Abstract：
:Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16α-carbonitrile (PCN) for 4 days and subsequently either fasted for 5 hours or after 4-hour fast treated with intragastric glucose 1 hour before sample collection. Gene expression microarray study indicated that PCN both induced and repressed much higher number of genes in the glucose fed mice and the induction of multiple well-established PXR target genes was potentiated by glucose. A subset of genes, including bile acid synthesis gene Cyp8b1, responded in an opposite direction during fasting and after glucose feeding. PXR knockout abolished these effects. In agreement with the Cyp8b1 regulation, PCN also modified the bile acid composition in the glucose fed mice. Contribution of glucose, insulin and glucagon on the observed nutritional effects was investigated in primary hepatocytes. However, only mild impact on PXR function was observed. These results show that nutritional status modifies the PXR regulated transcriptome both qualitatively and quantitatively and reveal a complex crosstalk between PXR and energy homeostasis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Hassani-Nezhad-Gashti F,Kummu O,Karpale M,Rysä J,Hakkola Jdoi
10.1038/s41598-019-53101-9subject
Has Abstractpub_date
2019-11-13 00:00:00pages
16728issue
1issn
2045-2322pii
10.1038/s41598-019-53101-9journal_volume
9pub_type
杂志文章abstract：:Electronic textiles have garnered significant attention as smart technology for next-generation wearable electronic devices. The existing power sources lack compatibility with wearable devices due to their limited flexibility, high cost, and environment unfriendliness. In this work, we demonstrate bamboo fabric as a s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70182-z
更新日期：2020-08-06 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep45235. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46913
更新日期：2017-12-22 00:00:00
abstract：:Cold-inducible RNA-binding protein (CIRP), released into the circulation during sepsis, causes lung injury via an as yet unknown mechanism. Since endoplasmic reticulum (ER) stress is associated with acute lung injury (ALI), we hypothesized that CIRP causes ALI via induction of ER stress. To test this hypothesis, we st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41363
更新日期：2017-01-27 00:00:00
abstract：:3-D modeling of coupled thermo-hydro-mechanical (THM) processes in enhanced geothermal systems using the control volume finite element code was done. In a first, a comparative analysis on the effects of coupled processes, operational parameters and reservoir parameters on heat extraction was conducted. We found that s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14273-4
更新日期：2017-12-06 00:00:00
abstract：:This study aimed to evaluate the effects of ketorolac, a commonly used non-steroidal anti-inflammatory drug (NSAID) as patient controlled intravenous infusion analgesia (PCIA) for the patients underwent radical cystectomy (RC) due to bladder cancer regarding post-operational indices of recovery. Total seventy patients...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-22677-z
更新日期：2018-03-15 00:00:00
abstract：:Infection after renal transplantation remains a major cause of morbidity and death, especially infection from the extensively drug-resistant bacteria, A. baumannii. A total of fourteen A. baumannii isolates were isolated from the donors' preserved fluid from DCD (donation after cardiac death) renal transplantation and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01683-7
更新日期：2017-05-16 00:00:00
abstract：:Present-day terrestrial analogue sites are crucial ground truth proxies for studying life in geochemical conditions close to those assumed to be present on early Earth or inferred to exist on other celestial bodies (e.g. Mars, Europa). Although hypersaline sapropels are border-of-life habitats with moderate occurrence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06232-w
更新日期：2017-07-21 00:00:00
abstract：:High-altitude-adapted ectotherms can escape competition from dominant species by tolerating low temperatures at cooler elevations, but climate change is eroding such advantages. Studies evaluating broad-scale impacts of global change for high-altitude organisms often overlook the mitigating role of biotic factors. Yet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80077-8
更新日期：2021-01-08 00:00:00
abstract：:Accurate evaluation of individual risk of intravenous immunoglobin (IVIG)-resistance is critical for adopting regimens for the first treatment and prevention of coronary artery lesions (CALs) in patients with Kawasaki disease (KD). METHODS:The KD patients hospitalized in Chongqing Children's Hospital, in west China, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39330-y
更新日期：2019-02-11 00:00:00
abstract：:The gut microbiota (GM) is related to obesity and other metabolic diseases. To detect GM markers for obesity in patients with different metabolic abnormalities and investigate their relationships with clinical indicators, 1,914 Chinese adults were enrolled for 16S rRNA gene sequencing in this retrospective study. Base...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-49462-w
更新日期：2019-09-17 00:00:00
abstract：:LiYF4:Eu nanophosphors with a single tetragonal phase are synthesized, and various strategies to enhance the Eu(3+) emission from the nanophosphors are investigated. The optimized Eu(3+) concentration is 35 mol%, and the red emission peaks due to the (5)D0 →(7)FJ (J = 1 and 2) transitions of Eu(3+) ions are further en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07866
更新日期：2015-01-19 00:00:00
abstract：:Neuronal activity-dependent synaptic plasticity, a basis for learning and memory, is tightly correlated with the pattern of increase in intracellular Ca(2+) concentration ([Ca(2+)](i)). Here, using combined application of electrophysiological experiments and systems biological simulation, we show that such a correlati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00143
更新日期：2011-01-01 00:00:00
abstract：:Chronic inflammation-associated bone destruction, which is observed in rheumatoid arthritis (RA) and periodontitis, is mediated by excessive osteoclastogenesis. We showed previously that γ-glutamyltranspeptidase (GGT), an enzyme involved in glutathione metabolism, acts as an endogenous activator of such pathological o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35930
更新日期：2016-10-24 00:00:00
abstract：:Obesity affects male fertility and maternal diabetes affects the offspring sperm epigenome. However, the effects of in utero exposure to maternal glucose intolerance in combination with postnatal high fat, high sucrose (HFHS) diet consumption on offspring spermatogenesis is not clear. The present study was designed to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25950-3
更新日期：2018-05-16 00:00:00
abstract：:The autonomic nervous system (ANS) regulates tissue homeostasis and remodelling through antagonistic effects of noradrenergic sympathetic and cholinergic parasympathetic signalling. Despite numerous reports on the induction of sympathetic neurons from human pluripotent stem cells (hPSCs), no induction methods have eff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66303-3
更新日期：2020-06-11 00:00:00
abstract：:We report a method to generate a 3D motor neuron model with segregated and directed axonal outgrowth. iPSC-derived motor neurons are cultured in extracellular matrix gel in a microfluidic platform. Neurons extend their axons into an adjacent layer of gel, whereas dendrites and soma remain predominantly in the somal co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81335-z
更新日期：2021-01-22 00:00:00
abstract：:Soil moisture is an important variable for land-climate and hydrological interactions. To investigate emergent large-scale, long-term interactions between soil moisture and other key hydro-climatic variables (precipitation, actual evapotranspiration, runoff, temperature), we analyze monthly values and anomalies of the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61621-y
更新日期：2020-03-16 00:00:00
abstract：:Nanostructured (NS) and ultrafine-grained (UFG) materials have high strength and relatively low ductility. Their toughness has not been comprehensively investigated. Here we report the Charpy impact behavior and the corresponding microstructural evolutions in UFG Cu with equi-axed and elongated grains which were prepa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44783
更新日期：2017-03-17 00:00:00
abstract：:With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22626-w
更新日期：2018-03-14 00:00:00
abstract：:The basic leucine zipper (bZIP) is a widely known transcription factors family in eukaryotes. In plants, the role of bZIP proteins are crucial in various biological functions such as plant growth and development, seed maturation, response to light signal and environmental stress. To date, bZIP protein family has been ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72390-z
更新日期：2020-09-23 00:00:00
abstract：:Mechanistic exploration of the origins of the unparalleled soil microbial biodiversity represents a vast and uncharted scientific frontier. Quantification of candidate mechanisms that promote and sustain such diversity must be linked with microbial functions and measurable biophysical interactions at appropriate scale...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00881
更新日期：2012-01-01 00:00:00
abstract：:Obesity, often represented by higher body mass index (BMI), is not yet fully understood as a potential risk factor for poor clinical outcomes of prostate cancer (PCa) after radical prostatectomy (RP). This study aimed to evaluate the relationship between BMI and biochemical recurrence (BCR)-free survival in RP patient...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30473-y
更新日期：2018-08-10 00:00:00
abstract：:A highly sensitive microwave near-field sensor based on electrically-small planar resonators is proposed for highly accurate characterization of dielectric materials. The proposed sensor was developed in a robust complete-cycle topology optimization procedure wherein first the sensing area was pixelated. By maximizing...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49767-w
更新日期：2019-09-16 00:00:00
abstract：:Antibiotics contamination in food products is of increasing concern due to their potential threat on human health. Herein solid-phase extraction based on magnetic molecularly imprinted polymers coupled with internal extractive electrospray ionization mass spectrometry (MMIPs-SPE-iEESI-MS) was designed for the quantita...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15202-1
更新日期：2017-11-07 00:00:00
abstract：:We aimed to investigate whether the newborns of mothers with maternal depression (MD) had lower vitamin D levels than newborns of non-MD (NMD) mothers and identify the potential mechanism underlying this association. Maternal depressive symptoms in late pregnancy and concentrations of cord blood 25 hydroxyvitamin D (2...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01778-1
更新日期：2017-05-08 00:00:00
abstract：:This is the first description of a Mediterranean mesophotic coral reef. The bioconstruction extended for 2.5 km along the Italian Adriatic coast in the bathymetric range -30/-55 m. It appeared as a framework of coral blocks mostly built by two scleractinians, Phyllangia americana mouchezii (Lacaze-Duthiers, 1897) and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40284-4
更新日期：2019-03-05 00:00:00
abstract：:Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in hea...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-40343-w
更新日期：2019-03-06 00:00:00
abstract：:This study was to investigate effects of progesterone vaginal sustained-release gel and intramuscular injection of progesterone on frozen-thawed embryos transfer in 3013 patients receiving vaginal progesterone sustained-release gel and progesterone injection in artificial cycle for frozen-thawed embryo transfer. All p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51717-5
更新日期：2019-10-24 00:00:00
abstract：:Here, we combine elicitors and transcriptomics to investigate the inducible biosynthesis of the ginsenoside from the Panax quinquefolium. Treatment of P. quinquefolium adventitious root with methyl jasmonate (MJ) results in an increase in ginsenoside content (43.66 mg/g compared to 8.32 mg/g in control group). Therefo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37263
更新日期：2016-11-23 00:00:00
abstract：:Despite advances in diabetic wound care, the significant number of amputations that occur every year demands more effective therapeutics. Herein, we offer an aminated polyethersulfone nanofiber-expanded human umbilical cord blood-derived CD34+ cells (henceforth CD34+ cells) effective therapy, tested in cutaneous wound...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44932-7
更新日期：2019-06-10 00:00:00
