Abstract：
:Agr family includes three groups of genes, Ag1, Agr2 and Agr3, which encode the thioredoxin domain-containing secreted proteins and have been shown recently to participate in regeneration of the amputated body appendages in amphibians. By contrast, higher vertebrates have only Agr2 and Agr3, but lack Ag1, and have low ability to regenerate the body appendages. Thus, one may hypothesize that loss of Ag1 in evolution could be an important event that led to a decline of the regenerative capacity in higher vertebrates. To test this, we have studied now the expression and role of Ag1 in the regeneration of fins of a representative of another large group of lower vertebrates, the fish Danio rerio. As a result, we have demonstrated that amputation of the Danio fins, like amputation of the body appendages in amphibians, elicits an increase of Ag1 expression in cells of the stump. Furthermore, down-regulation of DAg1 by injections of Vivo-morpholino antisense oligonucleotides resulted in a retardation of the fin regeneration. These data are in a good agreement with the assumption that the loss of Ag1 in higher vertebrates ancestors could lead to the reduction of the regenerative capacity in their modern descendants.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ivanova AS,Shandarin IN,Ermakova GV,Minin AA,Tereshina MB,Zaraisky AGdoi
10.1038/srep08123subject
Has Abstractpub_date
2015-01-29 00:00:00pages
8123issn
2045-2322pii
srep08123journal_volume
5pub_type
杂志文章abstract：:Low temperature influences multiple physiological processes in fish. To explore the adaptability of the large yellow croaker (Larimichthys crocea) to low temperature, the concentrations of glycerol, blood urea nitrogen (BUN), and triglycerides (TG) in plasma, as well as the expression levels of metabolism-related gene...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37274-3
更新日期：2019-02-25 00:00:00
abstract：:Arsenic contamination of groundwater is a serious concern worldwide. The research gaps in removing arsenic are selectivity, regeneration and effective removal rate at neutral pH levels. In this study, we discussed the reasons of the high arsenic adsorption from groundwater of our previously developed adsorbent, a cati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48233-x
更新日期：2019-08-15 00:00:00
abstract：:Hemodialysis patients are a special group of patients with higher mortality rates. Hemodialysis patients with vitamin D deficiency {plasma levels of 25-hydroxyvitamin D [25(OH)D] below 20 ng/mL} are associated with even higher mortality rates. The prognostic importance of vitamin D deficiency in hemodialysis patients ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64359-9
更新日期：2020-05-05 00:00:00
abstract：:Previous studies have shown that rabbit IgG antibodies against Schistosoma mansoni egg antigens (SmSEA) cross-react with allergens in natural rubber latex, peanuts and grass and tree pollens. Here we describe antigenic molecules that cross-react with rabbit anti-S. mansoni IgG antibodies in extracts of the house dust ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59892-6
更新日期：2020-02-25 00:00:00
abstract：:The prognostic value of current multigene assays for breast cancer is limited to hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer. Despite the prognostic significance of immune response-related genes in breast cancer, immune gene signatures have not been incorporated int...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80274-5
更新日期：2021-01-08 00:00:00
abstract：:The self-cleaning property is usually connected to superhydrophobic surfaces (SHSs) where the dust particles can be easily removed by the rolling motion of droplets. It seems that superhydrophobicity (its durability is questionable nowadays) is a necessity. However here, it is disclosed that self-cleaning can also be ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38239
更新日期：2016-12-05 00:00:00
abstract：:One of the major drawbacks of cheminformatics is a large amount of information present in the datasets. In the majority of cases, this information contains redundant instances that affect the analysis of similarity measurements with respect to drug design and discovery. Therefore, using classical methods such as the p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71502-z
更新日期：2020-09-02 00:00:00
abstract：:Learning a skilled movement often requires changing multiple dimensions of movement in a coordinated manner. Serial training is one common approach to learning a new movement pattern, where each feature is learned in isolation from the others. Once one feature is learned, we move on to the next. However, when learning...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56319-9
更新日期：2019-12-24 00:00:00
abstract：:A glassy carbon electrode (GC) immobilized with chitosan (CHI)@reduced graphene (rGO)-polyaniline (PAni)/ferritin (Frt)/glucose oxidase (GOx) bioelectrode was prepared. The prepared electrode was characterized by using cyclic voltammetry (CV), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67253-6
更新日期：2020-06-26 00:00:00
abstract：:We used swept-source (SS) optical coherence tomography (OCT) and OCT angiography (OCTA) to investigate the effects of moderate physical exercise on retinal and choroidal vessel densities (VDs) and thicknesses in children. One eye in each of 40 myopic children (mean age, 11.70 years) and 18 emmetropic children (mean ag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81770-y
更新日期：2021-01-21 00:00:00
abstract：:The structural characterization correlated to the processing control of hierarchical structure of planar heterojunction perovskite layer is still incomplete due to the limitations of conventional microscopy and X-ray diffraction. This present study performed the simultaneously grazing-incidence small-angle scattering ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13657
更新日期：2015-09-04 00:00:00
abstract：:Near-infrared sensitization of monolayer MoS2 is here achieved via the covalent attachment of a novel heteroleptic nickel bis-dithiolene complex into sulfur vacancies in the MoS2 structure. Photocurrent action spectroscopy of the sensitized films reveals a discreet contribution from the sensitizer dye centred around 1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53186-2
更新日期：2019-11-13 00:00:00
abstract：:Despite our increasing understanding of zebrafish heart development and regeneration, there is limited information about the distribution of endothelial cells (ECs) in the adult zebrafish heart. Here, we investigate and compare the distribution of cardiac ECs (cECs) in adult mouse and zebrafish ventricles. Surprisingl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02461-1
更新日期：2017-06-02 00:00:00
abstract：:Chemical reagents used in traditional mineral processing can be toxic and hazardous for the environment. Therefore, the use of biotechnological methods is becoming increasingly important. Great hopes are being placed in the use of microorganisms for bio-beneficiation of raw materials. However, assessment of adhesion a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49406-4
更新日期：2019-09-10 00:00:00
abstract：:Aldosterone and the Mineralocorticoid Receptor (MR) control hydroelectrolytic homeostasis and alterations of mineralocorticoid signaling pathway are involved in the pathogenesis of numerous human diseases, justifying the need to decipher molecular events controlling MR expression level. Here, we show in renal cells th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04838-8
更新日期：2017-07-06 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-75949-y
更新日期：2020-10-28 00:00:00
abstract：:The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42383-8
更新日期：2019-04-10 00:00:00
abstract：:We present a new collusion attack to a kind of quantum secret sharing schemes with entangled states. Using this attack, an unauthorized set of agents can gain access to the shared secret without the others' cooperation. Furthermore, we establish a general model for this kind of quantum secret sharing schemes and then ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02543-0
更新日期：2017-05-30 00:00:00
abstract：:A polymer coating as polycaprolactone (PCL) is applied to improve the initial corrosion resistance of biodegradable magnesium. In addition, plasma electrolytic oxidation (PEO) is performed to increase adhesion between the polymer and the metal. However, when a complex-shaped material such as a screw is implanted in a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31359-9
更新日期：2018-09-05 00:00:00
abstract：:Little is known about the relationship between soil microbial communities and soil properties in southern boreal forests. To further our knowledge about that relationship, we compared the soil samples in southern boreal forests of the Greater Khingan Mountains-the southernmost boreal forest biome in the world. The for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79206-0
更新日期：2020-12-16 00:00:00
abstract：:The sustainable use of common pool resources has become a significant global challenge. It is now widely accepted that specific mechanisms such as community-based management strategies, institutional responses such as resource privatization, information availability and emergent social norms can be used to constrain i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02151-y
更新日期：2017-05-23 00:00:00
abstract：:The transient silencing effects currently demonstrated by nonviral siRNA delivery systems limit the therapeutic utility of RNAi, but it remains a technical challenge to prolong duration of gene silencing. We have developed a T7 autogene-based hybrid mRNA/DNA system to enable long-term expression of shRNA in cytoplasm ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39407-8
更新日期：2019-02-28 00:00:00
abstract：:Obesity affects male fertility and maternal diabetes affects the offspring sperm epigenome. However, the effects of in utero exposure to maternal glucose intolerance in combination with postnatal high fat, high sucrose (HFHS) diet consumption on offspring spermatogenesis is not clear. The present study was designed to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25950-3
更新日期：2018-05-16 00:00:00
abstract：:An optimization method to reconstruct the object profile is performed by using a flexible laser plane and bi-planar references. The bi-planar references are considered as flexible benchmarks to realize the transforms among two world coordinate systems on the bi-planar references, the camera coordinate system and the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19928-4
更新日期：2018-01-24 00:00:00
abstract：:Light beams with extraordinary spatial structures, such as the Airy beam (AB), the Bessel-Gaussian beam (BGB) and the Laguerre-Gaussian beam (LGB), are widely studied and applied in many optical scenarios. We report on preparation of light beams with controllable spatial structures through sum frequency generation (SF...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05650
更新日期：2014-07-10 00:00:00
abstract：:In this report, a facile and effective one-pot oxidation-assisted dealloying protocol has been developed to massively synthesize monolithic core-shell architectured nanoporous copper@cuprous oxide nanonetworks (C-S NPC@Cu2O NNs) by chemical dealloying of melt-spun Al 37 at.% Cu alloy in an oxygen-rich alkaline solutio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36084
更新日期：2016-11-10 00:00:00
abstract：:Human learners can generalize a new concept from a small number of samples. In contrast, conventional machine learning methods require large amounts of data to address the same types of problems. Humans have cognitive biases that promote fast learning. Here, we developed a method to reduce the gap between human beings...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25679-z
更新日期：2018-05-09 00:00:00
abstract：:We hereby report for the first time on the design, manufacturing and testing of a three-dimensional (3D) nearly-periodic, locally resonant phononic crystal (PnC). Most of the research effort on PnCs and metamaterials has been focused on the enhanced dynamic properties arising from their periodic design. Lately, additi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75977-8
更新日期：2020-11-04 00:00:00
abstract：:Programmed death-1 (PD-1) is an immunosuppressive receptor functionally bound with programmed death-ligand 1 (PD-L1), which has been reported in various malignancies. However, only a few studies are available for the clinical significance of PD-1/PD-L1 in nasopharyngeal carcinoma (NPC). In this study, we aim to invest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43627
更新日期：2017-03-03 00:00:00
abstract：:A high prevalence of obstructive sleep apnea (OSA) has been reported in Down syndrome (DS) owing to the coexistence of multiple predisposing factors related to its genetic abnormality, posing a challenge for the management of OSA. We hypothesized that DS mice recapitulate craniofacial abnormalities and upper airway ob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78278-2
更新日期：2020-12-07 00:00:00
