Abstract：
:Since its first implementation in otolaryngological surgery nearly a century ago, the surgical microscope has improved the accuracy and the safety of microsurgeries. However, the microscope shows only a magnified surface view of the surgical region. To overcome this limitation, either optical coherence tomography (OCT) or photoacoustic microscopy (PAM) has been independently combined with conventional surgical microscope. Herein, we present a near-infrared virtual intraoperative photoacoustic optical coherence tomography (NIR-VISPAOCT) system that combines both PAM and OCT with a conventional surgical microscope. Using optical scattering and absorption, the NIR-VISPAOCT system simultaneously provides surgeons with real-time comprehensive biological information such as tumor margins, tissue structure, and a magnified view of the region of interest. Moreover, by utilizing a miniaturized beam projector, it can back-project 2D cross-sectional PAM and OCT images onto the microscopic view plane. In this way, both microscopic and cross-sectional PAM and OCT images are concurrently displayed on the ocular lens of the microscope. To verify the usability of the NIR-VISPAOCT system, we demonstrate simulated surgeries, including in vivo image-guided melanoma resection surgery and in vivo needle injection of carbon particles into a mouse thigh. The proposed NIR-VISPAOCT system has potential applications in neurosurgery, ophthalmological surgery, and other microsurgeries.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee D,Lee C,Kim S,Zhou Q,Kim J,Kim Cdoi
10.1038/srep35176subject
Has Abstractpub_date
2016-10-12 00:00:00pages
35176issn
2045-2322pii
srep35176journal_volume
6pub_type
杂志文章abstract：:Recent advances in microfluidic cell cultures enable the construction of in vitro human skin models that can be used for drug toxicity testing, disease study. However, current in vitro skin model have limitations to emulate real human skin due to the simplicity of model. In this paper, we describe the development of '...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37471
更新日期：2016-11-21 00:00:00
abstract：:Peritoneal macrophages play a critical role in the control of infectious and inflammatory diseases. Although recent progress on murine peritoneal macrophages has revealed multiple aspects on their origin and mechanisms involved in their maintenance in this compartment, little is known on the characteristics of human p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30787-x
更新日期：2018-08-24 00:00:00
abstract：:Gold nanoparticle radiosensitization represents a novel technique in enhancement of ionising radiation dose and its effect on biological systems. Variation between theoretical predictions and experimental measurement is significant enough that the mechanism leading to an increase in cell killing and DNA damage is stil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19442
更新日期：2016-01-20 00:00:00
abstract：:Salix matsudana is a deciduous, rapidly growing willow species commonly cultivated in China, which can tolerate drought, salt, and heavy metal stress conditions. Selection of suitable reference genes for quantitative real-time PCR is important for normalizing the expression of the key genes associated with various str...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40290
更新日期：2017-01-25 00:00:00
abstract：:The Asian citrus psyllid (ACP; Diaphorina citri) is the vector of Candidatus Liberibacter asiaticus (CLas) that is associated with the devastating Huanglongbing (HLB; citrus greening disease). This pest of Asian origin has spread into the Americas and more recently into a few countries in East Africa. During recent su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66380-4
更新日期：2020-06-10 00:00:00
abstract：:An investigation was carried out to assess the effect of the P content on the microstructure and mechanical properties of ZCuPb20Sn5 alloy. Alloys of various compositions, (0.05, 0.1, 0.2, 0.3, 0.5% wt.% P) were melted in a melting furnace under 1200 °C and cast into metal mould, the hardness, strength and elongation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49441-1
更新日期：2019-09-16 00:00:00
abstract：:Oxygen tolerance of selenium-containing [NiFeSe] hydrogenases (Hases) is attributable to the high reducing power of the selenocysteine residue, which sustains the bimetallic Ni-Fe catalytic center in the large subunit. Genes encoding [NiFeSe] Hases are inherited by few sulphate-reducing δ-proteobacteria globally distr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19742
更新日期：2016-01-28 00:00:00
abstract：:Given our vast lignocellulosic biomass reserves and the difficulty in bioprocessing them without expensive pretreatment and fuel separation steps, the conversion of lignocellulosic biomass directly into electricity would be beneficial. Here we report the previously unexplored capabilities of thermophilic Geobacillus s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72866-y
更新日期：2020-10-12 00:00:00
abstract：:The therapeutic effects of C16, which is an inhibitor of RNA-dependent protein kinase (PKR), on growth of hepatocellular carcinoma (HCC) cells and tumor progression in vitro and in vivo were evaluated. Huh7 cells, a human HCC cell line, were used. The effects of C16 on cell viability were evaluated with the MTT assay,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61579-x
更新日期：2020-03-20 00:00:00
abstract：:The aim of the current study is to assess whether total bile acid (TBA) level in first trimester pregnancy is associated with gestational diabetes mellitus (GDM). Biochemical parameters including serum TBA of 742 pregnant women were collected within 12 weeks of gestation and compared. At 24-28th weeks of gestation, 75...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34070
更新日期：2016-09-26 00:00:00
abstract：:The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25445-1
更新日期：2018-05-14 00:00:00
abstract：:The polychaetous annelid Neanthes acuminata complex has a widespread distribution, with the California population referred to as N. arenaceodentata. The reproductive pattern in this complex is unique, in that the female reproduces once and then dies, whereas the male can reproduce up to nine times. The male incubates ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13561
更新日期：2015-09-04 00:00:00
abstract：:Uterosacral ligaments (USLs) provide structural support to the female pelvic floor, and a loss of USL structural integrity or biomechanical function may induce pelvic organ prolapse (POP). Alterations in extracellular matrix composition and organization dictate USL mechanical function. Changes in USL microstructure an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64192-0
更新日期：2020-04-30 00:00:00
abstract：:The aim of this study was to assess the association between the shoulder tenderness and the inflammatory changes on magnetic resonance imaging (MRI) in the rheumatoid shoulder. Forty-one shoulders of 41 patients with rheumatoid arthritis (RA) were examined. We evaluated synovitis, erosion and bone marrow edema, by cou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55938-6
更新日期：2019-12-20 00:00:00
abstract：:Most organisms are able to maintain systemic water homeostasis over a wide range of external or dietary osmolarities. The excretory system, composed of the kidneys in mammals and the Malpighian tubules and hindgut in insects, can increase water conservation and absorption to maintain systemic water homeostasis, which ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07993
更新日期：2015-01-23 00:00:00
abstract：:Neural networks can efficiently encode the probability distribution of errors in an error correcting code. Moreover, these distributions can be conditioned on the syndromes of the corresponding errors. This paves a path forward for a decoder that employs a neural network to calculate the conditional distribution, then...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11266-1
更新日期：2017-09-08 00:00:00
abstract：:Delivering and expressing a gene of interest in cells or living animals has become a pivotal technique in biomedical research and gene therapy. Among viral delivery systems, adeno-associated viruses (AAVs) are relatively safe and demonstrate high gene transfer efficiency, low immunogenicity, stable long-term expressio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49624-w
更新日期：2019-09-19 00:00:00
abstract：:Abiotic synthesis of biomolecules is an essential step for the chemical origin of life. Many attempts have succeeded in synthesizing biomolecules, including amino acids and nucleobases (e.g., via spark discharge, impact shock, and hydrothermal heating), from reduced compounds that may have been limited in their availa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66112-8
更新日期：2020-06-08 00:00:00
abstract：:Literacy success is critical to unlocking a child's potential and enhancing their future wellbeing. Thus, the early identification and redressing of literacy needs is vital. Pacific children have, on average, the lowest literacy achievement levels in New Zealand. However, this population is very diverse. This study so...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29939-w
更新日期：2018-08-17 00:00:00
abstract：:Increasing population has posed insurmountable challenges to agriculture in the provision of future food security, particularly in the Middle East and North Africa (MENA) region where biophysical conditions are not well-suited for agriculture. Iran, as a major agricultural country in the MENA region, has long been in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08066-y
更新日期：2017-08-09 00:00:00
abstract：:Oral lichen planus (OLP) is a common, chronic relapsing inflammatory disorder of the mucous membranes, which causes major discomfort. Current treatment includes topical/systemic glucocorticoids, immune modulators and systemic immunosuppressants, which may lead to considerable side-effects. The aim of this study was to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58548-9
更新日期：2020-02-03 00:00:00
abstract：:Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real ana...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56176-6
更新日期：2019-12-24 00:00:00
abstract：:Many environmental flow (e-flow) studies and applications have predominantly used state-(i.e., at a single time point) and rate-(i.e., temporal change) based demographic characteristics of species representing lower trophic levels (e.g., fish communities) to build flow-ecology relationships, rather than using a proces...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79532-3
更新日期：2020-12-18 00:00:00
abstract：:Generally confinement size is considered to determine the dimensionality of nanostructures. While the exciton Bohr radius is used as a criterion to define either weak or strong confinement in optical experiments, the binding energy of confined excitons is difficult to measure experimentally. One alternative is to use ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40026
更新日期：2017-01-05 00:00:00
abstract：:In spite of its prevalence in animals and plants, endogenous nitric oxide (NO) has been rarely reported in fungi. We present here our observations on production of intracellular NO and its possible roles during development of Neurospora crassa, a model filamentous fungus. Intracellular NO was detected in hypha 8-16 ho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30037
更新日期：2016-07-18 00:00:00
abstract：:Toll-like receptors (TLRs), as innate immunity sensors, play critical roles in immune responses. Six SNPs of TLR3, TLR7, and TLR8 were genotyped to determine their associations with systemic lupus erythematosus (SLE) and clinical manifestations of SLE. TLR7 SNP rs3853839 was independently associated with SLE susceptib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03792
更新日期：2014-01-21 00:00:00
abstract：:Bacteria show sophisticated control of their cellular organization, and many bacteria deploy different polar landmark proteins to organize the cell pole. Super-resolution microscopy, such as Photo-Activated Localization Microscopy (PALM), provides the nanoscale localization of molecules and is crucial for better under...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43051-7
更新日期：2019-04-30 00:00:00
abstract：:Topological objects of nontrivial spin or dipolar field textures, such as skyrmions, merons, and vortices, interacting with applied external fields in ferroic materials are of great scientific interest as an intriguing playground of unique physical phenomena and novel technological paradigms. The quest for new topolog...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35199
更新日期：2016-10-07 00:00:00
abstract：:Chronic inflammation-associated bone destruction, which is observed in rheumatoid arthritis (RA) and periodontitis, is mediated by excessive osteoclastogenesis. We showed previously that γ-glutamyltranspeptidase (GGT), an enzyme involved in glutathione metabolism, acts as an endogenous activator of such pathological o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35930
更新日期：2016-10-24 00:00:00
abstract：:The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticles surface to maximize biolo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01209-1
更新日期：2017-05-02 00:00:00
