Abstract：
:There is relatively little literature on adjuvant radiotherapy after radical nephroureterectomy with bladder cuff excision (RNU) for patients with upper tract urothelial carcinoma (UTUC). This study was designed to determine the efficacy of adjuvant radiotherapy for patients with pT3N0M0 UTUC. We retrospectively reviewed 198 patients treated with RNU between December 2001 and January 2015. Postoperative radiotherapy was administered in 40 (20.2%) of patients. Patients who received radiotherapy were younger than those that did not (65.2 vs. 70.5 years, p = 0.023). With median follow up of 29.1 months, Kaplan-Meier analysis with the log-rank test demonstrated no significant differences between those omitting vs receiving adjuvant radiotherapy in regards to 2-year rates of overall survival (72.0% vs. 73.4%, p = 0.979), cancer-specific survival (73.2% vs. 75.3%, p = 0.844), and recurrence-free survival (61.2% vs. 66.3%, p = 0.742). However, in multivariable analysis with Cox regression, young age, absence of chronic kidney disease, negative lymphovascular invasion, negative surgical margin, and adjuvant chemotherapy were also associated with better cancer-specific survival. In conclusion, adjuvant radiotherapy did not offer any significant benefit in terms of overall, cancer-specific, and recurrence-free survivals in patients with pT3N0M0 UTUC after RNU. More effective systemic adjuvant chemotherapy is necessary to improve the outcome of these patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Huang YC,Chang YH,Chiu KH,Shindel AW,Lai CHdoi
10.1038/srep38175subject
Has Abstractpub_date
2016-12-02 00:00:00pages
38175issn
2045-2322pii
srep38175journal_volume
6pub_type
杂志文章abstract：:Terahertz pulse time-domain holography is the ultimate technique allowing the evaluating a propagation of pulse broadband terahertz wavefronts and analyze their spatial, temporal and spectral evolution. We have numerically analyzed pulsed broadband terahertz Gauss-Bessel beam's both spatio-temporal and spatio-spectral...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19830-z
更新日期：2018-01-23 00:00:00
abstract：:III-nitride materials have been linked with a vast number of exciting applications from power electronics to solar cells. Herein, polycrystalline InN, GaN and systematically controlled InxGa1-xN composite thin films are fabricated on FTO glass by a facile, low-cost and scalable aerosol assisted chemical vapor depositi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38882-3
更新日期：2019-02-19 00:00:00
abstract：:Groundwater aquifers are an essential source of drinking water, and must be protected against contamination. Phosphogypsum stacks originating from the processing of phosphate rock contain small amounts of radionuclides, such as 226Ra. In September 2016, a sinkhole located beneath a phosphogypsum stack collapsed under ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29541-0
更新日期：2018-07-30 00:00:00
abstract：:Cutaneous allodynia (CA) is a pain in response to non-nociceptive stimulation and a marker of central sensitisation. Probable migraine (PM) is a migraine subtype that fulfils all but one criterion of migraine. Headache intensity and the disability of individuals with PM are similar or lower than individuals with migra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82080-z
更新日期：2021-01-28 00:00:00
abstract：:The coherent state preparation and control of single quantum systems is an important prerequisite for the implementation of functional quantum devices. Prominent examples for such systems are semiconductor quantum dots, which exhibit a fine structure split single exciton state and a V-type three level structure, given...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10313
更新日期：2015-05-22 00:00:00
abstract：:A strain glass state was found to be located between B2-B19' (cubic to monoclinic) phase transition and B2-R (cubic to rhombohedral) phase transition in Ti49Ni51 alloys after aging process. After a short time aging, strong strain glass transition was observed, because the size of the precipitates is small, which means...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13377
更新日期：2015-08-26 00:00:00
abstract：:Infantile hemangiomas are the most common infantile benign vascular tumor. While most infantile hemangiomas proliferate then involute, some may persist and require treatment for reasons including risk of disfigurement or functional impairment. Treatments currently include observation, pharmacological therapy, laser, c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21670
更新日期：2016-02-15 00:00:00
abstract：:The microtubule cytoskeleton is composed of α-tubulin and β-tubulin heterodimers, and it serves to regulate the shape, motility, and division of a cell. Post-translational modifications including acetylation are closely associated with the functional aspects of the microtubule, involving in a number of pathological di...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27775
更新日期：2016-06-08 00:00:00
abstract：:We aimed to establish the collective influence of four lifestyle practices (physical activity, diet, smoking and alcohol consumption) on the prevalence and incidence of AMD. At baseline, 2428 participants aged 49+ with complete lifestyle and AMD data were examined, and of these, 1903 participants were re-examined 15 y...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04697-3
更新日期：2017-06-28 00:00:00
abstract：:Lack of effective anti-metastatic drugs creates a major hurdle for metastatic lung cancer therapy. For successful lung cancer treatment, there is a strong need of newer therapeutics with metastasis-inhibitory potential. In the present study, we determined the anti-metastatic and anti-angiogenic potential of a natural ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21860
更新日期：2016-02-24 00:00:00
abstract：:From 2010 to 2012, large outbreaks of EV-A71-related- hand foot and mouth disease (HFMD) occurred annually in China. Some cases had neurological complications and were closely associated with fatal cardiopulmonary collapse, but not all children with central nervous system (CNS) involvement demonstrated a poor prognosi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23444
更新日期：2016-03-22 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-37133-1
更新日期：2018-12-14 00:00:00
abstract：:The pathophysiology of stress cardiomyopathy (SCM), also known as takotsubo syndrome, is poorly understood. SCM usually occurs sporadically, often in association with a stressful event, but clusters of cases are reported after major natural disasters. There is some evidence that this is a familial condition. We have e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25827-5
更新日期：2018-05-15 00:00:00
abstract：:Atherosclerotic arteries exhibit characteristic constrictions and substantial deviations from cylindrical shape. Therefore, determining the artery's cross-section along the centerline is challenging, although high-resolution isotropic three-dimensional data are available. Herein, we apply high-resolution computed tomo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50711-1
更新日期：2019-10-04 00:00:00
abstract：:Implantable cardioverter-defibrillators (ICD) are meant to fight life-threatening ventricular arrhythmias and reduce overall mortality. Ironically, life-saving shocks themselves have been shown to be independently associated with an increased mortality. We sought to identify myocardial changes at the protein level imm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77346-x
更新日期：2020-11-20 00:00:00
abstract：:Drug-resistant tuberculosis (TB) is a serious global problem, and pathogen factors involved in the transmission of isoniazid (INH)-resistant TB have not been fully investigated. We performed whole genome sequencing of 332 clinical Mycobacterium tuberculosis (Mtb) isolates collected from patients newly diagnosed with s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51812-7
更新日期：2019-10-25 00:00:00
abstract：:Most Group I Clostridium botulinum strains harbor botulinum neurotoxin (bont) genes on their chromosome, while some carry these genes (including bont/a, bont/b, and bont/f) on large plasmids. Prior work in our laboratory demonstrated that Group I BoNT plasmids were mobilized to C. botulinum recipient strains containin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21342-9
更新日期：2018-02-15 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-74322-3
更新日期：2020-10-06 00:00:00
abstract：:Podocyte injury has been suggested to induce phenotypic alteration of glomerular podocytes and accelerate the detachment of podocytes from the glomeruli resulting in podocyturia. However, it is not clear whether podocyte phenotypic alteration occurs in the urine of women with preeclampsia (PE). Seventy-seven and 116 p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24258
更新日期：2016-04-07 00:00:00
abstract：:Hedgehog interacting protein (Hhip) is essential for islet formation and beta-cell proliferation during pancreatic development; abnormally elevated Hhip expression has been linked to human pancreatitis. Here, we investigate the role of Hhip in modulating insulin secretion in adult Hhip mice (Hhip +/- vs. Hhip+/+) fed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47633-3
更新日期：2019-08-01 00:00:00
abstract：:Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25706-z
更新日期：2018-05-08 00:00:00
abstract：:Protective antigen (PA) of Bacillus anthracis is being considered as a vaccine candidate against anthrax and its production has been explored in several heterologous host systems. Since the systems tested introduced adverse issues such as inclusion body formation and endotoxin contamination, the production from B. ant...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34196-y
更新日期：2018-10-31 00:00:00
abstract：:Early-life stress in adolescence has a long-lasting influence on brain function in adulthood, and it is mostly recognized as a predisposing factor for mental illnesses, such as anxiety and posttraumatic stress disorder. Previous studies also indicated that adolescent predictable chronic mild stress (PCMS) in early lif...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08017-7
更新日期：2017-08-10 00:00:00
abstract：:Aluminum (Al) toxicity is a serious problem for rice crop productivity in acidic soils worldwide. The present work was conducted to look out for the alteration in ROS homeostasis; metabolic fingerprint; and morphology in two contrasting Indica rice cultivars of North East India (NE India) to Al toxicity. Al stress led...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45158-3
更新日期：2019-06-18 00:00:00
abstract：:Millimeter wave (MMW)-induced heating represents a promising alternative for non-invasive hyperthermia of superficial skin cancer, such as melanoma. Pulsed MMW-induced heating of tumors allows for reaching high peak temperatures without overheating surrounding tissues. Herein, for the first time, we evaluate apoptotic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51731-7
更新日期：2019-10-24 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-61263-0
更新日期：2020-03-11 00:00:00
abstract：:Anammox is a cost-effective process to treat nitrogenous wastewater. In this work, excitation-emission matrix (EEM) fluorescence spectroscopy was used to characterize the intracellular and extracellular substances of anammox sludge during reactor operation of 276 days. Four main fluorophores were identified from the i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39289
更新日期：2017-01-16 00:00:00
abstract：:Soil microorganisms play a crucial role in the biogeochemical cycling of nutrient elements and maintaining soil health. We aimed to investigate the response of bacteria communities to organic farming over different crops (rice, tea and vegetable) along the middle and lower reaches of the Yangtze River of China. Compar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35046
更新日期：2016-10-11 00:00:00
abstract：:Here we report a method for improving the magnetic field sensitivity of an ensemble of Nitrogen-Vacancy (NV) centres in 12C-enriched diamond aligned along the [111] crystal axis. The preferentially-aligned NV centres are fabricated by a Plasma Enhanced Chemical Vapour Deposition (PECVD) process and their concentration...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42314-7
更新日期：2019-04-08 00:00:00
abstract：:A p-i-n junction diode constructed by the locally doped network of single-walled carbon nanotubes (SWNTs) was investigated. In this diode, the two opposite ends of the SWNT-network channel were selectively doped by triethyloxonium hexachloroantimonate (OA) and polyethylenimine (PEI) to obtain the air-stable p- and n-t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23319
更新日期：2016-03-21 00:00:00
