Abstract:
:Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared environment, and genetic correlations of fetal growth measures (abdominal circumference (AC), humerus length (HL), femur length (FL), and estimated fetal weight (EFW)) in a prospective cohort of dichorionic twin gestations recruited through the NICHD Fetal Growth Studies. Structural equation models were fit at the end of first trimester, during mid-gestation, late second trimester, and third trimester of pregnancy. The contribution of fetal genetics on fetal size increased with gestational age, peaking in late second trimester (AC = 53%, HL = 57%, FL = 72%, EFW = 71%; p < 0.05). In contrast, shared environment explained most of phenotypic variations in fetal growth in the first trimester (AC = 50%, HL = 54%, FL = 47%, EFW = 54%; p < 0.05), suggesting that the first trimester presents an intervention opportunity for a more optimal early fetal growth. Genetic correlations between growth traits (range 0.34-1.00; p < 0.05) were strongest at the end of first trimester and declined with gestation, suggesting that different fetal growth measures are more likely to be influenced by the same genes in early pregnancy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Workalemahu T,Grantz KL,Grewal J,Zhang C,Louis GMB,Tekola-Ayele Fdoi
10.1038/s41598-018-25706-zsubject
Has Abstractpub_date
2018-05-08 00:00:00pages
7274issue
1issn
2045-2322pii
10.1038/s41598-018-25706-zjournal_volume
8pub_type
杂志文章abstract::The malaria vaccine BK-SE36 is a recombinant protein (SE36) based on the Honduras 1 serine repeat antigen-5 of Plasmodium falciparum, adsorbed to aluminium hydroxide gel. The phase Ib trial in Uganda demonstrated the safety and immunogenicity of BK-SE36. Ancillary analysis in the follow-up study of 6-20 year-old volun...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/srep34363
更新日期:2016-10-05 00:00:00
abstract::Studies focusing on biofilm assembly in deep-sea environments are rarely conducted. To examine the effects of substrate type on microbial community assembly, biofilms were developed on different substrates for different durations at two locations in the Red Sea: in a brine pool and in nearby bottom water (NBW) adjacen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06647
更新日期:2014-10-17 00:00:00
abstract::Influenza virus is a significant cause of morbidity and mortality, with worldwide seasonal epidemics. The duration and quality of humoral immunity and generation of immunological memory to vaccines is critical for protective immunity. In the current study, we examined the long-lasting protective efficacy of chimeric V...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40226
更新日期:2017-01-09 00:00:00
abstract::The interpenetrating morphology formed by the electron donor and acceptor materials is critical for the performance of polymer:fullerene bulk heterojunction (BHJ) photovoltaic (PV) cells. In this work we carried out a systematic investigation on a high PV efficiency (>6%) BHJ system consisting of a newly developed 5,6...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05211
更新日期:2014-06-09 00:00:00
abstract::Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is present in domesticated mammals with a low mammary cancer incidence. Sp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77639-1
更新日期:2020-11-25 00:00:00
abstract::Drying and aging paint dispersions display a wealth of complex phenomena that make their study fascinating yet challenging. To meet the growing demand for sustainable, high-quality paints, it is essential to unravel the microscopic mechanisms underlying these phenomena. Visualising the governing dynamics is, however, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34383
更新日期:2016-09-29 00:00:00
abstract::Tench (Tinca tinca L.) is one of the most valued species of the Cyprinidae. This species is commercially important and has been intensively domesticated in recent years. To avoid excessive production losses, the health of farm fish must be maintained. Characterization of the tench gut microbiome can help achieve this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61351-1
更新日期:2020-03-10 00:00:00
abstract::Unlike individual, free-floating planktonic bacteria, biofilms are surface-attached communities of slow- or non-replicating bacteria encased within a protective extracellular polymeric matrix enabling persistent bacterial populations to tolerate high concentrations of antimicrobials. Our current antibacterial arsenal ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01045-3
更新日期:2017-05-17 00:00:00
abstract::Resin composites containing reinforcing inert glass fillers combined with bioactive glass (BG) can aid in the prevention of secondary caries, which is a major cause of failure of contemporary composite restorations. A series of previous studies on experimental resin composites filled with BG 45S5 has demonstrated that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54035-y
更新日期:2019-11-21 00:00:00
abstract::The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and the subsequent development of protocols for their differentiation into disease-relevant cell types have enabled in-depth molecular analyses of multiple disease states as hitherto impossible. Neurons differentiated from patient...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28420
更新日期:2016-06-24 00:00:00
abstract::The interfacial Dzyaloshinskii-Moriya interaction (DMI) is an essential ingredient for stabilizing chiral spin configurations in spintronic applications. Here, via first-principles calculations, we reveal the influence of lattice strain on DMI in Co/Pt interface. We observed a considerable enhancement for a certain la...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69360-w
更新日期:2020-07-23 00:00:00
abstract::In many real-world networks, the ability to withstand targeted or global attacks; extinctions; or shocks is vital to the survival of the network itself, and of dependent structures such as economies (for financial networks) or even the planet (for ecosystems). Previous attempts to characterise robustness include neste...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59959-4
更新日期:2020-02-25 00:00:00
abstract::In this paper, we present the design, fabrication and optical characterization of computer-generated holograms (CGH) encoding information for light beams carrying orbital angular momentum (OAM). Through the use of a numerical code, based on an iterative Fourier transform algorithm, a phase-only diffractive optical ele...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18147-7
更新日期:2017-12-21 00:00:00
abstract::Brain hypometabolism is a common epilepsy-related finding in both patients and animal models. Fluorodeoxyglucose positron emission tomography studies have shown that recurrent seizures lead to reduced glucose metabolism in certain brain regions, but no studies have definitively determined whether this induces epilepto...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05038-0
更新日期:2017-07-19 00:00:00
abstract::The influenza virus neuraminidase (NA) is essential for the virus life cycle. The rise of resistance mutations against current antiviral therapies has increased the need for the development of novel inhibitors. Recent efforts have targeted a cavity adjacent to the catalytic site (the 150-cavity) in addition to the pri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02871
更新日期:2013-10-16 00:00:00
abstract::The Lhasa terrane is a key region for understanding the paleoelevation of the southern Tibetan Plateau after India-Asia collision. The Gerze Basin, located in the northern part of the Lhasa terrane, is a shortening-related basin. We discovered Lagena laevis (Bandy) fossils in upper Eocene strata of the Gerze Basin. Th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27508
更新日期:2016-06-08 00:00:00
abstract::Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39345-5
更新日期:2019-02-22 00:00:00
abstract::We aimed to investigate the association of smoking and physical exercise on ventricular function and structure, determined by cardiac magnetic resonance imaging (CMR), in subjects without known cardiovascular diseases. A total of 381 participants (median age 57 years) of the Cooperative Health Research in the Region o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54956-8
更新日期:2019-12-09 00:00:00
abstract::Fiber lasers with flexible spectral manipulation property could provide a flexible tool for scenes where the temporal coherence property accounts, for example, coherent sensing/communication and nonlinear frequency conversion. Due to the good laser performance and relative simplicity of implementation, random fiber la...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20664-y
更新日期:2018-02-01 00:00:00
abstract::The morphology of hexagonal phase NaYF4:Er(3+) nanorods synthesized by hydrothermal method changed greatly after a continuing calcination, along with a phase transformation to cubic phase. Photoluminescence (PL) spectra indicated that mid-infrared (MIR) emission was obtained in both hexagonal and cubic phase NaYF4:Er(...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29871
更新日期:2016-07-25 00:00:00
abstract::Photosynthetic activity is indispensable for plant growth and survival and it depends on the synthesis of plastidial isoprenoids as chlorophylls and carotenoids. In the non-mevalonate pathway (MEP), the 1-deoxy-D-xylulose-5-phosphate synthase 1 (DXS1) enzyme has been postulated to catalyze the rate-limiting step in th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45333
更新日期:2017-03-28 00:00:00
abstract::Leaf functional traits have attracted the attention of ecologists for several decades, but few studies have systematically assessed leaf morphological traits (termed "economic traits"), stomatal (termed "hydraulic"), and anatomical traits of entire forest communities, thus it is unclear whether their relationships are...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42335-2
更新日期:2019-04-09 00:00:00
abstract::Liver segmentation is an essential procedure in computer-assisted surgery, radiotherapy, and volume measurement. It is still a challenging task to extract liver tissue from 3D CT images owing to nearby organs with similar intensities. In this paper, an automatic approach integrating multi-dimensional features into gra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28787-y
更新日期:2018-07-16 00:00:00
abstract::Brain diseases including neurological disorders and tumors remain under treated due to the challenge to access the brain, and blood-brain barrier (BBB) restricting drug delivery which, also profoundly limits the development of pharmacological treatment. Focused ultrasound (FUS) with microbubbles is the sole method to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25904-9
更新日期:2018-05-22 00:00:00
abstract::We study the effects of electrical and chemical autapse on the temporal coherence or firing regularity of single stochastic Hodgkin-Huxley neurons and scale-free neuronal networks. Also, we study the effects of chemical autapse on the occurrence of spatial synchronization in scale-free neuronal networks. Irrespective ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30914
更新日期:2016-08-02 00:00:00
abstract::Topical anesthetics are widely applied in order to relieve the discomfort and anxiety caused by needle insertion and other painful superficial interventions at the oral cavity. So far, there are no commercially available effective topical anesthetic formulations for that purpose, and the most of developments are relat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68247-0
更新日期:2020-07-09 00:00:00
abstract::In community ecology, it is important to understand the distribution of communities along environmental and spatial gradients. However, it is common for the residuals of models investigating those relationships to be very high (> 50%). It is believed that species' intrinsic characteristics such as rarity can contribut...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76833-5
更新日期:2020-11-13 00:00:00
abstract::Malaria-associated acute lung injury (ALI) is a frequent complication of severe malaria that is often caused by "excessive" immune responses. To better understand the mechanism of ALI in malaria infection, here we investigated the roles of galectin (Gal)-1, 3, 8, 9 and the receptors of Gal-9 (Tim-3, CD44, CD137, and P...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32024
更新日期:2016-08-24 00:00:00
abstract::Converging evidence has proved the attentional bias of Internet addicts (IAs) on network information. However, previous studies have neither explained how characteristics of network information are detected by IAs with priority nor proved whether this advantage is in line with the unconscious and automatic process. To...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25442-4
更新日期:2018-06-12 00:00:00
abstract::Relocation of earthquakes recorded by the agency for meteorology, climatology and geophysics (BMKG) in Indonesia and inversions of global positioning system (GPS) data reveal clear seismic gaps to the south of the island of Java. These gaps may be related to potential sources of future megathrust earthquakes in the re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72142-z
更新日期:2020-09-17 00:00:00