In-depth characterization of a novel live-attenuated Mayaro virus vaccine candidate using an immunocompetent mouse model of Mayaro disease.

abstract：:Chronic venous disease (CVD) is a multifactorial condition representing one of the most common disorders among populations of Western countries. The heritability of about 17% suggests genetic risk factors in CVD etiology. However, so far the genetic causes are unknown. We undertook the hitherto first genome-wide assoc...

journal_title：Scientific reports

authors： Ellinghaus E,Ellinghaus D,Krusche P,Greiner A,Schreiber C,Nikolaus S,Gieger C,Strauch K,Lieb W,Rosenstiel P,Frings N,Fiebig A,Schreiber S,Franke A

更新日期：2017-04-04 00:00:00

abstract：:Pond-dwelling cyclic parthenogens are often proposed to be highly vagile. However, the Holarctic biogeography of parthenogens has been hampered by very limited sampling in the eastern Palearctic. Here we examine the geographic boundaries, diversity, and connectivity across the Palearctic for the Daphnia curvirostris c...

journal_title：Scientific reports

authors： Kotov AA,Taylor DJ

更新日期：2019-05-02 00:00:00

abstract：:Although the clinical importance of extragraft bone formation (ExGBF) and bridging (ExGBB) has been reported, few studies have investigated the biomechanical influences of ExGBF on the motion segment. In this study, ExGBF was simulated at the C5-C6 motion segment after anterior cervical discectomy and fusion using a d...

journal_title：Scientific reports

authors： Park WM,Jin YJ

更新日期：2019-12-11 00:00:00

abstract：:Maternal obesity in pregnancy increases the risk of adverse long-term health outcomes in both mother and offspring. A population-based cohort of prospectively collected routine antenatal healthcare data collected between January 2003 and September 2017 at University Hospital Southampton, UK was utilised to investigate...

journal_title：Scientific reports

authors： Ziauddeen N,Roderick PJ,Macklon NS,Alwan NA

更新日期：2019-06-24 00:00:00

abstract：:The micro-capillary condensation of a new high boiling point organic reagent (HBPO), is studied in a periodic mesoporous oxide (PMO) with ∼34 % porosity and k-value ∼2.3. At a partial pressure of 3 mT, the onset of micro-capillary condensation occurs around +20 °C and the low-k matrix is filled at -20 °C. The condense...

journal_title：Scientific reports

authors： Chanson R,Zhang L,Naumov S,Mankelevich YA,Tillocher T,Lefaucheux P,Dussart R,Gendt S,Marneffe JF

更新日期：2018-01-30 00:00:00

abstract：:The mammalian Major Histocompatibility Complex (MHC) region contains several gene families characterized by highly polymorphic loci with extensive nucleotide diversity, copy number variation of paralogous genes, and long repetitive sequences. This structural complexity has made it difficult to construct a reliable ref...

journal_title：Scientific reports

authors： Viļuma A,Mikko S,Hahn D,Skow L,Andersson G,Bergström TF

更新日期：2017-03-31 00:00:00

abstract：:ANO1 is a calcium-activated chloride channel that is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and other cancers. While ANO1 expression negatively correlates with survival in several cancers, its epigenetic regulation is poorly understood. We analyzed HNSCC samples from TCGA and a separ...

journal_title：Scientific reports

authors： Finegersh A,Kulich S,Guo T,Favorov AV,Fertig EJ,Danilova LV,Gaykalova DA,Califano JA,Duvvuri U

更新日期：2017-11-09 00:00:00

abstract：:Caspase-3-related DEVDase activity is initiated upon apoptosis in unfertilized starfish eggs. In this study, we cloned a starfish procaspase-3 corresponding to mammalian effector caspase containing a CARD that is similar to the amino terminal CARD of mammalian capsase-9, and we named it procaspase-3/9. Recombinant pro...

journal_title：Scientific reports

authors： Tamura R,Takada M,Sakaue M,Yoshida A,Ohi S,Hirano K,Hayakawa T,Hirohashi N,Yura K,Chiba K

更新日期：2018-01-25 00:00:00

abstract：:Solar thermoelectric generators (STEGs), which are used for various applications, (particularly small size electronic devices), have optical concentration systems for high energy conversion efficiency. In this study, a refraction-assisted STEG (R-STEG) is designed based on phase-change materials. As the phase-change m...

journal_title：Scientific reports

authors： Kim MS,Kim MK,Jo SE,Joo C,Kim YJ

更新日期：2016-06-10 00:00:00

abstract：:Circulating levels of Brain Derived Neurotrophic Factor (BDNF) are lower in coronary heart disease (CHD) than in healthy subjects and are associated with coronary events and mortality. However, the mechanism(s) underling this association is not fully understood. We hypothesize that BDNF may influence fibrin fiber stru...

journal_title：Scientific reports

authors： Amadio P,Porro B,Sandrini L,Fiorelli S,Bonomi A,Cavalca V,Brambilla M,Camera M,Veglia F,Tremoli E,Barbieri SS

更新日期：2019-01-23 00:00:00

abstract：:Size effect is of great importance in micro forming processes. In this paper, micro cylinder compression was conducted to investigate the deformation behavior of bulk metallic glasses (BMGs) in supercooled liquid region with different deformation variables including sample size, temperature and strain rate. It was fou...

journal_title：Scientific reports

authors： Yao D,Deng L,Zhang M,Wang X,Tang N,Li J

更新日期：2015-01-28 00:00:00

abstract：:Ensembles of fcc nickel nanowires have been synthesized with defined mean sizes in the interior of single-wall carbon nanotubes. The method allows the intrinsic nature of single-domain magnets to emerge with large coercivity as their size becomes as small as the exchange length of nickel. By means of X-ray magnetic ci...

journal_title：Scientific reports

authors： Shiozawa H,Briones-Leon A,Domanov O,Zechner G,Sato Y,Suenaga K,Saito T,Eisterer M,Weschke E,Lang W,Peterlik H,Pichler T

更新日期：2015-10-13 00:00:00

abstract：:Therizinosaurian theropods evolved many highly specialized osteological features in association with their bulky proportions, which were unusual in the context of the generally gracile Theropoda. Here we report a new therizinosaur, Lingyuanosaurus sihedangensis gen. et sp. nov., based on a specimen recovered from the ...

journal_title：Scientific reports

authors： Yao X,Liao CC,Sullivan C,Xu X

更新日期：2019-03-22 00:00:00

abstract：:Technical guidelines for magnetic resonance imaging (MRI) of the small bowel (SB) in the setting of inflammatory bowel diseases (IBDs) were detailed in a 2017 consensus issued by European Society of Gastrointestinal and Abdominal Radiology (ESGAR) and European Society of Pediatric Radiology (ESPR); however, MRI for no...

journal_title：Scientific reports

authors： Lu J,Zhou Z,Morelli JN,Yu H,Luo Y,Hu X,Li Z,Hu D,Shen Y

更新日期：2019-10-01 00:00:00

abstract：:Structural polymeric materials incorporating a microencapsulated liquid healing agent demonstrate the ability to autonomously heal cracks. Understanding how an advancing crack interacts with the microcapsules is critical to optimizing performance through tailoring the size, distribution and density of these capsules. ...

journal_title：Scientific reports

authors： McDonald SA,Coban SB,Sottos NR,Withers PJ

更新日期：2019-11-28 00:00:00

abstract：:During the search for a potent antifungal drug, a cell-permeable metabolite was isolated from a soil isolate taxonomically identified as Penicillium radicum. The strain was found to be a potent antifungal agent. Production conditions of the active compound were optimized and the active compound was isolated, purified,...

journal_title：Scientific reports

authors： Singh V,Praveen V,Tripathi D,Haque S,Somvanshi P,Katti SB,Tripathi CK

更新日期：2015-07-10 00:00:00

abstract：:Epigenetic deregulation, such as the reduction of histone acetylation levels, is thought to be causally linked to various maladies associated with aging. Consequently, histone deacetylase inhibitors are suggested to serve as epigenetic therapy by increasing histone acetylation. However, previous work suggests that man...

journal_title：Scientific reports

authors： Becker L,Nogueira MS,Klima C,de Angelis MH,Peleg S

更新日期：2018-03-08 00:00:00

abstract：:Hollow silica spheres (HSS) with special interior spaces, high specific surface area and excellent adsorption and permeability performance were synthesized via micelle-template method using cetyl trimethyl ammonium bromide (CTAB) micelles as soft template and tetraethoxysilane (TEOS) as silica precursor. SEM, TEM, FT-...

journal_title：Scientific reports

authors： Bao Y,Wang T,Kang Q,Shi C,Ma J

更新日期：2017-04-21 00:00:00

abstract：:Myostatin (Mstn) is a conserved negative regulator of skeletal muscle mass in mammals. However, whether precise disruption of Mstn in livestock can be achieved and safely used to improve meat productivity has not been proven. We applied CRISPR/Cas9 system to generate Mstn knock-out (KO) rabbits and goats and then anal...

journal_title：Scientific reports

authors： Guo R,Wan Y,Xu D,Cui L,Deng M,Zhang G,Jia R,Zhou W,Wang Z,Deng K,Huang M,Wang F,Zhang Y

更新日期：2016-07-15 00:00:00

abstract：:Although 3,5,3'-triiodothyronine (T3) is considered to be the primary bioactive thyroid hormone (TH) due to its high affinity for TH nuclear receptors (TRs), new data suggest that 3,5-diiodothyronine (T2) can also regulate transcriptional networks. To determine the functional relevance of these bioactive THs, RNA-seq ...

journal_title：Scientific reports

authors： Olvera A,Martyniuk CJ,Buisine N,Jiménez-Jacinto V,Sanchez-Flores A,Sachs LM,Orozco A

更新日期：2017-11-08 00:00:00

abstract：:Open-ended evolution (OEE) is relevant to a variety of biological, artificial and technological systems, but has been challenging to reproduce in silico. Most theoretical efforts focus on key aspects of open-ended evolution as it appears in biology. We recast the problem as a more general one in dynamical systems theo...

journal_title：Scientific reports

authors： Adams A,Zenil H,Davies PCW,Walker SI

更新日期：2017-04-20 00:00:00

abstract：:For a number of years nanomaterials have been continuously devised and comprehensively investigated because of the growing demand for them and their multifarious applications, especially in medicine. This paper reports on the properties of SrF2 nanoparticles (NPs) for applications in biomedicine, showing effective way...

journal_title：Scientific reports

authors： Przybylska D,Ekner-Grzyb A,Grześkowiak BF,Grzyb T

更新日期：2019-06-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Sheu JR,Chen ZC,Jayakumar T,Chou DS,Yen TL,Lee HN,Pan SH,Hsia CH,Yang CH,Hsieh CY

更新日期：2020-04-06 00:00:00

abstract：:Temperature index (TI) models are convenient for modelling glacier ablation since they require only a few input variables and rely on simple empirical relations. The approach is generally assumed to be reliable at lower elevations (below 3500 m above sea level, a.s.l) where air temperature (Ta) relates well to the ene...

journal_title：Scientific reports

authors： Litt M,Shea J,Wagnon P,Steiner J,Koch I,Stigter E,Immerzeel W

更新日期：2019-03-27 00:00:00

abstract：:Graphene's unique physical and chemical properties make it an attractive platform for use in micro- and nanoelectronic devices. However, electrostatically controlling the flow of electrons in graphene can be challenging as a result of Klein tunneling, where electrons normally incident to a one-dimensional potential ba...

journal_title：Scientific reports

authors： Walls JD,Hadad D

更新日期：2015-02-13 00:00:00

abstract：:Transplantation of cardiomyocytes derived from induced pluripotent stem cell (iPSC-CMs) is a promising approach for increasing functional CMs during end-stage heart failure. Although major histocompatibility complex (MHC) class I matching between donor cells and recipient could reduce acquired immune rejection, innate...

journal_title：Scientific reports

authors： Nakamura Y,Miyagawa S,Yoshida S,Sasawatari S,Toyofuku T,Toda K,Sawa Y

更新日期：2019-07-25 00:00:00

abstract：:Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 201...

journal_title：Scientific reports

authors： Zhou DC,Zhang H,Luo ZM,Zhu QX,Zhou CF

更新日期：2016-11-08 00:00:00

abstract：:Identification of cancer prognostic genes is important in that it can lead to accurate outcome prediction and better therapeutic trials for cancer patients. Many computational approaches have been proposed to achieve this goal; however, there is room for improvement. Recent developments in deep learning techniques can...

journal_title：Scientific reports

authors： Choi J,Oh I,Seo S,Ahn J

更新日期：2018-09-13 00:00:00

abstract：:Sepsis is an infection-induced systemic inflammatory syndrome and a major cause of death for critically ill patients. Here, we examined whether the absence of Sprouty-related EVH1-domain-containing protein 2 (Spred2), a negative regulator of the Ras/Raf/ERK/MAPK pathway, influences host defense against polymicrobial s...

journal_title：Scientific reports

authors： Itakura J,Sato M,Ito T,Mino M,Fushimi S,Takahashi S,Yoshimura T,Matsukawa A

更新日期：2017-10-09 00:00:00

abstract：:This work serves as a proof-of-concept for bacterially derived SimCells (Simple Cells), which contain the cell machinery from bacteria and designed DNA (or potentially a simplified genome) to instruct the cell to carry out novel, specific tasks. SimCells represent a reprogrammable chassis without a native chromosome, ...

journal_title：Scientific reports

authors： Rampley CPN,Davison PA,Qian P,Preston GM,Hunter CN,Thompson IP,Wu LJ,Huang WE

更新日期：2017-08-03 00:00:00