Fabrication of magneto-controlled moveable architecture to develop reusable electrochemical biosensors.

Abstract:

:Electrochemical biosensors have been studied intensively for several decades. Numerous sensing concepts and related interface architectures have been developed. However, all such architectures suffer a trade-off: simple architectures favour usability, whereas complex architectures favour better performance. To overcome this problem, we propose a novel concept by introducing a magneto-controlled moveable architecture (MCMA) instead of the conventional surface-fixed architecture. As a model, human breast cancer cells were used in this study. The results showed that a detection range from 100 to 1 × 10(6) cells could be achieved. Moreover, the whole detection cycle, including the measurement and the regeneration, could be completed in only 2 min. Thus, usability and excellent performance can be achieved in a single biosensor.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zhu X,Feng C,Ye Z,Chen Y,Li G

doi

10.1038/srep04169

subject

Has Abstract

pub_date

2014-02-25 00:00:00

pages

4169

issn

2045-2322

pii

srep04169

journal_volume

4

pub_type

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