Single-step cycle pulse operation of the label-free electrochemiluminescence immunosensor based on branched polypyrrole for carcinoembryonic antigen detection.

abstract：:Bilirubin neurotoxicity has been studied for decades and has been shown to affect various mechanisms via significant modulation of gene expression. This suggests that vital regulatory mechanisms of gene expression, such as epigenetic mechanisms, could play a role in bilirubin neurotoxicity. Histone acetylation has rec...

journal_title：Scientific reports

authors： Vianello E,Zampieri S,Marcuzzo T,Tordini F,Bottin C,Dardis A,Zanconati F,Tiribelli C,Gazzin S

更新日期：2018-09-12 00:00:00

abstract：:Aiming to promote low-cost production of protein-rich forage rice and resource recycling from wastewater treatment plants, a pot experiment was conducted to assess the possibility to substitute mineral fertilizers with composted sewage sludge (CSS) with/without top-dressing with treated municipal wastewater (TWW). Res...

journal_title：Scientific reports

authors： Phung LD,Ichikawa M,Pham DV,Sasaki A,Watanabe T

更新日期：2020-06-23 00:00:00

abstract：:Lipid droplet (LD)-associated hydrolase (LDAH) is a newly identified LD protein abundantly expressed in tissues that predominantly store triacylglycerol (TAG). However, how LDAH regulates TAG metabolism remains unknown. We found that upon oleic acid loading LDAH translocalizes from the ER to newly formed LDs, and indu...

journal_title：Scientific reports

authors： Goo YH,Son SH,Paul A

更新日期：2017-06-02 00:00:00

abstract：:Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-st...

journal_title：Scientific reports

authors： Yao J,Yuan Y,Zheng F,Zhan CG

更新日期：2016-02-29 00:00:00

abstract：:Herein, the formation and electrochemical performance of a novel binder-free turbostratic stacked/ well-ordered stacked δ-MnO2-carbon fiber composite cathodes in deep eutectic solvent (DES) based zinc-ion battery (ZIB) is reported. Results of morphological, elemental, and structural analyses revealed directly grown an...

journal_title：Scientific reports

authors： Corpuz RD,De Juan LMZ,Praserthdam S,Pornprasertsuk R,Yonezawa T,Nguyen MT,Kheawhom S

更新日期：2019-10-22 00:00:00

abstract：:The preferential degeneration of Substantia nigra dopamine midbrain neurons (SN DA) causes the motor-symptoms of Parkinson's disease (PD). Voltage-gated L-type calcium channels (LTCCs), especially the Cav1.3-subtype, generate an activity-related oscillatory Ca(2+) burden in SN DA neurons, contributing to their degener...

journal_title：Scientific reports

authors： Poetschke C,Dragicevic E,Duda J,Benkert J,Dougalis A,DeZio R,Snutch TP,Striessnig J,Liss B

更新日期：2015-09-18 00:00:00

abstract：:Scanning micro-mirror actuators are silicon-based oscillatory micro-electro-mechanical systems (MEMS). They enable laser distance measurements for automotive LIDAR applications as well as projection modules for the consumer market. For MEMS applications, the geometric structure is typically designed to serve a number ...

journal_title：Scientific reports

authors： Nabholz U,Schatz F,Mehner JE,Degenfeld-Schonburg P

更新日期：2019-03-08 00:00:00

abstract：:'Big data' in healthcare encompass measurements collated from multiple sources with various degrees of data quality. These data require quality control assessment to optimise quality for clinical management and for robust large-scale data analysis in healthcare research. Height and weight data represent one of the mos...

journal_title：Scientific reports

authors： Phan HTT,Borca F,Cable D,Batchelor J,Davies JH,Ennis S

更新日期：2020-06-23 00:00:00

abstract：:How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that we...

journal_title：Scientific reports

authors： Honda Y,Higashibata A,Matsunaga Y,Yonezawa Y,Kawano T,Higashitani A,Kuriyama K,Shimazu T,Tanaka M,Szewczyk NJ,Ishioka N,Honda S

更新日期：2012-01-01 00:00:00

abstract：:This work considers the effects of the Hurst exponent (H) on the local electric field distribution and the slope of the Fowler-Nordheim (FN) plot when considering the cold field electron emission properties of rough Large-Area Conducting Field Emitter Surfaces (LACFESs). A LACFES is represented by a self-affine Weiers...

journal_title：Scientific reports

authors： de Assis TA

更新日期：2015-06-02 00:00:00

abstract：:Deer are an iconic group of large mammals that originated in the Early Miocene of Eurasia (ca. 19 Ma). While there is some consensus on key relationships among their members, on the basis of molecular- or morphology-based analyses, or combined approaches, many questions remain, and the bony labyrinth has shown conside...

journal_title：Scientific reports

authors： Mennecart B,DeMiguel D,Bibi F,Rössner GE,Métais G,Neenan JM,Wang S,Schulz G,Müller B,Costeur L

更新日期：2017-10-13 00:00:00

abstract：:Lipids play an important role in energy storage, membrane structure stabilization and signaling. Parasitoids are excellent models to study lipidomics because a majority of them do not accumulate during their free-living life-stage. Studies on parasitoids have mostly focused on the changes in the lipids and gene transc...

journal_title：Scientific reports

authors： Gao X,Luo J,Lü L,Zhang L,Zhang S,Cui J

更新日期：2018-05-17 00:00:00

abstract：:Measuring handgrip strength is the initial step to diagnose sarcopenia. To investigate whether the serum creatinine (Cr)/cystatin C (CysC) ratio could serve as a case-finding tool for low handgrip strength, we conducted a diagnostic accuracy study. Adults (aged ≥ 40 years) with normal renal function were recruited. Tr...

journal_title：Scientific reports

authors： Tan L,Li R,Hu X,Zhu Y,Bao T,Zuo Y,Yang M

更新日期：2020-08-20 00:00:00

abstract：:Specific HPV genotypes have been recognized as risk factors inducing head and neck cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect accurately High Risk HPV DNA in Formalin Fixed Paraffin Embedded (FFPE) and oral cytobrush samples and compare the results with conventional PCR. Repea...

journal_title：Scientific reports

authors： Harlé A,Guillet J,Thomas J,Sastre-Garau X,Rouyer M,Ramacci C,Gilson P,Dubois C,Dolivet G,Leroux A,Salleron J,Merlin JL

更新日期：2018-07-27 00:00:00

abstract：:A. baumannii infections are becoming more and more serious health issues with rapid emerging of multidrug and extremely drug resistant strains, and therefore, there is an urgent need for the development of nonantibiotic-based intervention strategies. This study aimed at identifying whether an outer membrane protein wi...

journal_title：Scientific reports

authors： Huang W,Yao Y,Wang S,Xia Y,Yang X,Long Q,Sun W,Liu C,Li Y,Chu X,Bai H,Yao Y,Ma Y

更新日期：2016-02-08 00:00:00

abstract：:The study aimed to explore the epidemiology and clinical characteristics of chronic osteomyelitis observed in a northern China hospital. Clinical data of 255 patients with chronic osteomyelitis from January 2007 to January 2014 were collected and analyzed, including general information, disease data, treatment and fol...

journal_title：Scientific reports

authors： Ma X,Han S,Ma J,Chen X,Bai W,Yan W,Wang K

更新日期：2018-10-05 00:00:00

abstract：:Amplification of liver injury is mediated by macrophages but the signaling by which the macrophage inflammasome enhances liver injury is not completely understood. The CCAAT/Enhancer Binding Protein-β (C/EBPβ) is a critical signaling molecule for macrophages because expression of a dominant inhibitor of C/EBPβ DNA-bin...

journal_title：Scientific reports

authors： Buck M,Solis-Herruzo J,Chojkier M

更新日期：2016-04-12 00:00:00

abstract：:Pterostilbene (PT), the natural dimethylated analog of resveratrol (RSV), is a potent anticarcinogen for non-small-cell lung cancer (NSCLC), but its anti-NSCLC mechanisms remain unclear. In this study, we show that PT treatment time- and dose-dependently enhanced the endoplasmic reticulum stress (ERS) signaling (i.e.,...

journal_title：Scientific reports

authors： Ma Z,Yang Y,Di S,Feng X,Liu D,Jiang S,Hu W,Qin Z,Li Y,Lv J,Fan C,Yan X,Li X

更新日期：2017-08-14 00:00:00

abstract：:Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells. Mechanistical...

journal_title：Scientific reports

authors： Gao XH,Zhang YL,Zhang ZY,Guo SS,Chen XB,Guo YZ

更新日期：2020-01-08 00:00:00

abstract：:To determine the association of birth weight (BW) and waist circumference (WC) on cardiovascular disease (CVD). The longitudinal cohort study consisted of 745 participants who were able to provide their birth weight information and were followed from 2002 to 2014. During the follow-up, 83 events of CVD were confirmed....

journal_title：Scientific reports

authors： Tian J,Qiu M,Li Y,Zhang X,Wang H,Sun S,Sharp NS,Tong W,Zeng H,Zheng S,Song X,Wang W,Ning G

更新日期：2017-08-29 00:00:00

abstract：:Surface-enhanced Raman spectroscopy (SERS) is considered a highly promising technology for different analytical purposes. The applications of SERS are still quite limited due its relatively poor quantitative repeatability and the fact that SERS is very sensitive to oxidation, which is a challenge especially with silve...

journal_title：Scientific reports

authors： Matikainen A,Nuutinen T,Itkonen T,Heinilehto S,Puustinen J,Hiltunen J,Lappalainen J,Karioja P,Vahimaa P

更新日期：2016-11-16 00:00:00

abstract：:Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer's disease (AD) neuropathology, including neurofibrillary tangles and neuritic plaques. The expression of amyloid precursor pro...

journal_title：Scientific reports

authors： Wu Y,Zhang S,Xu Q,Zou H,Zhou W,Cai F,Li T,Song W

更新日期：2016-03-03 00:00:00

abstract：:TRPV1 is a polymodal nociceptor for diverse physical and chemical stimuli that interact with different parts of the channel protein. Recent cryo-EM studies revealed detailed channel structures, opening the door for mapping structural elements mediating activation by each stimulus. Towards this goal, here we have combi...

journal_title：Scientific reports

authors： Ma L,Yang F,Vu S,Zheng J

更新日期：2016-09-26 00:00:00

abstract：:To increase the yield potential while limiting the environmental impact of N management practices is an important issue in rice cultivation. The large-grain rice cultivar Akita 63 showed higher N-use efficiency for grain production. To elucidate this, we analyzed yield characteristics of Akita 63 in comparison with th...

journal_title：Scientific reports

authors： Makino A,Kaneta Y,Obara M,Ishiyama K,Kanno K,Kondo E,Suzuki Y,Mae T

更新日期：2020-07-22 00:00:00

abstract：:Mask ventilation and coughing during oro-tracheal suctioning produce aerosols that enhance nosocomial transmission of respiratory infections. We examined the extent of exhaled air dispersion from a human-patient-simulator during mask ventilation by different groups of healthcare workers and coughing bouts. The simulat...

journal_title：Scientific reports

authors： Chan MTV,Chow BK,Lo T,Ko FW,Ng SS,Gin T,Hui DS

更新日期：2018-01-09 00:00:00

abstract：:The insect membrane-protein, Torso, is a member of the receptor-tyrosine-kinase family, and is activated by its ligand, prothoracicotropic hormone (PTTH). Although PTTH is one of the most important regulators of insect development, the mechanism of Torso activation by the hormone has remained elusive. In this study, u...

journal_title：Scientific reports

authors： Konogami T,Yang Y,Ogihara MH,Hikiba J,Kataoka H,Saito K

更新日期：2016-03-01 00:00:00

abstract：:Although accumulating evidence indicates that both β-catenin and osterix (Osx) are essential for bone and tooth development, few studies have investigated the interaction of these two key proteins in the context of cementogenesis. In this study, we used transgenic mice with constitutively active β-catenin and inactive...

journal_title：Scientific reports

authors： Choi H,Kim TH,Yang S,Lee JC,You HK,Cho ES

更新日期：2017-08-15 00:00:00

abstract：:The neurology of male sexuality has been poorly studied owing to difficulties in studying brain circuitry in humans. Dopamine (DA) is essential for both physiological and behavioural responses, including the regulation of sexuality. Previous studies have revealed that alterations in DA synthesis in dopaminergic neuron...

journal_title：Scientific reports

authors： Chen SL,Chen YH,Wang CC,Yu YW,Tsai YC,Hsu HW,Wu CL,Wang PY,Chen LC,Lan TH,Fu TF

更新日期：2017-03-15 00:00:00

abstract：:Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in both MS patients an...

journal_title：Scientific reports

authors： Khan RS,Baumann B,Dine K,Song Y,Dunaief JL,Kim SF,Shindler KS

更新日期：2019-08-12 00:00:00

abstract：:Enrichment of colloidal particles in continuous flow has not only numerous applications but also poses a great challenge in controlling physical forces that are required for achieving particle enrichment. Here, we for the first time experimentally demonstrate the electrokinetically-driven continuous-flow enrichment of...

journal_title：Scientific reports

authors： Zhao C,Ge Z,Song Y,Yang C

更新日期：2017-09-07 00:00:00