Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles.


:The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on the silver-silica core-shell nanoparticles surface to maximize biological responses. The obtained silver nanoparticles coated with mesoporous silica functionalized with ampicillin presented remarkable antimicrobial effects against susceptible and antibiotic-resistant Escherichia coli. In addition, these structures were not cell-death inducers and different steps of the mitotic cell cycle (prophase, anaphase and metaphase) were clearly identified. The superior biological results were attributed to a proper and tailored synthesis strategy.


Sci Rep


Scientific reports


de Oliveira JFA,Saito Â,Bido AT,Kobarg J,Stassen HK,Cardoso MB




Has Abstract


2017-05-02 00:00:00












  • Dynamic Changes in the Splenic Transcriptome of Chickens during the Early Infection and Progress of Marek's Disease.

    abstract::Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek's disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumorigenesis, the dynamic splenic transcriptome of GaHV2-infected chickens during early infection and pathogenic phases has been determi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dang L,Teng M,Li HW,Li HZ,Ma SM,Zhao P,Li XJ,Deng RG,Zhang GP,Luo J

    更新日期:2017-09-14 00:00:00

  • Arbuscular mycorrhizal enhancement of phosphorus uptake and yields of maize under high planting density in the black soil region of China.

    abstract::Arbuscular mycorrhizal (AM) symbioses are an attractive means of improving the efficiency of soil phosphorus (P) that difficult to be used by plants and may provide a sustainable way of maintaining high yields while reducing P applications. However, quantifying the contribution of indigenous AM fungi on phosphorus upt...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Hou L,Zhang X,Feng G,Li Z,Zhang Y,Cao N

    更新日期:2021-01-13 00:00:00

  • GABA accretion reduces Lsi-1 and Lsi-2 gene expressions and modulates physiological responses in Oryza sativa to provide tolerance towards arsenic.

    abstract::GABA counteracts wide range of stresses through regulation of GABA shunt pathway in plants. Although, GABA assisted tolerance against As toxicity in plants is still unexplored. We have examined GABA induced tolerance in rice seedlings with two exposure periods of GABA i.e., short term and long term. Results showed tha...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kumar N,Dubey AK,Upadhyay AK,Gautam A,Ranjan R,Srikishna S,Sahu N,Behera SK,Mallick S

    更新日期:2017-08-18 00:00:00

  • Contextual experience modifies functional connectome indices of topological strength and efficiency.

    abstract::Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional connectivity in rodent...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Pompilus M,Colon-Perez LM,Grudny MM,Febo M

    更新日期:2020-11-16 00:00:00

  • DirtyGenes: testing for significant changes in gene or bacterial population compositions from a small number of samples.

    abstract::High throughput genomics technologies are applied widely to microbiomes in humans, animals, soil and water, to detect changes in bacterial communities or the genes they carry, between different environments or treatments. We describe a method to test the statistical significance of differences in bacterial population ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Shaw LM,Blanchard A,Chen Q,An X,Davies P,Tötemeyer S,Zhu YG,Stekel DJ

    更新日期:2019-02-20 00:00:00

  • Transferrin-targeted porous silicon nanoparticles reduce glioblastoma cell migration across tight extracellular space.

    abstract::Mortality of glioblastoma multiforme (GBM) has not improved over the last two decades despite medical breakthroughs in the treatment of other types of cancers. Nanoparticles hold tremendous promise to overcome the pharmacokinetic challenges and off-target adverse effects. However, an inhibitory effect of nanoparticles...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Sheykhzadeh S,Luo M,Peng B,White J,Abdalla Y,Tang T,Mäkilä E,Voelcker NH,Tong WY

    更新日期:2020-02-11 00:00:00

  • Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors.

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yelshanskaya MV,Saotome K,Singh AK,Sobolevsky AI

    更新日期:2016-01-07 00:00:00

  • The TIR/BB-loop mimetic AS-1 prevents Ang II-induced hypertensive cardiac hypertrophy via NF-κB dependent downregulation of miRNA-143.

    abstract::Untreated pathological cardiac hypertrophy, which can be caused by sustained systemic hypertension, may lead to heart failure. In the present study, we investigated whether AS-1 had attenuating effects on hypertension-induced cardiac hypertrophy, and whether this process was mediated by the regulation of miRNA-143. To...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Song J,Xie Q,Wang L,Lu Y,Liu P,Yang P,Chen R,Shao C,Qiao C,Wang Z,Yan J

    更新日期:2019-04-23 00:00:00

  • Resonantly Enhanced Betatron Hard X-rays from Ionization Injected Electrons in a Laser Plasma Accelerator.

    abstract::Ultrafast betatron x-ray emission from electron oscillations in laser wakefield acceleration (LWFA) has been widely investigated as a promising source. Betatron x-rays are usually produced via self-injected electron beams, which are not controllable and are not optimized for x-ray yields. Here, we present a new method...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Huang K,Li YF,Li DZ,Chen LM,Tao MZ,Ma Y,Zhao JR,Li MH,Chen M,Mirzaie M,Hafz N,Sokollik T,Sheng ZM,Zhang J

    更新日期:2016-06-08 00:00:00

  • Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women.

    abstract::We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dugas LR,Bernabé BP,Priyadarshini M,Fei N,Park SJ,Brown L,Plange-Rhule J,Nelson D,Toh EC,Gao X,Dong Q,Sun J,Kliethermes S,Gottel N,Luke A,Gilbert JA,Layden BT

    更新日期:2018-11-20 00:00:00

  • The greenhouse gas offset potential from seagrass restoration.

    abstract::Awarding CO2 offset credits may incentivize seagrass restoration projects and help reverse greenhouse gas (GHG) emissions from global seagrass loss. However, no study has quantified net GHG removal from the atmosphere from a seagrass restoration project, which would require coupled Corg stock and GHG flux enhancement ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Oreska MPJ,McGlathery KJ,Aoki LR,Berger AC,Berg P,Mullins L

    更新日期:2020-04-30 00:00:00

  • Statistical modeling and optimization of heterogeneous Fenton-like removal of organic pollutant using fibrous catalysts: a full factorial design.

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Morshed MN,Pervez MN,Behary N,Bouazizi N,Guan J,Nierstrasz VA

    更新日期:2020-09-30 00:00:00

  • A Bioactive Chemical Markers Based Strategy for Quality Assessment of Botanical Drugs: Xuesaitong Injection as a Case Study.

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yang Z,Shao Q,Ge Z,Ai N,Zhao X,Fan X

    更新日期:2017-05-25 00:00:00

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gao H,Liu DE,Li Y,Wu X,Tan H

    更新日期:2021-01-11 00:00:00

  • C/EBPβ-Thr217 Phosphorylation Stimulates Macrophage Inflammasome Activation and Liver Injury.

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Buck M,Solis-Herruzo J,Chojkier M

    更新日期:2016-04-12 00:00:00

  • Wavelength of light and photophobia in inherited retinal dystrophy.

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Otsuka Y,Oishi A,Miyata M,Oishi M,Hasegawa T,Numa S,Ikeda HO,Tsujikawa A

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  • Enhancing succinic acid biosynthesis in Escherichia coli by engineering its global transcription factor, catabolite repressor/activator (Cra).

    abstract::This study was initiated to improve E. coli succinate production by engineering the E. coli global transcription factor, Cra (catabolite repressor/activator). Random mutagenesis libraries were generated through error-prone PCR of cra. After re-screening and mutation site integration, the best mutant strain was Tang154...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhu LW,Xia ST,Wei LN,Li HM,Yuan ZP,Tang YJ

    更新日期:2016-11-04 00:00:00

  • Alexithymia and emotional reactions to odors.

    abstract::Alexithymia is a psychological construct characterized by deficits in processing emotional stimuli. However, little is known about the processing of odours in alexithymia, even though there is extensive proof that emotion and olfaction are closely linked. The present study is aimed at investigating how alexithymic ind...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Cecchetto C,Rumiati RI,Aiello M

    更新日期:2017-10-26 00:00:00

  • Minicollagen cysteine-rich domains encode distinct modes of polymerization to form stable nematocyst capsules.

    abstract::The stinging capsules of cnidarians, nematocysts, function as harpoon-like organelles with unusual biomechanical properties. The nanosecond discharge of the nematocyst requires a dense protein network of the capsule structure withstanding an internal pressure of up to 150 bar. Main components of the capsule are short ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Tursch A,Mercadante D,Tennigkeit J,Gräter F,Özbek S

    更新日期:2016-05-11 00:00:00

  • Microcantilever Actuation by Laser Induced Photoacoustic Waves.

    abstract::We present here a combined theoretical and experimental investigation on effective excitation of microcantilever by using photoacoustic waves. The photoacoustic waves arose from a vibrating Al foil induced by an intensity-modulated laser. We demonstrate that, superior to photothermal excitation, this new configuration...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gao N,Zhao D,Jia R,Liu D

    更新日期:2016-01-27 00:00:00

  • Synergetic effect of the Onion CHI gene on the PAP1 regulatory gene for enhancing the flavonoid profile of tomato skin.

    abstract::Tomatoes are known to have ameliorative effects on cardiovascular disease and cancer. The nutritional value of tomatoes can be enhanced by increasing flavonoids content through genetic modification. The regulatory gene PAP1 (production of anthocyanin pigment 1) from Arabidopsis is reported to increase initial flavonoi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lim W,Li J

    更新日期:2017-09-28 00:00:00

  • Grass and tree cover responses to intra-seasonal rainfall variability vary along a rainfall gradient in African tropical grassy biomes.

    abstract::Although it is well known that mean annual rainfall (MAR) and rainfall seasonality have a key role in influencing the distribution of tree and grass cover in African tropical grassy biomes (TGBs), the impact of intra-seasonal rainfall variability on these distributions is less agreed upon. Since the prevalent mechanis...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: D'Onofrio D,Sweeney L,von Hardenberg J,Baudena M

    更新日期:2019-02-20 00:00:00

  • Enhancement of Colonic Absorptive Function after the Massive Resection of the Small Intestine Based on the Creation of an Artificial Colonic Valve.

    abstract::The colon can have an absorptive function similar to that of the small intestine after the massive resection of the small bowel. To improve colonic absorptive function, we created a valve in the colon (artificial colonic valve, ACV). ACVs were created in 20 rats that had 80 percent of their small intestine resected, w...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Deng G,Deng Z

    更新日期:2020-01-21 00:00:00

  • A mesophotic black coral forest in the Adriatic Sea.

    abstract::A forest of the black coral Antipathella subpinnata was found from 52 to 80 m depth in three different sites at Tremiti Islands Marine Protected Area (MPA; Mediterranean Sea), with two of them hosting a monospecific forest on horizontal and vertical substrates. Colonies of A. subpinnata showed a mean density between 0...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chimienti G,De Padova D,Mossa M,Mastrototaro F

    更新日期:2020-05-22 00:00:00

  • Injection-modulated polarity conversion by charge carrier density control via a self-assembled monolayer for all-solution-processed organic field-effect transistors.

    abstract::We demonstrated modulation of charge carrier densities in all-solution-processed organic field-effect transistors (OFETs) by modifying the injection properties with self-assembled monolayers (SAMs). The all-solution-processed OFETs based on an n-type polymer with inkjet-printed Ag electrodes were fabricated as a test ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Roh J,Lee T,Kang CM,Kwak J,Lang P,Horowitz G,Kim H,Lee C

    更新日期:2017-04-12 00:00:00

  • High-throughput metagenome analysis of the Sarcoptes scabiei internal microbiota and in-situ identification of intestinal Streptomyces sp.

    abstract::Multiple parasitic arthropods of medical importance depend on symbiotic bacteria. While the link between scabies and secondary bacterial infections causing post infective complications of Group A streptococcal and staphylococcal pyoderma is increasingly recognized, very little is known about the microbiota of Sarcopte...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Swe PM,Zakrzewski M,Waddell R,Sriprakash KS,Fischer K

    更新日期:2019-08-13 00:00:00

  • Genome-wide atlas of alternative polyadenylation in the forage legume red clover.

    abstract::Studies on prevalence and significance of alternative polyadenylation (APA) in plants have been so far limited mostly to the model plants. Here, a genome-wide analysis of APA was carried out in different tissue types in the non-model forage legume red clover (Trifolium pratense L). A profile of poly(A) sites in differ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chakrabarti M,Dinkins RD,Hunt AG

    更新日期:2018-07-27 00:00:00

  • Sex-specific patterns of gene expression following influenza vaccination.

    abstract::Sex-based variations in the immune response to the influenza vaccines was reported, however, the genetic basis responsible for the sex variations in the immune response toward the influenza vaccines remains unclear. Here, the genes responsible for sex-specific responses after vaccination with trivalent inactivated inf...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wen F,Guo J,Li Z,Huang S

    更新日期:2018-09-10 00:00:00

  • A pilot clinical study of the therapeutic antibody against canine PD-1 for advanced spontaneous cancers in dogs.

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    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Igase M,Nemoto Y,Itamoto K,Tani K,Nakaichi M,Sakurai M,Sakai Y,Noguchi S,Kato M,Tsukui T,Mizuno T

    更新日期:2020-10-27 00:00:00

  • Characterization of donor and recipient CD8+ tissue-resident memory T cells in transplant nephrectomies.

    abstract::Tissue-resident memory T (TRM) cells are characterized by their surface expression of CD69 and can be subdivided in CD103+ and CD103- TRM cells. The origin and functional characteristics of TRM cells in the renal allograft are largely unknown. To determine these features we studied TRM cells in transplant nephrectomie...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: de Leur K,Dieterich M,Hesselink DA,Corneth OBJ,Dor FJMF,de Graav GN,Peeters AMA,Mulder A,Kimenai HJAN,Claas FHJ,Clahsen-van Groningen MC,van der Laan LJW,Hendriks RW,Baan CC

    更新日期:2019-04-12 00:00:00