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OCT Amplitude and Speckle Statistics of Discrete Random Media.

Abstract：

:Speckle, amplitude fluctuations in optical coherence tomography (OCT) images, contains information on sub-resolution structural properties of the imaged sample. Speckle statistics could therefore be utilized in the characterization of biological tissues. However, a rigorous theoretical framework relating OCT speckle statistics to structural tissue properties has yet to be developed. As a first step, we present a theoretical description of OCT speckle, relating the OCT amplitude variance to size and organization for samples of discrete random media (DRM). Starting the calculations from the size and organization of the scattering particles, we analytically find expressions for the OCT amplitude mean, amplitude variance, the backscattering coefficient and the scattering coefficient. We assume fully developed speckle and verify the validity of this assumption by experiments on controlled samples of silica microspheres suspended in water. We show that the OCT amplitude variance is sensitive to sub-resolution changes in size and organization of the scattering particles. Experimentally determined and theoretically calculated optical properties are compared and in good agreement.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Almasian M,van Leeuwen TG,Faber DJ

doi

10.1038/s41598-017-14115-3

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

14873

issue

1

issn

2045-2322

pii

10.1038/s41598-017-14115-3

journal_volume

7

pub_type

杂志文章

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