenroth KJ,Zhang J

更新日期：2017-06-08 00:00:00