Exosomal miR-126 as a circulating biomarker in non-small-cell lung cancer regulating cancer progression.

abstract：:There is relatively little literature on adjuvant radiotherapy after radical nephroureterectomy with bladder cuff excision (RNU) for patients with upper tract urothelial carcinoma (UTUC). This study was designed to determine the efficacy of adjuvant radiotherapy for patients with pT3N0M0 UTUC. We retrospectively revie...

journal_title：Scientific reports

authors： Huang YC,Chang YH,Chiu KH,Shindel AW,Lai CH

更新日期：2016-12-02 00:00:00

abstract：:The mechanisms by which the airborne pathogen Mycobacterium tuberculosis spreads within the lung and leaves its primary niche to colonize other organs, thus inducing extrapulmonary forms of tuberculosis (TB) in humans, remains poorly understood. Herein, we used a transcriptomic approach to investigate the host cell ge...

journal_title：Scientific reports

authors： Polena H,Boudou F,Tilleul S,Dubois-Colas N,Lecointe C,Rakotosamimanana N,Pelizzola M,Andriamandimby SF,Raharimanga V,Charles P,Herrmann JL,Ricciardi-Castagnoli P,Rasolofo V,Gicquel B,Tailleux L

更新日期：2016-09-12 00:00:00

abstract：:This article shows that nanodiamonds can transmigrate through the insect cuticle easily, and the doses used were not hemocytotoxic and did not cause inhibition of cellular and humoral immune responses in larvae, pupae and adults of Tenebrio molitor. The examination of the nanodiamond biodistribution in insect cells de...

journal_title：Scientific reports

authors： Czarniewska E,Nowicki P,Kuczer M,Schroeder G

更新日期：2019-07-17 00:00:00

abstract：:The type II bacterial CRISPR/Cas9 system is rapidly becoming popular for genome-engineering due to its simplicity, flexibility, and high efficiency. Recently, targeted knock-in of a long DNA fragment via homology-independent DNA repair has been achieved in zebrafish using CRISPR/Cas9 system. This raised the possibilit...

journal_title：Scientific reports

authors： Kimura Y,Hisano Y,Kawahara A,Higashijima S

更新日期：2014-10-08 00:00:00

abstract：:We aimed to investigate the efficacy and safety of primary retropupillary iris claw intraocular lens (R-IOL) implantation in patients with complete intraocular lens (IOL) dislocation. In this single-center retrospective case series, we reviewed the medical records of patients who underwent R-IOL implantation surgery w...

journal_title：Scientific reports

authors： Choi EY,Lee CH,Kang HG,Han JY,Byeon SH,Kim SS,Koh HJ,Kim M

更新日期：2021-01-12 00:00:00

abstract：:Polymer-derived silicon oxycarbide (SiCO) presents excellent performance for high temperature and lithium-ion battery applications. Current experiments have provided some information on nano-structure of SiCO, while it is very challenging for experiments to take further insight into the molecular structure and its rel...

journal_title：Scientific reports

authors： Liao N,Zhang M,Zhou H,Xue W

更新日期：2017-02-14 00:00:00

abstract：:Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this stud...

journal_title：Scientific reports

authors： Takeuchi H,Taki Y,Nouchi R,Yokoyama R,Nakagawa S,Iizuka K,Sakaki K,Araki T,Nozawa T,Ikeda S,Yokota S,Hanawa S,Magistro D,Kotozaki Y,Sasaki Y,Dos S Kawata KH,Kawashima R

更新日期：2020-07-28 00:00:00

abstract：:A novel sesquiterpene methylcyclopentenedione, penicilliumin B (1), was obtained from a deep sea-derived fungus Penicillium sp. F00120, together with three known sesquiterpene cyclohexenones (2-4). Penicilliumin B (1), presenting the first example with the sesquiterpene cyclopentenedione skeleton as natural products, ...

journal_title：Scientific reports

authors： Lin X,Wu Q,Yu Y,Liang Z,Liu Y,Zhou L,Tang L,Zhou X

更新日期：2017-09-07 00:00:00

abstract：:Previous studies on the associations between dietary antioxidant vitamins and the risk of cervical cancer remain inconsistent, and little evidence is available for serum antioxidant vitamins, which provide more accurate measurements of these nutrients. We conducted a case-control study of 458 incident cases with invas...

journal_title：Scientific reports

authors： Guo L,Zhu H,Lin C,Che J,Tian X,Han S,Zhao H,Zhu Y,Mao D

更新日期：2015-09-04 00:00:00

abstract：:The physiological importance of CD151 tetraspanin is known from somatic cells and its outside-in signalling through integrins was described. In male germ cells, two tetraspanins, CD9 and CD81, are involved in sperm-egg membrane fusion, and similarly to integrins, they occupy characteristic regions. We report here on a...

journal_title：Scientific reports

authors： Jankovicova J,Frolikova M,Palenikova V,Valaskova E,Cerny J,Secova P,Bartokova M,Horovska L,Manaskova-Postlerova P,Antalikova J,Komrskova K

更新日期：2020-03-09 00:00:00

abstract：:Double-strand breaks (DSBs) are the most lethal DNA damages induced by ionising radiation (IR) and their efficient repair is crucial to limit genomic instability. The cellular DSB response after low IR doses is of particular interest but its examination requires the analysis of high cell numbers. Here, we present an a...

journal_title：Scientific reports

authors： Lengert N,Mirsch J,Weimer RN,Schumann E,Haub P,Drossel B,Löbrich M

更新日期：2018-11-23 00:00:00

abstract：:Electrode materials which exhibit high conductivities in both oxidising and reducing atmospheres are in high demand for solid oxide fuel cells (SOFCs) and solid oxide electrolytic cells (SOECs). In this paper, we investigated Cu-doped SrFe0.9Nb0.1O3-δ finding that the primitive perovskite oxide SrFe0.8Cu0.1Nb0.1O3-δ (...

journal_title：Scientific reports

authors： Lan R,Cowin PI,Sengodan S,Tao S

更新日期：2016-08-22 00:00:00

abstract：:Most traits of agricultural importance are quantitative traits controlled by numerous genes. However, it remains unclear about the molecular mechanisms underpinning quantitative traits. Here, we report the molecular characteristics of the genes controlling three quantitative traits randomly selected from three diverse...

journal_title：Scientific reports

authors： Zhang M,Liu YH,Xu W,Smith CW,Murray SC,Zhang HB

更新日期：2020-06-22 00:00:00

abstract：:The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossove...

journal_title：Scientific reports

authors： van der Klaauw AA,Ziauddeen H,Keogh JM,Henning E,Dachi S,Fletcher PC,Farooqi IS

更新日期：2017-06-27 00:00:00

abstract：:The effect of AM fungi spatial distribution on individual plant development may determine the dynamics of the whole plant community. We investigated whether clonal plants display, like for other resources, a foraging or a specialization response, to adapt to the distribution of AM fungi. Two separate experiments were ...

journal_title：Scientific reports

authors： Vannier N,Bittebiere AK,Vandenkoornhuyse P,Mony C

更新日期：2016-11-25 00:00:00

abstract：:In this work we study the entropy of the Gibbs state corresponding to a graph. The Gibbs state is obtained from the Laplacian, normalized Laplacian or adjacency matrices associated with a graph. We calculated the entropy of the Gibbs state for a few classes of graphs and studied their behavior with changing graph orde...

journal_title：Scientific reports

authors： Glos A,Krawiec A,Pawela Ł

更新日期：2021-01-11 00:00:00

abstract：:Verteporfin (VP), a light-activated drug used in photodynamic therapy for the treatment of choroidal neovascular membranes, has also been shown to be an effective inhibitor of malignant cells. Recently, studies have demonstrated that, even without photo-activation, VP may still inhibit certain tumor cell lines, includ...

journal_title：Scientific reports

authors： Al-Moujahed A,Brodowska K,Stryjewski TP,Efstathiou NE,Vasilikos I,Cichy J,Miller JW,Gragoudas E,Vavvas DG

更新日期：2017-08-08 00:00:00

abstract：:The accurate staging of liver fibrosis is of paramount importance to determine the state of disease progression, therapy responses, and to optimize disease treatment strategies. Non-linear optical microscopy techniques such as two-photon excitation fluorescence (TPEF) and second harmonic generation (SHG) can image the...

journal_title：Scientific reports

authors： Stanciu SG,Xu S,Peng Q,Yan J,Stanciu GA,Welsch RE,So PT,Csucs G,Yu H

更新日期：2014-04-10 00:00:00

abstract：:Across boundary currents, zooplankton are subject to strong oceanographic gradients and hence strong selective pressures. How such gradients interact with the speciation process of pelagic organisms is still poorly understood in the open ocean realm. Here we report on genetic diversity within the pelagic copepod Pleur...

journal_title：Scientific reports

authors： González CE,Goetze E,Escribano R,Ulloa O,Victoriano P

更新日期：2020-01-24 00:00:00

abstract：:Given the prevalence of poor adherence to therapy and the biases of self-reporting across healthcare, we hypothesized that an engaging, personalized therapy may improve adherence and treatment outcomes in the home. We tested this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for whic...

journal_title：Scientific reports

authors： Xiao S,Gaier ED,Mazow ML,Stout AU,Travers DA,Angjeli E,Wu HC,Binenbaum G,Hunter DG

更新日期：2020-05-20 00:00:00

abstract：:We explored the potential relevance of aqueous lysophosphatidic acid (LPA) and autotaxin (ATX) levels on postoperative outcomes of trabeculectomy, and the effects of ATX on fibrotic response in cultured human conjunctiva fibroblast (HCF) cells. We enrolled 70 glaucomatous eyes which underwent trabeculectomy, and quant...

journal_title：Scientific reports

authors： Igarashi N,Honjo M,Kurano M,Yatomi Y,Igarashi K,Kano K,Aoki J,Aihara M

更新日期：2018-07-27 00:00:00

abstract：:Chronic inflammation can be a major driver of the failure of a variety of organs, including chronic kidney disease (CKD). The NLR family pyrin domain-containing 3 (NLRP3) inflammasome has been shown to play a pivotal role in inflammation in a mouse kidney disease model. Nuclear factor erythroid 2-related factor 2 (Nrf...

journal_title：Scientific reports

authors： Sogawa Y,Nagasu H,Iwase S,Ihoriya C,Itano S,Uchida A,Kidokoro K,Taniguchi S,Takahashi M,Satoh M,Sasaki T,Suzuki T,Yamamoto M,Horng T,Kashihara N

更新日期：2017-08-18 00:00:00

abstract：:Here we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load of C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log10CFU after two weeks of treatment via aerosol d...

journal_title：Scientific reports

authors： Upadhyay R,Sanchez-Hidalgo A,Wilusz CJ,Lenaerts AJ,Arab J,Yeh J,Stefanisko K,Tarasova NI,Gonzalez-Juarrero M

更新日期：2018-11-09 00:00:00

abstract：:Concerns related to pulmonary toxicity and non-specificity of nanoparticles have limited their clinical applications for aerosol delivery of chemotherapeutics in lung cancer. We hypothesized that pulmonary surfactant mimetic nanoparticles that offer pH responsive release specifically in tumor may be a possible solutio...

journal_title：Scientific reports

authors： Joshi N,Shirsath N,Singh A,Joshi KS,Banerjee R

更新日期：2014-11-18 00:00:00

abstract：:Studies of personality have suggested that dissimilarities in ability to cope with stressful situations results in differing tendency to develop addictive behaviors. The present study used selectively bred stress-resilient, socially-dominant (Dom) and stress-vulnerable, socially-submissive (Sub) mice to investigate th...

journal_title：Scientific reports

authors： Yanovich C,Kirby ML,Michaelevski I,Yadid G,Pinhasov A

更新日期：2018-01-29 00:00:00

abstract：:Increased interest in poly(ethylene terephthalate) (PET)-degrading enzymes (PETases) have generated efforts to find mutants with improved catalytic activity and thermostability. Here, we present a simple and fast method to determine relative enzyme kinetics through bulk absorbance measurements of released products ove...

journal_title：Scientific reports

authors： Zhong-Johnson EZL,Voigt CA,Sinskey AJ

更新日期：2021-01-13 00:00:00

abstract：:Modeling the dynamic nature of protein-ligand binding with atomistic simulations is one of the main challenges in computational biophysics, with important implications in the drug design process. Although in the past few years hardware and software advances have significantly revamped the use of molecular simulations,...

journal_title：Scientific reports

authors： Lecina D,Gilabert JF,Guallar V

更新日期：2017-08-16 00:00:00

abstract：:Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of AMD to include another extracellular deposit, reticular pseudodruse...

journal_title：Scientific reports

authors： Mishra Z,Ganegoda A,Selicha J,Wang Z,Sadda SR,Hu Z

更新日期：2020-06-12 00:00:00

abstract：:Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard treatment for metastatic castration resistant prostate cancer (mCRPC), but it inevitably leads to the development of resistance. Since the introduction of highly efficient AR signalling inhibitors, approximately 20% of mCRPC pat...

journal_title：Scientific reports

authors： Handle F,Prekovic S,Helsen C,Van den Broeck T,Smeets E,Moris L,Eerlings R,Kharraz SE,Urbanucci A,Mills IG,Joniau S,Attard G,Claessens F

更新日期：2019-09-24 00:00:00

abstract：:During infection with non-enveloped viruses, antibodies stimulate immunity from inside cells by activating the cytosolic Fc receptor TRIM21. This intracellular humoral response relies on opsonized viral particles reaching the cytosol intact but the antigenic and kinetic constraints involved are unknown. We have solved...

journal_title：Scientific reports

authors： Bottermann M,Lode HE,Watkinson RE,Foss S,Sandlie I,Andersen JT,James LC

更新日期：2016-11-24 00:00:00