Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior.

abstract：:In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in visceral adipose tissue (VAT) that involves extracellular matrix deposition, angiogenesis, sympathetic innervation, and adipo...

journal_title：Scientific reports

authors： Chang JC,Durinck S,Chen MZ,Martinez-Martin N,Zhang JA,Lehoux I,Li H,Lin M,Wu J,Bainbridge TW,Ernst JA,Ramani SR,Paduchuri S,Kates L,Solon M,Buechler MB,Castiglioni A,Thai M,Breart B,Modrusan Z,Peterson AS,Turley

更新日期：2019-06-20 00:00:00

abstract：:The aberrant accumulation of ubiquitinated protein aggregates in cells plays a critical role in the pathogenesis of several degenerative diseases, including Parkinson disease (PD) and cystic fibrosis (CF). In this study, we found that Ras GTPase-activating protein-binding protein 1 (G3BP1) inhibits ubiquitinated prote...

journal_title：Scientific reports

authors： Anisimov S,Takahashi M,Kakihana T,Katsuragi Y,Kitaura H,Zhang L,Kakita A,Fujii M

更新日期：2019-09-09 00:00:00

abstract：:Undertaking behaviour is an essential activity in social insects. Corpses are often recognized by a postmortem change in a chemical signature. Reticulitermes flavipes responded to corpses within minutes of death. This undertaking behaviour did not change with longer postmortem time (24 h); however, R. flavipes exhibit...

journal_title：Scientific reports

authors： Sun Q,Haynes KF,Zhou X

更新日期：2013-01-01 00:00:00

abstract：:Many animals use sounds produced by conspecifics for mate identification. Female insects and anuran amphibians, for instance, use acoustic cues to localize, orient toward and approach conspecific males prior to mating. Here we present a novel technique that utilizes multiple, distributed sound-indication devices and a...

journal_title：Scientific reports

authors： Aihara I,Bishop PJ,Ohmer MEB,Awano H,Mizumoto T,Okuno HG,Narins PM,Hero JM

更新日期：2017-09-05 00:00:00

abstract：:Macrophages play an important role in the inflammatory process that contributes to the development of abdominal aortic aneurysm (AAA). Studies of human and mouse AAA tissue reveal expanded populations of macrophages producing an abundance of pro-inflammatory cytokines, including TNF-α, IL-12p40 and high level of metal...

journal_title：Scientific reports

authors： Yan H,Hu Y,Akk A,Ye K,Bacon J,Pham CTN

更新日期：2019-07-18 00:00:00

abstract：:Network analysis is an important tool to analyze the structure of complex systems such as tropical forests. Here, we infer spatial proximity networks in tropical forests by using network science. First, we focus on tree neighborhoods to derive spatial tree networks from forest inventory data. In a second step, we cons...

journal_title：Scientific reports

authors： Schmid JS,Taubert F,Wiegand T,Sun IF,Huth A

更新日期：2020-08-06 00:00:00

abstract：:Synesthesia, an anomalous blending of senses in which stimulation of one sensory modality produces sensation in a different modality, provides a unique opportunity to study how multimodal information is represented in the human brain. We investigated how pitch classes (do, re, mi, etc.) are associated with the three d...

journal_title：Scientific reports

authors： Itoh K,Sakata H,Kwee IL,Nakada T

更新日期：2017-12-19 00:00:00

abstract：:We introduce a simple criterion to identify two-dimensional (2D) materials based on the comparison between experimental lattice constants and lattice constants mainly obtained from Materials-Project (MP) density functional theory (DFT) calculation repository. Specifically, if the relative difference between the two la...

journal_title：Scientific reports

authors： Choudhary K,Kalish I,Beams R,Tavazza F

更新日期：2017-07-12 00:00:00

abstract：:Traditional methods employed to discover new antibiotics are both a time-consuming and financially-taxing venture. This has led researchers to mine existing libraries of clinical molecules in order to repurpose old drugs for new applications (as antimicrobials). Such an effort led to the discovery of auranofin, a drug...

journal_title：Scientific reports

authors： Thangamani S,Mohammad H,Abushahba MF,Sobreira TJ,Hedrick VE,Paul LN,Seleem MN

更新日期：2016-03-03 00:00:00

abstract：:It was previously demonstrated that microRNA-199a (miR-199a) was down-regulated in testicular germ cell tumor (TGCT) partially caused by hypermethylation of its promoter. miR-199a is encoded by two loci in the human genome, miR-199a-1 on chromosome (Chr) 19 and miR-199a-2 on Chr 1. Both loci encode the same miR-199a. ...

journal_title：Scientific reports

authors： Chen BF,Suen YK,Gu S,Li L,Chan WY

更新日期：2014-09-18 00:00:00

abstract：:A three-dimensional semiclassical model is used to study double ionization of Ar when driven by a near-infrared and near-single-cycle laser pulse for intensities ranging from 0.85 × 1014 W/cm2 to 5 × 1014 W/cm2. Asymmetry parameters, distributions of the sum of the two electron momentum components along the direction ...

journal_title：Scientific reports

authors： Chen A,Kübel M,Bergues B,Kling MF,Emmanouilidou A

更新日期：2017-08-08 00:00:00

abstract：:Low back pain (LBP) is a widespread debilitating disorder of significant socio-economic importance and intervertebral disc (IVD) degeneration has been implicated in its pathogenesis. Despite its high prevalence the underlying causes of LBP and IVD degeneration are not well understood. Recent work in musculoskeletal de...

journal_title：Scientific reports

authors： Wiet MG,Piscioneri A,Khan SN,Ballinger MN,Hoyland JA,Purmessur D

更新日期：2017-10-02 00:00:00

abstract：:Common features of immune-metabolic and inflammatory diseases such as metabolic syndrome, diabetes, obesity and cardiovascular diseases are an altered gut microbiota composition and a systemic pro-inflammatory state. We demonstrate that active immunization against the outer membrane protein of bacteria present in the ...

journal_title：Scientific reports

authors： Saita D,Ferrarese R,Foglieni C,Esposito A,Canu T,Perani L,Ceresola ER,Visconti L,Burioni R,Clementi M,Canducci F

更新日期：2016-07-07 00:00:00

abstract：:We formerly developed an automatic colony count system based on the time-lapse shadow image analysis (TSIA). Here this system has been upgraded and applied to practical rapid decision. A microbial sample was spread on/in an agar plate with 90 mm in diameter as homogeneously as possible. We could obtain the results wit...

journal_title：Scientific reports

authors： Ogawa H,Nasu S,Takeshige M,Saito M,Matsuoka H

更新日期：2015-05-15 00:00:00

abstract：:Tumorigenesis is driven by genetic alterations that perturb the signaling networks regulating proliferation or cell death. In order to block tumor growth, one has to precisely know how these signaling pathways function and interplay. Here, we identified the transcription factor Ets21C as a pivotal regulator of tumor g...

journal_title：Scientific reports

authors： Toggweiler J,Willecke M,Basler K

更新日期：2016-10-07 00:00:00

abstract：:We characterised changes in reproductive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the menopause (reproductive age) in mid-life women and explored their associations with lifestyle and reproductive factors. We used data from 1608 women from a UK cohort who had repeat hormone measures and expe...

journal_title：Scientific reports

authors： Soares AG,Kilpi F,Fraser A,Nelson SM,Sattar N,Welsh PI,Tilling K,Lawlor DA

更新日期：2020-12-04 00:00:00

abstract：:Phytoplasmas are transmitted by insect vectors in a persistent propagative manner; however, detailed movements and multiplication patterns of phytoplasmas within vectors remain elusive. In this study, spatiotemporal dynamics of onion yellows (OY) phytoplasma in its vector Macrosteles striifrons were investigated by im...

journal_title：Scientific reports

authors： Koinuma H,Maejima K,Tokuda R,Kitazawa Y,Nijo T,Wei W,Kumita K,Miyazaki A,Namba S,Yamaji Y

更新日期：2020-03-09 00:00:00

abstract：:Oryza coarctata (KKLL; 2n = 4x = 48, 665 Mb) also known as Porteresia coarctata is an extreme halophyte species of genus Oryza. Using Illumina and Nanopore reads, we achieved the assembled genome size of 569.9 Mb, accounting 85.69% of the estimated genome size with N50 of 1.85 Mb and 19.89% repetitive region. We also ...

journal_title：Scientific reports

authors： Mondal TK,Rawal HC,Chowrasia S,Varshney D,Panda AK,Mazumdar A,Kaur H,Gaikwad K,Sharma TR,Singh NK

更新日期：2018-09-12 00:00:00

abstract：:Biological hydrogen production is based on activity of specific enzymes called hydrogenases. Hydrogenases are oxygen sensitive metalloenzymes containing Ni and/or Fe atoms at the active site, catalyzing reversible reduction of protons. Generally, [Fe-Fe] hydrogenases prefer proton reduction to molecular hydrogen, a po...

journal_title：Scientific reports

authors： Mangayil R,Karp M,Lamminmäki U,Santala V

更新日期：2016-10-27 00:00:00

abstract：:Cartilage loss is a leading cause of disability among adults and effective therapy remains elusive. Neonatal chondrocytes (NChons) are an attractive allogeneic cell source for cartilage repair, but their clinical translation has been hindered by scarce donor availability. Here we examine the potential for catalyzing c...

journal_title：Scientific reports

authors： Lai JH,Kajiyama G,Smith RL,Maloney W,Yang F

更新日期：2013-12-19 00:00:00

abstract：:Most of the current studies on myocardial strain are mainly applied in patients with sinus rhythm because the image quality of arrhythmias obtained with conventional scanning sequences does not meet diagnostic needs. Here, we intend to assess left ventricular (LV) global myocardial strain in patients with arrhythmias ...

journal_title：Scientific reports

authors： Chen H,Xie RM,Zhao L,Zhang XY,Zhao YK,Wang Z,Xie GX,Ma XH

更新日期：2020-06-09 00:00:00

abstract：:Deriving cell populations from human embryonic stem cells (hESCs) for cell-based therapy is considered a promising strategy to achieve functional cells, yet its translation to clinical practice depends on achieving fully defined differentiated cells. In this work, we generated a miRNA-responsive lethal mRNA construct ...

journal_title：Scientific reports

authors： Elovic E,Etzion S,Cohen S

更新日期：2019-10-10 00:00:00

abstract：:Although the association between social support and postpartum depression has been previously investigated, its causal relationship remains unclear. Therefore, we examined prospectively whether social support during pregnancy affected postpartum depression. Social support and depressive symptoms were assessed by Japan...

journal_title：Scientific reports

authors： Morikawa M,Okada T,Ando M,Aleksic B,Kunimoto S,Nakamura Y,Kubota C,Uno Y,Tamaji A,Hayakawa N,Furumura K,Shiino T,Morita T,Ishikawa N,Ohoka H,Usui H,Banno N,Murase S,Goto S,Kanai A,Masuda T,Ozaki N

更新日期：2015-05-29 00:00:00

abstract：:Pain is a harmful sensation that arises from noxious stimuli. Transient receptor potential ankyrin 1 (TRPA1) is one target for studying pain mechanisms. TRPA1 is activated by various stimuli such as noxious cold, pungent natural products and environmental irritants. Since TRPA1 is an attractive target for pain therapy...

journal_title：Scientific reports

authors： Gupta R,Saito S,Mori Y,Itoh SG,Okumura H,Tominaga M

更新日期：2016-11-22 00:00:00

abstract：:Silicon is the second most common element on the Earth's crust and its oxide (SiO(2)) the most abundant mineral. Silica and silicates are widely used in medicine and industry as well as in micro- and nano-optics and electronics. However, the fabrication of glass fibres and components requires high temperature and non-...

journal_title：Scientific reports

authors： Polini A,Pagliara S,Camposeo A,Cingolani R,Wang X,Schröder HC,Müller WE,Pisignano D

更新日期：2012-01-01 00:00:00

abstract：:The 28,000-year-old remains of a woolly mammoth, named 'Yuka', were found in Siberian permafrost. Here we recovered the less-damaged nucleus-like structures from the remains and visualised their dynamics in living mouse oocytes after nuclear transfer. Proteomic analyses demonstrated the presence of nuclear components ...

journal_title：Scientific reports

authors： Yamagata K,Nagai K,Miyamoto H,Anzai M,Kato H,Miyamoto K,Kurosaka S,Azuma R,Kolodeznikov II,Protopopov AV,Plotnikov VV,Kobayashi H,Kawahara-Miki R,Kono T,Uchida M,Shibata Y,Handa T,Kimura H,Hosoi Y,Mitani T,Matsumo

更新日期：2019-03-11 00:00:00

abstract：:A series of nanocomposites of cobalt embedded in N-doped nanoporous carbons, carbon nanotubes or hollow carbon onions have been synthesized by a one-step carbonization of metal-organic-framework ZIF-67. The effect of the carbonization temperature on the structural evolution of the resulting nanocomposites has been inv...

journal_title：Scientific reports

authors： Chen B,Ma G,Zhu Y,Xia Y

更新日期：2017-07-13 00:00:00

abstract：:Modern megaherbivore community richness is limited by bottom-up controls, such as resource limitation and resultant dietary competition. However, the extent to which these same controls impacted the richness of fossil megaherbivore communities is poorly understood. The present study investigates the matter with refere...

journal_title：Scientific reports

authors： Mallon JC

更新日期：2019-10-28 00:00:00

abstract：:Extreme weather events and pest outbreaks decrease rice yields and increase their variability, presenting challenges for the agricultural agenda to increase rice productivity and yield stability in Asia. The integration of azolla, fish and ducks has been shown to create robust systems that maintain high yields under h...

journal_title：Scientific reports

authors： Khumairoh U,Lantinga EA,Schulte RPO,Suprayogo D,Groot JCJ

更新日期：2018-10-03 00:00:00

abstract：:The advent of flexible optoelectronic devices has accelerated the development of semiconducting polymeric materials. We seek to replace conventional expensive semiconducting photodetector materials with our cost-effective composite system. We demonstrate in this work the successful fabrication of a photoconductive com...

journal_title：Scientific reports

authors： Tong Y,Zhao X,Tan MC,Zhao R

更新日期：2015-11-16 00:00:00