Abstract:
:Identifying the occurrence mechanism of drug-induced side effects (SEs) is critical for design of drug target and new drug development. The expression of genes in biological processes is regulated by transcription factors(TFs) and/or microRNAs. Most of previous studies were focused on a single level of gene or gene sets, while studies about regulatory relationships of TFs, miRNAs and biological processes are very rare. Discovering the complex regulating relations among TFs, gene sets and miRNAs will be helpful for researchers to get a more comprehensive understanding about the mechanism of side reaction. In this study, a framework was proposed to construct the relationship network of gene sets, miRNAs and TFs involved in side effects. Through the construction of this network, the potential complex regulatory relationship in the occurrence process of the side effects was reproduced. The SE-gene set network was employed to characterize the significant regulatory SE-gene set interaction and molecular basis of accompanied side effects. A total of 117 side effects complex modules including four types of regulating patterns were obtained from the SE-gene sets-miRNA/TF complex regulatory network. In addition, two cases were used to validate the complex regulatory modules which could more comprehensively interpret occurrence mechanism of side effects.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jia X,Jin Q,Liu X,Bian X,Wang Y,Liu L,Ma H,Tan F,Gu M,Chen Xdoi
10.1038/s41598-017-06083-5subject
Has Abstractpub_date
2017-07-20 00:00:00pages
5962issue
1issn
2045-2322pii
10.1038/s41598-017-06083-5journal_volume
7pub_type
杂志文章abstract::Filth flies cause billions of dollars of losses annually to the animal production industry. Fluralaner is a relatively new pesticide currently sold for control of fleas, ticks, and mites on companion animals and poultry. We examined the efficacy of fluralaner against three species of filth flies. Insecticide-susceptib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68121-z
更新日期:2020-07-07 00:00:00
abstract::A collection of ancient Roman orichalcum coins, i.e., a copper-zinc alloy, minted under the reigns from Caesar to Domitianus, have been characterised using scanning electron microscopy (SEM-EDS) and electron microprobe analysis (EMPA). We studied, for the first time, coins emitted by Romans after the reforms of August...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48941-4
更新日期:2019-09-03 00:00:00
abstract::We aimed to assess feasibility of a support vector machine (SVM) texture classifier to discriminate pathologic infiltration patterns from the normal bone marrows in MRI. This retrospective study included 467 cases, which were split into a training (n = 360) and a test set (n = 107). A sagittal T1-weighted lumbar spina...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42579-y
更新日期:2019-04-15 00:00:00
abstract::Speckle, amplitude fluctuations in optical coherence tomography (OCT) images, contains information on sub-resolution structural properties of the imaged sample. Speckle statistics could therefore be utilized in the characterization of biological tissues. However, a rigorous theoretical framework relating OCT speckle s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14115-3
更新日期:2017-11-01 00:00:00
abstract::Myosin X (Myo10), an actin-associated molecular motor, has a clear role in filopodia induction and cell migration in vitro, but its role in vivo in mammals is not well understood. Here, we investigate the role of Myo10 in melanocyte lineage and melanoma induction. We found that Myo10 knockout (Myo10KO) mice exhibit a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28717-y
更新日期:2018-07-11 00:00:00
abstract::Optical resolution photoacoustic microscopy (OR-PAM) is a non-invasive, label-free method of in vivo imaging with microscopic resolution and high optical contrast. Based on intrinsic contrasts, OR-PAM has expanded to include in vivo vessel imaging, flow cytometry, physiological parameter analysis, and single-cell char...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13224-3
更新日期:2017-10-17 00:00:00
abstract::Blood platelets are instrumental in blood clotting and are thus heavily involved in early wound closure. After adhering to a substrate they spread by forming protrusions like lamellipodia and filopodia. However, the interaction of these protrusions with the physical environment of platelets while spreading is not full...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22357
更新日期:2016-03-03 00:00:00
abstract::Highly coordinated and coincidental patterns of activity-dependent mechanisms ("fire together wire together") are thought to serve as inductive signals during synaptogenesis, enabling neuronal pairing between specific sub-sets of excitatory partners. However, neither the nature of activity triggers, nor the "activity ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09523
更新日期:2015-04-01 00:00:00
abstract::Routine antimicrobial susceptibility testing (AST) can prevent deaths due to bacteria and reduce the spread of multi-drug-resistance, but cannot be regularly performed in resource-limited-settings due to technological challenges, high-costs, and lack of trained professionals. We demonstrate an automated and cost-effec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39203
更新日期:2016-12-15 00:00:00
abstract::Figure-ground segregation is the process by which the visual system identifies image elements of figures and segregates them from the background. Previous studies examined figure-ground segregation in the visual cortex of monkeys where figures elicit stronger neuronal responses than backgrounds. It was demonstrated in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36087-8
更新日期:2018-12-12 00:00:00
abstract::Clobetasol propionate (CLO) is a potent glucocorticoid used to treat inflammation-based skin, scalp, and hair disorders. In such conditions, hair follicles (HF) are not only the target site but can also act as drug reservoirs when certain formulations are topically applied. Recently, we have demonstrated nanostructure...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56760-w
更新日期:2020-01-13 00:00:00
abstract::The objective of this meta-analysis is to compare hybrid surgery (HS) and cervical discectomy and fusion (ACDF) for multilevel cervical degenerative disc diseases (DDD). Systematic searches of all published studies through March 2015 were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep13454
更新日期:2015-08-26 00:00:00
abstract::Water, methane, and ammonia are commonly considered to be the key components of the interiors of Uranus and Neptune. Modelling the planets' internal structure, evolution, and dynamo heavily relies on the properties of the complex mixtures with uncertain exact composition in their deep interiors. Therefore, characteris...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46561-6
更新日期:2019-07-12 00:00:00
abstract::The pace of two-dimensional materials (2DM) research has been greatly accelerated by the ability to identify exfoliated thicknesses down to a monolayer from their optical contrast. Since this process requires time-consuming and error-prone manual assignment to avoid false-positives from image features with similar con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23922-1
更新日期:2018-04-23 00:00:00
abstract::Switching magnetizations with femtosecond circularly polarized lasers may have revolutionary impacts on magnetic data storage and relevant applications. Achievements in ferrimagnetic and ferromagnetic materials of various structures strongly imply a general phenomenon of fundamental atom-laser interaction. Rotating an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41294
更新日期:2017-01-24 00:00:00
abstract::Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the failure of normal glucose-stimulated insulin secretion (GSIS) from p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39681-6
更新日期:2019-02-27 00:00:00
abstract::Extracellular vesicles (EVs) such as exosomes and microvesicles serve as messengers of intercellular network, allowing exchange of cellular components between cells. EVs carry lipids, proteins, and RNAs derived from their producing cells, and have potential as biomarkers specific to cell types and even cellular states...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33935
更新日期:2016-09-23 00:00:00
abstract::The bacterial translational GTPase EF4/LepA is structurally similar to the canonical elongation factor EF-G. While sharing core structural features with other translational GTPases, the function of EF4 remains unknown. Recent structural data locates the unique C-terminal domain (CTD) of EF4 in proximity to the ribosom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08573
更新日期:2015-02-25 00:00:00
abstract::We have demonstrated a proof-of-principle experiment of reference-frame-independent phase coding quantum key distribution (RFI-QKD) over an 80-km optical fiber. After considering the finite-key bound, we still achieve a distance of 50 km. In this scenario, the phases of the basis states are related by a slowly time-va...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03617
更新日期:2014-01-09 00:00:00
abstract::Few-layered transition metal dichalcogenides (TMDs) are known as true two-dimensional materials, with excellent semiconducting properties and strong light-matter interaction. Thus, TMDs are attractive materials for semitransparent and flexible solar cells for use in various applications. Hoewver, despite the recent pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12287-6
更新日期:2017-09-20 00:00:00
abstract::Discovery of novel biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Serum metabolite profiling of ST-elevation myocardial infarction (STEMI), unstable angina (UA) and healthy controls was performed using gas chromatography mass spectrometry (GC/MS), solid-phase microextraction coupled to ga...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36359
更新日期:2016-11-08 00:00:00
abstract::Pinellia (Pinellia ternata (Thunb.) Breit.), as important medicinal plant, has been used to treat various ailments for a long time. The sixteen ploid plant (2n = 16 * 13 = 208) Pinellia T2Plus line was obtained from an octoploid (2n = 8 * 13 = 104) T2 line by chromosome-doubling technique. Compared with T2 line, the c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61512-2
更新日期:2020-03-12 00:00:00
abstract::The persistent public health threat of animal to human transmission of influenza A virus (IAV) has stimulated interest in rapid and accurate detection of all IAV subtypes in clinical specimens of animal origin. In this study, a new set of primers and probes was designed for one-step pan-IAV reverse-transcription fluor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30015
更新日期:2016-07-22 00:00:00
abstract::The ability of radial glial progenitors (RGPs) to generate cortical neurons is determined by local extracellular factors and signaling pathways intrinsic to RGPs. Here we find that GPR157, an orphan G protein-coupled receptor, localizes to RGPs' primary cilia exposed to the cerebrospinal fluid (CSF). GPR157 couples wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25180
更新日期:2016-05-04 00:00:00
abstract::Halophilic proteins subjected to below about 15% salt in vitro denature through misfolding, aggregation and/or precipitation. Halobacteria, however, have been detected in environments of fluctuating salinity such as coastal salterns and even around fresh water springs in the depths of the Dead Sea. In order to identif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59681-1
更新日期:2020-02-24 00:00:00
abstract::Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates facilitation of neurotransmitter release through phosphorylation. On...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08237-x
更新日期:2017-08-11 00:00:00
abstract::Electron-hole exchange interaction in semiconductor quantum dots (QDs) splits the band-edge exciton manifold into optically active ("bright") and passive ("dark") states, leading to a complicated exciton fine structure. In the present work, we resolve by atomistic million-atom many-body pseudopotential calculations th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09812-y
更新日期:2017-08-24 00:00:00
abstract::In many vertebrates, acoustic cues to body size are encoded in resonance frequencies of the vocal tract ("formants"), rather than in the rate of tissue vibration in the sound source ("pitch"). Anatomical constraints on the vocal tract's size render formants honest cues to size in many bird and mammal species, but it i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01948-1
更新日期:2017-05-12 00:00:00
abstract::Animals that experience situations likely to induce negative emotions show changes in judgment associated with pessimism. Few studies have focused on whether animals express stable differences in pessimism and whether these differences are related to personality traits. The first aim of this study was to explore if da...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17214-3
更新日期:2018-01-23 00:00:00
abstract::The extracellular matrix (ECM) is a dynamic, bioactive structure critical to organ development, structure and function. Excessive remodeling of the ECM is a hallmark of a variety of inflammatory conditions including vascular disease. Endothelin-1 (ET1) synthesis is understood to promote cardiovascular diseases includi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07610-0
更新日期:2017-08-08 00:00:00