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Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy.

Abstract：

:In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in visceral adipose tissue (VAT) that involves extracellular matrix deposition, angiogenesis, sympathetic innervation, and adipose tissue browning. Obese VAT is predominated by pro-inflammatory M1 macrophages; cold exposure induces an M1-to-M2 shift in macrophage composition and dramatic changes in macrophage gene expression in both M1 and M2 macrophages. Antibody-mediated CSF1R blocking prevented the cold-induced recruitment of adipose tissue M2 macrophages, suggesting the role of CSF1R signaling in the process. These cold-induced effects in obese VAT are phenocopied by an administration of the FGF21-mimetic antibody, consistent with its action to stimulate sympathetic nerves. Collectively, these studies illuminate adaptive visceral adipose tissue plasticity in obese mice in response to cold stress and antibody-based metabolic therapy.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Chang JC,Durinck S,Chen MZ,Martinez-Martin N,Zhang JA,Lehoux I,Li H,Lin M,Wu J,Bainbridge TW,Ernst JA,Ramani SR,Paduchuri S,Kates L,Solon M,Buechler MB,Castiglioni A,Thai M,Breart B,Modrusan Z,Peterson AS,Turley

doi

10.1038/s41598-019-45354-1

subject

Has Abstract

pub_date

2019-06-20 00:00:00

pages

8833

issue

1

issn

2045-2322

pii

10.1038/s41598-019-45354-1

journal_volume

9

pub_type

杂志文章

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