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24-hour-restraint stress induces long-term depressive-like phenotypes in mice.

Abstract：

:There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. In this study, we subjected mice to 24-hour-restraint to simulate the trapping episode, and investigated the acute (2 days after the restraint) and long-term (35 days after the restraint) impacts. Surprisingly, we found that the mice displayed depression-like behaviors, decreased glucose uptake in brain and reduced adult hippocampal neurogenesis 35 days after the restraint. Differential expression profiling based on microarrays suggested that genes and pathways related to depression and other mental disorders were differentially expressed in both PFC and hippocampus. Furthermore, the depression-like phenotypes induced by 24-hour-restraint could be reversed by fluoxetine, a type of antidepressant drug. These findings demonstrated that a single severe stressful event could produce long-term depressive-like phenotypes. Moreover, the 24-hour-restraint stress mice could also be used for further studies on mood disorders.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Chu X,Zhou Y,Hu Z,Lou J,Song W,Li J,Liang X,Chen C,Wang S,Yang B,Chen L,Zhang X,Song J,Dong Y,Chen S,He L,Xie Q,Chen X,Li W

doi

10.1038/srep32935

subject

Has Abstract

pub_date

2016-09-09 00:00:00

pages

32935

issn

2045-2322

pii

srep32935

journal_volume

6

pub_type

杂志文章

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