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Geographic variation in baseline innate immune function does not follow variation in aridity along a tropical environmental gradient.

Abstract：

:Geographic variation in aridity determines environmental productivity patterns, including large-scale variability in pathogens, vectors and associated diseases. If disease risk decreases with increasing aridity and is matched by immune defense, we predict a decrease in innate immune function along a gradient of increasing aridity from the cool-wet forest to the hot-dry Sahel, from south to north in Nigeria. We sampled blood and measured five innate immune indices from 286 Common Bulbuls Pycnonotus barbatus between 6 and 13°N. We sampled in the dry season; we resampled the first location (Jos) also as the last sample location to test temporal change in immune function. Immune indices did not decrease with aridity. One immune index, nitric oxide concentration showed a weak quadratic pattern. In Jos, ovotransferrin concentration, haemagglutination and haemolysis titres increased 12 weeks into the dry season, contrary to expectations that immune indices should decrease with increased dryness. In this tropical system, innate immune function does not decrease with increasing aridity but temporal factors within a location may influence immune function more strongly than spatial variation in aridity, suggesting that immune variation does not follow a simple environmental productivity pattern. Consequently, caution should probably be exercised in predicting effects of climate variability on immune function or disease risk.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Nwaogu CJ,Cresswell W,Tieleman BI

doi

10.1038/s41598-020-62806-1

subject

Has Abstract

pub_date

2020-04-03 00:00:00

pages

5909

issue

1

issn

2045-2322

pii

10.1038/s41598-020-62806-1

journal_volume

10

pub_type

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