Vascular Remodelling Relates to an Elevated Oscillatory Shear Index and Relative Residence Time in Spontaneously Hypertensive Rats.

abstract：:MicroRNAs (miRNAs) are important regulators involved in various cancers, including colorectal cancer (CRC). The functions and mechanisms of the miRNAs involved in CRC progress and metastasis are largely unknown. In this study, miRNA microarray analysis was performed to screen crucial miRNAs involved in CRC progress, a...

journal_title：Scientific reports

authors： Li Q,Liang X,Wang Y,Meng X,Xu Y,Cai S,Wang Z,Liu J,Cai G

更新日期：2016-05-31 00:00:00

abstract：:Myostatin (MSTN) is a dominant inhibitor of skeletal muscle development and growth. Mutations in MSTN gene can lead to muscle hypertrophy or double-muscled (DM) phenotype in cattle, sheep, dog and human. However, there has not been reported significant muscle phenotypes in pigs in association with MSTN mutations. Pigs...

journal_title：Scientific reports

authors： Qian L,Tang M,Yang J,Wang Q,Cai C,Jiang S,Li H,Jiang K,Gao P,Ma D,Chen Y,An X,Li K,Cui W

更新日期：2015-09-24 00:00:00

abstract：:RAS genotyping is mandatory to predict anti-EGFR monoclonal antibodies (mAbs) therapy resistance and BRAF genotyping is a relevant prognosis marker in patients with metastatic colorectal cancer. Although the role of hotspot mutations is well defined, the impact of uncommon mutations is still unknown. In this study, we...

journal_title：Scientific reports

authors： Franczak C,Kandathil SM,Gilson P,Husson M,Rouyer M,Demange J,Leroux A,Merlin JL,Harlé A

更新日期：2019-05-08 00:00:00

abstract：:The first instar larva of a species of the Australian endemic genus Aenigmetopia Malloch is described for the first time, along with the first instar larvae of three other Australian species representing the genera Amobia Robineau-Desvoidy and Protomiltogramma Townsend. Larval morphology was analysed using a combinati...

journal_title：Scientific reports

authors： Szpila K,Walczak K,Johnston NP,Pape T,Wallman JF

更新日期：2021-01-29 00:00:00

abstract：:TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA), originally identified as an adaptor protein of TRAF6, has recently been shown to be involved in innate immunity, induced by a pathogen-associated molecular pattern (PAMP). ADP-β-D-manno-heptose, a newly identified PAMP, binds to alpha-kinase 1 (A...

journal_title：Scientific reports

authors： Nakamura T,Hashikawa C,Okabe K,Yokote Y,Chirifu M,Toma-Fukai S,Nakamura N,Matsuo M,Kamikariya M,Okamoto Y,Gohda J,Akiyama T,Semba K,Ikemizu S,Otsuka M,Inoue JI,Yamagata Y

更新日期：2020-03-20 00:00:00

abstract：:The main feature of the present numerical model is to explore the behavior of Maxwell nanoliquid moving within two horizontal rotating disks. The disks are stretchable and subjected to a magnetic field in axial direction. The time dependent characteristics of thermal conductivity have been considered to scrutinize the...

journal_title：Scientific reports

authors： Ahmadian A,Bilal M,Khan MA,Asjad MI

更新日期：2020-10-13 00:00:00

abstract：:Analysis of the developing proteome has been complicated by a lack of tools that can be easily employed to label and identify newly synthesized proteins within complex biological mixtures. Here, we demonstrate that the methionine analogs azidohomoalanine and homopropargylglycine can be globally incorporated into the p...

journal_title：Scientific reports

authors： Calve S,Witten AJ,Ocken AR,Kinzer-Ursem TL

更新日期：2016-08-30 00:00:00

abstract：:Misfolding of translated proteins occurs in all domains of life. In most cells, misfolded proteins coalesce in discrete aggregates at distinct cellular locations. In many bacteria, including mycobacteria, protein aggregates are located at the cellular pole. Yet the mechanism by which aggregates are sorted to the mycob...

journal_title：Scientific reports

authors： Zhang YW,Zhu JH,Wang ZQ,Wu Y,Meng X,Zheng X,Javid B

更新日期：2019-10-10 00:00:00

abstract：:Awarding CO2 offset credits may incentivize seagrass restoration projects and help reverse greenhouse gas (GHG) emissions from global seagrass loss. However, no study has quantified net GHG removal from the atmosphere from a seagrass restoration project, which would require coupled Corg stock and GHG flux enhancement ...

journal_title：Scientific reports

authors： Oreska MPJ,McGlathery KJ,Aoki LR,Berger AC,Berg P,Mullins L

更新日期：2020-04-30 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Hassan R,Tantawy M,Gouda NA,Elzayat MG,Gabra S,Nabih A,Diab AA,El-Hadidi M,Bakry U,Shoeb MR,Elanany M,Shalaby L,Sayed AA

更新日期：2020-04-29 00:00:00

abstract：:GPS-derived Total Electron Content (TEC) is an integrated quantity; hence it is difficult to relate the detection of ionospheric perturbations in TEC to a precise altitude. As TEC is weighted by the maximum ionospheric density, the corresponding altitude (hmF2) is, generally, assumed as the perturbation detection alti...

journal_title：Scientific reports

authors： Thomas D,Bagiya MS,Sunil PS,Rolland L,Sunil AS,Mikesell TD,Nayak S,Mangalampalli S,Ramesh DS

更新日期：2018-08-14 00:00:00

abstract：:We herein report the construction of a novel azo-linked conjugated microporous polymers (Ag@AzoTPE-CMP), which possesses permanent porous structure and Ag+ loading up of 7.62% in the skeleton as effective sorption sites. Ag@AzoTPE-CMP shows considerable adsorption capacity of iodine of 202 wt% in iodine vapor at 350 K...

journal_title：Scientific reports

authors： Liu M,Yao C,Liu C,Xu Y

更新日期：2018-09-19 00:00:00

abstract：:Evidence suggest that overexpression of hypoxia-inducible factor-1α (HIF-1α) is linked to multidrug resistance of epilepsy. Here we explored whether aberrant expression of HIF-1α is regulated by miRNAs. Genome-wide microRNA expression profiling was performed on temporal cortex resected from mesial temporal lobe epilep...

journal_title：Scientific reports

authors： Li Y,Huang C,Feng P,Jiang Y,Wang W,Zhou D,Chen L

更新日期：2016-08-24 00:00:00

abstract：:The behavior of water confined at the nanoscale plays a fundamental role in biological processes and technological applications, including protein folding, translocation of water across membranes, and filtration and desalination. Remarkably, nanoscale confinement drastically alters the properties of water. Using molec...

journal_title：Scientific reports

authors： Gao Z,Giovambattista N,Sahin O

更新日期：2018-04-18 00:00:00

abstract：:Risk stratification is crucial in prevention. Circulating microRNAs have been proposed as biomarkers in cardiovascular disease. Here a miR panel consisting of miRs related to different cardiovascular pathophysiologies, was evaluated to predict outcome in the context of prevention. MiR-34a, miR-223, miR-378, miR-499 an...

journal_title：Scientific reports

authors： Keller T,Boeckel JN,Groß S,Klotsche J,Palapies L,Leistner D,Pieper L,Stalla GK,Lehnert H,Silber S,Pittrow D,Maerz W,Dörr M,Wittchen HU,Baumeister SE,Völker U,Felix SB,Dimmeler S,Zeiher AM

更新日期：2017-07-03 00:00:00

abstract：:Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects on the carnitine palmitoyl-transferase 1a (CPT1a). We used this compound to evaluate the role of fatty acid oxidation in rapidly proliferating T cells following costimulation through the C...

journal_title：Scientific reports

authors： O'Connor RS,Guo L,Ghassemi S,Snyder NW,Worth AJ,Weng L,Kam Y,Philipson B,Trefely S,Nunez-Cruz S,Blair IA,June CH,Milone MC

更新日期：2018-04-19 00:00:00

abstract：:The last decade has seen an exponential expansion of interest in conjugating multiple enzymes of cascades in close proximity to each other, with the overarching goal being to accelerate the overall reaction rate. However, some evidence has emerged that there is no effect of proximity channeling on the reaction velocit...

journal_title：Scientific reports

authors： Kuzmak A,Carmali S,von Lieres E,Russell AJ,Kondrat S

更新日期：2019-01-24 00:00:00

abstract：:Polarization control using single plasmonic nanoantennas is of interest for subwavelength optical components in nano-optical circuits and metasurfaces. Here, we investigate the role of two mechanisms for polarization conversion by plasmonic antennas: Structural asymmetry and plasmon hybridization through strong coupli...

journal_title：Scientific reports

authors： Wiecha PR,Black LJ,Wang Y,Paillard V,Girard C,Muskens OL,Arbouet A

更新日期：2017-01-19 00:00:00

abstract：:We fabricate a nonlinear optical device based on a fiber pigtail cross-section coated with a single-layer graphene grown by chemical vapor deposition (CVD) method. Using the fabricated graphene-assisted nonlinear optical device and employing Nyquist 16-ary quadrature amplitude modulation (16-QAM) signal, we experiment...

journal_title：Scientific reports

authors： Hu X,Zeng M,Long Y,Liu J,Zhu Y,Zou K,Zhang F,Fu L,Wang J

更新日期：2016-03-02 00:00:00

abstract：:Understanding the behaviour of humpback whale mother-calf pairs and the acoustic environment on their breeding grounds is fundamental to assessing the biological and ecological requirements needed to ensure a successful migration and survival of calves. Therefore, on a breeding/resting ground, Exmouth Gulf, Western Au...

journal_title：Scientific reports

authors： Bejder L,Videsen S,Hermannsen L,Simon M,Hanf D,Madsen PT

更新日期：2019-01-25 00:00:00

abstract：:Cystatin C (CysC) is implicated in neuroprotection and repair in the nervous system in response to diverse neurotoxic conditions. In addition to being secreted from cells in a soluble form, CysC is released by cells in association with extracellular vesicles (EVs), including exosomes. We demonstrate that EVs containin...

journal_title：Scientific reports

authors： Pérez-González R,Sahoo S,Gauthier SA,Kim Y,Li M,Kumar A,Pawlik M,Benussi L,Ghidoni R,Levy E

更新日期：2019-07-31 00:00:00

abstract：:WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H d...

journal_title：Scientific reports

authors： Zhu J,Vasilopoulou M,Davazoglou D,Kennou S,Chroneos A,Schwingenschlögl U

更新日期：2017-01-18 00:00:00

abstract：:Chemical separation has great importance in industrial applications. Separation of xylene isomers still prevails to be one of the most important challenges in chemical industry, due to the large amount of commercial use of p-xylene in the production of beverage bottles, fibers and films. A novel Zn(II)-based dynamic c...

journal_title：Scientific reports

authors： Mukherjee S,Joarder B,Manna B,Desai AV,Chaudhari AK,Ghosh SK

更新日期：2014-07-21 00:00:00

abstract：:The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. Because in vivo experimental methods are unable to isolate or control individual factors of the TME and in vitro models often do ...

journal_title：Scientific reports

authors： Nikmaneshi MR,Firoozabadi B,Mozafari A,Munn LL

更新日期：2020-02-20 00:00:00

abstract：:Multishelled NiO hollow microspheres for high-performance supercapacitors have been prepared and the formation mechanism has been investigated. By using resin microspheres to absorb Ni(2+) and subsequent proper calcinations, the shell numbers, shell spacing and exterior shell structure were facilely controlled via var...

journal_title：Scientific reports

authors： Qi X,Zheng W,Li X,He G

更新日期：2016-09-12 00:00:00

abstract：:In many real-world networks, the ability to withstand targeted or global attacks; extinctions; or shocks is vital to the survival of the network itself, and of dependent structures such as economies (for financial networks) or even the planet (for ecosystems). Previous attempts to characterise robustness include neste...

journal_title：Scientific reports

authors： Burleson-Lesser K,Morone F,Tomassone MS,Makse HA

更新日期：2020-02-25 00:00:00

abstract：:There is a growing desire to integrate the food requirements of predators living in marine ecosystems impacted by humans into sustainable fisheries management. We used non-invasive video-recording, photography and focal observations to build time-energy budget models and to directly estimate the fish mass delivered to...

journal_title：Scientific reports

authors： Gaglio D,Sherley RB,Ryan PG,Cook TR

更新日期：2018-05-29 00:00:00

abstract：:The prognosis of malignancies has improved in recent years, subsequent primary cancers (SPCs) have become more frequent. This study investigates the patterns of lung cancer involved multiple primary cancers. We enrolled 206,619 primary lung cancer patients and 2,071,922 patients with other primary malignancies from Su...

journal_title：Scientific reports

authors： Mao R,Chen T,Zhou F,Jiang W,Yang X,Ai Z,Li M,Qin L,Wang L,Fei K,Chen C

更新日期：2017-07-25 00:00:00

abstract：:In zebrafish, the role of matrix metalloproteinases (MMPs) in the inflammatory phase of heart regeneration following cryoinjury remains poorly understood. Here, we demonstrated an increase in MMP enzymatic activity and elevated expression of mmp9 and mmp13 in the injured area (IA) of hearts from as early as 1 day post...

journal_title：Scientific reports

authors： Xu S,Webb SE,Lau TCK,Cheng SH

更新日期：2018-05-08 00:00:00

abstract：:Drug resistance caused by excessive and indiscriminate antibiotic usage has become a serious public health problem. The need of finding new antibacterial drugs is more urgent than ever before. Tyrosyl-tRNA synthase was proved to be a potent target in combating drug-resistant bacteria. In silico methodologies including...

journal_title：Scientific reports

authors： Li S,Fan J,Peng C,Chang Y,Guo L,Hou J,Huang M,Wu B,Zheng J,Lin L,Xiao G,Chen W,Liao G,Guo J,Sun P

更新日期：2017-09-14 00:00:00