Abstract:
:Night-workers, transcontinental travelers and individuals that regularly shift their sleep timing, suffer from circadian desynchrony and are at risk to develop metabolic disease, cancer, and mood disorders, among others. Experimental and clinical studies provide evidence that food intake restricted to the normal activity phase is a potent synchronizer for the circadian system and can prevent the detrimental metabolic effects associated with circadian disruption. As an alternative, we hypothesized that a timed piece of chocolate scheduled to the onset of the activity phase may be sufficient stimulus to synchronize circadian rhythms under conditions of shift-work or jet-lag. In Wistar rats, a daily piece of chocolate coupled to the onset of the active phase (breakfast) accelerated re-entrainment in a jet-lag model by setting the activity of the suprachiasmatic nucleus (SCN) to the new cycle. Furthermore, in a rat model of shift-work, a piece of chocolate for breakfast prevented circadian desynchrony, by increasing the amplitude of the day-night c-Fos activation in the SCN. Contrasting, chocolate for dinner prevented re-entrainment in the jet-lag condition and favored circadian desynchrony in the shift-work models. Moreover, chocolate for breakfast resulted in low body weight gain while chocolate for dinner boosted up body weight. Present data evidence the relevance of the timing of a highly caloric and palatable meal for circadian synchrony and metabolic function.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Escobar C,Espitia-Bautista E,Guzmán-Ruiz MA,Guerrero-Vargas NN,Hernández-Navarrete MÁ,Ángeles-Castellanos M,Morales-Pérez B,Buijs RMdoi
10.1038/s41598-020-63227-wsubject
Has Abstractpub_date
2020-04-10 00:00:00pages
6243issue
1issn
2045-2322pii
10.1038/s41598-020-63227-wjournal_volume
10pub_type
杂志文章abstract::MDN1/Rea1, as an AAA-type ATPase, is predicted to be the largest protein involved in pre-ribosome maturation in most organisms. However, its function in plant growth and development is poorly understood. Here, we characterized a novel Arabidopsis mutant, dwarf &short root (dsr) 1, which shows pleiotropic developmental...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36446
更新日期:2016-11-08 00:00:00
abstract::In total, 303 randomly selected clinical Mycobacterium tuberculosis (MTB) isolates from 303 patients (collected January to December 2012) in central Taiwan were examined. The major lineages found were Beijing (N = 114, 37.62%), Haarlem (N = 76, 25.08%) and East African-Indian (EAI) (N = 42, 13.86%). Notably, younger p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05674-6
更新日期:2017-07-14 00:00:00
abstract::The immune system is constantly challenged, being required to protect the organism against a wide variety of infectious pathogens and, at the same time, to avoid autoimmune disorders. One of the most important molecules involved in these events is the Major Histocompatibility Complex class I (MHC-I), responsible for b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18413
更新日期:2015-12-17 00:00:00
abstract::Three-dimensional (3D) image reconstruction of tumors based on serial histological sectioning is one of the most powerful methods for accurate high-resolution visualization of tumor structures. However, 3D histological reconstruction of whole tumor has not yet been achieved. We established a high-resolution 3D model o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76081-7
更新日期:2020-11-03 00:00:00
abstract::In the interfacial superconductor Bi2Te3/Fe1+yTe, two dimensional superconductivity occurs in direct vicinity to the surface state of a topological insulator. If this state were to become involved in superconductivity, under certain conditions a topological superconducting state could be formed, which is of high inter...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32508
更新日期:2016-09-02 00:00:00
abstract::Perhaps, oxidative stress progresses pupation in some Lepidopteran insects; however, the reasons for this remain obscure. In our previous study, we clarified Bombyx mori SOD1 (BmSOD1) and B. mori SOD2 (BmSOD2) proteins respond in common to ultraviolet irradiation (UV) oxidative stress and metamorphosis. This result st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51163-3
更新日期:2019-10-11 00:00:00
abstract::Although oxide-based resistive switching memory (OxRAM) is one of the strong next-generation high capacity memory candidates, it has the critical disadvantage that deviations of resistance levels is too severe to be adopted as a high capacity memory device. More specifically, it is known that the larger on/off current...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35838-x
更新日期:2019-01-22 00:00:00
abstract::Extracellular vesicles (EVs) are membrane surrounded structures released by cells, which have been increasingly recognized as mediators of intercellular communication. Recent reports indicate that EVs participate in important biological processes and could serve as potential source for cancer biomarkers. As an attract...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24669
更新日期:2016-04-19 00:00:00
abstract::Phlebotomine sand flies are remarkable vectors of several etiologic agents (virus, bacterial, trypanosomatid Leishmania), posing a heavy health burden for human populations mainly located at developing countries. Their intestinal microbiota is involved in a wide range of biological and physiological processes, and cou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53769-z
更新日期:2019-11-28 00:00:00
abstract::We employ nematic liquid crystals as the nonlinear medium to recover noisy images via stochastic resonance, in which nonlinear coupling allows signals to grow at the expense of noise. The process is theoretically analyzed and the cross-correlation is numerically calculated. It is found that the quality of output image...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40676-6
更新日期:2019-03-08 00:00:00
abstract::Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. Human embr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17685
更新日期:2015-12-02 00:00:00
abstract::Besides clinical characteristics, easy-accessible laboratory markers could be of value to refine risk stratification in peripheral artery disease. In the current study, we investigated whether α-hydroxybutyrate dehydrogenase (HBDH) is associated with atherothrombotic events in 83 stable patients undergoing infrainguin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54899-0
更新日期:2019-12-03 00:00:00
abstract::In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop progressive visual field loss even though their intraocular pressures ar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78731-2
更新日期:2020-12-10 00:00:00
abstract::Ruminants obtain nutrients from microbial fermentation of plant material, primarily in their rumen, a multilayered forestomach. How the different layers of the rumen wall respond to diet and influence microbial fermentation, and how these process are regulated, is not well understood. Gene expression correlation netwo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39022
更新日期:2016-12-14 00:00:00
abstract::Circadian disruption resulting from exposure to irregular light-dark patterns and sleep deprivation has been associated with beta amyloid peptide (Aβ) aggregation, which is a major event in Alzheimer's disease (AD) pathology. We exposed 5XFAD mice and littermate controls to dim-light vs. bright-light photophases to in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68199-5
更新日期:2020-07-10 00:00:00
abstract::The bioactive plant diterpene oridonin displays important pharmacological activities and is widely used in traditional Chinese medicine; however, its molecular mechanism of action is still incompletely described. In vitro and in vivo data have demonstrated anti-tumor activity of oridonin and its ability to interfere w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35088-x
更新日期:2018-11-13 00:00:00
abstract::A growing interest in healthy eating has lead to an increase in the consumption of vegetables, associated with a rising number of bacterial outbreaks related to fresh produce. This is the case of the outbreak in Germany, caused by a O104:H4 enteroaggregative E. coli strain lysogenic for a Stx phage. Temperate Stx phag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08169-6
更新日期:2017-08-10 00:00:00
abstract::On-chip integration of optical detection units into the microfluidic systems for online monitoring is highly desirable for many applications and is also well in line with the spirit of optofluidics technology-fusion of optics and microfluidics for advanced functionalities. This paper reports the construction of a UV-V...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28928
更新日期:2016-06-29 00:00:00
abstract::The pathophysiological mechanism involved in side effects of radiation therapy, and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation-induced intestinal injury and suggested that this role could be driven by an e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15738
更新日期:2015-10-29 00:00:00
abstract::The causes underlying sex differences in lifespan are strongly debated. While females commonly outlive males in humans, this is generally less pronounced in societies before the demographic transition to low mortality and fertility rates. Life-history theory suggests that reduced reproduction should benefit female lif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24672
更新日期:2016-04-18 00:00:00
abstract::Field electron emission (FEE) properties of vertically aligned hexagonal boron nitride nanowalls (hBNNWs) grown on Si have been markedly enhanced through the use of nitrogen doped nanocrystalline diamond (nNCD) films as an interlayer. The FEE properties of hBNNWs-nNCD heterostructures show a low turn-on field of 15.2 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29444
更新日期:2016-07-11 00:00:00
abstract::V2O5 based materials are attractive cathode alternatives due to the many oxidation state switches of vanadium bringing about a high theoretical specific capacity. However, significant capacity losses are eminent for crystalline V2O5 phases related to the irreversible phase transformations and/or vanadium dissolution s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07113
更新日期:2014-11-19 00:00:00
abstract::During development, cell division often generates two daughters with different developmental fates. Distinct daughter identities can result from the physical polarity and size asymmetry itself, as well as the subsequent activation of distinct fate programmes in each daughter. Asymmetric divisions are a feature of the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01675-7
更新日期:2017-06-14 00:00:00
abstract::Combined treatment with 5-aminolevulinic acid (5-ALA) and X-rays improves tumor suppression in vivo. This is because the accumulated protoporphyrin IX from 5-ALA enhances the generation of ROS by the X-ray irradiation. In the present study, a high-energy medical linear accelerator was used instead of a non-medical low...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21152-z
更新日期:2018-02-09 00:00:00
abstract::To date, the cell and molecular mechanisms regulating tendon healing are poorly understood. Here, we establish a novel model of tendon regeneration using neonatal mice and show that neonates heal via formation of a 'neo-tendon' that differentiates along the tendon specific lineage with functional restoration of gait a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45238
更新日期:2017-03-23 00:00:00
abstract::There remain parts of our planet that are seldom visited by humans, let alone scientists. In such locations, crowd-sourced or citizen scientist data can be critical in describing biodiversity and detecting change. Rangitāhua, the Kermadec Islands, are 750 km from the nearest human-habitation. Although our knowledge of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60136-w
更新日期:2020-02-21 00:00:00
abstract::A chronic antigenic stimulation is believed to sustain the leukemogenic development of chronic lymphocytic leukemia (CLL) and most of lymphoproliferative malignancies developed from mature B cells. Reproducing a proliferative stimulation ex vivo is critical to decipher the mechanisms of leukemogenesis in these maligna...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36853-8
更新日期:2019-01-24 00:00:00
abstract::Given our vast lignocellulosic biomass reserves and the difficulty in bioprocessing them without expensive pretreatment and fuel separation steps, the conversion of lignocellulosic biomass directly into electricity would be beneficial. Here we report the previously unexplored capabilities of thermophilic Geobacillus s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72866-y
更新日期:2020-10-12 00:00:00
abstract::High-entropy alloys (HEAs) have inspired considerable interest due to their attractive physical and mechanical properties. In this work, the microstructural evolution induced by different heat treatments on rapidly solidified hypoeutectic precursors of a Fe26.7Co26.7Ni26.7Si8.9B11 HEA is investigated and correlated wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36464-3
更新日期:2019-01-23 00:00:00
abstract::In this paper we report a low complexity compression method that is suitable for compact optical scanning holography (OSH) systems with different optical settings. Our proposed method can be divided into 2 major parts. First, an automatic decision maker is applied to select the rows of holographic pixels to be scanned...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34724
更新日期:2016-10-06 00:00:00