Clinical and microbiological characteristics, and impact of therapeutic strategies on the outcomes of children with candidemia.

Abstract:

:We aimed to determine the clinical and microbiological characteristics of Candida bloodstream infections in children and the impact of therapeutic strategies on outcomes. All pediatric patients with candidemia from a medical center in Taiwan over a 13-year period (2003-2015) were included and a total of 262 patients with 319 episodes of candidemia were analyzed. Overall susceptibility to fluconazole was 86.1%. Cumulative mortality at 7 and 30 days after the first episode of candidemia was 13.4% and 25.2%, respectively. The overall in-hospital mortality rate was 35.1%. The treatment outcomes did not change over the study period. Multivariate analysis showed that delayed catheter removal (odds ratio [OR], 5.52; 95% confidence interval [CI]: 2.97-10.25), septic shock (OR, 5.49; 95% CI: 2.85-10.57), and breakthrough candidemia (OR, 3.66; 95% CI: 1.43-9.35) were independently associated with clinical treatment failure. In children with candidemia, underlying renal insufficiency and hematological/oncological malignancy, delayed catheter removal, and septic shock at onset were independently associated final in-hospital mortality. Analyzing the subgroup of non-neonatal children did not change the findings. We concluded overall mortality of pediatric candidemia remains high during the past decade. Prompt early catheter removal and aggressive treatment strategy in patients with septic shock would be critical to improve outcomes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Tsai MH,Hsu JF,Chu SM,Chang PJ,Lai MY,Wu IH,Huang HR,Chiang MC,Fu RH,Lu JJ

doi

10.1038/s41598-017-01123-6

subject

Has Abstract

pub_date

2017-04-24 00:00:00

pages

1083

issue

1

issn

2045-2322

pii

10.1038/s41598-017-01123-6

journal_volume

7

pub_type

杂志文章
  • Evaluation of permeability applicability based on continuum mechanics law in fluid flow through graphene membrane.

    abstract::Graphene is expected to be used in separation applications such as desalination. However, it is difficult to predict the flow phenomena at the nanoscale using the conventional continuum law. Particularly at a Knudsen number (Kn) of >0.1, which is applied in filtration, it has been reported that not even slip boundary ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49131-y

    authors: Yamada T,Matsuzaki R

    更新日期:2019-09-03 00:00:00

  • An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis.

    abstract::Metastasis suppressor genes (MS genes) are genes that play important roles in inhibiting the process of cancer metastasis without preventing growth of the primary tumor. Identification of these genes and understanding their functions are critical for investigation of cancer metastasis. Recent studies on cancer metasta...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15478

    authors: Zhao M,Li Z,Qu H

    更新日期:2015-10-21 00:00:00

  • Conformations and molecular interactions of poly-γ-glutamic acid as a soluble microbial product in aqueous solutions.

    abstract::Soluble microbial products (SMPs) are of significant concern in the natural environment and in engineered systems. In this work, poly-γ-glutamic acid (γ-PGA), which is predominantly produced by Bacillus sp., was investigated in terms of pH-induced conformational changes and molecular interactions in aqueous solutions;...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13152-2

    authors: Wang LL,Chen JT,Wang LF,Wu S,Zhang GZ,Yu HQ,Ye XD,Shi QS

    更新日期:2017-10-06 00:00:00

  • Quantum correlation dynamics subjected to critical spin environment with short-range anisotropic interaction.

    abstract::Short-range interaction among the spins can not only results in the rich phase diagram but also brings about fascinating phenomenon both in the contexts of quantum computing and information. In this paper, we investigate the quantum correlation of the system coupled to a surrounding environment with short-range anisot...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32634

    authors: Guo JL,Zhang XZ

    更新日期:2016-09-06 00:00:00

  • Experimental immunological demyelination enhances regeneration in autograft-repaired long peripheral nerve gaps.

    abstract::Peripheral nerve long gap defects are a clinical challenge in the regeneration field. Despite the wide variety of surgical techniques and therapies, autografting is the "gold standard" for peripheral nerve gap reconstruction. The pathological process of Wallerian degeneration from the time of acute injury to efficient...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39828

    authors: Ge J,Zhu S,Yang Y,Liu Z,Hu X,Huang L,Quan X,Wang M,Huang J,Li Y,Luo Z

    更新日期:2016-12-23 00:00:00

  • TCRP1 transcriptionally regulated by c-Myc confers cancer chemoresistance in tongue and lung cancer.

    abstract::Previously, we cloned a new gene termed 'tongue cancer resistance-associated protein 1' (TCRP1), which modulates tumorigenesis, enhances cisplatin (cDDP) resistance in cancers, and may be a potential target for reversing drug resistance. However, the mechanisms for regulating TCRP1 expression remain unclear. Herein, w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03763-0

    authors: Jia X,Zhang Z,Luo K,Zheng G,Lu M,Song Y,Liu H,Qiu H,He Z

    更新日期:2017-06-16 00:00:00

  • Frequency and Phase Characteristics of Candle Flame Oscillation.

    abstract::The combustion of candles exhibits a variety of dynamical behaviors. Binding several candles together will result in flickering of candle flames, which is generally described as a nonlinear oscillator. The impact on the frequency of the flame by several factors, such as the arrangement, the number and the asymmetry of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36754-w

    authors: Chen T,Guo X,Jia J,Xiao J

    更新日期:2019-01-23 00:00:00

  • Prognostic relevance of programmed cell death 1 ligand 2 (PDCD1LG2/PD-L2) in patients with advanced stage colon carcinoma treated with chemotherapy.

    abstract::Colorectal cancer (CRC) is the leading cause of cancer-related mortality worldwide. Although the role of tumor programmed cell death 1 ligand 1 (PD-L1) in suppressing antitumor immunity has been validated in various malignances, the impact of PD-L2 (PD-L2/PDCD1LG2) within tumors remains elusive. Here, we examined tumo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79419-3

    authors: Huang KC,Chiang SF,Chen TW,Chen WT,Yang PC,Ke TW,Chao KSC

    更新日期:2020-12-18 00:00:00

  • Controlled Defect Based Ultra Broadband Full-sized Metamaterial Absorber.

    abstract::Metamaterial full-sized absorber structures are numerically and experimentally investigated in GHz region and then examined in THz frequency. By manipulating monitoring the number and the position of the defect elements in conventional unit cells, the optimal integrative absorber structures are generated. The proposed...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27920-1

    authors: Tran MC,Le DH,Pham VH,Do HT,Le DT,Dang HL,Vu DL

    更新日期:2018-06-22 00:00:00

  • Efficacy of Electrical Stimulators for Bone Healing: A Meta-Analysis of Randomized Sham-Controlled Trials.

    abstract::Electrical stimulation is a common adjunct used to promote bone healing; its efficacy, however, remains uncertain. We conducted a meta-analysis of randomized sham-controlled trials to establish the efficacy of electrical stimulation for bone healing. We identified all trials randomizing patients to electrical or sham ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1038/srep31724

    authors: Aleem IS,Aleem I,Evaniew N,Busse JW,Yaszemski M,Agarwal A,Einhorn T,Bhandari M

    更新日期:2016-08-19 00:00:00

  • An improved method for detecting circulating microRNAs with S-Poly(T) Plus real-time PCR.

    abstract::We herein describe a simple, sensitive and specific method for analysis of circulating microRNAs (miRNA), termed S-Poly(T) Plus real-time PCR assay. This new method is based on our previously developed S-Poly(T) method, in which a unique S-Poly(T) primer is used during reverse-transcription to increase sensitivity and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15100

    authors: Niu Y,Zhang L,Qiu H,Wu Y,Wang Z,Zai Y,Liu L,Qu J,Kang K,Gou D

    更新日期:2015-10-13 00:00:00

  • Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis.

    abstract::Targeting epigenetic reader proteins by small molecule inhibitors represents a new therapeutic concept in autoimmune diseases such as rheumatoid arthritis (RA). Although inhibitors targeting bromodomain protein 1 (BRD1) are in development, the function of BRD1 has hardly been studied. We investigated the therapeutic p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29127-w

    authors: Klein K,Kato M,Frank-Bertoncelj M,Kolling C,Ciurea A,Gay S,Ospelt C

    更新日期:2018-07-24 00:00:00

  • Rapid Brownian Motion Primes Ultrafast Reconstruction of Intrinsically Disordered Phe-Gly Repeats Inside the Nuclear Pore Complex.

    abstract::Conformational behavior of intrinsically disordered proteins, such as Phe-Gly repeat domains, alters drastically when they are confined in, and tethered to, nan channels. This has challenged our understanding of how they serve to selectively facilitate translocation of nuclear transport receptor (NTR)-bearing macromol...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29991

    authors: Moussavi-Baygi R,Mofrad MR

    更新日期:2016-07-29 00:00:00

  • Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo.

    abstract::Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34699-8

    authors: Frost HK,Andersson T,Johansson S,Englund-Johansson U,Ekström P,Dahlin LB,Johansson F

    更新日期:2018-11-13 00:00:00

  • Early visualization of skin burn severity using a topically applied dye-loaded liquid bandage.

    abstract::Skin burns are a significant source of injury in both military and civilian sectors. They are especially problematic in low resource environments where non-fatal injuries can lead to high morbidity rates, prolonged hospitalization, and disability. These multifaceted wounds can be highly complex and must be quickly dia...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65747-x

    authors: Nguyen JQ,Marks HL,Everett T,Haire T,Carlsson A,Chan R,Evans CL

    更新日期:2020-06-09 00:00:00

  • The mapping of cancer incidence and mortality trends in the UK from 1980-2013 reveals a potential for overdiagnosis.

    abstract::The incidence of cancer in the United Kingdom has increased significantly over the last four decades. The aim of this study was to examine trends in UK cancer incidence and mortality by cancer site and assess the potential for overdiagnosis. Using Cancer Research UK incidence and mortality data for the period (1971-20...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32844-x

    authors: Oke JL,O'Sullivan JW,Perera R,Nicholson BD

    更新日期:2018-10-02 00:00:00

  • SPARK-MSNA: Efficient algorithm on Apache Spark for aligning multiple similar DNA/RNA sequences with supervised learning.

    abstract::Multiple sequence alignment (MSA) is an integral part of molecular biology. But handling massive number of large sequences is still a bottleneck for most of the state-of-the-art software tools. Knowledge driven algorithms utilizing features of input sequences, such as high similarity in case of DNA sequences, can help...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42966-5

    authors: Vineetha V,Biji CL,Nair AS

    更新日期:2019-04-29 00:00:00

  • Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients.

    abstract::Anti-EGFR antibodies are effective in therapies for late-stage colorectal cancer (CRC); however, many tumours are unresponsive or develop resistance. We performed genomic analysis of intrinsic and acquired resistance to anti-EGFR therapy in prospectively collected tumour samples from 25 CRC patients receiving cetuxima...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51981-5

    authors: Bray SM,Lee J,Kim ST,Hur JY,Ebert PJ,Calley JN,Wulur IH,Gopalappa T,Wong SS,Qian HR,Ting JC,Liu J,Willard MD,Novosiadly RD,Park YS,Park JO,Lim HY,Kang WK,Aggarwal A,Kim HC,Reinhard C

    更新日期:2019-10-25 00:00:00

  • MtrA of the sodium ion pumping methyltransferase binds cobalamin in a unique mode.

    abstract::In the three domains of life, vitamin B12 (cobalamin) is primarily used in methyltransferase and isomerase reactions. The methyltransferase complex MtrA-H of methanogenic archaea has a key function in energy conservation by catalysing the methyl transfer from methyl-tetrahydromethanopterin to coenzyme M and its coupli...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28226

    authors: Wagner T,Ermler U,Shima S

    更新日期:2016-06-21 00:00:00

  • Differential Expression of Genes and DNA Methylation associated with Prenatal Protein Undernutrition by Albumen Removal in an avian model.

    abstract::Previously, long-term effects on body weight and reproductive performance have been demonstrated in the chicken model of prenatal protein undernutrition by albumen removal. Introduction of such persistent alterations in phenotype suggests stable changes in gene expression. Therefore, a genome-wide screening of the hep...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20837

    authors: Willems E,Guerrero-Bosagna C,Decuypere E,Janssens S,Buyse J,Buys N,Jensen P,Everaert N

    更新日期:2016-02-10 00:00:00

  • Gene and lncRNA co-expression network analysis reveals novel ceRNA network for triple-negative breast cancer.

    abstract::Breast cancer is the most frequently diagnosed malignancy among women, and triple-negative breast cancer (TNBC) is a highly aggressive subtype. Increasing evidence has shown that lncRNAs are involved in tumor growth, cell-cycle, and apoptosis through interactions with miRNAs or mRNAs. However, there is still limited d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51626-7

    authors: Le K,Guo H,Zhang Q,Huang X,Xu M,Huang Z,Yi P

    更新日期:2019-10-22 00:00:00

  • Repellency Assessment of Nepeta cataria Essential Oils and Isolated Nepetalactones on Aedes aegypti.

    abstract::There is an increased need for improved and affordable insect repellents to reduce transmission of rapidly spreading diseases with high mortality rates. Natural products are often used when DEET cannot be afforded or accessed and when consumers choose not to use a synthetic repellent. The essential oils from two newly...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36814-1

    authors: Reichert W,Ejercito J,Guda T,Dong X,Wu Q,Ray A,Simon JE

    更新日期:2019-02-06 00:00:00

  • Impedance-based analysis of Natural Killer cell stimulation.

    abstract::The use of impedance-based label free cell analysis is increasingly popular and has many different applications. Here, we report that a real-time cell analyzer (RTCA) can be used to study the stimulation of Natural Killer (NK) cells. Engagement of NK cells via plate-bound antibodies directed against different activati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23368-5

    authors: Fasbender F,Watzl C

    更新日期:2018-03-21 00:00:00

  • Mitochondrial genomes of the key zooplankton copepods Arctic Calanus glacialis and North Atlantic Calanus finmarchicus with the longest crustacean non-coding regions.

    abstract::We determined the nearly complete mitochondrial genomes of the Arctic Calanus glacialis and its North Atlantic sibling Calanus finmarchicus, which are key zooplankton components in marine ecosystems. The sequenced part of C. glacialis mitogenome is 27,342 bp long and consists of two contigs, while for C. finmarchicus ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13807-0

    authors: Weydmann A,Przyłucka A,Lubośny M,Walczyńska KS,Serrão EA,Pearson GA,Burzyński A

    更新日期:2017-10-20 00:00:00

  • PI3K induces B-cell development and regulates B cell identity.

    abstract::Phosphoinositide-3 kinase (PI3K) signaling is important for the survival of numerous cell types and class IA of PI3K is specifically required for the development of B cells but not for T cell development. Here, we show that class IA PI3K-mediated signals induce the expression of the transcription factor Pax5, which pl...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19460-5

    authors: Abdelrasoul H,Werner M,Setz CS,Okkenhaug K,Jumaa H

    更新日期:2018-01-22 00:00:00

  • An innovative magnetic state generator using machine learning techniques.

    abstract::We propose a new efficient algorithm to simulate magnetic structures numerically. It contains a generative model using a complex-valued neural network to generate k-space information. The output information is hermitized and transformed into real-space spin configurations through an inverse fast Fourier transform. The...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53411-y

    authors: Kwon HY,Kim NJ,Lee CK,Yoon HG,Choi JW,Won C

    更新日期:2019-11-13 00:00:00

  • Robust profiling of microRNAs and isomiRs in human plasma exosomes across 46 individuals.

    abstract::microRNAs (miRNAs) are small double stranded RNA molecules consisting of two complementary strands called the 5p and 3p arms. Following imprecise processing and/or addition of nucleotides at the ends, miRNA biogenesis can give rise to variants called isomiRs. Exosomes are small vesicles released by cells. They have at...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56593-7

    authors: Karlsen TA,Aae TF,Brinchmann JE

    更新日期:2019-12-27 00:00:00

  • Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction.

    abstract::Cancer cachexia is a complex multi-organ syndrome characterized by body weight loss, weakness, muscle atrophy and fat depletion. With a prevalence of 1 million people in Europe and only limited therapeutic options, there is a high medical need for new approaches to treat cachexia. Our latest results highlighted microb...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-30569-5

    authors: Pötgens SA,Brossel H,Sboarina M,Catry E,Cani PD,Neyrinck AM,Delzenne NM,Bindels LB

    更新日期:2018-08-17 00:00:00

  • Metabolic phenotyping for monitoring ovarian cancer patients.

    abstract::Epithelial ovarian cancer (EOC) is the most deadly of the gynecological cancers. New approaches and better tools for monitoring treatment efficacy and disease progression of EOC are required. In this study, metabolomics using rapid resolution liquid chromatography mass spectrometry was applied to a systematic investig...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23334

    authors: Ke C,Li A,Hou Y,Sun M,Yang K,Cheng J,Wang J,Ge T,Zhang F,Li Q,Li J,Wu Y,Lou G,Li K

    更新日期:2016-03-21 00:00:00

  • Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres.

    abstract::The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed Lf-Doxo-PMNSs for combined chemo-MF-PTT. The PMNSs were synthesized by hydrothermal method an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62429-6

    authors: Sharifi M,Hasan A,Nanakali NMQ,Salihi A,Qadir FA,Muhammad HA,Shekha MS,Aziz FM,Amen KM,Najafi F,Yousefi-Manesh H,Falahati M

    更新日期:2020-04-03 00:00:00