Silibinin, A Natural Blend In Polytherapy Formulation For Targeting Cd44v6 Expressing Colon Cancer Stem Cells.

abstract：:The alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is known to trigger the adaptive response by inducing the ada-regulon - consisting of three DNA repair enzymes Ada, AlkB, AlkA and the enigmatic AidB. We have applied custom designed tiling arrays to study transcriptional changes in Escherichia coli foll...

journal_title：Scientific reports

authors： Booth JA,Thomassen GO,Rowe AD,Weel-Sneve R,Lagesen K,Kristiansen KI,Bjørås M,Rognes T,Lindvall JM

更新日期：2013-10-25 00:00:00

abstract：:Freshwater mussels are ecosystem engineers and keystone species in aquatic environments. Unfortunately, due to dramatic declines this fauna is among the most threatened globally. Here, we clarify the taxonomy and biogeography of Russian Unionidae species based on the most comprehensive multi-locus dataset sampled to d...

journal_title：Scientific reports

authors： Bolotov IN,Kondakov AV,Konopleva ES,Vikhrev IV,Aksenova OV,Aksenov AS,Bespalaya YV,Borovskoy AV,Danilov PP,Dvoryankin GA,Gofarov MY,Kabakov MB,Klishko OK,Kolosova YS,Lyubas AA,Novoselov AP,Palatov DM,Savvinov GN,Solom

更新日期：2020-02-20 00:00:00

abstract：:Formic acid (FA) has been used for decades to control Varroa destructor, one of the most important parasites of the western honey bee, Apis mellifera. The rather unselective molecular mode of action of FA and its possible effects on honeybees have long been a concern of beekeepers, as it has undesirable side effects t...

journal_title：Scientific reports

authors： Genath A,Sharbati S,Buer B,Nauen R,Einspanier R

更新日期：2020-12-14 00:00:00

abstract：:The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossove...

journal_title：Scientific reports

authors： van der Klaauw AA,Ziauddeen H,Keogh JM,Henning E,Dachi S,Fletcher PC,Farooqi IS

更新日期：2017-06-27 00:00:00

abstract：:The environmental fate of the herbicide fenoxaprop-ethyl (FE) in water, sediment and water-sediment microcosm was studied and degradation products fenoxaprop (FA), ethyl-2-(4-hydroxyphenoxy)propanoate (EHPP), 2-(4-hydroxyphenoxy)propanoic acid (HPPA) and 6-chloro-2,3-dihydrobenzoxazol-2-one (CDHB) were monitored. FE, ...

journal_title：Scientific reports

authors： Jing X,Yao G,Liu D,Liu M,Wang P,Zhou Z

更新日期：2016-05-26 00:00:00

abstract：:Laser speckle flowmetry suffers from a debated quantification of the inverse relation between decorrelation time (τc) and blood flow velocity (V), i.e. 1/τc = αV. Using a modified microcirculation imager (integrated sidestream dark field - laser speckle contrast imaging [SDF-LSCI]), we experimentally investigate on th...

journal_title：Scientific reports

authors： Nadort A,Kalkman K,van Leeuwen TG,Faber DJ

更新日期：2016-04-29 00:00:00

abstract：:The weak correlation between pain and structural changes in knee osteoarthritis is widely reported. In a previous within-person, knee-matched case-control study among Caucasians, the severity of radiographic osteoarthritis (ROA) was strongly associated with both the presence of frequent knee pain and pain severity. We...

journal_title：Scientific reports

authors： Wang K,Kim HA,Felson DT,Xu L,Kim DH,Nevitt MC,Yoshimura N,Kawaguchi H,Lin J,Kang X,Zhang Y

更新日期：2018-01-22 00:00:00

abstract：:Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD have been carried out by now. In this study, we conducted a two-stage bivariate genome-wide association study (BGWAS) of the KBD...

journal_title：Scientific reports

authors： Hao J,Wang W,Wen Y,Xiao X,He A,Guo X,Yang T,Liu X,Shen H,Chen X,Tian Q,Deng HW,Zhang F

更新日期：2016-08-22 00:00:00

abstract：:Electrosprays operate in several modes depending on the flow rate and electric potential. This allows the deposition of droplets containing nanoparticles into discrete nanodot arrays to fabricate various electronic devices. In this study, seven different suspensions with varying properties were investigated. In the dr...

journal_title：Scientific reports

authors： Castillo-Orozco E,Kar A,Kumar R

更新日期：2017-07-11 00:00:00

abstract：:Risk of malaria in infants can be influenced by prenatal factors. In this study, the potential for placental parasitemia at delivery in predicting susceptibility of infants to Plasmodium falciparum (Pf) infections was evaluated. Seventy-two newborns of mothers who were placental malaria negative (PM-) and of mothers w...

journal_title：Scientific reports

authors： Tassi Yunga S,Fouda GG,Sama G,Ngu JB,Leke RGF,Taylor DW

更新日期：2018-01-09 00:00:00

abstract：:The Klein tunneling of optical waves near the Dirac points in the metal-dielectric multilayer metamaterials is theoretically investigated and demonstrated through the coupled-mode theory under the tight-binding approximation and the rigorous band structure analysis based on the transfer-matrix method. The optical anal...

journal_title：Scientific reports

authors： Sun L,Gao J,Yang X

更新日期：2017-08-29 00:00:00

abstract：:Mycobacterium spp. are renowned for being the causative agent of diseases like leprosy, Buruli ulcer and tuberculosis in human beings. With more and more mycobacterial genomes being sequenced, any knowledge generated from comparative genomic analysis would provide better insights into the biology, evolution, phylogeny...

journal_title：Scientific reports

authors： Choo SW,Ang MY,Dutta A,Tan SY,Siow CC,Heydari H,Mutha NV,Wee WY,Wong GJ

更新日期：2015-12-15 00:00:00

abstract：:Night-workers, transcontinental travelers and individuals that regularly shift their sleep timing, suffer from circadian desynchrony and are at risk to develop metabolic disease, cancer, and mood disorders, among others. Experimental and clinical studies provide evidence that food intake restricted to the normal activ...

journal_title：Scientific reports

authors： Escobar C,Espitia-Bautista E,Guzmán-Ruiz MA,Guerrero-Vargas NN,Hernández-Navarrete MÁ,Ángeles-Castellanos M,Morales-Pérez B,Buijs RM

更新日期：2020-04-10 00:00:00

abstract：:We demonstrated an abnormal double-peak (annular shaped) energy deposition through dual-wavelength synthesis of the fundamental frequency (ω) and the second-harmonic frequency (2ω) of a femtosecond (fs) Ti:sapphire laser. The annular shaped distribution of the dual-wavelength fs laser was confirmed through real beam s...

journal_title：Scientific reports

authors： Han W,Jiang L,Li X,Wang Q,Wang S,Hu J,Lu Y

更新日期：2017-12-11 00:00:00

abstract：:Based on the geological conditions of overburden rock, the dynamic development law of overburden breakage was investigated by theoretical analysis and similarity model experiments in this paper. The formula of the compressive strength and No. ratio was obtained by testing the compressive strength of cylinder samples o...

journal_title：Scientific reports

authors： Zhu H,Fang S,Huo Y,Guo J,Wu Y,Hu L

更新日期：2020-04-16 00:00:00

abstract：:To pattern electrical metal contacts, electron beam lithography or photolithography are commonly utilized, and these processes require polymer resists with solvents. During the patterning process the graphene surface is exposed to chemicals, and the residue on the graphene surface was unable to be completely removed b...

journal_title：Scientific reports

authors： Tien DH,Park JY,Kim KB,Lee N,Seo Y

更新日期：2016-05-12 00:00:00

abstract：:Semi-arid ecosystems are key contributors to the global carbon cycle and may even dominate the inter-annual variability (IAV) and trends of the land carbon sink, driven largely by the El Niño-Southern Oscillation (ENSO). The linkages between dynamics of semi-arid ecosystems and climate at the hemispheric scale however...

journal_title：Scientific reports

authors： Zhang A,Jia G,Epstein HE,Xia J

更新日期：2017-02-09 00:00:00

abstract：:Drug-resistant bacteria represent a significant global threat. Given the dearth of new antibiotics, host-directed therapies (HDTs) are especially desirable. As IFN-gamma (IFNγ) plays a central role in host resistance to intracellular bacteria, including Mycobacterium tuberculosis, we searched for small molecules to au...

journal_title：Scientific reports

authors： Bhattacharya B,Chatterjee S,Devine WG,Kobzik L,Beeler AB,Porco JA Jr,Kramnik I

更新日期：2016-04-18 00:00:00

abstract：:Massive gully land consolidation projects, launched in China's Loess Plateau, aim to restore 2667 [Formula: see text] agricultural lands in total by consolidating 2026 highly eroded gullies. This effort represents a social engineering project where the economic development and livelihood of the farming families are cl...

journal_title：Scientific reports

authors： Yan Q,Kumar P,Wang Y,Zhao Y,Lin H,Ran Q,An Z,Zhou W

更新日期：2020-10-09 00:00:00

abstract：:Shewanella species are facultative anaerobic bacteria that colonize redox-stratified habitats where O2 and nutrient concentrations fluctuate. The model species Shewanella oneidensis MR-1 possesses genes coding for three terminal oxidases that can perform O2 respiration: a bd-type quinol oxidase and cytochrome c oxidas...

journal_title：Scientific reports

authors： Le Laz S,Kpebe A,Bauzan M,Lignon S,Rousset M,Brugna M

更新日期：2016-01-27 00:00:00

abstract：:To improve the performance of solar photovoltaic devices one should mitigate three types of losses: optical, electrical and thermal. However, further reducing the optical and electrical losses in modern photovoltaic devices is becoming increasingly costly. Therefore, there is a rising interest in minimizing the therma...

journal_title：Scientific reports

authors： Vaillon R,Dupré O,Cal RB,Calaf M

更新日期：2018-09-03 00:00:00

abstract：:Precision Medicine in Oncology requires tailoring of therapeutic strategies to individual cancer patients. Due to the limited quantity of tumor samples, this proves to be difficult, especially for early stage cancer patients whose tumors are small. In this study, we exploited a 2.4 × 2.4 centimeters polydimethylsiloxa...

journal_title：Scientific reports

authors： Wong AH,Li H,Jia Y,Mak PI,Martins RPDS,Liu Y,Vong CM,Wong HC,Wong PK,Wang H,Sun H,Deng CX

更新日期：2017-08-22 00:00:00

abstract：:Interactions between microalgae and bacteria are often obligatory for harmful algal blooms (HABs). Here, we investigated the specific bacterial communities associated with Alexandrium tamarense and Cochlodinium polykrikoides, which cause ecological and economic damage during their blooms. To this end, the bacterial me...

journal_title：Scientific reports

authors： Shin H,Lee E,Shin J,Ko SR,Oh HS,Ahn CY,Oh HM,Cho BK,Cho S

更新日期：2018-03-28 00:00:00

abstract：:In vivo, bone morphogenetic protein 2 (BMP-2) exists both in solution and bound to the extracellular matrix (ECM). While these two modes of presentation are known to influence cell behavior distinctly, their role in the niche microenvironment and their functional relevance in the genesis of a biological response has s...

journal_title：Scientific reports

authors： Fitzpatrick V,Fourel L,Destaing O,Gilde F,Albigès-Rizo C,Picart C,Boudou T

更新日期：2017-01-30 00:00:00

abstract：:It has been thought that incretin signaling prevents arteriosclerosis, and very recently anti-arteriosclerotic effects through GLP-1 receptor were finally demonstrated in clinical human study. The purpose of this study was to investigate how vascular GLP-1 receptor expression is influenced in human subjects. First, we...

journal_title：Scientific reports

authors： Kimura T,Obata A,Shimoda M,Shimizu I,da Silva Xavier G,Okauchi S,Hirukawa H,Kohara K,Mune T,Moriuchi S,Hiraoka A,Tamura K,Chikazawa G,Ishida A,Yoshitaka H,Rutter GA,Kaku K,Kaneto H

更新日期：2018-07-13 00:00:00

abstract：:Excessive or misdirected artificial light at night (ALAN) produces light pollution that influences several aspects of the biology and ecology of birds, including disruption of circadian rhythms and disorientation during flight. Many migrating birds traverse large expanses of land twice every year at night when ALAN il...

journal_title：Scientific reports

authors： Cabrera-Cruz SA,Smolinsky JA,Buler JJ

更新日期：2018-02-19 00:00:00

abstract：:Calcium regulation plays a central role in cardiac function. Several variants in the calcium channel Cav1.2 have been implicated in arrhythmic syndromes. We screened patients with Brugada syndrome, short QT syndrome, early repolarisation syndrome, and idiopathic ventricular fibrillation to determine the frequency and ...

journal_title：Scientific reports

authors： Blancard M,Debbiche A,Kato K,Cardin C,Sabrina G,Gandjbakhch E,Probst V,Haissaguerre M,Extramiana F,Hocini M,Olivier G,Leenhardt A,Guicheney P,Rougier JS

更新日期：2018-10-02 00:00:00

abstract：:The nutrient ecological stoichiometry of plants and soil is important for the growth and dynamics of species, but the stoichiometric relationships among leaf, litter, and soil remain poorly understood. We analyzed the carbon (C), nitrogen (N), and phosphorus (P) stoichiometry of the leaves, litter, and soil for 31 spe...

journal_title：Scientific reports

authors： Zhang G,Zhang P,Peng S,Chen Y,Cao Y

更新日期：2017-09-18 00:00:00

abstract：:Genetic divergences among mammalian strains are presented phenotypically in various aspects of physical appearance such as body shape and facial features. Yet how genetic diversity is expressed in brain function still remains unclear. Functional connectivity has been shown to be a valuable approach in characterizing t...

journal_title：Scientific reports

authors： Huang SM,Wu YL,Peng SL,Peng HH,Huang TY,Ho KC,Wang FN

更新日期：2016-02-22 00:00:00

abstract：:One of the challenges that plasma research encounters is how to generate a large-scale plasma plume at atmospheric pressure. Through utilizing a third electrode biased by a direct-current voltage, a longer plasma plume is generated by a plasma jet in dielectric barrier discharge configurations. Results indicate that t...

journal_title：Scientific reports

authors： Li X,Li Y,Zhang P,Jia P,Dong L

更新日期：2016-10-19 00:00:00