Author Correction: Aberrant expression of the COX2/PGE2 axis is induced by activation of the RAF/MEK/ERK pathway in BRAFV595E canine urothelial carcinoma.

abstract：:Stem and progenitor cells of the submandibular salivary gland (SMG) give rise to, maintain, and regenerate the multiple lineages of mature epithelial cells including those belonging to the ductal, acinar, basal and myoepithelial subtypes. Here we have exploited single cell RNA-sequencing and in vivo genetic lineage tr...

journal_title：Scientific reports

authors： Song EC,Min S,Oyelakin A,Smalley K,Bard JE,Liao L,Xu J,Romano RA

更新日期：2018-09-19 00:00:00

abstract：:The κ opioid receptor (κOR) is a member of G-protein-coupled receptors, and is considered as a promising drug target for treating neurological diseases. κOR selective 6'-GNTI was proved to be a G-protein biased agonist, whereas 5'-GNTI acts as an antagonist. To investigate the molecular mechanism of how these two liga...

journal_title：Scientific reports

authors： Cheng J,Sun X,Li W,Liu G,Tu Y,Tang Y

更新日期：2016-01-08 00:00:00

abstract：:Iron deposits are a phenotypic trait of tumor-associated macrophages (TAMs). Histological iron imaging and contrast-agent free magnetic resonance imaging (MRI) can detect these deposits, but their presence  in human cancer, and correlation with immunotherapeutic response is largely untested. Here, primarily using thes...

journal_title：Scientific reports

authors： Leftin A,Ben-Chetrit N,Joyce JA,Koutcher JA

更新日期：2019-01-29 00:00:00

abstract：:Shear-waves are the most energetic body-waves radiated from an earthquake, and are responsible for the destruction of engineered structures. In both short-term emergency response and long-term risk forecasting of disaster-resilient built environment, it is critical to predict spatially accurate distribution of shear-w...

journal_title：Scientific reports

authors： Kotha SR,Cotton F,Bindi D

更新日期：2019-01-30 00:00:00

abstract：:The protein interface is key to understand protein function, providing a vital insight on how proteins interact with each other and with other molecules. Over the years, many computational methods to compare protein structures were developed, yet evaluating interface similarity remains a very difficult task. Here, we ...

journal_title：Scientific reports

authors： Budowski-Tal I,Kolodny R,Mandel-Gutfreund Y

更新日期：2018-05-29 00:00:00

abstract：:Ischemic stroke after radiofrequency catheter ablation (RFCA) in atrial fibrillation (AF) patients is a great challenge for electrophysiologists. We performed this retrospective study to evaluate clinical and echocardiographic characteristics associated with increased risk of ischemic stroke following RFCA. A total of...

journal_title：Scientific reports

authors： Kim YG,Shim J,Oh SK,Lee KN,Choi JI,Kim YH

更新日期：2019-05-07 00:00:00

abstract：:Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared...

journal_title：Scientific reports

authors： Workalemahu T,Grantz KL,Grewal J,Zhang C,Louis GMB,Tekola-Ayele F

更新日期：2018-05-08 00:00:00

abstract：:It is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other membrane-distal. Previous studies had implicated only the membrane-distal subdomain in ligand recognition. Here, we report ...

journal_title：Scientific reports

authors： Machuca MA,Johnson KS,Liu YC,Steer DL,Ottemann KM,Roujeinikova A

更新日期：2017-10-26 00:00:00

abstract：:Flattening of a carbon nanotube results in the formation of a carbon nanoribbon with well-defined edges. In addition, a switching of the flattening direction by about a right angle yields a carbon nanotetrahedron at the switching point in a nanoribbon. Here, we report that chains of carbon nanotetrahedra/nanoribbons a...

journal_title：Scientific reports

authors： Kohno H,Hasegawa T

更新日期：2015-02-12 00:00:00

abstract：:Phospholipase A2-like (PLA2-like) proteins contribute to the development of muscle necrosis in Viperidae snake bites and are not efficiently neutralized by current antivenom treatments. The toxic mechanisms of PLA2-like proteins are devoid of catalytic activity and not yet fully understood, although structural and fun...

journal_title：Scientific reports

authors： Borges RJ,Lemke N,Fontes MRM

更新日期：2017-11-14 00:00:00

abstract：:The static synchronous series compensator (SSSC) can add a series reactance to the transmission line, and when it is fed using auxiliary signals, it can participate in damping inter-area oscillations by changing the series reactance. In this paper, the effect of the SSSC on small-signal stability is investigated. The ...

journal_title：Scientific reports

authors： Naderipour A,Abdul-Malek Z,Ramachandaramurthy VK,Miveh MR,Moghaddam MJH,Guerrero JM

更新日期：2020-07-22 00:00:00

abstract：:In recent years, active targeting strategies by ligand modification have emerged to enhance tumor accumulation of NP, but their clinical application was strictly restricted due to the complex preparation procedures, poor stability and serious toxicity. An effective and clinical translational strategy is required to sa...

journal_title：Scientific reports

authors： Hu G,Cun X,Ruan S,Shi K,Wang Y,Kuang Q,Hu C,Xiao W,He Q,Gao H

更新日期：2016-06-08 00:00:00

abstract：:Even when speakers are not actively doing another task, they can be interfered in their speech planning by concurrent auditory stimuli. In this study, we used picture naming with passive hearing, or active listening, combined to high-density electroencephalographic (EEG) recordings to investigate the locus and origin ...

journal_title：Scientific reports

authors： Fargier R,Laganaro M

更新日期：2019-03-29 00:00:00

abstract：:Lung cancer is one of the leading causes of cancer-related deaths. It is diagnosed mostly at the locally advanced or metastatic stage. Recently, micro RNAs (miRs) and their distribution in circulation have been implicated in physiological and pathological processes. In this study, miR-126 was evaluated in serum, exoso...

journal_title：Scientific reports

authors： Grimolizzi F,Monaco F,Leoni F,Bracci M,Staffolani S,Bersaglieri C,Gaetani S,Valentino M,Amati M,Rubini C,Saccucci F,Neuzil J,Tomasetti M,Santarelli L

更新日期：2017-11-10 00:00:00

abstract：:This study was performed to compare the area of the foveal avascular zone (FAZ-area) obtained by three optical coherence tomography angiography (OCTA) instruments. This was a cross-sectional, non-interventional study of twenty-seven healthy right eyes. The superficial and deep FAZ-area was measured manually with three...

journal_title：Scientific reports

authors： Shiihara H,Sakamoto T,Yamashita T,Kakiuchi N,Otsuka H,Terasaki H,Sonoda S

更新日期：2017-08-29 00:00:00

abstract：:Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is complex and has not been fully understood. C10orf99 was a recently identified human antimicrobial peptide whose mRNA expression is elevated in psoriatic human skin samples. In this study, we investigated the functional roles ...

journal_title：Scientific reports

authors： Chen C,Wu N,Duan Q,Yang H,Wang X,Yang P,Zhang M,Liu J,Liu Z,Shao Y,Zheng Y

更新日期：2018-06-05 00:00:00

abstract：:Humans bargaining over money tend to reject unfair offers, whilst chimpanzees bargaining over primary rewards of food do not show this same motivation to reject. Whether such reciprocal fairness represents a predominantly human motivation has generated considerable recent interest. We induced either moderate or severe...

journal_title：Scientific reports

authors： Wright ND,Hodgson K,Fleming SM,Symmonds M,Guitart-Masip M,Dolan RJ

更新日期：2012-01-01 00:00:00

abstract：:Methylated non-CpGs (mCpH; H means A, C, and T) have emerged as key epigenetic marks in mammalian embryonic stem cells (ESCs) and neurons, regulating cell type-specific functions. In these two cell types, mCpHs show distinct motifs and correlations to transcription that could be a key in understanding the cell type-sp...

journal_title：Scientific reports

authors： Lee JH,Park SJ,Nakai K

更新日期：2017-09-12 00:00:00

abstract：:Whole-room indirect calorimeters (WRICs) have traditionally been used for real-time resting metabolic rate (RMR) measurements, while metabolic rate (MR) during short-interval exercises has commonly been measured by metabolic carts (MCs). This study aims to investigate the feasibility of incorporating short-interval ex...

journal_title：Scientific reports

authors： Chen S,Scott C,Pearce JV,Farrar JS,Evans RK,Celi FS

更新日期：2020-08-31 00:00:00

abstract：:Spinal Muscular Atrophy (SMA) is a monogenic neurodegenerative disorder and the leading genetic cause of infantile mortality. While several functions have been ascribed to the SMN (survival motor neuron) protein, their specific contribution to the disease has yet to be fully elucidated. We hypothesized that some, but ...

journal_title：Scientific reports

authors： Osman EY,Bolding MR,Villalón E,Kaifer KA,Lorson ZC,Tisdale S,Hao Y,Conant GC,Pires JC,Pellizzoni L,Lorson CL

更新日期：2019-07-01 00:00:00

abstract：:Post-glycosylphosphatidylinositol (GPI) attachment to proteins 3, also known as PGAP3 or PERLD1 (PER1-like domain-containing protein 1), participates in the lipid remodeling process of glycosylphosphatidylinositol (GPI) anchor proteins during post-translational modification. Functional defect in PERLD1 was previously ...

journal_title：Scientific reports

authors： Sio YY,Anantharaman R,Lee SQE,Matta SA,Ng YT,Chew FT

更新日期：2020-01-20 00:00:00

abstract：:We present a concept and prototype of a memory element based on current driven magneto-impedance (MI) effect that stores the binary data (0, 1) as the orientation of the magnetization. The magnetization orientation in the surface layer with tilted anisotropy easy axis can be switched controllably between two stable st...

journal_title：Scientific reports

authors： Ipatov M,Zhukova V,Zhukov A,Gonzalez J

更新日期：2016-10-26 00:00:00

abstract：:Emergency granulopoiesis occurs in response to severe microbial infection. However, whether and how other blood components, particularly monocytes/macrophages and their progenitors, including hematopoietic stem/progenitor cells (HSPCs), participate in the process and the underlying molecular mechanisms remain unknown....

journal_title：Scientific reports

authors： Hou Y,Sheng Z,Mao X,Li C,Chen J,Zhang J,Huang H,Ruan H,Luo L,Li L

更新日期：2016-11-11 00:00:00

abstract：:Exo70, a key component of the Exocyst complex, plays important roles in human cancer progression beyond exocytosis. However, the expression of Exo70 and its prognostic value for patients with colon cancer has not been well investigated to date. In this study, we observed that the mRNA and protein levels of Exo70 were ...

journal_title：Scientific reports

authors： Xiao L,Zheng K,Lv X,Hou J,Xu L,Zhao Y,Song F,Fan Y,Cao H,Zhang W,Hong X,Zhan YY,Hu T

更新日期：2017-07-11 00:00:00

abstract：:Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas. Understanding how the properties of the excitation light source and PpIX fluorescence interact with the surgical microscope is critical for effective us...

journal_title：Scientific reports

authors： Belykh E,Miller EJ,Patel AA,Bozkurt B,Yağmurlu K,Robinson TR,Nakaji P,Spetzler RF,Lawton MT,Nelson LY,Seibel EJ,Preul MC

更新日期：2018-08-22 00:00:00

abstract：:Lysophospholipids (LPLs) are known to have potentially important roles in the initiation and maintenance of neuropathic pain in animal models. This study investigated the association between the clinical severity of lumbar spinal stenosis (LSS) and the cerebrospinal fluid (CSF) levels of LPLs, using human samples. We ...

journal_title：Scientific reports

authors： Hayakawa K,Kurano M,Ohya J,Oichi T,Kano K,Nishikawa M,Uranbileg B,Kuwajima K,Sumitani M,Tanaka S,Aoki J,Yatomi Y,Chikuda H

更新日期：2019-06-24 00:00:00

abstract：:Plants adapted to extreme conditions can be at high risk from climate change; arctic-alpine plants, in particular, could "run out of space" as they are out-competed by expansion of woody vegetation. Mountain regions could potentially provide safe sites for arctic-alpine plants in a warmer climate, but empirical eviden...

journal_title：Scientific reports

authors： Clarke CL,Edwards ME,Gielly L,Ehrich D,Hughes PDM,Morozova LM,Haflidason H,Mangerud J,Svendsen JI,Alsos IG

更新日期：2019-12-23 00:00:00

abstract：:Studies of past human-landscape interactions rely upon the integration of archaeological, biological and geological information within their geographical context. However, detecting the often ephemeral traces of human activities at a landscape scale remains difficult with conventional archaeological field survey. Geop...

journal_title：Scientific reports

authors： De Smedt P,Van Meirvenne M,Herremans D,De Reu J,Saey T,Meerschman E,Crombé P,De Clercq W

更新日期：2013-01-01 00:00:00

abstract：:Gravity perception plays a key role in how plants develop and adapt to environmental changes. However, more than a century after the pioneering work of Darwin, little is known on the sensing mechanism. Using a centrifugal device combined with growth kinematics imaging, we show that shoot gravitropic responses to stead...

journal_title：Scientific reports

authors： Chauvet H,Pouliquen O,Forterre Y,Legué V,Moulia B

更新日期：2016-10-14 00:00:00

abstract：:Membrane protein oligomerization mediates a wide range of biological events including signal transduction, viral infection and membrane curvature induction. However, the relative contributions of protein-protein and protein-membrane interactions to protein oligomerization remain poorly understood. Here, we used the Ca...

journal_title：Scientific reports

authors： Tao M,Isas JM,Langen R

更新日期：2020-03-24 00:00:00