Trophic factor-induced activity 'signature' regulates the functional expression of postsynaptic excitatory acetylcholine receptors required for synaptogenesis.

abstract：:A novel label-free electrochemiluminescence (ECL) immunosensor based on luminol functional-Au NPs@polypyrrole has been developed for the detection of carcinoembryonic antigen (CEA). In this work, polypyrrole prepared by chemical polymerization provided a large surface area to load amounts of gold nanoparticles (Au NPs...

journal_title：Scientific reports

authors： Zhu W,Wang Q,Ma H,Lv X,Wu D,Sun X,Du B,Wei Q

更新日期：2016-04-19 00:00:00

abstract：:Broadband acoustic absorbers with thin thickness are highly desired in practical situations such as architectural acoustics, yet it is still challenging to achieve high absorption by using structure with limited thickness. Here we report the theoretical optimal design, numerical simulation and experimental demonstrati...

journal_title：Scientific reports

authors： Gao YX,Lin YP,Zhu YF,Liang B,Yang J,Yang J,Cheng JC

更新日期：2020-07-01 00:00:00

abstract：:Selective enhancement of GABAergic inhibition is thought to impact many vital brain functions and interferes with the genesis and/or progression of numerous brain disorders. Here, we show that selectively increasing NMDA receptor activity in inhibitory neurons using an NMDAR positive allosteric modulator (PAM) elevate...

journal_title：Scientific reports

authors： Deng D,Masri S,Yao L,Ma X,Cao X,Yang S,Bao S,Zhou Q

更新日期：2020-07-20 00:00:00

abstract：:Recently, graphene nanomesh (GNM) has attracted great attentions due to its unique porous structure, abundant active sites, finite band gap and possesses potential applications in the fields of electronics, gas sensor/storage, catalysis, etc. Therefore, diverse GNMs with different physical and chemical properties are ...

journal_title：Scientific reports

authors： Zhang J,Song H,Zeng D,Wang H,Qin Z,Xu K,Pang A,Xie C

更新日期：2016-08-26 00:00:00

abstract：:Mayaro virus (MAYV) is endemic in South American countries where it is responsible for sporadic outbreaks of acute febrile illness. The hallmark of MAYV infection is a highly debilitating and chronic arthralgia. Although MAYV emergence is a potential threat, there are no specific therapies or licensed vaccine. In this...

journal_title：Scientific reports

authors： Mota MTO,Costa VV,Sugimoto MA,Guimarães GF,Queiroz-Junior CM,Moreira TP,de Sousa CD,Santos FM,Queiroz VF,Passos I,Hubner J,Souza DG,Weaver SC,Teixeira MM,Nogueira ML

更新日期：2020-03-24 00:00:00

abstract：:Cold environments dominate the Earth's biosphere and the resident microorganisms play critical roles in fulfilling global biogeochemical cycles. However, only few studies have examined the molecular basis of thermosensing; an ability that microorganisms must possess in order to respond to environmental temperature and...

journal_title：Scientific reports

authors： Najnin T,Siddiqui KS,Taha T,Elkaid N,Kornfeld G,Curmi PM,Cavicchioli R

更新日期：2016-04-07 00:00:00

abstract：:Pt/K2CO3/MgAlOx-reduced graphene oxide (Pt/K/MgAlOx-rGO) hybrids were synthesized, characterized and tested as a promising NOx storage and reduction (NSR) catalyst. Mg-Al layered double hydroxides (LDHs) were grown on rGO via in situ hydrothermal crystallization. The structure and morphology of samples were thoroughly...

journal_title：Scientific reports

authors： Mei X,Yan Q,Lu P,Wang J,Cui Y,Nie Y,Umar A,Wang Q

更新日期：2017-02-16 00:00:00

abstract：:Three main surveillance systems (laboratory-confirmed, influenza-like illness (ILI) and nationwide Notifiable Infectious Diseases Reporting Information System (NIDRIS)) have been used for influenza surveillance in China. However, it is unclear which surveillance system is more reliable in developing influenza early wa...

journal_title：Scientific reports

authors： Yang X,Liu D,Wei K,Liu X,Meng L,Yu D,Li H,Li B,He J,Hu W

更新日期：2018-02-12 00:00:00

abstract：:Field cress (Lepidium campestre L.), despite its potential as a sustainable alternative oilseed plant, has been underutilized, and no prior attempts to characterize the genome at the genetic or molecular cytogenetic level have been conducted. Genetic maps are the foundation for anchoring and orienting annotated genome...

journal_title：Scientific reports

authors： Desta ZA,Kolano B,Shamim Z,Armstrong SJ,Rewers M,Sliwinska E,Kushwaha SK,Parkin IAP,Ortiz R,de Koning DJ

更新日期：2019-11-19 00:00:00

abstract：:Magnetic-charge ordering and corresponding magnetic/monopole phase transitions in spin ices are the emergent topics of condensed matter physics. In this work, we investigate a series of magnetic-charge (monopole) phase transitions in artificial square spin ice model using the conserved monopole density algorithm. It i...

journal_title：Scientific reports

authors： Xie YL,Du ZZ,Yan ZB,Liu JM

更新日期：2015-10-29 00:00:00

abstract：:Lack of standardization and unblinding threaten the research of mechanisms involved in expectancy effects on pain. We evaluated a computer-controlled virtual experimenter (VEx) to avoid these issues. Fifty-four subjects underwent a baseline-retest heat pain protocol. Between sessions, they received an expectancy manip...

journal_title：Scientific reports

authors： Horing B,Beadle SC,Inks Z,Robb A,Muth ER,Babu SV

更新日期：2020-11-23 00:00:00

abstract：:Graphene grown directly on germanium is a possible route for the integration of graphene into nanoelectronic devices as well as it is of great interest for materials science. The morphology of the interface between graphene and germanium influences the electronic properties and has not already been completely elucidat...

journal_title：Scientific reports

authors： Mendoza CD,Figueroa NS,Maia da Costa MEH,Freire FL Jr

更新日期：2019-08-29 00:00:00

abstract：:This report investigated dislocation-twin boundary (TB) interactions that cause the TB to disappear and turn into a high-angle grain boundary (GB). The evolution of the microstructural characteristics of Hadfield steel was shown as a function of severe plastic deformation processing time. Sessile Frank partial disloca...

journal_title：Scientific reports

authors： Zhang F,Feng X,Yang Z,Kang J,Wang T

更新日期：2015-03-11 00:00:00

abstract：:The most important goals of brain network analyses are to (a) detect pivotal regions and connections that contribute to disproportionate communication flow, (b) integrate global information, and (c) increase the brain network efficiency. Most centrality measures assume that information propagates in networks with the ...

journal_title：Scientific reports

authors： Kwon H,Choi YH,Lee JM

更新日期：2019-04-11 00:00:00

abstract：:Negative hemodynamic response has been widely reported in blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies, however its origin is still controversial. Optical intrinsic signal (OIS) imaging can be used to study brain activity by simultaneously recording hemodynamic signals at diff...

journal_title：Scientific reports

authors： Ma Z,Cao P,Sun P,Zhao L,Li L,Tong S,Lu Y,Yan Y,Chen Y,Chai X

更新日期：2016-02-10 00:00:00

abstract：:In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in response to unilateral ureteric obstruction in the mouse, and pr...

journal_title：Scientific reports

authors： Smith ER,Tan SJ,Holt SG,Hewitson TD

更新日期：2017-06-13 00:00:00

abstract：:The intrauterine environment is particularly vulnerable to environmental exposures. We previously established a mouse model that provided evidence for pregnancy complications and placental anti-angiogenesis in response to Aroclor 1254 (A-1254), a mixture of polychlorinated biphenyls (PCBs). Importantly, these effects ...

journal_title：Scientific reports

authors： Kalkunte S,Huang Z,Lippe E,Kumar S,Robertson LW,Sharma S

更新日期：2017-01-10 00:00:00

abstract：:LncRNAs have emerged as a novel class of critical regulators of cancer. We aimed to construct a landscape of lncRNAs and their potential target genes in lung adenocarcinoma. Genome-wide expression of lncRNAs and mRNAs was determined using microarray. qRT-PCR was performed to validate the expression of the selected lnc...

journal_title：Scientific reports

authors： Peng Z,Wang J,Shan B,Yuan F,Li B,Dong Y,Peng W,Shi W,Cheng Y,Gao Y,Zhang C,Duan C

更新日期：2017-11-10 00:00:00

abstract：:Aluminium alloys are re-evaluated as most feasible way to satisfy the industrial needs of light-weight structural materials. However, unlike conventional structural metals such as iron and titanium, aluminium does not have easily accessible secondary phases, which means that aluminium-based alloys cannot be strengthen...

journal_title：Scientific reports

authors： Tsuru T,Shimizu K,Yamaguchi M,Itakura M,Ebihara K,Bendo A,Matsuda K,Toda H

更新日期：2020-04-06 00:00:00

abstract：:Epilepsy is a widespread neurological disease characterized by abnormal neuronal activity resulting in recurrent seizures. There is mounting evidence that a circadian system disruption, involving clock genes and their downstream transcriptional regulators, is associated with epilepsy. In this study, we characterized t...

journal_title：Scientific reports

authors： Rambousek L,Gschwind T,Lafourcade C,Paterna JC,Dib L,Fritschy JM,Fontana A

更新日期：2020-02-28 00:00:00

abstract：:Many animals use sounds produced by conspecifics for mate identification. Female insects and anuran amphibians, for instance, use acoustic cues to localize, orient toward and approach conspecific males prior to mating. Here we present a novel technique that utilizes multiple, distributed sound-indication devices and a...

journal_title：Scientific reports

authors： Aihara I,Bishop PJ,Ohmer MEB,Awano H,Mizumoto T,Okuno HG,Narins PM,Hero JM

更新日期：2017-09-05 00:00:00

abstract：:To improve estimates of the long-term response of the marine carbon system to climate change a better understanding of the seasonal and interannual variability is needed. We use high-frequency multi-year data at three locations identified as climate change hotspots: two sites located close to South Pacific boundary cu...

journal_title：Scientific reports

authors： C Pardo P,Tilbrook B,van Ooijen E,Passmore A,Neill C,Jansen P,Sutton AJ,Trull TW

更新日期：2019-05-20 00:00:00

abstract：:From 2010 to 2012, large outbreaks of EV-A71-related- hand foot and mouth disease (HFMD) occurred annually in China. Some cases had neurological complications and were closely associated with fatal cardiopulmonary collapse, but not all children with central nervous system (CNS) involvement demonstrated a poor prognosi...

journal_title：Scientific reports

authors： Long L,Xu L,Xiao Z,Hu S,Luo R,Wang H,Lu X,Xu Z,Yao X,Zhou L,Long H,Gong J,Song Y,Zhao L,Luo K,Zhang M,Feng L,Yang L,Sheng X,Fan X,Xiao B

更新日期：2016-03-22 00:00:00

abstract：:Mitochondria-generated reactive oxygen species (mROS) are frequently associated with DNA damage and cell cycle arrest, but physiological increases in mROS serve to regulate specific cell functions. T3 is a major regulator of mROS, including hydrogen peroxide (H2O2). Here we show that exogenous thyroid hormone (T3) adm...

journal_title：Scientific reports

authors： Tan L,Bogush N,Naib H,Perry J,Calvert JW,Martin DIK,Graham RM,Naqvi N,Husain A

更新日期：2019-11-27 00:00:00

abstract：:We have developed a framework to convert an arbitrary integer factorization problem to an executable Ising model by first writing it as an optimization function then transforming the k-bit coupling (k ≥ 3) terms to quadratic terms using ancillary variables. Our resource-efficient method uses [Formula: see text] binary...

journal_title：Scientific reports

authors： Jiang S,Britt KA,McCaskey AJ,Humble TS,Kais S

更新日期：2018-12-05 00:00:00

abstract：:Following radiation induced DNA damage, several repair pathways are activated to help preserve genome integrity. Double Strand Breaks (DSBs), which are highly toxic, have specified repair pathways to address them. The main repair pathways used to resolve DSBs are Non-Homologous End Joining (NHEJ) and Homologous Recomb...

journal_title：Scientific reports

authors： Ingram SP,Warmenhoven JW,Henthorn NT,Smith EAK,Chadwick AL,Burnet NG,Mackay RI,Kirkby NF,Kirkby KJ,Merchant MJ

更新日期：2019-04-23 00:00:00

abstract：:Light's polarisation contains information about its source and interactions, from distant stars to biological samples. Polarimeters can recover this information, but reliance on birefringent or rotating optical elements limits their wavelength range and stability. Here we present a static, single-shot polarimeter base...

journal_title：Scientific reports

authors： Hawley RD,Cork J,Radwell N,Franke-Arnold S

更新日期：2019-02-25 00:00:00

abstract：:Tumor microenvironment favors tumor cells to promote their growth and metastasis such as migration, invasion, and angiogenesis. IL-1β, one of the inflammatory cytokines released from myeloid cells in tumor microenvironment, plays an important role in development and progress of tumor. The activation of inflammasome is...

journal_title：Scientific reports

authors： Lee HE,Lee JY,Yang G,Kang HC,Cho YY,Lee HS,Lee JY

更新日期：2019-08-22 00:00:00

abstract：:Coral reefs face a crisis due to local and global anthropogenic stressors. A large proportion of the ~50% coral loss on the Great Barrier Reef has been attributed to outbreaks of the crown-of-thorns-seastar (COTS). A widely assumed cause of primary COTS outbreaks is increased larval survivorship due to higher food ava...

journal_title：Scientific reports

authors： Uthicke S,Logan M,Liddy M,Francis D,Hardy N,Lamare M

更新日期：2015-02-12 00:00:00

abstract：:Noninvasive, safe and cost-effective cell viability assay is important in many fields of biological research such as cell culture and counting. We examined ten typical natural pigments extracted from food to find that Monascus pigment (MP) or anthocyanin pigment (AP: purple sweet potato and purple cabbage) with Tris (...

journal_title：Scientific reports

authors： Yamashita K,Tokunaga E

更新日期：2020-07-03 00:00:00