In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury.

Abstract:

:The pathophysiological mechanism involved in side effects of radiation therapy, and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation-induced intestinal injury and suggested that this role could be driven by an endothelium-dependent mechanism. We investigated whether endothelial-specific PAI-1 deletion could affect radiation-induced intestinal injury. We created a mouse model with a specific deletion of PAI-1 in the endothelium (PAI-1KO(endo)) by a Cre-LoxP system. In a model of radiation enteropathy, survival and intestinal radiation injury were followed as well as intestinal gene transcriptional profile and inflammatory cells intestinal infiltration. Irradiated PAI-1KO(endo) mice exhibited increased survival, reduced acute enteritis severity and attenuated late fibrosis compared with irradiated PAI-1(flx/flx) mice. Double E-cadherin/TUNEL labeling confirmed a reduced epithelial cell apoptosis in irradiated PAI-1KO(endo). High-throughput gene expression combined with bioinformatic analyses revealed a putative involvement of macrophages. We observed a decrease in CD68(+)cells in irradiated intestinal tissues from PAI-1KO(endo) mice as well as modifications associated with M1/M2 polarization. This work shows that PAI-1 plays a role in radiation-induced intestinal injury by an endothelium-dependent mechanism and demonstrates in vivo that the endothelium is directly involved in the progression of radiation-induced enteritis.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Rannou E,François A,Toullec A,Guipaud O,Buard V,Tarlet G,Mintet E,Jaillet C,Iruela-Arispe ML,Benderitter M,Sabourin JC,Milliat F

doi

10.1038/srep15738

subject

Has Abstract

pub_date

2015-10-29 00:00:00

pages

15738

issn

2045-2322

pii

srep15738

journal_volume

5

pub_type

杂志文章
  • Influence of dietary supplementation with Bacillus licheniformis and Saccharomyces cerevisiae as alternatives to monensin on growth performance, antioxidant, immunity, ruminal fermentation and microbial diversity of fattening lambs.

    abstract::Alternatives to antibiotics for improving productivity and maintaining the health of livestock health are urgently needed. The scope of this research was conducted to investigate the effects of two alternatives (Bacillus licheniformis and Saccharomyces cerevisiae) to monensin on growth performance, antioxidant capacit...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35081-4

    authors: Jia P,Cui K,Ma T,Wan F,Wang W,Yang D,Wang Y,Guo B,Zhao L,Diao Q

    更新日期:2018-11-12 00:00:00

  • Potential of recombinant Mycobacterium paragordonae expressing HIV-1 Gag as a prime vaccine for HIV-1 infection.

    abstract::Recombinant Mycobacterium strains such as recombinant BCG (rBCG) have received considerable attention for the HIV-1 vaccine development. Recently, we described a temperature-sensitive Mycobacterium paragordonae (Mpg) strain as a novel live tuberculosis vaccine that is safer and showed an enhanced protective effect aga...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51875-6

    authors: Kim BJ,Kim BR,Kook YH,Kim BJ

    更新日期:2019-10-29 00:00:00

  • Unifying complexity and information.

    abstract::Complex systems, arising in many contexts in the computer, life, social, and physical sciences, have not shared a generally-accepted complexity measure playing a fundamental role as the Shannon entropy H in statistical mechanics. Superficially-conflicting criteria of complexity measurement, i.e. complexity-randomness ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01585

    authors: Ke DG

    更新日期:2013-01-01 00:00:00

  • Metal-free carbon nanotubes: synthesis, and enhanced intrinsic microwave absorption properties.

    abstract::In order to clearly understand the intrinsic microwave absorption properties of carbon nanomaterials, we proposed an efficient strategy to synthesize high purity metal-free carbon nanotubes (CNTs) over water-soluble K2CO3 particles through chemical vapor decomposition and water-washing process. The comparison results ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28310

    authors: Qi X,Xu J,Hu Q,Deng Y,Xie R,Jiang Y,Zhong W,Du Y

    更新日期:2016-06-21 00:00:00

  • Probing rapid carbon fixation in fast-growing seaweed Ulva meridionalis using stable isotope 13C-labelling.

    abstract::The high growth rate of Ulva seaweeds makes it a potential algal biomass resource. In particular, Ulva meridionalis grows up to fourfold a day. Here, we demonstrated strong carbon fixation by U. meridionalis using 13C stable isotope labelling and traced the 13C flux through sugar metabolites with isotope-ratio mass sp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77237-1

    authors: Tsubaki S,Nishimura H,Imai T,Onda A,Hiraoka M

    更新日期:2020-11-23 00:00:00

  • Uniform and accelerated degradation of pure iron patterned by Pt disc arrays.

    abstract::Pure iron has been confirmed as a promising biodegradable metal. However, the degradation rate of pure iron should be accelerated to meet the clinical requirements. In this work, two different designs of platinum disc arrays, including sizes of Φ20 μm × S5 μm and Φ4 μm × S4 μm, have been coated on the surface of pure ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23627

    authors: Huang T,Zheng Y

    更新日期:2016-04-01 00:00:00

  • New insights into the relationship between taste perception and oral microbiota composition.

    abstract::Fairly poor data are available on the relationship between taste perception, food preferences and oral microbiota. In the present study, we investigated the hypothesis that subjects with higher responsiveness to 6-n-propylthiuracil (PROP) might be characterized by a different taste sensitivity and tongue microbiota co...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40374-3

    authors: Cattaneo C,Gargari G,Koirala R,Laureati M,Riso P,Guglielmetti S,Pagliarini E

    更新日期:2019-03-05 00:00:00

  • Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis.

    abstract::It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00431-1

    authors: Yu ZJ,Zeng L,Luo XQ,Geng XR,Xu R,Chen K,Yang G,Luo X,Liu ZQ,Liu ZG,Liu DB,Yang PC,Li HB

    更新日期:2017-04-03 00:00:00

  • Movement patterns of the grey field slug (Deroceras reticulatum) in an arable field.

    abstract::We report the results of an experiment on radio-tracking of individual grey field slugs in an arable field and associated data modelling designed to investigate the effect of slug population density in their movement. Slugs were collected in a commercial winter wheat field in which a 5x6 trapping grid had been establi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74643-3

    authors: Ellis J,Petrovskaya N,Forbes E,Walters KFA,Petrovskii S

    更新日期:2020-10-21 00:00:00

  • Induction of Germ Cell-like Cells from Porcine Induced Pluripotent Stem Cells.

    abstract::The ability to generate germ cells from pluripotent stem cells (PSCs) is valuable for human regenerative medicine and animal breeding. Germ cell-like cells (GCLCs) have been differentiated from mouse and human PSCs, but not from porcine PSCs, which are considered an ideal model for stem cell applications. Here, we dev...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27256

    authors: Wang H,Xiang J,Zhang W,Li J,Wei Q,Zhong L,Ouyang H,Han J

    更新日期:2016-06-06 00:00:00

  • Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation.

    abstract::The p53 protein is a key mediator of the cellular response to various stress signals. In response to DNA damage, the concentration of p53 can temporally oscillate with fluctuations in both the amplitude and period. The underlying mechanism for p53 variability is not fully understood. Here, we construct a core regulato...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41904-9

    authors: Wang DG,Wang S,Huang B,Liu F

    更新日期:2019-04-10 00:00:00

  • Geographic variation in baseline innate immune function does not follow variation in aridity along a tropical environmental gradient.

    abstract::Geographic variation in aridity determines environmental productivity patterns, including large-scale variability in pathogens, vectors and associated diseases. If disease risk decreases with increasing aridity and is matched by immune defense, we predict a decrease in innate immune function along a gradient of increa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62806-1

    authors: Nwaogu CJ,Cresswell W,Tieleman BI

    更新日期:2020-04-03 00:00:00

  • Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G.

    abstract::The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family proteins bind RNA and single-stranded DNA, and create C-to-U base modifications through cytidine deaminase activity. APOBEC3G restricts human immunodeficiency virus 1 (HIV-1) infection by creating hypermutations in proviral DNA, while HIV-1-e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40783

    authors: Chen R,Zhao X,Wang Y,Xie Y,Liu J

    更新日期:2017-01-18 00:00:00

  • Structure modulated charge transfer in carbon atomic wires.

    abstract::sp-Hybridized carbon atomic wires are appealing systems with large property tunability. In particular, their electronic properties are intimately related to length, structure, and type of functional end-groups as well as to other effects such as the intermolecular charge transfer with metal nanoparticles. Here, by a c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38367-9

    authors: Milani A,Barbieri V,Facibeni A,Russo V,Li Bassi A,Lucotti A,Tommasini M,Tzirakis MD,Diederich F,Casari CS

    更新日期:2019-02-07 00:00:00

  • Measuring Tumor Mutational Burden (TMB) in Plasma from mCRPC Patients Using Two Commercial NGS Assays.

    abstract::Tumor tissue mutational burden (TMB) has emerged as a promising predictive biomarker for immune checkpoint therapy. Measuring TMB from circulating tumor DNA (ctDNA) found in plasma is attractive in tissue-constrained indications. We compared the performance of two plasma-based commercial TMB assays including the effec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37128-y

    authors: Qiu P,Poehlein CH,Marton MJ,Laterza OF,Levitan D

    更新日期:2019-01-14 00:00:00

  • On/off switching of bit readout in bias-enhanced tunnel magneto-Seebeck effect.

    abstract::Thermoelectric effects in magnetic tunnel junctions are promising to serve as the basis for logic devices or memories in a "green" information technology. However, up to now the readout contrast achieved with Seebeck effects was magnitudes smaller compared to the well-established tunnel magnetoresistance effect. Here,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08945

    authors: Boehnke A,Milnikel M,von der Ehe M,Franz C,Zbarsky V,Czerner M,Rott K,Thomas A,Heiliger C,Reiss G,Münzenberg M

    更新日期:2015-03-10 00:00:00

  • Irregular and suppressed elastic deformation by a structural twist in cellulose nanofibre models.

    abstract::The elastic responsiveness of single cellulose nanofibres is important for advanced analysis of biological tissues and their use in sophisticated functional materials. However, the mechanical responsiveness derived from the twisted structure of cellulose nanofibres (CNFs) has remained unexplored. In this study, finite...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80890-1

    authors: Uetani K,Uto T,Suzuki N

    更新日期:2021-01-12 00:00:00

  • Structural characterization of site-modified nanocapsid with monodispersed gold clusters.

    abstract::Hepatitis E Virus-like particles self-assemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions. Previously, the nanocapsid was engineered to specifically bind and enter breast cancer cells, where successful tumor targeting was demonstrated in animal models. In the p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17171-x

    authors: Stark MC,Baikoghli MA,Lahtinen T,Malola S,Xing L,Nguyen M,Nguyen M,Sikaroudi A,Marjomäki V,Häkkinen H,Cheng RH

    更新日期:2017-12-06 00:00:00

  • Iterative consensus spectral clustering improves detection of subject and group level brain functional modules.

    abstract::Specialized processing in the brain is performed by multiple groups of brain regions organized as functional modules. Although, in vivo studies of brain functional modules involve multiple functional Magnetic Resonance Imaging (fMRI) scans, the methods used to derive functional modules from functional networks of the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63552-0

    authors: Gupta S,Rajapakse JC

    更新日期:2020-05-05 00:00:00

  • Increased temperature has no consequence for behavioral manipulation despite effects on both partners in the interaction between a crustacean host and a manipulative parasite.

    abstract::Parasites alter many traits of their hosts. In particular, parasites known as "manipulative" may increase their probability of transmission by inducing phenotypic alterations in their intermediate hosts. Although parasitic-induced alterations can modify species' ecological roles, the proximate factors modulating this ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68577-z

    authors: Labaude S,Cézilly F,De Marco L,Rigaud T

    更新日期:2020-07-15 00:00:00

  • Rapid-response low infrared emission broadband ultrathin plasmonic light absorber.

    abstract::Plasmonic nanostructures can significantly advance broadband visible-light absorption, with absorber thicknesses in the sub-wavelength regime, much thinner than conventional broadband coatings. Such absorbers have inherently very small heat capacity, hence a very rapid response time, and high light power-to-temperatur...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07181

    authors: Tagliabue G,Eghlidi H,Poulikakos D

    更新日期:2014-11-24 00:00:00

  • Evaluating differential nanoparticle accumulation and retention kinetics in a mouse model of traumatic brain injury via Ktrans mapping with MRI.

    abstract::Traumatic brain injury (TBI) is a leading cause of injury-related death worldwide, yet there are no approved neuroprotective therapies that improve neurological outcome post-injury. Transient opening of the blood-brain barrier following injury provides an opportunity for passive accumulation of intravenously administe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52622-7

    authors: Miller HA,Magsam AW,Tarudji AW,Romanova S,Weber L,Gee CC,Madsen GL,Bronich TK,Kievit FM

    更新日期:2019-11-06 00:00:00

  • Disorder versus two transport lifetimes in a strongly correlated electron liquid.

    abstract::We report on angle-dependent measurements of the sheet resistances and Hall coefficients of electron liquids in SmTiO3/SrTiO3/SmTiO3 quantum well structures, which were grown by molecular beam epitaxy on (001) DyScO3. We compare their transport properties with those of similar structures grown on LSAT [(La0.3Sr0.7)(Al...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10841-w

    authors: Marshall PB,Kim H,Stemmer S

    更新日期:2017-09-04 00:00:00

  • Discrimination of three Ephedra species and their geographical origins based on multi-element fingerprinting by inductively coupled plasma mass spectrometry.

    abstract::Discrimination of species and geographical origins of traditional Chinese medicine (TCM) is essential to prevent adulteration and inferior problems. We studied Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A.Mey. and Ephedra przewalskii Bge. to investigate the relationship between inorganic element content and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28558-9

    authors: Ma X,Fan L,Mao F,Zhao Y,Yan Y,Tian H,Xu R,Peng Y,Sui H

    更新日期:2018-07-06 00:00:00

  • Mapping the ecological dimensions and potential distributions of endangered relic shrubs in western Ordos biodiversity center.

    abstract::Potential distributions of endemic relic shrubs in western Ordos were poorly mapped, which hindered our implementation of proper conservation. Here we investigated the applicability of ecological niche modeling for endangered relic shrubs to detect areas of priority for biodiversity conservation and analyze difference...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26268

    authors: Zhu GP,Li HQ,Zhao L,Man L,Liu Q

    更新日期:2016-05-20 00:00:00

  • Ultralow-current-density and bias-field-free spin-transfer nano-oscillator.

    abstract::The spin-transfer nano-oscillator (STNO) offers the possibility of using the transfer of spin angular momentum via spin-polarized currents to generate microwave signals. However, at present STNO microwave emission mainly relies on both large drive currents and external magnetic fields. These issues hinder the implemen...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01426

    authors: Zeng Z,Finocchio G,Zhang B,Khalili Amiri P,Katine JA,Krivorotov IN,Huai Y,Langer J,Azzerboni B,Wang KL,Jiang H

    更新日期:2013-01-01 00:00:00

  • Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.

    abstract::Phelan McDermid Syndrome (PMDS) is a genetic disorder characterized by features of Autism spectrum disorders. Similar to reports of Zn deficiency in autistic children, we have previously reported high incidence of Zn deficiency in PMDS. However, the underlying mechanisms are currently not well understood. Here, using ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45190

    authors: Pfaender S,Sauer AK,Hagmeyer S,Mangus K,Linta L,Liebau S,Bockmann J,Huguet G,Bourgeron T,Boeckers TM,Grabrucker AM

    更新日期:2017-03-27 00:00:00

  • Exosome surface glycans reflect osteogenic differentiation of mesenchymal stem cells: Profiling by an evanescent field fluorescence-assisted lectin array system.

    abstract::Extracellular vesicles (EVs) carry information between cells in the form of biomolecules. Such molecules have been found to serve as biomarkers. Glycans attached to surface molecules on EVs are involved in their cellular uptake. In this study, we examined glycan profiles of small EVs which are generally termed exosome...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47760-x

    authors: Shimoda A,Sawada SI,Sasaki Y,Akiyoshi K

    更新日期:2019-08-08 00:00:00

  • IgE-mediated enhancement of CD4(+) T cell responses requires antigen presentation by CD8α(-) conventional dendritic cells.

    abstract::IgE, forming an immune complex with small proteins, can enhance the specific antibody and CD4(+) T cell responses in vivo. The effects require the presence of CD23 (Fcε-receptor II)(+) B cells, which capture IgE-complexed antigens (Ag) in the circulation and transport them to splenic B cell follicles. In addition, als...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28290

    authors: Ding Z,Dahlin JS,Xu H,Heyman B

    更新日期:2016-06-16 00:00:00

  • The possibility to make choices modulates feature-based effects of reward.

    abstract::When making decisions, humans can maximize the positive outcome of their actions by choosing the option associated with the highest reward. We have recently shown that choices modulate effects of reward via a bias in spatial attention: Locations associated with a lower reward are anticipatorily suppressed, as indicate...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42255-1

    authors: Heuer A,Wolf C,Schütz AC,Schubö A

    更新日期:2019-04-08 00:00:00