Abstract:
:The positioning of electrodes in electrical impedance myography (EIM) is critical for accurately assessing disease progression and effectiveness of treatment. In human and animal trials for neuromuscular disorders, inconsistent electrode positioning adds errors to the muscle impedance. Despite its importance, how the reproducibility of resistance and reactance, the two parameters that define EIM, are affected by changes in electrode positioning remains unknown. In this paper, we present a novel approach founded on biophysical principles to study the reproducibility of resistance and reactance to electrode misplacements. The analytical framework presented allows the user to quantify a priori the effect on the muscle resistance and reactance using only one parameter: the uncertainty placing the electrodes. We also provide quantitative data on the precision needed to position the electrodes and the minimum muscle length needed to achieve a pre-specified EIM reproducibility. The results reported here are confirmed with finite element model simulations and measurements on five healthy subjects. Ultimately, our data can serve as normative values to enhance the reliability of EIM as a biomarker and facilitate comparability of future human and animal studies.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Sanchez B,Pacheck A,Rutkove SBdoi
10.1038/srep32615subject
Has Abstractpub_date
2016-09-02 00:00:00pages
32615issn
2045-2322pii
srep32615journal_volume
6pub_type
杂志文章abstract::Soil components (e.g., clays, bacteria and humic substances) are known to produce mineral-organic composites in natural systems. Herein, batch sorption isotherms, isothermal titration calorimetry (ITC), and Cd K-edge EXAFS spectroscopy were applied to investigate the binding characteristics of Cd on montmorillonite(Mo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19499
更新日期:2016-01-21 00:00:00
abstract::Birgus latro (coconut crab) is an edible crustacean that has experienced serious overharvesting throughout its whole habitat range; however, the negative effects of overharvesting on the genetic diversity within B. latro populations have not been elucidated. Here, we report sex ratio, body size, and genetic diversity ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66712-4
更新日期:2020-06-22 00:00:00
abstract::What is it like to be invisible? This question has long fascinated man and has been the central theme of many classic literary works. Recent advances in materials science suggest that invisibility cloaking of the human body may be possible in the not-so-distant future. However, it remains unknown how invisibility affe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09831
更新日期:2015-04-23 00:00:00
abstract::Monitoring marine top predators is fundamental for assessing the health and functioning of open ocean ecosystems. Although recently tracking observations have substantially increased, factors determining the horizontal exploration of the ocean by marine predators are still largely unknown, especially at the scale of b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18063
更新日期:2015-12-15 00:00:00
abstract::Protein glycosylation has been described as the most abundant and complex post-translational modification occurring in nature. Recent studies have enhanced our view of how this modification occurs in bacteria highlighting the role of protein glycosylation in various processes such as biofilm formation, virulence and h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23170-3
更新日期:2018-03-16 00:00:00
abstract::Some key behavioural traits of Autism Spectrum Disorders (ASD) have been hypothesized to be due to impairments in the early activation of subcortical orienting mechanisms, which in typical development bias newborns to orient to relevant social visual stimuli. A challenge to testing this hypothesis is that autism is us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26395
更新日期:2016-05-20 00:00:00
abstract::The increasing performance of optical lattice clocks has made them attractive for scientific applications in space and thus has pushed the development of their components including the interrogation lasers of the clock transitions towards being suitable for space, which amongst others requires making them more power e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33973
更新日期:2016-09-26 00:00:00
abstract::Optimized mesoporous photocatalyst endowed with high specific surface area and large pore size was synthesized by sol-gel method. These large pore mesoporous materials (33.39 nm) were conducive to the movement of larger molecules or groups in pore path and for effective use of active sites. The high specific surface a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29902
更新日期:2016-07-19 00:00:00
abstract::Mild cognitive impairment (MCI) is a heterogeneous syndrome with two main clinical subtypes, amnestic (aMCI) and non-amnestic (naMCI). The analysis of heart rate variability (HRV) is a tool to assess autonomic function. Cognitive and autonomic processes are linked via the central autonomic network. Autonomic dysfuncti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68131-x
更新日期:2020-07-15 00:00:00
abstract::Many outbreaks of A(H1N1)pdm09 influenza have occurred in schools with a high population density. Containment of school outbreaks is predicted to help mitigate pandemic influenza. Understanding disease transmission characteristics within the school setting is critical to implementing effective control measures. Based ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05982
更新日期:2014-08-07 00:00:00
abstract::The aim of this study was to compare the effects of an aerobic training program with a strength training program on body composition and energy expenditure in overweight or obese (29.06 ± 3.49 kg/m2) young adults (21.96 ± 1.90 years). Subjects (N = 109) were randomly assigned to one of three groups: a control group (C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62249-8
更新日期:2020-03-24 00:00:00
abstract::Cold atmospheric plasma (CAP), a technology based on quasi-neutral ionized gas at low temperatures, is currently being evaluated as a new highly selective alternative addition to existing cancer therapies. Here, we present a first attempt to identify the mechanism of CAP action. CAP induced a robust ~2-fold G2/M incre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00636
更新日期:2012-01-01 00:00:00
abstract::Our study purpose was to evaluate mitochondrial (mt)DNA and RNA in peripheral blood mononuclear cells (PBMCs) and body shape changes (BSC) in HBV-infected patients. mtDNA and mtRNA were measured in PBMCs. The presence of BSC was evaluated through a questionnaire and clinical evaluation. A total of 157 subjects were en...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-020-58837-3
更新日期:2020-02-06 00:00:00
abstract::Calciprotein particles (CPP) are solid-phase calcium-phosphate bound to serum protein fetuin-A and dispersed as colloids in the blood. Recent clinical studies indicated that serum CPP levels were increased with decline of renal function and associated with inflammation and vascular calcification. However, CPP assays u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19677-4
更新日期:2018-01-19 00:00:00
abstract::The product of the meiosis-expressed gene 1 (MEIG1) is found in the cell bodies of spermatocytes and recruited to the manchette, a structure unique to elongating spermatids, by Parkin co-regulated gene (PACRG). This complex is essential for targeting cargo to the manchette during sperm flagellum assembly. Here we show...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18278
更新日期:2016-01-04 00:00:00
abstract::The etiology of insulin resistance in Type 1 Diabetes (T1D) is unknown, however it affects approximately 20% of T1D patients. Intramyocellular lipids (IMCL) have been identified as a mechanism of insulin resistance. We examined skeletal muscle of T1D rats to determine if alterations in lipid metabolism were evident an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26379
更新日期:2016-05-20 00:00:00
abstract::The success of filamentous fungi in colonizing most natural environments can be largely attributed to their ability to form an expanding interconnected network, the mycelium, or thallus, constituted by a collection of hyphal apexes in motion producing hyphae and subject to branching and fusion. In this work, we charac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57808-y
更新日期:2020-02-21 00:00:00
abstract::Magnetic nanoparticles dissipate heat when exposed to alternating magnetic fields (AMFs), making them suitable for cancer hyperthermia. Therapeutic heating applications demand accurate characterization of the heating power dissipated by the particles. Specific loss power (SLP) generated by magnetic nanoparticles is es...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07088-w
更新日期:2017-07-27 00:00:00
abstract::Given the complex nature of the interaction between gas and solid atoms, the development of nanoscale science and technology has engendered a need for further understanding of gas transport behavior through nanopores and more tractable models for large-scale simulations. In the present paper, we utilize molecular dyna...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23629
更新日期:2016-03-29 00:00:00
abstract::Macroscopic rhythms are often signatures of healthy functioning in living organisms, but they are still poorly understood on their microscopic bases. Globally interacting oscillators with heterogeneous couplings are here considered. Thorough theoretical and numerical analyses indicate the presence of multiple phase tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31278-9
更新日期:2018-08-28 00:00:00
abstract::Boolean networks are widely used to model gene regulatory networks and to design therapeutic intervention strategies to affect the long-term behavior of systems. In this paper, we investigate the less-studied one-bit perturbation, which falls under the category of structural intervention. Previous works focused on fin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26247
更新日期:2016-05-19 00:00:00
abstract::Emerging evidence suggests that the mammalian target of rapamcyin (mTOR) pathway is associated with radio-resistance in cancer treatment. We hypothesised that phosphorylated ribosomal S6 kinase 1 (p-S6K1), a major downstream regulator of the mTOR pathway, may play a role in predicting radio-resistance. Therefore, we e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57496-8
更新日期:2020-01-20 00:00:00
abstract::Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine and drug discovery. In this study, we performed comparative studies between deep neural networks (DNN) and othe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73681-1
更新日期:2020-10-08 00:00:00
abstract::Pt/K2CO3/MgAlOx-reduced graphene oxide (Pt/K/MgAlOx-rGO) hybrids were synthesized, characterized and tested as a promising NOx storage and reduction (NSR) catalyst. Mg-Al layered double hydroxides (LDHs) were grown on rGO via in situ hydrothermal crystallization. The structure and morphology of samples were thoroughly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42862
更新日期:2017-02-16 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-40293-3
更新日期:2019-04-09 00:00:00
abstract::Antiphospholipid syndrome is associated with an increased risk of thrombosis and pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however, whether endogenous Anxa5 prevents foetal loss during normal pregnancy. We found significant reductions in litter size and foetal weight in Anxa5-null...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00827
更新日期:2012-01-01 00:00:00
abstract::Mechanical interlocking is widely applied in industry and general lives of human beings. In this work, we realized the control of locking or sliding states of cotton fibers on the metal surfaces with slightly different textures through traditional machining. Three types of sliding states, i.e., locking, one-way slidin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25403
更新日期:2016-05-09 00:00:00
abstract::It is widely acknowledged that transcriptional diversity largely contributes to biological regulation in eukaryotes. Since the advent of second-generation sequencing technologies, a large number of RNA sequencing studies have considerably improved our understanding of transcriptome complexity. However, it still remain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08138-z
更新日期:2017-08-09 00:00:00
abstract::Either hardness or toughness has been the core interest in scientific exploration and technological pursuit for a long time. However, it is still a big challenge to enhance the hardness and toughness at the same time, since the improvement of one side is always at the expense of the other one. Here, we have succeeded ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09807-9
更新日期:2017-08-24 00:00:00
abstract::Detailed measurement of cell phenotype information from digital fluorescence images has the potential to greatly advance biomedicine in various disciplines such as patient diagnostics or drug screening. Yet, the complexity of cell conformations presents a major barrier preventing effective determination of cell bounda...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02266
更新日期:2013-01-01 00:00:00