Abstract:
:Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α play crucial roles in regulating cold-induced thermogenesis in brown adipose tissue (BAT). PGC-1α and NT-PGC-1α are highly induced by cold in BAT and subsequently bind to and coactivate many transcription factors to regulate expression of genes involved in mitochondrial biogenesis, fatty acid oxidation, respiration and thermogenesis. To identify the complete repertoire of PGC-1α and NT-PGC-1α target genes in BAT, we analyzed genome-wide DNA-binding and gene expression profiles. We find that PGC-1α-/NT-PGC-1α binding broadly associates with cold-mediated transcriptional activation. In addition to their known target genes in mitochondrial biogenesis and oxidative metabolism, PGC-1α and NT-PGC-1α additionally target a broad spectrum of genes involved in diverse biological pathways including ubiquitin-dependent protein catabolism, ribonucleoprotein complex biosynthesis, phospholipid biosynthesis, angiogenesis, glycogen metabolism, phosphorylation, and autophagy. Our findings expand the number of genes and biological pathways that may be regulated by PGC-1α and NT-PGC-1α and provide further insight into the transcriptional regulatory network in which PGC-1α and NT-PGC-1α coordinate a comprehensive transcriptional response in BAT in response to cold.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chang JS,Ghosh S,Newman S,Salbaum JMdoi
10.1038/s41598-018-26244-4subject
Has Abstractpub_date
2018-05-18 00:00:00pages
7876issue
1issn
2045-2322pii
10.1038/s41598-018-26244-4journal_volume
8pub_type
杂志文章abstract::In order to clearly understand the intrinsic microwave absorption properties of carbon nanomaterials, we proposed an efficient strategy to synthesize high purity metal-free carbon nanotubes (CNTs) over water-soluble K2CO3 particles through chemical vapor decomposition and water-washing process. The comparison results ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28310
更新日期:2016-06-21 00:00:00
abstract::DNA condensation is a ubiquitous phenomenon in biology, yet the physical basis for it has remained elusive. Here, we have explored the mechanism of DNA condensation through the protamine-DNA interaction, and by examining on it the influence of DNA binding drugs. We observed that the DNA condensation is accompanied by ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41975-8
更新日期:2019-04-10 00:00:00
abstract::We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67516-2
更新日期:2020-06-29 00:00:00
abstract::Studies focusing on biofilm assembly in deep-sea environments are rarely conducted. To examine the effects of substrate type on microbial community assembly, biofilms were developed on different substrates for different durations at two locations in the Red Sea: in a brine pool and in nearby bottom water (NBW) adjacen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06647
更新日期:2014-10-17 00:00:00
abstract::MicroRNAs are potent regulators of gene expression that have been widely implicated in reproduction and embryo development. Recent studies have demonstrated that miR-21, a microRNA extensively studied in the context of disease, is important in multiple facets of reproductive biology including folliculogenesis, ovulati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29874-w
更新日期:2018-08-01 00:00:00
abstract::The obesity-associated inflammation of white adipose tissue (WAT) is one of the factors leading to the development of related diseases such as insulin resistance and liver steatosis. Recently, microRNAs (miRNAs) were identified as important regulators of WAT functions. Herein, we cultured human Simpson-Golabi-Behmel s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38339
更新日期:2016-12-06 00:00:00
abstract::Reconstructed annual streamflows using tree-ring chronologies provide useful information on moisture availability during the pre-historic period, but they have limitations in estimating high flows due to the upper bound on soil water holding capacity and trees' metabolic growth limits. We propose a hybrid approach tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23294-6
更新日期:2018-03-21 00:00:00
abstract::We propose a quantum secure group communication protocol for the purpose of sharing the same message among multiple authorized users. Our protocol can remove the need for key management that is needed for the quantum network built on quantum key distribution. Comparing with the secure quantum network based on BB84, we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21743-w
更新日期:2018-03-01 00:00:00
abstract::The freshwater snail Oncomelania hupensis is the unique intermediate host of the blood fluke Schistosoma japonicum, which is the major cause of schistosomiasis. The snail inhabits two contrasting environments: the hilly and marshland regions. The hilly snails are smaller in size and have the typical smooth shell, wher...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16084-z
更新日期:2017-11-17 00:00:00
abstract::The dependences of spreading and differentiation of stem cells plated on hydrogel and silicone gel substrates on the rigidity and porosity of the substrates have recently been a subject of some controversy. In experiments on human mesenchymal stem cells plated on soft, medium rigidity, and hard silicone gels we show t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33411
更新日期:2016-09-21 00:00:00
abstract::Acute chest syndrome (ACS) is a major complication of sickle cell anaemia (SCA) and a leading cause for hospital admissions and death. We aimed to study the spectrum of clinical and laboratory features of ACS and to assess the predisposing factors and predictors of severity. A retrospective case-control cohort was stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59258-y
更新日期:2020-02-12 00:00:00
abstract::The ability to assemble nano- and micro- sized colloidal components into highly ordered configurations is often cited as the basis for developing advanced materials. However, the dynamics of stochastic grain boundary formation and motion have not been quantified, which limits the ability to control and anneal polycrys...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06132
更新日期:2014-08-20 00:00:00
abstract::We investigated whether dogs remember their spontaneous past actions relying on episodic-like memory. Dogs were trained to repeat a small set of actions upon request. Then we tested them on their ability to repeat other actions produced by themselves, including actions performed spontaneously in everyday situations. D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67302-0
更新日期:2020-06-26 00:00:00
abstract::This study investigates physicochemical impact of ultrasonic irradiations on surface topography of woven fabrics. In a simultaneous in-situ sonochemical method, the synthesis and coating of zinc oxide nanoparticles (ZnO NPs) on woven textiles were successfully achieved. Different instruments i.e. Alambeta, moisture ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78305-2
更新日期:2020-12-03 00:00:00
abstract::Because of the pathogenicity and low incidence of avian influenza virus infections in humans, the immune correlates of protection for avian influenza vaccines cannot be determined from clinical studies. Here, we used the ferret model to address this for an avian influenza H5N1 vaccine. Using oil-in-water adjuvants, we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44727
更新日期:2017-03-17 00:00:00
abstract::Selective removal of lignin and other recalcitrant compounds, collectively registered as acid-unhyrolyzable residue (AUR), results in bleaching of leaf litter, but the importance of bleaching in decomposition processes on forest soil has not been fully evaluated. The aims of this study were to elucidate the occurrence...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81206-7
更新日期:2021-01-19 00:00:00
abstract::Despite of the great scientific and technology interest, highly ordered full-Heusler L21-Co2MnAl films have remained a big challenge in terms of the availability and the electrical transport. Here we report the controllable growth and the intriguing transport behavior of epitaxial L21-Co2MnAl films, which exhibit a lo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42931
更新日期:2017-02-20 00:00:00
abstract::Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform is presented which provides automated molecularly imprinted solid-phase extraction (MISPE) followed by liquid chromatography-mass spectrometry...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44298
更新日期:2017-03-17 00:00:00
abstract::Bioartificial livers (BAL) may offer acute liver failure (ALF) patients an opportunity for cure without liver transplantation. We evaluated the efficacy of a spheroid-based BAL system, containing aggregates of porcine hepatocytes, in a porcine model of ALF. ALF pigs were divided into three groups. The control group co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03424-2
更新日期:2017-06-19 00:00:00
abstract::Attention can be allocated to mental representations to select information from working memory. To date, it remains ambiguous whether such retroactive shifts of attention involve the inhibition of irrelevant information or the prioritization of relevant information. Investigating asymmetries in posterior alpha-band os...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70004-2
更新日期:2020-08-17 00:00:00
abstract::Knowledge of the direct role humans have had in changing the landscape requires the perspective of historical and archaeological sources, as well as climatic and ecologic processes, when interpreting paleoecological records. People directly impact land at the local scale and land use decisions are strongly influenced ...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-018-20286-4
更新日期:2018-02-01 00:00:00
abstract::Inhalation exposure to airborne respirable crystalline silica (RCS) poses major health risks in many industrial environments. There is a need for new sensitive instruments and methods for in-field or near real-time measurement of crystalline silica aerosol. The objective of this study was to develop an approach, using...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14363-3
更新日期:2017-10-24 00:00:00
abstract::Biofilm formation in flea gut is important for flea-borne transmission of Yersinia pestis. There are enhancing factors (HmsHFRS, HmsCDE, and HmsT) and inhibiting one (HmsP) for Yersinia pestis biofilm formation. The RcsAB regulatory complex acts as a repressor of Yesinia biofilm formation, and adaptive pseudogenizatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09566
更新日期:2015-04-01 00:00:00
abstract::Hyperspectral imaging technique was employed to determine spatial distributions of chlorophyll (Chl), and carotenoid (Car) contents in cucumber leaves in response to angular leaf spot (ALS). Altogether, 196 hyperspectral images of cucumber leaves with five infection severities of ALS were captured by a hyperspectral i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27790
更新日期:2016-06-10 00:00:00
abstract::A soil remediation method based on magnetic beneficiation is reported. A new magnetic solid chelator powder, FS@IDA (core-shell Fe3O4@SiO2 nanoparticles coated with iminodiacetic acid chelators), was used as a reactive magnetic carrier to selectively capture non-magnetic heavy metals in soil by chelation and removal b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21027
更新日期:2016-02-16 00:00:00
abstract::Exchange bias (EB) of magnetic nanoparticles (MNPs) in the nanoscale regime has been extensively studied by researchers, which have opened up a novel approach in tuning the magnetic anisotropy properties of magnetic nanoparticles (MNPs) in prospective application of biomedical research such as magnetic hyperthermia. I...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75669-3
更新日期:2020-10-29 00:00:00
abstract::The Lhasa terrane is a key region for understanding the paleoelevation of the southern Tibetan Plateau after India-Asia collision. The Gerze Basin, located in the northern part of the Lhasa terrane, is a shortening-related basin. We discovered Lagena laevis (Bandy) fossils in upper Eocene strata of the Gerze Basin. Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27508
更新日期:2016-06-08 00:00:00
abstract::On the basis of diet induced obesity and KO mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin resistance. However, outcomes using iNOS KO mice have so far remained inconclusive. The present study aimed to assess IR in iNOS KO mice after 5 weeks of LFD feed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41009
更新日期:2017-01-20 00:00:00
abstract::To understand the role of commensal gut bacteria on the progression of cognitive decline in Alzheimer's disease via the microbiota-gut-brain axis, we isolated anti-inflammatory Bifidobacterium longum (NK46) from human gut microbiota, which potently inhibited gut microbiota endotoxin production and suppressed NF-κB act...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48342-7
更新日期:2019-08-14 00:00:00
abstract::The recent past has seen impressive progress in the treatment of various malignancies using immunotherapy. One of the most promising approaches involves immune checkpoint inhibitors. However, the clinical results with these agents have demonstrated variability in the response. Pancreatic cancer, in particular, has pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41251-9
更新日期:2019-03-18 00:00:00