Abstract:
:Mammalian parental genomes contribute differently to early embryonic development. Before activation of the zygotic genome, the maternal genome provides all transcripts and proteins required for the transition from a highly specialized oocyte to a pluripotent embryo. Depletion of these maternally-encoded transcripts frequently results in failure of preimplantation embryonic development, but their functions in this process are incompletely understood. We found that female mice lacking NLRP2 are subfertile because of early embryonic loss and the production of fewer offspring that have a wide array of developmental phenotypes and abnormal DNA methylation at imprinted loci. By demonstrating that NLRP2 is a member of the subcortical maternal complex (SCMC), an essential cytoplasmic complex in oocytes and preimplantation embryos with poorly understood function, we identified imprinted postzygotic DNA methylation maintenance, likely by directing subcellular localization of proteins involved in this process, such as DNMT1, as a new crucial role of the SCMC for mammalian reproduction.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mahadevan S,Sathappan V,Utama B,Lorenzo I,Kaskar K,Van den Veyver IBdoi
10.1038/srep44667subject
Has Abstractpub_date
2017-03-20 00:00:00pages
44667issn
2045-2322pii
srep44667journal_volume
7pub_type
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