Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles.

abstract：:Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek's disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumorigenesis, the dynamic splenic transcriptome of GaHV2-infected chickens during early infection and pathogenic phases has been determi...

journal_title：Scientific reports

authors： Dang L,Teng M,Li HW,Li HZ,Ma SM,Zhao P,Li XJ,Deng RG,Zhang GP,Luo J

更新日期：2017-09-14 00:00:00

abstract：:Arbuscular mycorrhizal (AM) symbioses are an attractive means of improving the efficiency of soil phosphorus (P) that difficult to be used by plants and may provide a sustainable way of maintaining high yields while reducing P applications. However, quantifying the contribution of indigenous AM fungi on phosphorus upt...

journal_title：Scientific reports

authors： Hou L,Zhang X,Feng G,Li Z,Zhang Y,Cao N

更新日期：2021-01-13 00:00:00

abstract：:GABA counteracts wide range of stresses through regulation of GABA shunt pathway in plants. Although, GABA assisted tolerance against As toxicity in plants is still unexplored. We have examined GABA induced tolerance in rice seedlings with two exposure periods of GABA i.e., short term and long term. Results showed tha...

journal_title：Scientific reports

authors： Kumar N,Dubey AK,Upadhyay AK,Gautam A,Ranjan R,Srikishna S,Sahu N,Behera SK,Mallick S

更新日期：2017-08-18 00:00:00

abstract：:Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional connectivity in rodent...

journal_title：Scientific reports

authors： Pompilus M,Colon-Perez LM,Grudny MM,Febo M

更新日期：2020-11-16 00:00:00

abstract：:High throughput genomics technologies are applied widely to microbiomes in humans, animals, soil and water, to detect changes in bacterial communities or the genes they carry, between different environments or treatments. We describe a method to test the statistical significance of differences in bacterial population ...

journal_title：Scientific reports

authors： Shaw LM,Blanchard A,Chen Q,An X,Davies P,Tötemeyer S,Zhu YG,Stekel DJ

更新日期：2019-02-20 00:00:00

abstract：:Mortality of glioblastoma multiforme (GBM) has not improved over the last two decades despite medical breakthroughs in the treatment of other types of cancers. Nanoparticles hold tremendous promise to overcome the pharmacokinetic challenges and off-target adverse effects. However, an inhibitory effect of nanoparticles...

journal_title：Scientific reports

authors： Sheykhzadeh S,Luo M,Peng B,White J,Abdalla Y,Tang T,Mäkilä E,Voelcker NH,Tong WY

更新日期：2020-02-11 00:00:00

abstract：:AMPA subtype ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission across excitatory synapses in the central nervous system. Each AMPA receptor is composed of four multi-domain subunits that are organized into layers of two amino-terminal domain (ATD) dimers, two ligand-binding domain ...

journal_title：Scientific reports

authors： Yelshanskaya MV,Saotome K,Singh AK,Sobolevsky AI

更新日期：2016-01-07 00:00:00

abstract：:Untreated pathological cardiac hypertrophy, which can be caused by sustained systemic hypertension, may lead to heart failure. In the present study, we investigated whether AS-1 had attenuating effects on hypertension-induced cardiac hypertrophy, and whether this process was mediated by the regulation of miRNA-143. To...

journal_title：Scientific reports

authors： Song J,Xie Q,Wang L,Lu Y,Liu P,Yang P,Chen R,Shao C,Qiao C,Wang Z,Yan J

更新日期：2019-04-23 00:00:00

abstract：:Ultrafast betatron x-ray emission from electron oscillations in laser wakefield acceleration (LWFA) has been widely investigated as a promising source. Betatron x-rays are usually produced via self-injected electron beams, which are not controllable and are not optimized for x-ray yields. Here, we present a new method...

journal_title：Scientific reports

authors： Huang K,Li YF,Li DZ,Chen LM,Tao MZ,Ma Y,Zhao JR,Li MH,Chen M,Mirzaie M,Hafz N,Sokollik T,Sheng ZM,Zhang J

更新日期：2016-06-08 00:00:00

abstract：:We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed...

journal_title：Scientific reports

authors： Dugas LR,Bernabé BP,Priyadarshini M,Fei N,Park SJ,Brown L,Plange-Rhule J,Nelson D,Toh EC,Gao X,Dong Q,Sun J,Kliethermes S,Gottel N,Luke A,Gilbert JA,Layden BT

更新日期：2018-11-20 00:00:00

abstract：:Awarding CO2 offset credits may incentivize seagrass restoration projects and help reverse greenhouse gas (GHG) emissions from global seagrass loss. However, no study has quantified net GHG removal from the atmosphere from a seagrass restoration project, which would require coupled Corg stock and GHG flux enhancement ...

journal_title：Scientific reports

authors： Oreska MPJ,McGlathery KJ,Aoki LR,Berger AC,Berg P,Mullins L

更新日期：2020-04-30 00:00:00

abstract：:This work focuses on the optimization of heterogeneous Fenton-like removal of organic pollutant (dye) from water using newly developed fibrous catalysts based on a full factorial experimental design. This study aims to approximate the feasibility of heterogeneous Fenton-like removal process and optionally make predict...

journal_title：Scientific reports

authors： Morshed MN,Pervez MN,Behary N,Bouazizi N,Guan J,Nierstrasz VA

更新日期：2020-09-30 00:00:00

abstract：:Current chemical markers based quality assessment methods largely fail to reflect intrinsic chemical complexity and multiple mechanisms of action of botanical drugs (BD). The development of novel quality markers is greatly needed. Here we propose bioactive chemical markers (BCM), defined as a group of chemo-markers th...

journal_title：Scientific reports

authors： Yang Z,Shao Q,Ge Z,Ai N,Zhao X,Fan X

更新日期：2017-05-25 00:00:00

abstract：:Live birth is the most important concern for assisted reproductive technology (ART) patients. Therefore, in the medical reproductive centre, obstetricians often need to answer the following question: "What are the chances that I will have a healthy baby after ART treatment?" To date, our obstetricians have no referenc...

journal_title：Scientific reports

authors： Gao H,Liu DE,Li Y,Wu X,Tan H

更新日期：2021-01-11 00:00:00

abstract：:Amplification of liver injury is mediated by macrophages but the signaling by which the macrophage inflammasome enhances liver injury is not completely understood. The CCAAT/Enhancer Binding Protein-β (C/EBPβ) is a critical signaling molecule for macrophages because expression of a dominant inhibitor of C/EBPβ DNA-bin...

journal_title：Scientific reports

authors： Buck M,Solis-Herruzo J,Chojkier M

更新日期：2016-04-12 00:00:00

abstract：:Inherited retinal dystrophy (IRD) patients often experience photophobia. However, its mechanism has not been elucidated. This study aimed to investigate the main wavelength of light causing photophobia in IRD and difference among patients with different phenotypes. Forty-seven retinitis pigmentosa (RP) and 22 cone-rod...

journal_title：Scientific reports

authors： Otsuka Y,Oishi A,Miyata M,Oishi M,Hasegawa T,Numa S,Ikeda HO,Tsujikawa A

更新日期：2020-09-09 00:00:00

abstract：:This study was initiated to improve E. coli succinate production by engineering the E. coli global transcription factor, Cra (catabolite repressor/activator). Random mutagenesis libraries were generated through error-prone PCR of cra. After re-screening and mutation site integration, the best mutant strain was Tang154...

journal_title：Scientific reports

authors： Zhu LW,Xia ST,Wei LN,Li HM,Yuan ZP,Tang YJ

更新日期：2016-11-04 00:00:00

abstract：:Alexithymia is a psychological construct characterized by deficits in processing emotional stimuli. However, little is known about the processing of odours in alexithymia, even though there is extensive proof that emotion and olfaction are closely linked. The present study is aimed at investigating how alexithymic ind...

journal_title：Scientific reports

authors： Cecchetto C,Rumiati RI,Aiello M

更新日期：2017-10-26 00:00:00

abstract：:The stinging capsules of cnidarians, nematocysts, function as harpoon-like organelles with unusual biomechanical properties. The nanosecond discharge of the nematocyst requires a dense protein network of the capsule structure withstanding an internal pressure of up to 150 bar. Main components of the capsule are short ...

journal_title：Scientific reports

authors： Tursch A,Mercadante D,Tennigkeit J,Gräter F,Özbek S

更新日期：2016-05-11 00:00:00

abstract：:We present here a combined theoretical and experimental investigation on effective excitation of microcantilever by using photoacoustic waves. The photoacoustic waves arose from a vibrating Al foil induced by an intensity-modulated laser. We demonstrate that, superior to photothermal excitation, this new configuration...

journal_title：Scientific reports

authors： Gao N,Zhao D,Jia R,Liu D

更新日期：2016-01-27 00:00:00

abstract：:Tomatoes are known to have ameliorative effects on cardiovascular disease and cancer. The nutritional value of tomatoes can be enhanced by increasing flavonoids content through genetic modification. The regulatory gene PAP1 (production of anthocyanin pigment 1) from Arabidopsis is reported to increase initial flavonoi...

journal_title：Scientific reports

authors： Lim W,Li J

更新日期：2017-09-28 00:00:00

abstract：:Although it is well known that mean annual rainfall (MAR) and rainfall seasonality have a key role in influencing the distribution of tree and grass cover in African tropical grassy biomes (TGBs), the impact of intra-seasonal rainfall variability on these distributions is less agreed upon. Since the prevalent mechanis...

journal_title：Scientific reports

authors： D'Onofrio D,Sweeney L,von Hardenberg J,Baudena M

更新日期：2019-02-20 00:00:00

abstract：:The colon can have an absorptive function similar to that of the small intestine after the massive resection of the small bowel. To improve colonic absorptive function, we created a valve in the colon (artificial colonic valve, ACV). ACVs were created in 20 rats that had 80 percent of their small intestine resected, w...

journal_title：Scientific reports

authors： Deng G,Deng Z

更新日期：2020-01-21 00:00:00

abstract：:A forest of the black coral Antipathella subpinnata was found from 52 to 80 m depth in three different sites at Tremiti Islands Marine Protected Area (MPA; Mediterranean Sea), with two of them hosting a monospecific forest on horizontal and vertical substrates. Colonies of A. subpinnata showed a mean density between 0...

journal_title：Scientific reports

authors： Chimienti G,De Padova D,Mossa M,Mastrototaro F

更新日期：2020-05-22 00:00:00

abstract：:We demonstrated modulation of charge carrier densities in all-solution-processed organic field-effect transistors (OFETs) by modifying the injection properties with self-assembled monolayers (SAMs). The all-solution-processed OFETs based on an n-type polymer with inkjet-printed Ag electrodes were fabricated as a test ...

journal_title：Scientific reports

authors： Roh J,Lee T,Kang CM,Kwak J,Lang P,Horowitz G,Kim H,Lee C

更新日期：2017-04-12 00:00:00

abstract：:Multiple parasitic arthropods of medical importance depend on symbiotic bacteria. While the link between scabies and secondary bacterial infections causing post infective complications of Group A streptococcal and staphylococcal pyoderma is increasingly recognized, very little is known about the microbiota of Sarcopte...

journal_title：Scientific reports

authors： Swe PM,Zakrzewski M,Waddell R,Sriprakash KS,Fischer K

更新日期：2019-08-13 00:00:00

abstract：:Studies on prevalence and significance of alternative polyadenylation (APA) in plants have been so far limited mostly to the model plants. Here, a genome-wide analysis of APA was carried out in different tissue types in the non-model forage legume red clover (Trifolium pratense L). A profile of poly(A) sites in differ...

journal_title：Scientific reports

authors： Chakrabarti M,Dinkins RD,Hunt AG

更新日期：2018-07-27 00:00:00

abstract：:Sex-based variations in the immune response to the influenza vaccines was reported, however, the genetic basis responsible for the sex variations in the immune response toward the influenza vaccines remains unclear. Here, the genes responsible for sex-specific responses after vaccination with trivalent inactivated inf...

journal_title：Scientific reports

authors： Wen F,Guo J,Li Z,Huang S

更新日期：2018-09-10 00:00:00

abstract：:Inhibition of programmed death 1 (PD-1), expressed on activated T cells, can break through immune resistance and elicit durable responses in human melanoma as well as other types of cancers. Canine oral malignant melanoma is one of the most aggressive tumors bearing poor prognosis due to its high metastatic potency. H...

journal_title：Scientific reports

authors： Igase M,Nemoto Y,Itamoto K,Tani K,Nakaichi M,Sakurai M,Sakai Y,Noguchi S,Kato M,Tsukui T,Mizuno T

更新日期：2020-10-27 00:00:00

abstract：:Tissue-resident memory T (TRM) cells are characterized by their surface expression of CD69 and can be subdivided in CD103+ and CD103- TRM cells. The origin and functional characteristics of TRM cells in the renal allograft are largely unknown. To determine these features we studied TRM cells in transplant nephrectomie...

journal_title：Scientific reports

authors： de Leur K,Dieterich M,Hesselink DA,Corneth OBJ,Dor FJMF,de Graav GN,Peeters AMA,Mulder A,Kimenai HJAN,Claas FHJ,Clahsen-van Groningen MC,van der Laan LJW,Hendriks RW,Baan CC

更新日期：2019-04-12 00:00:00