Fine-tuning of macrophage activation using synthetic rocaglate derivatives.

abstract：:We report the detection of genomic signatures of giant viruses (GVs) in the metagenomes of three environment samples from Mumbai, India, namely, a pre-filter of a household water purifier, a sludge sample from wastewater treatment plant (WWTP), and a drying bed sample of the same WWTP. The de novo assembled contigs of...

journal_title：Scientific reports

authors： Chatterjee A,Sicheritz-Pontén T,Yadav R,Kondabagil K

更新日期：2019-03-06 00:00:00

abstract：:Accumulated evidence suggests that activated pancreatic stellate cells (PSCs) serve as the main source of the extracellular matrix proteins accumulated under the pathological conditions leading to pancreatic fibrosis in chronic pancreatitis (CP). However, little is known about the mechanisms of PSC activation. PSCs ha...

journal_title：Scientific reports

authors： Gao L,Lei XF,Miyauchi A,Noguchi M,Omoto T,Haraguchi S,Miyazaki T,Miyazaki A,Kim-Kaneyama JR

更新日期：2020-11-05 00:00:00

abstract：:Manual count of mitotic figures, which is determined in the tumor region with the highest mitotic activity, is a key parameter of most tumor grading schemes. It can be, however, strongly dependent on the area selection due to uneven mitotic figure distribution in the tumor section. We aimed to assess the question, how...

journal_title：Scientific reports

authors： Aubreville M,Bertram CA,Marzahl C,Gurtner C,Dettwiler M,Schmidt A,Bartenschlager F,Merz S,Fragoso M,Kershaw O,Klopfleisch R,Maier A

更新日期：2020-10-05 00:00:00

abstract：:Due to their convergent evolution, dogs have been suggested as a good model for the evolution of human social skills, such as tolerance and cooperativeness. However, recent studies have revealed that wolves (dogs' closest undomesticated relatives) are more tolerant and cooperative with conspecifics than dogs. It is st...

journal_title：Scientific reports

authors： Range F,Marshall-Pescini S,Kratz C,Virányi Z

更新日期：2019-03-07 00:00:00

abstract：:The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown. However, the recent discovery of the thick filament activation, a second pathway beside the well-known calcium mediated thin filament activation, is promising for eluc...

journal_title：Scientific reports

authors： Marcucci L,Washio T,Yanagida T

更新日期：2019-02-04 00:00:00

abstract：:Photocatalysis is a promising strategy to address the global environmental and energy challenges. However, the studies on the application of the photocatalytically degraded dye-polluted water and the multi-purpose use of one type of catalyst have remained sparse. In this report, we try to demonstrate a concept of mult...

journal_title：Scientific reports

authors： Zhang Q,Zhang Y,Meng Z,Tong W,Yu X,An Q

更新日期：2017-09-25 00:00:00

abstract：:miR1444s are functionally significant miRNAs targeting polyphenol oxidase (PPO) genes for cleavage. MIR1444 genes were reported only in Populus trichocarpa. Through the computational analysis of 215 RNA-seq data, four whole genome sequences of Salicaceae species and deep sequencing of six P. trichocarpa small RNA libr...

journal_title：Scientific reports

authors： Wang M,Li C,Lu S

更新日期：2017-01-10 00:00:00

abstract：:There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matr...

journal_title：Scientific reports

authors： Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

更新日期：2017-12-11 00:00:00

abstract：:Understanding drought-tolerance mechanisms and identifying genetic dominance are important for crop improvement. Setaria italica, which is extremely drought-tolerant, has been regarded as a model plant for studying stress biology. Moreover, different genotypes of S. italica have evolved various drought-tolerance/avoid...

journal_title：Scientific reports

authors： Tang S,Li L,Wang Y,Chen Q,Zhang W,Jia G,Zhi H,Zhao B,Diao X

更新日期：2017-08-30 00:00:00

abstract：:The ability of wild animals to respond flexibly to anthropogenic environmental changes, including agriculture, is critical to survival in human-impacted habitats. Understanding use of human foods by wildlife can shed light on the acquisition of novel feeding habits and how animals respond to human-driven land-use chan...

journal_title：Scientific reports

authors： McLennan MR,Hockings KJ

更新日期：2014-08-05 00:00:00

abstract：:Two important theories in spatial modelling relate to structural and spatial dependence. Structural dependence refers to environmental state-factor models, where an environmental property is modelled as a function of the states and interactions of environmental predictors, such as climate, parent material or relief. C...

journal_title：Scientific reports

authors： Behrens T,Viscarra Rossel RA

更新日期：2020-10-07 00:00:00

abstract：:In the surface-enhanced fluorescence (SEF) process, it is well known that the plasmonic nanostructure can enhance the light emission of fluorescent emitters. With the help of atomic force microscopy, a hybrid system consisting of a fluorescent nanodiamond and a gold nanoparticle was assembled step-by-step for in situ ...

journal_title：Scientific reports

authors： Zhao J,Cheng Y,Shen H,Hui YY,Wen T,Chang HC,Gong Q,Lu G

更新日期：2018-02-26 00:00:00

abstract：:Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several lines of evidence suggest that tanycytes may be involved in the regulation of energy homeostasis...

journal_title：Scientific reports

authors： Uranga RM,Millán C,Barahona MJ,Recabal A,Salgado M,Martinez F,Ordenes P,Elizondo-Vega R,Sepúlveda F,Uribe E,García-Robles MLÁ

更新日期：2017-06-16 00:00:00

abstract：:HIV-infected subjects under virological control still exhibit a persistent proinflammatory state. Thus, chronic HIV infection changes the host homeostasis towards an adapted immune response that may affect the outcome of coinfections. However, little is known about the impact of HIV infection on inflammatory amplifica...

journal_title：Scientific reports

authors： Hottz ED,Quirino-Teixeira AC,Valls-de-Souza R,Zimmerman GA,Bozza FA,Bozza PT

更新日期：2019-05-08 00:00:00

abstract：:The aim was to determine the effects of changing pulse duration and electrode size on muscle contractile properties. Thirty-six healthy young male participated in the study (age 24.8 ± 5.8 years; height 178.2 ± 0.6 cm; body mass 71.8 ± 7.3 kg; self-reported weekly moderate intensity activity 3.5 ± 1.2 h·week-1). Tensi...

journal_title：Scientific reports

authors： Piqueras-Sanchiz F,Martín-Rodríguez S,Pareja-Blanco F,Baraja-Vegas L,Blázquez-Fernández J,Bautista IJ,García-García Ó

更新日期：2020-05-18 00:00:00

abstract：:Based on an inverted bulk band order, antimony thin films presumably could become topological insulators if quantum confinement effect opens up a gap in the bulk bands. Coupling between topological surface states (TSS) from opposite surfaces, however, tends to degrade or even destroy their novel characters. Here the e...

journal_title：Scientific reports

authors： Yao G,Luo Z,Pan F,Xu W,Feng YP,Wang XS

更新日期：2013-01-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Venkatesulu BP,Sharma A,Pollard-Larkin JM,Sadagopan R,Symons J,Neri S,Singh PK,Tailor R,Lin SH,Krishnan S

更新日期：2020-06-30 00:00:00

abstract：:The rapid increase in use of electronic-cigarettes (e-cigarettes), especially among youth, raises the urgency for regulating bodies to make informed decisions, guidance, and policy on these products. This study evaluated cardiac function in an experimental model following exposure to e-cigarettes. We subjected C57BL/6...

journal_title：Scientific reports

authors： Shi H,Fan X,Horton A,Haller ST,Kennedy DJ,Schiefer IT,Dworkin L,Cooper CJ,Tian J

更新日期：2019-03-11 00:00:00

abstract：:The realization of reliable quantum channels, able to transfer a quantum state with high fidelity, is a fundamental step in the construction of scalable quantum devices. In this paper we describe a transmission scheme based on the genuinely quantum effect known as Bloch oscillations. The proposed protocol makes it pos...

journal_title：Scientific reports

authors： Tamascelli D,Olivares S,Rossotti S,Osellame R,Paris MG

更新日期：2016-05-18 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Brilha S,Ong CWM,Weksler B,Romero N,Couraud PO,Friedland JS

更新日期：2018-09-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Scholtes C,Bellemin S,Martin E,Carre-Pierrat M,Mollereau B,Gieseler K,Walter L

更新日期：2020-07-10 00:00:00

abstract：:Cathode materials always limit the performance of fuel cells while the commercial platinum-based catalysts hardly meet the requirements of low cost, durable and stable. Here a non-precious metal oxygen reduction reaction (ORR) electocatalyst based on titanium nitride/titanium carbonitride hierarchical structures (TNTC...

journal_title：Scientific reports

authors： Jin Z,Li P,Xiao D

更新日期：2014-10-22 00:00:00

abstract：:We report on an all-dielectric, polarization-independent angular filter with one-dimension (1D) photonic crystal (PC) composed of semiconductor compatible Si/SiO2 pairs. The near-symmetric directional band gap of p- and s-polarized components and Fabry-Pérot (F-P) resonances are utilized to realize efficient polarizat...

journal_title：Scientific reports

authors： Qian Q,Xu C,Wang C

更新日期：2017-11-29 00:00:00

abstract：:Changes in climate extremes pose far-reaching consequences to ecological processes and hydrologic cycles in alpine ecosystems of the arid mountain regions. Therefore, regional assessments in various climates and mountain regions are needed for understanding the uncertainties of the change trends for extreme climate ev...

journal_title：Scientific reports

authors： Lin P,He Z,Du J,Chen L,Zhu X,Li J

更新日期：2017-05-22 00:00:00

abstract：:Following facial nerve axotomy, nerve function is not fully restored even after reconstruction. This may be attributed to axon degeneration/neuronal death and sustained neuroinflammation. CD38 is an enzyme that catalyses the hydrolysis of nicotinamide adenine dinucleotide (NAD+) and is a candidate molecule for regulat...

journal_title：Scientific reports

authors： Takaso Y,Noda M,Hattori T,Roboon J,Hatano M,Sugimoto H,Brenner C,Yamamoto Y,Okamoto H,Higashida H,Ito M,Yoshizaki T,Hori O

更新日期：2020-10-20 00:00:00

abstract：:The contribution of paternal obesity to pregnancy outcomes has been little described. Our aims were to determine whether the effect of an antenatal maternal dietary and lifestyle intervention among women who are overweight or obese on newborn adiposity, was modified by paternal obesity. We conducted a secondary analys...

journal_title：Scientific reports

authors： Dodd JM,Du Plessis LE,Deussen AR,Grivell RM,Yelland LN,Louise J,Mcphee AJ,Robinson JS,Owens JA

更新日期：2017-05-08 00:00:00

abstract：:The combination of genome-edited human embryonic stem cells (hESCs) and subsequent neural differentiation is a powerful tool to study neurodevelopmental disorders. Since the naïve state of pluripotency has favourable characteristics for efficient genome-editing, we optimized a workflow for the CRISPR/Cas9 system in th...

journal_title：Scientific reports

authors： Jacobs EZ,Warrier S,Volders PJ,D'haene E,Van Lombergen E,Vantomme L,Van der Jeught M,Heindryckx B,Menten B,Vergult S

更新日期：2017-11-30 00:00:00

abstract：:Haemodynamic disorders are common clinical findings in hypertension and lead to adverse cardiovascular events. However, the haemodynamic conditions in hypertension models are poorly understood. This study aimed to observe the characteristics of haemodynamics in spontaneously hypertensive rats (SHRs) and antihypertensi...

journal_title：Scientific reports

authors： Chen Z,Yu H,Shi Y,Zhu M,Wang Y,Hu X,Zhang Y,Chang Y,Xu M,Gao W

更新日期：2017-05-17 00:00:00

abstract：:Although prolactin (PRL) and its receptor (PRLR) have been detected in glioblastoma multiforme (GBM), their role in its pathogenesis remains unclear. Our aim was to explore their contribution in GBM pathogenesis. We detected PRL and PRLR in all GBM cell lines tested. PRLR activation or overexpression using plasmid tra...

journal_title：Scientific reports

authors： Asad AS,Nicola Candia AJ,Gonzalez N,Zuccato CF,Abt A,Orrillo SJ,Lastra Y,De Simone E,Boutillon F,Goffin V,Seilicovich A,Pisera DA,Ferraris MJ,Candolfi M

更新日期：2019-12-20 00:00:00

abstract：:Previously we reported that LIM1863 colorectal cancer (CRC) cells secrete three distinct extracellular vesicle subtypes - two subpopulations of exosomes (apical EpCAM-Exos and basolateral A33-Exos) and shed microvesicles (sMVs) - with distinct protein and miRNA signatures. Here, we extend our omics approach to underst...

journal_title：Scientific reports

authors： Chen M,Xu R,Ji H,Greening DW,Rai A,Izumikawa K,Ishikawa H,Takahashi N,Simpson RJ

更新日期：2016-12-05 00:00:00