Improved risk stratification in prevention by use of a panel of selected circulating microRNAs.

abstract：:In mouse embryonic stem (mES) cells, ubiquitylation of histone H2A lysine 119 represses a large number of developmental genes and maintains mES cell pluripotency. It has been suggested that a number of H2A ubiquitin ligases as well as deubiquitylases and related peptide fragments contribute to a delicate balance betwe...

journal_title：Scientific reports

authors： Inoue D,Aihara H,Sato T,Mizusaki H,Doiguchi M,Higashi M,Imamura Y,Yoneda M,Miyanishi T,Fujii S,Okuda A,Nakagawa T,Ito T

更新日期：2015-11-16 00:00:00

abstract：:TiO2/graphene (TiO2-x/GR) composites, which are Ti(3+) self-doped TiO2 nanorods decorated on boron doped graphene sheets, were synthesized via a simple one-step hydrothermal method using low-cost NaBH4 as both a reducing agent and a boron dopant on graphene. The resulting TiO2 nanorods were about 200 nm in length with...

journal_title：Scientific reports

authors： Xing M,Li X,Zhang J

更新日期：2014-06-30 00:00:00

abstract：:Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, high-intensity monopolar pulsed electric fields to permanently disrupt cell membranes within a wel...

journal_title：Scientific reports

authors： Sano MB,Arena CB,Bittleman KR,DeWitt MR,Cho HJ,Szot CS,Saur D,Cissell JM,Robertson J,Lee YW,Davalos RV

更新日期：2015-10-13 00:00:00

abstract：:The morphological and topochemical changes in wood tissues in compression wood of Japanese cedar (Cryptomeria japonica) upon treated with two types of ionic liquids, 1-ethyl-3-methylimidazolium chloride ([C2mim][Cl]) and 1-ethylpyridinium bromide ([EtPy][Br]) were investigated. Compression wood tracheids were swollen ...

journal_title：Scientific reports

authors： Kanbayashi T,Miyafuji H

更新日期：2016-07-18 00:00:00

abstract：:The ability to form mineral structures under biological control is widespread among animals. In several species, specific proteins have been shown to be involved in biomineralization, but it is uncertain how they influence the shape of the growing biomineral and the resulting skeleton. Calcareous sponges are the only ...

journal_title：Scientific reports

authors： Voigt O,Adamska M,Adamski M,Kittelmann A,Wencker L,Wörheide G

更新日期：2017-04-13 00:00:00

abstract：:Increased ultraviolet B (UVB) radiation due to global change can affect plant growth and metabolism. Here, we evaluated the capacity of quinoa to resist under short acute UVB irradiation. Quinoa was daily exposed for 30 or 60 min to 1.69 W m-2 UVB. The results showed that 30 min exposure in 9 d-course did not cause se...

journal_title：Scientific reports

authors： Huarancca Reyes T,Scartazza A,Castagna A,Cosio EG,Ranieri A,Guglielminetti L

更新日期：2018-01-10 00:00:00

abstract：:NLRP3 inflammasomes recognize non-microbial danger signals and induce release of proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular disease. Because sterile inflammation is involved in doxorubicin (Dox)-induced cardiotoxicity, we investigated the role of NLRP3 inflammasomes...

journal_title：Scientific reports

authors： Kobayashi M,Usui F,Karasawa T,Kawashima A,Kimura H,Mizushina Y,Shirasuna K,Mizukami H,Kasahara T,Hasebe N,Takahashi M

更新日期：2016-05-26 00:00:00

abstract：:Decarboxylation of fatty acids over non-noble metal catalysts without added hydrogen was studied. Ni/C catalysts were prepared and exhibited excellent activity and maintenance for decarboxylation. Thereafter, the effects of nickel loading, catalyst loading, temperature, and carbon number on the decarboxylation of fatt...

journal_title：Scientific reports

authors： Wu J,Shi J,Fu J,Leidl JA,Hou Z,Lu X

更新日期：2016-06-13 00:00:00

abstract：:It has been a key issue for photovoltaic (PV) cells to survive under mechanical impacts by tiny dust. In this paper, the performance degradation and the damage behavior of PV cells subjected to massive dust impact are investigated using laser-shock driven particle impact experiments and mechanical modeling. The result...

journal_title：Scientific reports

authors： Xiao K,Wu X,Song X,Yuan J,Bai W,Wu C,Huang C

更新日期：2021-01-12 00:00:00

abstract：:This paper presents the design, simulation and low-cost fabrication of microfluidic channel for biomedical application. Channel is fabricated using soft lithography technique. Printed Circuit Board (PCB) is used to make the master for the channel. Channel pattern is transferred on PCB plate using toner transfer techni...

journal_title：Scientific reports

authors： Tiwari SK,Bhat S,Mahato KK

更新日期：2020-06-08 00:00:00

abstract：:The presence of genetically modified organisms (GMO) is commonly assessed using real-time PCR methods targeting the most common transgenic elements found in GMOs. Once the presence of GM material has been established using these screening methods, GMOs are further identified using a battery of real-time PCR methods, e...

journal_title：Scientific reports

authors： Boutigny AL,Fioriti F,Rolland M

更新日期：2020-09-15 00:00:00

abstract：:Neutrophil extracellular traps (NETs) extruded from neutrophils upon activation are composed of chromatin associated with cytosolic and granular proteins, which ensnare and kill microorganisms. This microbicidal mechanism named classical netosis has been shown to dependent on reactive oxygen species (ROS) generation b...

journal_title：Scientific reports

authors： Rochael NC,Guimarães-Costa AB,Nascimento MT,DeSouza-Vieira TS,Oliveira MP,Garcia e Souza LF,Oliveira MF,Saraiva EM

更新日期：2015-12-17 00:00:00

abstract：:Microalgal harvesting and dewatering are the main bottlenecks that need to be overcome to tap the potential of microalgae for production of valuable compounds. Water surface-floating microalgae form robust biofilms, float on the water surface along with gas bubbles entrapped under the biofilms, and have great potentia...

journal_title：Scientific reports

authors： Maeda Y,Nojima D,Sakurai M,Nomaguchi T,Ichikawa M,Ishizuka Y,Tanaka T

更新日期：2019-08-01 00:00:00

abstract：:Majority of novel X-ray crystal structures of proteins are currently solved using the anomalous diffraction signal provided by selenium after incorporation of selenomethionine instead of natural methionine by genetic engineering methods. However, selenium can be inserted into protein crystals in the form of selenourea...

journal_title：Scientific reports

authors： Luo Z

更新日期：2016-11-14 00:00:00

abstract：:Unlike individual, free-floating planktonic bacteria, biofilms are surface-attached communities of slow- or non-replicating bacteria encased within a protective extracellular polymeric matrix enabling persistent bacterial populations to tolerate high concentrations of antimicrobials. Our current antibacterial arsenal ...

journal_title：Scientific reports

authors： Yang H,Abouelhassan Y,Burch GM,Kallifidas D,Huang G,Yousaf H,Jin S,Luesch H,Huigens RW

更新日期：2017-05-17 00:00:00

abstract：:Acid-base homeostasis is critical for normal growth, development, and hearing function. The sodium-hydrogen exchanger 6 (NHE6), a protein mainly expressed in early and recycling endosomes, plays an important role in regulating organellar pH. Mutations in NHE6 cause complex, slowly progressive neurodegeneration. Little...

journal_title：Scientific reports

authors： Kucharava K,Brand Y,Albano G,Sekulic-Jablanovic M,Glutz A,Xian X,Herz J,Bodmer D,Fuster DG,Petkovic V

更新日期：2020-02-27 00:00:00

abstract：:Macrophages are an important component of the innate immune response. Priming and activation of macrophages is stimulated by cytokines (i.e IFNγ). However, growth hormone (GH) can also stimulate macrophage activation. Based on these observations, the goal of this work was to 1) to compare the transcriptome profile of ...

journal_title：Scientific reports

authors： Schneider A,Wood HN,Geden S,Greene CJ,Yates RM,Masternak MM,Rohde KH

更新日期：2019-12-18 00:00:00

abstract：:Over the last 5-10 years, optical coherence tomography (OCT) and atomic force microscopy (AFM) have been individually applied to monitor the morphological and mechanical properties of various single-species biofilms respectively. This investigation looked to combine OCT and AFM as a multi-scale approach to understand ...

journal_title：Scientific reports

authors： Pattem J,Davrandi M,Aguayo S,Allan E,Spratt D,Bozec L

更新日期：2018-04-09 00:00:00

abstract：:Decline in episodic memory performance usually causes the first clinical symptoms of Alzheimer's disease. At present, Alzheimer's disease can only be diagnosed at a very late stage when neurodegeneration and cognitive impairment is already irreversible. New early disease markers are needed for earlier and more efficie...

journal_title：Scientific reports

authors： Konki M,Lindgren N,Kyläniemi M,Venho R,Laajala E,Ghimire B,Lahesmaa R,Kaprio J,Rinne JO,Lund RJ

更新日期：2020-08-25 00:00:00

abstract：:Microtubule-associated protein 1B (MAP1B) is expressed predominantly during the early stages of development of the nervous system, where it regulates processes such as axonal guidance and elongation. Nevertheless, MAP1B expression in the brain persists in adult stages, where it participates in the regulation of the st...

journal_title：Scientific reports

authors： Bodaleo FJ,Montenegro-Venegas C,Henríquez DR,Court FA,Gonzalez-Billault C

更新日期：2016-07-18 00:00:00

abstract：:Giardia is a worldwide spread protozoan parasite colonizing in small intestines of vertebrates, causing Giardiasis. The controversy about whether it is an extremely primitive eukaryote or just a highly evolved parasite has become a fetter to its uses as a model for both evolutionary and parasitological studies for yea...

journal_title：Scientific reports

authors： Ye Q,Tian H,Chen B,Shao J,Qin Y,Wen J

更新日期：2017-08-25 00:00:00

abstract：:Internal solitary waves (ISWs) in the NE South China Sea (SCS) are tidally generated at the Luzon Strait. Their propagation, evolution, and dissipation processes involve numerous issues still poorly understood. Here, a novel method of seismic oceanography capable of capturing oceanic finescale structures is used to st...

journal_title：Scientific reports

authors： Tang Q,Wang C,Wang D,Pawlowicz R

更新日期：2014-06-20 00:00:00

abstract：:Although 3,5,3'-triiodothyronine (T3) is considered to be the primary bioactive thyroid hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiodothyronine (T2) can also regulate transcriptional networks. To determine the functional relevance of these bioactive THs, RNA-seq ...

journal_title：Scientific reports

authors： Olvera A,Martyniuk CJ,Buisine N,Jiménez-Jacinto V,Sanchez-Flores A,Sachs LM,Orozco A

更新日期：2017-11-08 00:00:00

abstract：:Prolyl oligopeptidase (PREP) inhibition by small-molecule inhibitors can reduce alpha-synuclein (aSyn) aggregation, a key player in Parkinson's disease pathology. However, the significance of PREP protein for aSyn aggregation and toxicity is not known. We studied this in vivo by using PREP knock-out mice with viral ve...

journal_title：Scientific reports

authors： Svarcbahs R,Julku UH,Norrbacka S,Myöhänen TT

更新日期：2018-01-24 00:00:00

abstract：:The stria vascularis (SV) in the cochlea generates and maintains the endocochlear potential, thereby playing a pivotal role in normal hearing. Knowing transcriptional profiles and gene regulatory networks of SV cell types establishes a basis for studying the mechanism underlying SV-related hearing loss. While we have ...

journal_title：Scientific reports

authors： Gu S,Olszewski R,Taukulis I,Wei Z,Martin D,Morell RJ,Hoa M

更新日期：2020-10-22 00:00:00

abstract：:Photoreceptor function is impaired in many retinal diseases like age-related macular degeneration. Currently, assessment of the photoreceptor function for the early diagnosis and monitoring of these diseases is either subjective, as in visual field testing, requires contact with the eye, like in electroretinography, o...

journal_title：Scientific reports

authors： Messner A,Werkmeister RM,Seidel G,Stegmann H,Schmetterer L,Aranha Dos Santos V

更新日期：2019-09-20 00:00:00

abstract：:A novel ignition hohlraum for indirect-drive inertial confinement fusion is proposed, which is named three-axis cylindrical hohlraum (TACH). TACH is a kind of 6 laser entrance holes (LEHs) hohlraum, which is orthogonally jointed of three cylindrical hohlraums. Laser beams are injected through every entrance hole with ...

journal_title：Scientific reports

authors： Kuang L,Li H,Jing L,Lin Z,Zhang L,Li L,Ding Y,Jiang S,Liu J,Zheng J

更新日期：2016-10-05 00:00:00

abstract：:Ionotropic glutamate receptors (iGluRs) are responsible for most of the fast excitatory communication between neurons in our brain. The GluD2 receptor is a puzzling member of the iGluR family: It is involved in synaptic plasticity, plays a role in human diseases, e.g. ataxia, binds glycine and D-serine with low affini...

journal_title：Scientific reports

authors： Tapken D,Steffensen TB,Leth R,Kristensen LB,Gerbola A,Gajhede M,Jørgensen FS,Olsen L,Kastrup JS

更新日期：2017-04-07 00:00:00

abstract：:In spite of its prevalence in animals and plants, endogenous nitric oxide (NO) has been rarely reported in fungi. We present here our observations on production of intracellular NO and its possible roles during development of Neurospora crassa, a model filamentous fungus. Intracellular NO was detected in hypha 8-16 ho...

journal_title：Scientific reports

authors： Pengkit A,Jeon SS,Son SJ,Shin JH,Baik KY,Choi EH,Park G

更新日期：2016-07-18 00:00:00

abstract：:Stochastic surface patterns form an important requirement to facilitate digital image correlation and to subsequently quantify material properties of various tissues when loaded and deformed without artefacts arising from material slippage. Depending on the samples' natural colour, a surface pattern is created by spec...

journal_title：Scientific reports

authors： Zwirner J,Ondruschka B,Scholze M,Hammer N

更新日期：2020-11-27 00:00:00