Abstract：
:Desensitisation with therapeutic plasma exchange (TPE) is essential for ABO-incompatible (ABO-I) liver transplants (LTs). However, excessive citrate load and coagulation disturbances after TPE have been poorly studied, in particular in cirrhotic patients with hypocapnic alkalosis, metabolic compensation and electrolyte imbalances. We retrospectively evaluated 1123 consecutive LT recipients (923 ABO-compatible [ABO-C], 200 ABO-I) from November 2008 to May 2015. TPE was generally performed a day before LT and blood sampling was performed before anaesthesia induction. We performed propensity score matching (PSM) and inverse probability treatment weighting (IPTW) analyses. In 199 PSM pairs, metabolic alkalosis was prevalent in ABO-I LT recipients (expectedly due to citrate conversion) with higher pH ≥ 7.50 (IPTW-adjusted odds ratio [aOR] = 2.23) than in ABO-C LT recipients. With increasing cirrhosis severity, the arterial pH and bicarbonate levels showed dose-dependent relationships, whereas mild hypoxaemia was more prevalent in ABO-I LT recipients. ABO-I LT recipients exhibited worsened hypokalaemia ≤3.0 mmol/l (17.6%, aOR = 1.44), hypomagnesaemia ≤1.7 mg/dl (27.6%, aOR = 3.43) and thrombocytopenia <30,000/µl (19.1%, aOR = 2.26) confirmed by lower maximal clot firmness (P = 0.001) in rotational thromboelastometry (EXTEM), which necessitated platelet transfusions. Preoperative identification of these change may prevent worsening of severe electrolyte disturbances and thrombocytopenia for optimal LT anaesthesia.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kwon HM,Jun IG,Lee J,Moon YJ,Jung KW,Jeong HW,Park YS,Song JG,Hwang GSdoi
10.1038/s41598-018-24887-xsubject
Has Abstractpub_date
2018-04-27 00:00:00pages
6679issue
1issn
2045-2322pii
10.1038/s41598-018-24887-xjournal_volume
8pub_type
杂志文章abstract：:To construct a machine learning algorithm model of lymph node metastasis (LNM) in patients with poorly differentiated-type intramucosal gastric cancer. 1169 patients with postoperative gastric cancer were divided into a training group and a test group at a ratio of 7:3. The model for lymph node metastasis was establis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80582-w
更新日期：2021-01-14 00:00:00
abstract：:The spin-transfer nano-oscillator (STNO) offers the possibility of using the transfer of spin angular momentum via spin-polarized currents to generate microwave signals. However, at present STNO microwave emission mainly relies on both large drive currents and external magnetic fields. These issues hinder the implemen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01426
更新日期：2013-01-01 00:00:00
abstract：:Graphene grown by high temperature molecular beam epitaxy on hexagonal boron nitride (hBN) forms continuous domains with dimensions of order 20 μm, and exhibits moiré patterns with large periodicities, up to ~30 nm, indicating that the layers are highly strained. Topological defects in the moiré patterns are observed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22440
更新日期：2016-03-01 00:00:00
abstract：:Myopic traction maculopathy (MTM) can cause vision disabilities in highly myopic eyes. This retrospective case series investigated the clinical outcomes of posterior scleral contraction (PSC) using genipin-cross-linked sclera as the material to treat MTM in highly myopic eyes. In total, 32 eyes from 29 highly myopic p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43256
更新日期：2017-02-21 00:00:00
abstract：:Canalization is a result of intrinsic developmental buffering that ensures phenotypic robustness under genetic variation and environmental perturbation. As a consequence, animal phenotypes are remarkably consistent within a species under a wide range of conditions, a property that seems contradictory to evolutionary c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16717
更新日期：2015-11-18 00:00:00
abstract：:Mutations in the CACNA1C gene are associated with ventricular tachycardia (VT). Although the CACNA1C mutations were well identified in patients with cardiac arrhythmias, mechanisms by which cardiac arrhythmias are generated in such genetic mutation conditions remain unclear. In this study, we identified a novel mechan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31262
更新日期：2016-08-09 00:00:00
abstract：:Current medications inadequately treat the symptoms of chronic pain experienced by over 50 million people in the United States, and may come with substantial adverse effects signifying the need to find novel treatments. One novel therapeutic target is the Transient Receptor Potential A1 channel (TRPA1), an ion channel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38852-9
更新日期：2019-02-20 00:00:00
abstract：:In this paper, we investigate the possibility of improving efficiency in non-radiative wireless power transfer (WPT) using metasurfaces embedded between two current varying coils and present a complete theoretical analysis of this system. We use a point-dipole approximation to calculate the fields of the coils. Based ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33174-8
更新日期：2018-10-05 00:00:00
abstract：:Protein analysis using high-performance thin-layer chromatography (HPTLC) is not commonly used but can complement traditional electrophoretic and mass spectrometric approaches in a unique way. Due to various detection protocols and possibilities for hyphenation, HPTLC protein analysis is a promising alternative for e....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26665
更新日期：2016-05-25 00:00:00
abstract：:Two Bidens species (Bidens pilosa and B. bipinnata) that originate from America have been introduced widely in pan-tropics, with the former regarded as a noxious invasive weed whereas the latter naturalized as a plant resource. Whether the two species exhibit different effects on the belowground system remains rarely ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11707-x
更新日期：2017-09-12 00:00:00
abstract：:We study the signatures of the collective modes of a superfluid Fermi gas in its linear response functions for the order-parameter and density fluctuations in the Random Phase Approximation (RPA). We show that a resonance associated to the Popov-Andrianov (or sometimes "Higgs") mode is visible inside the pair-breaking...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65371-9
更新日期：2020-07-14 00:00:00
abstract：:Mammalian sperm are unable to fertilize the egg immediately after ejaculation. To gain fertilization competence, they need to undergo a series of modifications inside the female reproductive tract, known as capacitation. Capacitation involves several molecular events such as phosphorylation cascades, hyperpolarization...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31557-5
更新日期：2018-09-06 00:00:00
abstract：:The LC8 family of small ~8 kD proteins are highly conserved and interact with multiple protein partners in eukaryotic cells. LC8-binding modulates target protein activity, often through induced dimerization via LC8:LC8 homodimers. Although many LC8-interactors have roles in signaling cascades, LC8's role in developing...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22726
更新日期：2016-03-14 00:00:00
abstract：:The room-temperature magnetic properties of ball-milled strontium hexaferrite particles consolidated by spark-plasma sintering are strongly influenced by the milling time. Scanning electron microscopy revealed the ball-milled SrFe12O19 particles to have sizes varying over several hundred nanometers. X-Ray powder-diffr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14112
更新日期：2015-09-15 00:00:00
abstract：:Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) is widely used for mRNA quantification. To accurately measure changing gene transcript levels under different experimental conditions, the use of appropriate reference gene transcripts is instrumental. In T cell immunology, suitable refer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66367-1
更新日期：2020-06-10 00:00:00
abstract：:Macrophages are an important component of the innate immune response. Priming and activation of macrophages is stimulated by cytokines (i.e IFNγ). However, growth hormone (GH) can also stimulate macrophage activation. Based on these observations, the goal of this work was to 1) to compare the transcriptome profile of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56017-6
更新日期：2019-12-18 00:00:00
abstract：:Our study is major to establish and validate a simple type||diabetes mellitus (T2DM) screening model for identifying high-risk individuals among Chinese adults. A total of 643,439 subjects who participated in the national health examination had been enrolled in this cross-sectional study. After excluding subjects with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68383-7
更新日期：2020-07-14 00:00:00
abstract：:High altitude pulmonary edema (HAPE) susceptibility is associated with EGLN1 polymorphisms, we hypothesized that HAPE-susceptible (HAPE-S, had HAPE episode in past) subjects may exhibit abnormal HIF1α levels in normoxic conditions. We measured HIF1α levels in HAPE-S and HAPE resistant (HAPE-R, no HAPE episode) individ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26468
更新日期：2016-05-23 00:00:00
abstract：:The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness, whereas inhibition of P2Rs promotes sleep. Infusion of a non-hy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29103-4
更新日期：2018-07-16 00:00:00
abstract：:Channelrhodopsins are light-gated ion channels of green algae used for the precise temporal and spatial control of transmembrane ion fluxes. The channelrhodopsin Chrimson from Chlamydomonas noctigama allows unprecedented deep tissue penetration due to peak absorption at 590 nm. We demonstrate by electrophysiological r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09600-8
更新日期：2017-08-30 00:00:00
abstract：:Plasmonically enhanced metal-insulator-metal (MIM) type structures are popular among perfect absorbers and photodetectors in which the field enhancement (for increased absorption) mechanism is directly coupled with collection (photocurrent) processes. In this work we propose a device structure that decouples absorptio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42349
更新日期：2017-02-09 00:00:00
abstract：:Sweet potato leaf curl virus (SPLCV) causes yield losses in sweet potato cultivation. Diagnostic techniques such as serological detection have been developed because these plant viruses are difficult to treat. Serological assays have been used extensively with recombinant antibodies such as whole immunoglobulin or sin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64996-0
更新日期：2020-05-15 00:00:00
abstract：:Demand for clinical decision support systems in medicine and self-diagnostic symptom checkers has substantially increased in recent years. Existing platforms rely on knowledge bases manually compiled through a labor-intensive process or automatically derived using simple pairwise statistics. This study explored an aut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05778-z
更新日期：2017-07-20 00:00:00
abstract：:Over the past few decades, two-dimensional (2D) and layered materials have emerged as new fields. Due to the zero-band-gap nature of graphene and the low photocatalytic performance of MoS2, more advanced semiconducting 2D materials have been prompted. As a result, semiconductor black phosphorus (BP) is a derived cutti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08691
更新日期：2015-03-03 00:00:00
abstract：:Nucleoplasmin (NP) is a pentameric histone chaperone that regulates the condensation state of chromatin in different cellular processes. We focus here on the interaction of NP with the histone octamer, showing that NP could bind sequentially the histone components to assemble an octamer-like particle, and crosslinked ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45726-7
更新日期：2019-07-01 00:00:00
abstract：:The definition of a precise illumination region is essential in many applications where the electromagnetic field should be confined in some specific volume. By using conventional structures, it is difficult to achieve an adequate confinement distance (or volume) with negligible levels of radiation leakage beyond it. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37739
更新日期：2016-11-25 00:00:00
abstract：:Haber-Bosch nitrogen (N) has been increasingly used in industrial products, e.g., nylon, besides fertilizer. Massive numbers of species of industrial reactive N (Nr) have emerged and produced definite consequences but receive little notice. Based on a comprehensive inventory, we show that (1) the industrial N flux has...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02579
更新日期：2013-01-01 00:00:00
abstract：:The absence of Ataxia-Telangiectasia mutated protein kinase (ATM) is associated with neurological, metabolic and cardiovascular defects. The protein has been associated with mitochondria and its absence results in mitochondrial dysfunction. Furthermore, it can be activated in the cytosol by mitochondrial oxidative str...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41108-1
更新日期：2019-03-18 00:00:00
abstract：:To understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the ~116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inflation of the O. sinensis ge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01869-z
更新日期：2017-05-11 00:00:00
abstract：:Nanometric biocompatible Metal-Organic Frameworks (nanoMOFs) are promising candidates for drug delivery. Up to now, most studies have targeted the intravenous route, related to pain and severe complications; whereas nanoMOFs for oral administration, a commonly used non-invasive and simpler route, remains however unexp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43099
更新日期：2017-03-03 00:00:00
