Abstract:
:Mitochondria-generated reactive oxygen species (mROS) are frequently associated with DNA damage and cell cycle arrest, but physiological increases in mROS serve to regulate specific cell functions. T3 is a major regulator of mROS, including hydrogen peroxide (H2O2). Here we show that exogenous thyroid hormone (T3) administration increases cardiomyocyte numbers in neonatal murine hearts. The mechanism involves signaling by mitochondria-generated H2O2 (mH2O2) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity towards H2O2 that activates c-Jun N-terminal kinase-2α2 (JNK2α2). JNK2α2, a relatively rare member of the JNK family of mitogen-activated protein kinases (MAPK), phosphorylates c-Jun, a component of the activator protein 1 (AP-1) early response transcription factor, resulting in enhanced insulin-like growth factor 1 (IGF-1) expression and activation of proliferative ERK1/2 signaling. This non-canonical mechanism of MAPK activation couples T3 actions on mitochondria to cell cycle activation. Although T3 is regarded as a maturation factor for cardiomyocytes, these studies identify a novel redox pathway that is permissive for T3-mediated cardiomyocyte proliferation-this because of the expression of a pro-proliferative JNK isoform that results in growth factor elaboration and ERK1/2 cell cycle activation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tan L,Bogush N,Naib H,Perry J,Calvert JW,Martin DIK,Graham RM,Naqvi N,Husain Adoi
10.1038/s41598-019-53705-1subject
Has Abstractpub_date
2019-11-27 00:00:00pages
17731issue
1issn
2045-2322pii
10.1038/s41598-019-53705-1journal_volume
9pub_type
杂志文章abstract::PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) expression is transiently elevated following low dose irradiation typically encountered in the workplace and from natural sources. This long non-coding RNA recruits epigenetic silencers for cis-acting repression of its neighbour...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01875-1
更新日期:2017-05-11 00:00:00
abstract::Oligomers populated during the early amyloid aggregation process are more toxic than mature fibrils, but pinpointing the exact toxic species among highly dynamic and heterogeneous aggregation intermediates remains a major challenge. β-barrel oligomers, structurally-determined recently for a slow-aggregating peptide de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28649-7
更新日期:2018-07-09 00:00:00
abstract::Mesenchymal stromal cells (MSCs) are a potential therapy for many chronic inflammatory diseases due to their regenerative, immunologic and anti-inflammatory properties. The two-way dialogue between MSCs and macrophages is crucial to tissue regeneration and repair. Previous research demonstrated that murine adipose-der...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56835-8
更新日期:2019-12-30 00:00:00
abstract::Foot-and-mouth disease (FMD) is a highly contagious disease of livestock affecting animal production and trade throughout Asia and Africa. Understanding FMD virus (FMDV) global movements and evolution can help to reconstruct the disease spread between endemic regions and predict the risks of incursion into FMD-free co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32693-8
更新日期:2018-10-02 00:00:00
abstract::Lin28 is an evolutionary conserved RNA-binding protein that plays important roles during embryonic development and tumorigenesis. It regulates gene expression through two different post-transcriptional mechanisms. The first one is based on the regulation of miRNA biogenesis, in particular that of the let-7 family, who...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81429-8
更新日期:2021-01-27 00:00:00
abstract::The novel neuropeptide spexin (SPX) was discovered to activate galanin receptor 2 (GALR2) and 3 (GALR3) but not galanin receptor 1 (GALR1). Although GALR2 is known to display a function, particularly in anxiety, depression, and appetite regulation, the further determination of its function would benefit from a more st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21453
更新日期:2016-02-24 00:00:00
abstract::This paper reports on 3D phase field simulations of IMC growth in Co/Sn and Cu/Sn solder systems. In agreement with experimental micrographs, we obtain uniform growth of the CoSn3 phase in Co/Sn solder joints and a non-uniform wavy morphology for the Cu6Sn5 phase in Cu/Sn solder joints. Furthermore, simulations were p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51179-9
更新日期:2019-10-16 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-30163-9
更新日期:2018-08-09 00:00:00
abstract::In this work, lamellar MnFe2O4 was successfully planted on a wood surface through the association of hydrogen bonds via the one-pot hydrothermal method. Simultaneously, the fluoroalkylsilane (FAS-17) on the surface of the MnFe2O4 layer formed long-chain or network macromolecules through a poly-condensation process and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35549
更新日期:2016-10-17 00:00:00
abstract::Osteogenesis is categorized into two groups based on developmental histology, intramembranous and endochondral ossification. The role of blood vessels during endochondral ossification is well known, while their role in intramembranous ossification, especially the intertissue pathway, is poorly understood. Here, we dem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27473
更新日期:2016-06-07 00:00:00
abstract::Aerogels have numerous applications due to their high surface area and low densities. However, creating aerogels from a large variety of materials has remained an outstanding challenge. Here, we report a new methodology to enable aerogel production with a wide range of materials. The method is based on the assembly of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00849
更新日期:2012-01-01 00:00:00
abstract::Untreatable bacterial infections caused by a perpetual increase of antibiotic resistant strains represent a serious threat to human healthcare in the 21(st) century. Conjugative DNA transfer is the most important mechanism for antibiotic resistance and virulence gene dissemination among bacteria and is mediated by a p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24643
更新日期:2016-04-22 00:00:00
abstract::Understanding the drivers of animal movement is significant for ecology and biology. Yet researchers have so far been unable to fully understand these drivers, largely due to low data resolution. In this study, we analyse a high-frequency movement dataset for a group of grazing cattle and investigate their spatiotempo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31967
更新日期:2016-08-24 00:00:00
abstract::Salinity is a critical abiotic stress, which significantly impacts the agricultural yield worldwide. Identification of the molecular mechanisms underlying the salt tolerance in euhalophyte Suaeda salsa is conducive to the development of salt-resistant crops. In the present study, high-throughput RNA sequencing was per...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61204-x
更新日期:2020-03-06 00:00:00
abstract::Seagrass meadows are among the four most productive marine ecosystems in the world. Zostera japonica (Z. japonica) is the most widely distributed species of seagrass in China. However, there is no reference genome or transcriptome available for Z. japonica, impeding progress in functional genomic and molecular ecology...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51176-y
更新日期:2019-10-10 00:00:00
abstract::Sphingobium sp. strain TCM1 can degrade tris(2-chloroethyl) phosphate (TCEP) to inorganic phosphate and 2-chloroethanol. A phosphotriesterase (PTE), phosphodiesterase (PDE) and phosphomonoesterase (PME) are believed to be involved in the degradation of TCEP. The PTE and PME that respectively catalyze the first and thi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03142-9
更新日期:2017-06-06 00:00:00
abstract::Recently, we reported that chemokine (C-X-C motif) receptor (CXCR)4 and atypical chemokine receptor 3 regulate α1-adrenergic receptors (α1-AR) through the formation of hetero-oligomeric complexes. Whether α1-ARs also regulate chemokine receptor function within such heteromeric receptor complexes is unknown. We observe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21096-4
更新日期:2018-02-09 00:00:00
abstract::Deforestation and forest degradation around the world endanger the functioning of ecosystems, climate stability, and conservation of biodiversity. We assessed the spatial and temporal dynamics of forest cover in Myanmar's Hkakabo Razi Landscape (HRL) to determine its integrity based on forest change and fragmentation ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70917-y
更新日期:2020-08-19 00:00:00
abstract::Agr family includes three groups of genes, Ag1, Agr2 and Agr3, which encode the thioredoxin domain-containing secreted proteins and have been shown recently to participate in regeneration of the amputated body appendages in amphibians. By contrast, higher vertebrates have only Agr2 and Agr3, but lack Ag1, and have low...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08123
更新日期:2015-01-29 00:00:00
abstract::In this study, ITS, ITS2, matK, rbcL and psbA-trnH in Rehmannia were successfully amplified and sequenced, but some ITS sequences need to be proofread according to ITS2 sequences. Compared with rbcL, matK and psbA-trnH, ITS and ITS2 had higher mutation rate and more information sites, and ITS2 had higher interspecific...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53752-8
更新日期:2019-11-21 00:00:00
abstract::The ability to inhibit previously employed strategies and flexibly adjust behavioural responses to external conditions may be critical for individual survival. However, it is unclear which factors predict their distribution across species. Here, we investigated social inhibition and behavioural flexibility in six prim...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21496-6
更新日期:2018-02-15 00:00:00
abstract::Autophagy is a cellular homeostatic mechanism where proteins and organelles are digested and recycled to provide an alternative source of building blocks and energy to cells. The role of autophagy in cancer microenvironment is still poorly understood. Here, we present a microfluidic system allowing monitoring of the c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02172-7
更新日期:2017-05-17 00:00:00
abstract::Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3). No effective FGFR3-targeted therapies for ACH are currently available. By drug repositioning strategies, we identified that meclozine, which has been used as ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07044-8
更新日期:2017-08-07 00:00:00
abstract::Two of the most common nonhuman animals that interact with humans are domestic dogs (Canis familiaris) and cats (Felis catus). In contrast to dogs, the ability of domestic cats to communicate with humans has not been explored thoroughly. We used a habituation-dishabituation method to investigate whether domestic cats ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40616-4
更新日期:2019-04-04 00:00:00
abstract::The major human pathogen Mycobacterium tuberculosis is rarely reported to cause disease in other animals. Cases in livestock are thought to occur through contact with infected handlers, but previous studies evaluating putative livestock-human transmission used typing techniques with limited resolution. Here, we undert...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54268-x
更新日期:2019-11-29 00:00:00
abstract::In this study, electromechanical characteristics of (1-x) Bi0.5Na0.5TiO3-xSrTiO3 (ST26, x = 0.26)/(1-y) Bi0.5Na0.5TiO3-ySrTiO3 (ST10, y = 0.1) (matrix/seed) composites were studied. The ST26 (high relaxor phase) and ST10 (a relaxor ferroelectric (RF), high ferroelectric phase) composite with large (r-ST26-ST10) and sm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32133-7
更新日期:2018-09-20 00:00:00
abstract::Arsenic contamination of groundwater is a serious concern worldwide. The research gaps in removing arsenic are selectivity, regeneration and effective removal rate at neutral pH levels. In this study, we discussed the reasons of the high arsenic adsorption from groundwater of our previously developed adsorbent, a cati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48233-x
更新日期:2019-08-15 00:00:00
abstract::Previous studies have shown that it is possible to nutritionally program gilthead seabream offspring through fish oil (FO) replacement by vegetable oils (VO) in the broodstock diet, to improve their ability to grow fast when fed low fish meal (FM) and FO diets during grow-out phase. However, in those studies broodstoc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72166-5
更新日期:2020-09-23 00:00:00
abstract::In the aftermath of the financial crisis of 2007-2009, the growing body of literature on financial networks has widely documented the predictive power of topological characteristics (e.g., degree centrality measures) to explain the systemic impact or systemic exposure of financial institutions. This study shows that c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74259-7
更新日期:2020-10-19 00:00:00
abstract::Spinal muscular atrophy (SMA) is caused by homozygous mutation of the survival motor neuron 1 (SMN1) gene. Disease severity inversely correlates to the amount of SMN protein produced from the homologous SMN2 gene. We show that SMN protein is naturally released in exosomes from all cell types examined. Fibroblasts from...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14313-z
更新日期:2017-10-24 00:00:00