Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles.

abstract：:The recently discovered two-dimensional (2D) semimetal 1 T´-MoTe2 exhibits colossal magnetoresistance and superconductivity, driving a strong research interest in the material's quantum phenomena. Unlike the typical hexagonal structure found in many 2D materials, the 1 T´-MoTe2 lattice has strong in-plane anisotropy. ...

journal_title：Scientific reports

authors： Song Q,Wang H,Pan X,Xu X,Wang Y,Li Y,Song F,Wan X,Ye Y,Dai L

更新日期：2017-05-11 00:00:00

abstract：:It is widely acknowledged that transcriptional diversity largely contributes to biological regulation in eukaryotes. Since the advent of second-generation sequencing technologies, a large number of RNA sequencing studies have considerably improved our understanding of transcriptome complexity. However, it still remain...

journal_title：Scientific reports

authors： Chen SY,Deng F,Jia X,Li C,Lai SJ

更新日期：2017-08-09 00:00:00

abstract：:Tradional antireflection coatings composed of dielectric layers usually require the thickness to be larger than quarter wavelength. Here, we demonstrate that materials with permittivity or permeability dominated by imaginary parts, i.e. lossy or gain media, can realize non-resonant antireflection coatings in deep sub-...

journal_title：Scientific reports

authors： Luo J,Li S,Hou B,Lai Y

更新日期：2016-06-28 00:00:00

abstract：:Agglomeration-triggered deactivation of supported platinum electrocatalysts markedly hinders their application in methanol oxidation reaction (MOR). In this study, graphene-supported nickel-iron layered double hydroxide (NiFe-LDH/rGO), in which Fe3+ was introduced to replace Ni2+ partially in the Ni(OH)2 lattice to pr...

journal_title：Scientific reports

authors： Han Y,Li P,Liu J,Wu S,Ye Y,Tian Z,Liang C

更新日期：2018-01-22 00:00:00

abstract：:Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16α-carbonitrile (PCN...

journal_title：Scientific reports

authors： Hassani-Nezhad-Gashti F,Kummu O,Karpale M,Rysä J,Hakkola J

更新日期：2019-11-13 00:00:00

abstract：:The overpopulation of abandoned and stray companion animals has become a global crisis. The main purpose of this study was to develop a novel nanomedicine-based antifertility compound for non-surgical castration of male animals. Mangosteen (Garcinia mangostana L) pericarp extract has been shown to exhibit anti-fertili...

journal_title：Scientific reports

authors： Yostawonkul J,Surassmo S,Namdee K,Khongkow M,Boonthum C,Pagseesing S,Saengkrit N,Ruktanonchai UR,Chatdarong K,Ponglowhapan S,Yata T

更新日期：2017-11-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Liu H,Lv P,Zhu Y,Wu H,Zhang K,Xu F,Zheng L,Zhao J

更新日期：2020-09-09 00:00:00

abstract：:Breast cancer transcriptome acquires a myriad of regulation changes, and splicing is critical for the cell to "tailor-make" specific functional transcripts. We systematically revealed splicing signatures of the three most common types of breast tumors using RNA sequencing: TNBC, non-TNBC and HER2-positive breast cance...

journal_title：Scientific reports

authors： Eswaran J,Horvath A,Godbole S,Reddy SD,Mudvari P,Ohshiro K,Cyanam D,Nair S,Fuqua SA,Polyak K,Florea LD,Kumar R

更新日期：2013-01-01 00:00:00

abstract：:Aerosol nanoparticle injectors are fundamentally important for experiments where container-free sample handling is needed to study isolated nanoparticles. The injector consists of a nebuliser, a differential pumping unit, and an aerodynamic lens to create and deliver a focused particle beam to the interaction point in...

journal_title：Scientific reports

authors： Klimešová E,Kulyk O,Gu Y,Dittrich L,Korn G,Hajdu J,Krikunova M,Andreasson J

更新日期：2019-06-20 00:00:00

abstract：:Genome-wide association studies (GWAS) have uncovered numerous variants associated with body mass index (BMI), waist circumference, and waist-to-hip ratio. Our study aims to investigate how these variants are linked to fat distribution. We genotyped 56 validated variants of BMI, waist circumference, and waist-to-hip r...

journal_title：Scientific reports

authors： Wang T,Ma X,Peng D,Zhang R,Sun X,Chen M,Yan J,Wang S,Yan D,He Z,Jiang F,Bao Y,Hu C,Jia W

更新日期：2016-02-05 00:00:00

abstract：:Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements. DGAT1 has been recognized as an anti-obesity target; however, its role in the tumor microenvironment remains unclear. We postulated that, in prostate cancer (...

journal_title：Scientific reports

authors： Nardi F,Franco OE,Fitchev P,Morales A,Vickman RE,Hayward SW,Crawford SE

更新日期：2019-02-28 00:00:00

abstract：:A comprehensive identification of sphingoid bases and ceramides in wild Cordyceps was performed by integrating a sequential chromatographic enrichment procedure and an UHPLC-ultrahigh definition-Q-TOF-MS based sphingolipidomic approach. A total of 43 sphingoid bases and 303 ceramides were identified from wild Cordycep...

journal_title：Scientific reports

authors： Mi JN,Han Y,Xu Y,Kou J,Wang JR,Jiang ZH

更新日期：2016-12-14 00:00:00

abstract：:Increasing influence of Atlantic water in the Arctic Ocean has the potential to significantly impact regional water temperature and salinity. Here we use a rDNA barcoding approach to reveal how microbial communities are partitioned into distinct assemblages across a gradient of Atlantic-Polar Water influence in the No...

journal_title：Scientific reports

authors： Carter-Gates M,Balestreri C,Thorpe SE,Cottier F,Baylay A,Bibby TS,Moore CM,Schroeder DC

更新日期：2020-11-06 00:00:00

abstract：:Aquaculture is a burgeoning industry, requiring diversification into new farmed species, which are often at risk from infectious disease. We used a mesocosm technique to investigate the susceptibility of sharpsnout seabream (Diplodus puntazzo) larvae to potential environmental pathogens in seawater compared to control...

journal_title：Scientific reports

authors： Katharios P,Seth-Smith HM,Fehr A,Mateos JM,Qi W,Richter D,Nufer L,Ruetten M,Guevara Soto M,Ziegler U,Thomson NR,Schlapbach R,Vaughan L

更新日期：2015-12-07 00:00:00

abstract：:Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked genes are transcriptionally repressed. This observation led to the hypoth...

journal_title：Scientific reports

authors： Kruger AN,Ellison Q,Brogley MA,Gerlinger ER,Mueller JL

更新日期：2018-06-12 00:00:00

abstract：:The implementation of HTS (high-throughput sequencing) approaches is rapidly changing our understanding of the lichen symbiosis, by uncovering high bacterial and fungal diversity, which is often host-specific. Recently, HTS methods revealed the presence of multiple photobionts inside a single thallus in several lichen...

journal_title：Scientific reports

authors： Paul F,Otte J,Schmitt I,Dal Grande F

更新日期：2018-06-05 00:00:00

abstract：:This study was designed to evaluate the prognostic value of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC). A comprehensive literature search for relevant studies was performed in Web of science, Embase and Pubmed. A total of nine studies with 2017 patients were included in this meta-analysis, an...

journal_title：Scientific reports

authors： Ma W,Zhang P,Qi J,Gu L,Zang M,Yao H,Shi X,Wang C,Jiang Y

更新日期：2016-10-14 00:00:00

abstract：:SOX7 as a tumor suppressor belongs to the SOX F gene subfamily and is associated with a variety of human cancers, including breast cancer, but the mechanisms involved are largely unclear. In the current study, we investigated the interactions between SOX7 and AXIN2 in their co-regulation on the Wnt/β-catenin signal pa...

journal_title：Scientific reports

authors： Liu H,Mastriani E,Yan ZQ,Yin SY,Zeng Z,Wang H,Li QH,Liu HY,Wang X,Bao HX,Zhou YJ,Kou JJ,Li D,Li T,Liu J,Liu Y,Yin L,Qiu L,Gong L,Liu SL

更新日期：2016-05-18 00:00:00

abstract：:A record 500,000 hectares burned in Portugal during the extreme wildfire season of 2017, with more than 120 human lives lost. Here we analyse the climatic factors responsible for the burned area (BA) from June to October series in Portugal for the period 1980-2017. Superposed onto a substantially stationary trend on B...

journal_title：Scientific reports

authors： Turco M,Jerez S,Augusto S,Tarín-Carrasco P,Ratola N,Jiménez-Guerrero P,Trigo RM

更新日期：2019-10-10 00:00:00

abstract：:Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors with low survival rates and the leading cause of death in neurofibromatosis type 1 (NF1) patients under 40 years old. Surgical resection is the standard of care for MPNSTs, but is often incomplete and can generate loss of function, necessitating t...

journal_title：Scientific reports

authors： Sweeney EE,Burga RA,Li C,Zhu Y,Fernandes R

更新日期：2016-11-11 00:00:00

abstract：:We report on an all-dielectric, polarization-independent angular filter with one-dimension (1D) photonic crystal (PC) composed of semiconductor compatible Si/SiO2 pairs. The near-symmetric directional band gap of p- and s-polarized components and Fabry-Pérot (F-P) resonances are utilized to realize efficient polarizat...

journal_title：Scientific reports

authors： Qian Q,Xu C,Wang C

更新日期：2017-11-29 00:00:00

abstract：:Electrochemical biosensors have been studied intensively for several decades. Numerous sensing concepts and related interface architectures have been developed. However, all such architectures suffer a trade-off: simple architectures favour usability, whereas complex architectures favour better performance. To overcom...

journal_title：Scientific reports

authors： Zhu X,Feng C,Ye Z,Chen Y,Li G

更新日期：2014-02-25 00:00:00

abstract：:The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala...

journal_title：Scientific reports

authors： Hakamata Y,Komi S,Moriguchi Y,Izawa S,Motomura Y,Sato E,Mizukami S,Kim Y,Hanakawa T,Inoue Y,Tagaya H

更新日期：2017-08-16 00:00:00

abstract：:Identifying the occurrence mechanism of drug-induced side effects (SEs) is critical for design of drug target and new drug development. The expression of genes in biological processes is regulated by transcription factors(TFs) and/or microRNAs. Most of previous studies were focused on a single level of gene or gene se...

journal_title：Scientific reports

authors： Jia X,Jin Q,Liu X,Bian X,Wang Y,Liu L,Ma H,Tan F,Gu M,Chen X

更新日期：2017-07-20 00:00:00

abstract：:Long-term monitoring of host-parasite interactions is important for understanding the consequences of infection on host fitness and population dynamics. In an eight-year survey of the loggerhead sea turtle (Caretta caretta) population nesting in Cabo Verde, we determined the spatiotemporal variation of Ozobranchus mar...

journal_title：Scientific reports

authors： Lockley EC,Fouda L,Correia SM,Taxonera A,Nash LN,Fairweather K,Reischig T,Durão J,Dinis H,Roque SM,Lomba JP,Dos Passos L,Cameron SJK,Stiebens VA,Eizaguirre C

更新日期：2020-10-29 00:00:00

abstract：:Graft contracture is a common problem associated with the regeneration processes of tissue-engineered bladders. Currently, most strategies used for incorporating bioactive molecules into biomaterial designs do not work during all phases of tissue regeneration. In this study, we used a growth factor-PLGA nanoparticle t...

journal_title：Scientific reports

authors： Jiang X,Lin H,Jiang D,Xu G,Fang X,He L,Xu M,Tang B,Wang Z,Cui D,Chen F,Geng H

更新日期：2016-02-08 00:00:00

abstract：:The peptidoglycan of Staphylococcus aureus is highly amidated. Amidation of α-D-isoglutamic acid in position 2 of the stem peptide plays a decisive role in the polymerization of cell wall building blocks. S. aureus mutants with a reduced degree of amidation are less viable and show increased susceptibility to methicil...

journal_title：Scientific reports

authors： Nöldeke ER,Muckenfuss LM,Niemann V,Müller A,Störk E,Zocher G,Schneider T,Stehle T

更新日期：2018-08-28 00:00:00

abstract：:Dynamic optical imaging (e.g. time delay integration imaging) is troubled by the motion blur fundamentally arising from mismatching between photo-induced charge transfer and optical image movements. Motion aberrations from the forward dynamic imaging link impede the acquiring of high-quality images. Here, we propose a...

journal_title：Scientific reports

authors： Li J,Liu Z

更新日期：2019-08-05 00:00:00

abstract：:Climate change vulnerability assessment (CCVA) has become a mainstay conservation decision support tool. CCVAs are recommended to incorporate three elements of vulnerability - exposure, sensitivity and adaptive capacity - yet, lack of data frequently leads to the latter being excluded. Further, weighted or unweighted ...

journal_title：Scientific reports

authors： Ofori BY,Stow AJ,Baumgartner JB,Beaumont LJ

更新日期：2017-10-11 00:00:00

abstract：:Our goal was to evaluate early results of the clinical application of autologous whole bone marrow stem cell transplantation (AWBMSCT) for critical limb ischemia (CLI) in patients with Buerger's disease. We retrospectively analyzed the data of 58 limbs of 37 patients (mean age, 43.0 years; range, 28-63 years; male, 91...

journal_title：Scientific reports

authors： Heo SH,Park YS,Kang ES,Park KB,Do YS,Kang KS,Kim DI

更新日期：2016-01-21 00:00:00