Reproducibility and differences in area of foveal avascular zone measured by three different optical coherence tomographic angiography instruments.

Abstract:

:This study was performed to compare the area of the foveal avascular zone (FAZ-area) obtained by three optical coherence tomography angiography (OCTA) instruments. This was a cross-sectional, non-interventional study of twenty-seven healthy right eyes. The superficial and deep FAZ-area was measured manually with three OCTA instruments: Triton (Topcon), RS3000 (Nidek), and CIRRUS (Zeiss). The intra-rater, inter-rater, and inter-instrument correlation coefficients (CC) were assessed. The intra-rater and inter-rater CC were significantly high for the superficial and deep FAZ-areas (P < 0.001). The inter-instrument CC (95% confidence interval) for the superficial FAZ-area was 0.920 (0.803-0.965) for Triton vs RS3000, 0.899 (0.575-0.965) for RS3000 vs CIRRUS, and was 0.963 (0.913-0.983) for CIRRUS vs Triton (P < 0.001). For the deep FAZ-area, the inter-instrument CC was 0.813 (0.633-0.910) for Triton vs RS3000, 0.694 (0.369-0.857) for RS3000 vs CIRRUS, and 0.679 (0.153-0.872) for CIRRUS vs Triton (P < 0.001). The superficial FAZ-area (mm2) was 0.264 ± 0.071 with Triton, 0.278 ± 0.072 with RS3000 and 0.257 ± 0.066 with CIRRUS. For deep FAZ-area, it was 0.617 ± 0.175 with Triton, 0.646 ± 0.178 with RS3000 and 0.719 ± 0.175 with CIRRUS. The FAZ-area from these instruments was clinically interchangeable. However, the absolute values of FAZ-area are significantly different among them. These differences must be considered in comparing the FAZ-areas from different OCTA instruments.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Shiihara H,Sakamoto T,Yamashita T,Kakiuchi N,Otsuka H,Terasaki H,Sonoda S

doi

10.1038/s41598-017-09255-5

subject

Has Abstract

pub_date

2017-08-29 00:00:00

pages

9853

issue

1

issn

2045-2322

pii

10.1038/s41598-017-09255-5

journal_volume

7

pub_type

杂志文章
  • Accumulation of minor alleles and risk prediction in schizophrenia.

    abstract::Schizophrenia is a common neuropsychiatric disorder with a lifetime risk of 1%. Accumulation of common polygenic variations has been found to be an important risk factor. Recent studies showed a role for the enrichment of minor alleles (MAs) of SNPs in complex diseases such as Parkinson's disease. Here we similarly st...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12104-0

    authors: He P,Lei X,Yuan D,Zhu Z,Huang S

    更新日期:2017-09-15 00:00:00

  • Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region.

    abstract::The repressive activity of ancestral histone-like proteins helps integrate transcription of foreign genes with discrepant AT content into existing regulatory networks. Our investigations indicate that the AT-rich discriminator region located between the -10 promoter element and the transcription start site of the regu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27780-9

    authors: Tapscott T,Kim JS,Crawford MA,Fitzsimmons L,Liu L,Jones-Carson J,Vázquez-Torres A

    更新日期:2018-06-21 00:00:00

  • Nano silica diaphragm in-fiber cavity for gas pressure measurement.

    abstract::We demonstrate an ultrahigh-sensitivity gas pressure sensor based on the Fabry-Perot interferometer employing a fiber-tip diaphragm-sealed cavity. The cavity is comprised of a silica capillary and ultrathin silica diaphragm with a thickness of 170 nm, with represents the thinnest silica diaphragm fabricated thus far b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-00931-0

    authors: Liu S,Wang Y,Liao C,Wang Y,He J,Fu C,Yang K,Bai Z,Zhang F

    更新日期:2017-04-11 00:00:00

  • Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen species.

    abstract::The AMP-activated kinase (AMPK) is a major energy sensor metabolic enzyme that is activated early during T cell immune responses but its role in the generation of effector T cells is still controversial. Using both in vitro and in vivo models of T cell proliferation, we show herein that AMPK is dispensable for early T...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78715-2

    authors: Lepez A,Pirnay T,Denanglaire S,Perez-Morga D,Vermeersch M,Leo O,Andris F

    更新日期:2020-12-10 00:00:00

  • Monitoring indices of bone inflammatory activity of the jaw using SPECT bone scintigraphy: a study of ARONJ patients.

    abstract::Development of quantitative analysis software has enabled application of several standardised uptake values (SUV) for bone analysis in single photon emission computed tomography (SPECT). The present retrospective study aimed to develop a reliable method of monitoring bone inflammatory activity in antiresorptive agent-...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68428-x

    authors: Hata H,Kitao T,Sato J,Asaka T,Ohga N,Imamachi K,Hirata K,Shiga T,Yamazaki Y,Kitagawa Y

    更新日期:2020-07-09 00:00:00

  • A quantitative analysis of 3D-cell distribution in regenerating muscle-skeletal system with synchrotron X-ray computed microtomography.

    abstract::One of the greatest enigmas of modern biology is how the geometry of muscular and skeletal structures are created and how their development is controlled during growth and regeneration. Scaling and shaping of vertebrate muscles and skeletal elements has always been enigmatic and required an advanced technical level in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32459-2

    authors: Tesařová M,Mancini L,Simon A,Adameyko I,Kaucká M,Elewa A,Lanzafame G,Zhang Y,Kalasová D,Szarowská B,Zikmund T,Novotná M,Kaiser J

    更新日期:2018-09-20 00:00:00

  • Seasonal consumption of polyphenol-rich fruits affects the hypothalamic leptin signaling system in a photoperiod-dependent mode.

    abstract::Leptin has a central role in the maintenance of energy homeostasis, and its sensitivity is influenced by both the photoperiod and dietary polyphenols. The aim of this study was to investigate the effect of seasonal consumption of polyphenol-rich fruits on the hypothalamic leptin signaling system in non-obese and obese...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31855-y

    authors: Ibars M,Aragonès G,Ardid-Ruiz A,Gibert-Ramos A,Arola-Arnal A,Suárez M,Bladé C

    更新日期:2018-09-11 00:00:00

  • Ultra-intense laser interaction with nanostructured near-critical plasmas.

    abstract::Near-critical plasmas irradiated at ultra-high laser intensities (I > 1018W/cm2) allow to improve the performances of laser-driven particle and radiation sources and to explore scenarios of great astrophysical interest. Near-critical plasmas with controlled properties can be obtained with nanostructured low-density ma...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22147-6

    authors: Fedeli L,Formenti A,Cialfi L,Pazzaglia A,Passoni M

    更新日期:2018-03-01 00:00:00

  • C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization.

    abstract::Y14 (RBM8A) is an RNA recognition motif-containing protein that forms heterodimers with MAGOH and serves as a core factor of the RNA surveillance machinery for the exon junction complex (EJC). The role of the Y14 C-terminal serine/arginine (RS) repeat-containing region, which has been reported to undergo modifications...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18765-1

    authors: Tatsuno T,Ishigaki Y

    更新日期:2018-01-12 00:00:00

  • Modification of distinct ion channels differentially modulates Ca2+ dynamics in primary cultured rat ventricular cardiomyocytes.

    abstract::Primary cultured cardiomyocytes show spontaneous Ca2+ oscillations (SCOs) which not only govern contractile events, but undergo derangements that promote arrhythmogenesis through Ca2+ -dependent mechanism. We systematically examined influence on SCOs of an array of ion channel modifiers by recording intracellular Ca2+...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40952

    authors: Li X,Shen L,Zhao F,Zou X,He Y,Zhang F,Zhang C,Yu B,Cao Z

    更新日期:2017-01-19 00:00:00

  • Strain induced piezoelectric effect in black phosphorus and MoS2 van der Waals heterostructure.

    abstract::The structural, electronic, transport and optical properties of black phosphorus/MoS2 (BP/MoS2) van der Waals (vdw) heterostructure are investigated by using first principles calculations. The band gap of BP/MoS2 bilayer decreases with the applied normal compressive strain and a semiconductor-to-metal transition is ob...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16448

    authors: Huang L,Li Y,Wei Z,Li J

    更新日期:2015-11-10 00:00:00

  • Effects of sagging breasts and other risk factors associated with mastalgia: a case-control study.

    abstract::The aim of this study is to compare patients with and without mastalgia and to analyze the factors affecting mastalgia and its severity. The patient's age, height, weight, educational status, marital status, and occupation were recorded in all subjects. In addition, the women were asked about the presence of any risk ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-82099-2

    authors: Çomçalı B,Kocaoz S,Özdemir BA,Parlak Ö,Korukluoğlu B

    更新日期:2021-01-29 00:00:00

  • Enhancement of guinea pig cytomegalovirus infection by two endogenously expressed components of the pentameric glycoprotein complex in epithelial cells.

    abstract::A better understanding of the mechanisms underlying cell tropisms and the efficiency of viral infection is critical for the development of vaccines and antiviral drugs for viral diseases. In this study, we worked on the entry mechanisms of guinea pig cytomegalovirus and found that endogenous expression of a combinatio...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65545-5

    authors: Okumura M,Matsuura-Miura M,Makino R,Miura T,Noguchi K,Majima R,Koshizuka T,Inoue N

    更新日期:2020-05-22 00:00:00

  • Scaffold-Hopping from Synthetic Drugs by Holistic Molecular Representation.

    abstract::The discovery of novel ligand chemotypes allows to explore uncharted regions in chemical space, thereby potentially improving synthetic accessibility, potency, and the drug-likeness of molecules. Here, we demonstrate the scaffold-hopping ability of the new Weighted Holistic Atom Localization and Entity Shape (WHALES) ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34677-0

    authors: Grisoni F,Merk D,Byrne R,Schneider G

    更新日期:2018-11-07 00:00:00

  • Is coaching experience associated with effective use of timeouts in basketball?

    abstract::Experience is an important asset in almost any professional activity. In basketball, there is believed to be a positive association between coaching experience and effective use of team timeouts. Here, we analyze both the extent to which a team's change in scoring margin per possession after timeouts deviate from the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00676

    authors: Saavedra S,Mukherjee S,Bagrow JP

    更新日期:2012-01-01 00:00:00

  • MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status.

    abstract::Cell competition is a cell-cell interaction by which a cell compares its fitness to that of neighboring cells. The cell with the relatively lower fitness level is the "loser" and actively eliminated, while the cell with the relatively higher fitness level is the "winner" and survives. Recent studies have shown that ce...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28383

    authors: Chiba T,Ishihara E,Miyamura N,Narumi R,Kajita M,Fujita Y,Suzuki A,Ogawa Y,Nishina H

    更新日期:2016-06-21 00:00:00

  • Nicotine absorption from electronic cigarette use: comparison between experienced consumers (vapers) and naïve users (smokers).

    abstract::Electronic cigarettes (ECs) are nicotine delivery devices that are proposed as tobacco harm reduction products to smokers. Nicotine delivery from ECs is potentially important in their efficacy as smoking substitutes. Herein, nicotine delivery from using a new-generation EC device (variable-wattage, set at 9 W) was eva...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11269

    authors: Farsalinos KE,Spyrou A,Stefopoulos C,Tsimopoulou K,Kourkoveli P,Tsiapras D,Kyrzopoulos S,Poulas K,Voudris V

    更新日期:2015-06-17 00:00:00

  • Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats.

    abstract::Schiff-based complexes as a source of cancer chemotherapeutic compounds have been subjected to the variety of anticancer studies. The in-vitro analysis confirmed the CdCl2(C14H21N3O2) complex possess cytotoxicity and apoptosis induction properties in colon cancer cells, so lead to investigate the inhibitory efficiency...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12379

    authors: Hajrezaie M,Shams K,Moghadamtousi SZ,Karimian H,Hassandarvish P,Emtyazjoo M,Zahedifard M,Majid NA,Mohd Ali H,Abdulla MA

    更新日期:2015-07-23 00:00:00

  • Electromagnetic surface waves supported by a resistive metasurface-covered metamaterial structure.

    abstract::This study examines the analytical and numerical solution of electromagnetic surface waves supported by a resistive metasurface-covered grounded metamaterial structure. To simulate the metamaterial, the Kramers-Kronig relation based on the causality principle is used, while the modeling of the resistive metasurface ha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72396-7

    authors: Yaqoob MZ,Ghaffar A,Alkanhal MAS,Naz MY,Alqahtani AH,Khan Y

    更新日期:2020-09-23 00:00:00

  • Spin-dependent manipulating of vector beams by tailoring polarization.

    abstract::We examine the spin-dependent manipulating of vector beams by tailoring the inhomogeneous polarization. The spin-dependent manipulating is attributed to the spin-dependent phase gradient in vector beams, which can be regarded as the intrinsic feature of inhomogeneous polarization. The desired polarization can be obtai...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34276

    authors: Zhou J,Zhang W,Liu Y,Ke Y,Liu Y,Luo H,Wen S

    更新日期:2016-09-28 00:00:00

  • Study on regeneration of waste powder activated carbon through pyrolysis and its adsorption capacity of phosphorus.

    abstract::The regeneration of WPAC through pyrolysis and its adsorption capacity of phosphorus were studied. The optimum conditions for WPAC regeneration were 650 °C and 2 h which resulted in a recovery of BET surface and total pore volume with a value of 1161.4 m2/g and 1.2176 m3/g. WPAC had a maximum PO43--P adsorption capaci...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-19131-x

    authors: Li Y,Jin H,Liu W,Su H,Lu Y,Li J

    更新日期:2018-01-15 00:00:00

  • Moral judgment modulates neural responses to the perception of other's pain: an ERP study.

    abstract::Morality and empathy are both crucial in building human society. Yet the relationship between them has been merely explored. The present study revealed how the morality influenced empathy for pain by comparing the ERPs elicited by pictures showing the targets' in pain primed by different moral information about the ta...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20851

    authors: Cui F,Ma N,Luo YJ

    更新日期:2016-02-11 00:00:00

  • Mitochondrial Genomes of Two Bombycoidea Insects and Implications for Their Phylogeny.

    abstract::The mitochondrial genome (mt genome) provides important information for understanding molecular evolution and phylogenetics. As such, the two complete mt genomes of Ampelophaga rubiginosa and Rondotia menciana were sequenced and annotated. The two circular genomes of A. rubiginosa and R. menciana are 15,282 and 15,636...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06930-5

    authors: Xin ZZ,Yu Liu,Zhu XY,Wang Y,Zhang HB,Zhang DZ,Zhou CL,Tang BP,Liu QN

    更新日期:2017-07-26 00:00:00

  • Cytoplasmic Transport Machinery of the SPF27 Homologue Num1 in Ustilago maydis.

    abstract::In the phytopathogenic basidiomycete Ustilago maydis, the Num1 protein has a pivotal function in hyphal morphogenesis. Num1 functions as a core component of the spliceosome-associated Prp19/CDC5 complex (NTC). The interaction of Num1 with the kinesin motor Kin1 suggests a connection between a component of the splicing...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21628-y

    authors: Zhou L,Obhof T,Schneider K,Feldbrügge M,Nienhaus GU,Kämper J

    更新日期:2018-02-26 00:00:00

  • Magma transport in sheet intrusions of the Alnö carbonatite complex, central Sweden.

    abstract::Magma transport through the Earth's crust occurs dominantly via sheet intrusions, such as dykes and cone-sheets, and is fundamental to crustal evolution, volcanic eruptions and geochemical element cycling. However, reliable methods to reconstruct flow direction in solidified sheet intrusions have proved elusive. Aniso...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27635

    authors: Andersson M,Almqvist BS,Burchardt S,Troll VR,Malehmir A,Snowball I,Kübler L

    更新日期:2016-06-10 00:00:00

  • Landscape of the spliced leader trans-splicing mechanism in Schistosoma mansoni.

    abstract::Spliced leader dependent trans-splicing (SLTS) has been described as an important RNA regulatory process that occurs in different organisms, including the trematode Schistosoma mansoni. We identified more than seven thousand putative SLTS sites in the parasite, comprising genes with a wide spectrum of functional class...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22093-3

    authors: Boroni M,Sammeth M,Gava SG,Jorge NAN,Macedo AM,Machado CR,Mourão MM,Franco GR

    更新日期:2018-03-01 00:00:00

  • Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis.

    abstract::Transforming growth factor β-1 (TGFβ-1)-induced phosphorylation of transcription factors Smad2 and Smad3 plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the molecular regulation of Smad2/Smad3 proteins stability remains a mystery. Here, we show that ubiquitin carboxyl-terminal...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33116

    authors: Nan L,Jacko AM,Tan J,Wang D,Zhao J,Kass DJ,Ma H,Zhao Y

    更新日期:2016-09-08 00:00:00

  • Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy.

    abstract::Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5'-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-onset severe seizures and subsequent encephalopathy. At present, 27 path...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70598-7

    authors: Barile A,Nogués I,di Salvo ML,Bunik V,Contestabile R,Tramonti A

    更新日期:2020-08-12 00:00:00

  • Phytoplankton alpha diversity indices response the trophic state variation in hydrologically connected aquatic habitats in the Harbin Section of the Songhua River.

    abstract::The relationship between biodiversity and ecological functioning is a central issue in freshwater ecology, but how this relationship is influenced by hydrological connectivity stress is still unknown. In this study we analyzed the dynamic of the phytoplankton alpha diversity indices and their relationships with trophi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78300-7

    authors: Meng F,Li Z,Li L,Lu F,Liu Y,Lu X,Fan Y

    更新日期:2020-12-07 00:00:00

  • Characterization and selection of functional yeast strains during sourdough fermentation of different cereal wholegrain flours.

    abstract::The increasing demand for healthy baked goods boosted studies on sourdough microbiota with beneficial metabolic traits, to be used as potential functional starters. Here, 139 yeasts isolated from cereal-based fermented foods were in vitro characterized for their phytase and antioxidant activities. The molecular charac...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69774-6

    authors: Palla M,Blandino M,Grassi A,Giordano D,Sgherri C,Quartacci MF,Reyneri A,Agnolucci M,Giovannetti M

    更新日期:2020-07-30 00:00:00